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Araceli Jarquin Campos, Lorenz Risch, Marc Baumann, Mette-Triin Purde, Sebastian Neuber, Harald Renz, Beatrice Mosimann, Luigi Raio, Markus Mohaupt, Daniel Surbek, Martin Risch
Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine. Pregnant women with evidence of SPS during the first trimester have an increased risk of developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized markers of endothelial dysfunction. The aim of this nested case-control study was to establish first-trimester reference intervals (RI) for markers of NO metabolism and to study these markers in women with evidence of SPS at the end of the first trimester...
February 20, 2019: Scandinavian Journal of Clinical and Laboratory Investigation
Luana Rossato, Erico S Loreto, Tarcieli P Venturini, Maria Isabel de Azevedo, Abdullah M S Al-Hatmi, Janio M Santurio, Sydney H Alves
Cryptococcus species are an encapsulated fungal pathogen that cause cryptococcal meningitis. There are limited therapeutic options for this infection. The management includes the use of different antifungals such as amphotericin B, flucytosine, or fluconazole, either alone or in combination. However, numerous therapeutic failures, as well as the limited effectiveness of such therapeutics, have been described. Diphenyl diselenide is a chemically synthesized molecule with was found to have antimicrobial activity...
February 18, 2019: Mycoses
Yao Wang, Xin-Fei Chen, Xiu-Li Xie, Meng Xiao, Yang Yang, Ge Zhang, Jing-Jia Zhang, Si-Meng Duan, Qian Zhang, Peng Zhang, Clement Tsui, Ying-Chun Xu
BACKGROUND AND PURPOSE: Bacteroides fragilis group isolates are most frequently isolated anaerobic pathogens. This study aimed to evaluate the accuracy of VITEK MS, Clin-ToF-II MS, Autof MS 1000 and VITEK 2 ANC card on the identification of clinical B. fragilis group isolates, as well as to determine their antimicrobial susceptibilities. METHODS: A total of 138 isolates of B. fragilis group isolates were identified with the three MALDI-TOF MS systems and VITEK 2 ANC cards...
January 4, 2019: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Sergio García-Fernández, María García-Castillo, German Bou, Jorge Calvo, Emilia Cercenado, Mercedes Delgado, Cristina Pitart, Xavier Mulet, Nuria Tormo, Diego López Mendoza, Jazmín Díaz-Regañón, Rafael Cantón
Patients in intensive care units (ICUs) present a high risk of developing an infection caused by multi-drug resistant (MDR) bacteria. Consequently, new antimicrobials and combinations are needed. We evaluated the activity of ceftolozane-tazobactam against Enterobacterales (n=400) and Pseudomonas aeruginosa (n=80) isolates collected from patients in Spanish intensive care units (ICUs) with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). Overall susceptibility of ceftolozane-tazobactam in P...
February 12, 2019: International Journal of Antimicrobial Agents
Mariëlle Rockland, Mike Marvin Ruth, Nicole Aalders, Lian Pennings, Wouter Hoefsloot, Melanie Wattenberg, Jakko van Ingen
Nontuberculous mycobacteria (NTM) cause severe opportunistic infections and have a rising incidence in most settings. Rising diagnostic need must be met by national reference laboratories, which rely on Clinical & Laboratory Standards Institute (CLSI) guideline approved manual readout of microtiter plates for antimicrobial susceptibility testing (AST) to determine antibiotic minimum inhibitory concentrations (MICs). Interpretation of these plates leads to different outcomes between laboratories. The SensiTitre™ Vizion™ Digital MIC Viewing System (Vizion) offers a more streamlined approach using semi-automated reading...
February 13, 2019: Journal of Clinical Microbiology
Melinda A B Petrina, Lisa A Cosentino, Harold C Wiesenfeld, Toni Darville, Sharon L Hillier
The CDC recommended outpatient treatment of pelvic inflammatory disease (PID) is an intramuscular dose of ceftriaxone plus 14 days of doxycycline, with or without metronidazole. European guidelines (2017) include moxifloxacin plus ceftriaxone as a first line regimen, particularly for women with Mycoplasma genitalium-associated PID. However, the susceptibility of bacteria recovered from the endometrium of women with PID to moxifloxacin is unknown. The in vitro antibiotic susceptibility of facultative and anaerobic bacteria recovered from endometrial biopsy samples were evaluated from 105 women having symptomatic PID and/or histologically confirmed endometritis...
February 9, 2019: Anaerobe
Ashutosh Singh, Pradeep K Singh, Theun de Groot, Anil Kumar, Purva Mathur, Bansidhar Tarai, Neelam Sachdeva, Gargi Upadhyaya, Smita Sarma, Jacques F Meis, Anuradha Chowdhary
Objectives: The emergence of fluconazole resistance in Candida parapsilosis healthcare-associated infections has recently been increasingly reported. Antifungal susceptibility profiles and mechanisms of fluconazole resistance in C. parapsilosis (n = 199) from nine hospitals in India collected over a period of 3 years were studied. Further, clonal transmission of fluconazole-resistant isolates in different hospitals was investigated. Methods: Antifungal susceptibility testing of five azoles, amphotericin B and 5-flucytosine was performed by the CLSI microbroth dilution method...
February 11, 2019: Journal of Antimicrobial Chemotherapy
Olga Rivero-Menendez, Manuel Cuenca-Estrella, Ana Alastruey-Izquierdo
Background: APX001A (E1210) is a novel broad-spectrum antifungal agent that inhibits Gwt1p, a protein that plays an important role in fungal cell wall integrity. Previous studies have shown that APX001A has broad activity against most species of Candida, Aspergillus, Scedosporium, Fusarium and Mucorales. Objectives: To investigate the in vitro activity of APX001A against 200 isolates belonging to 20 different species of Fusarium, Scedosporium, Lomentospora, Alternaria, cryptic species of Aspergillus and Mucorales...
February 6, 2019: Journal of Antimicrobial Chemotherapy
Helio S Sader, Rodrigo E Mendes, Michael A Pfaller, Robert K Flamm
Background: The management of endocarditis requires aggressive and prolonged antimicrobial treatment. We evaluated the in vitro activity of dalbavancin against bacteria from patients with infective endocarditis. Methods: A total of 626 Gram-positive organisms were collected from patients with a diagnosis of bacterial endocarditis in the USA (n = 222) and Europe (n = 404) from 2007 to 2017 via the SENTRY Antimicrobial Surveillance Program and were tested for susceptibility to dalbavancin and comparators by broth microdilution...
February 7, 2019: Journal of Antimicrobial Chemotherapy
Mohammad T Hedayati, Mahin Tavakoli, Maedeh Maleki, Somaye Heidari, Vida Mortezaee, Maryam Gheisari, Maryam Hassanzad, Maryam Sadat Mirenayat, Seyed Alireza Mahdaviani, Mihan Pourabdollah, Ali Akbar Velayati, Mahshid Vakili, Mahdi Abastabar, Iman Haghani, Jalal Jafarzadeh, Newsha Hedayati, Seyedmojtaba Seyedmousavi, Ana Alastruey-Izquierdo
In this present study, for the first time, we evaluated the cystic fibrosis (CF) patients for the Scedosporium species and their antifungal susceptibility against eight antifungal agents. During one-year period, 90 Sputum samples were collected from Iranian CF patients. All samples were evaluated by direct microscopic examination, culture onto four different media including Malt extract agar, Inhibitory mold agar, Brain Heart Infusion and Scedo-Select III. The mold isolated fungi were identified by PCR-Sequencing of ITS and β-tubulin genes...
February 8, 2019: Microbial Pathogenesis
Wei-Lun Liu, Yu-Tsung Huang, Min-Han Hsieh, Ing-Moi Hii, Yu-Lin Lee, Mao-Wang Ho, Chun-Eng Liu, Yen-Hsu Chen, Fu-Der Wang
Candida tropicalis is the second most common Candida species causing fungaemia in Taiwan, and decreased susceptibility to fluconazole has been reported. This study analysed the clinical characteristics of adult patients with C. tropicalis fungaemia and the antifungal susceptibilities of isolates at five tertiary hospitals in Taiwan (1 July 2011 to 30 June 2014). A standardised case record form was used retrospectively to collect demographic, clinical and microbiological characteristics, antifungal treatment and outcomes...
February 2019: International Journal of Antimicrobial Agents
Yuqi Yang, Yixin Zhang, Jiarui Li, Ping Cheng, Tianshi Xiao, Ishfaq Muhammad, Hongxiao Yu, Ruimeng Liu, Xiuying Zhang
BACKGROUND: Improper use of antimicrobials results in poor treatment and severe bacterial resistance. Breakpoints are routinely used in the clinical laboratory setting to guide clinical decision making. Therefore, the objective of this study was to establish antimicrobial susceptibility breakpoints for danofloxacin against Escherichia coli (E.coli), which is an important pathogen of digestive tract infections. RESULTS: The minimum inhibitory concentrations (MICs) of 1233 E...
February 4, 2019: BMC Veterinary Research
Deepti Singh, Rebecca Mendonsa, Mrunesh Koli, Mahesh Subramanian, Sandip Kumar Nayak
Structure-activity relationship (SAR) studies have led to significant improvement in desirable biological activity in different classes of molecules. A general consensus about the substitutions that improve the activity remains elusive in stilbene class of molecules especially in regard to antibacterial activity. Lack of this knowledge remains a major hurdle in developing stilbene based antibacterial molecules. A panel of gram positive and gram negative bacteria were employed for screening the comparative efficacy of the stilbenes...
January 31, 2019: Toxicology and Applied Pharmacology
Ebrahim Kouhsari, Masoumeh Douraghi, Marcela Krutova, Hashem Fakhre Yaseri, Malihe Talebi, Zohreh Baseri, Vahid Moqarabzadeh, Mohammad Sholeh, Nour Amirmozafari
OBJECTIVES: Clostridium difficile is the main causative agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis (PMC). The accumulation of antimicrobial resistance in C. difficile strains can drive Clostridium difficile infection (CDI) epidemiology. This study was undertaken in order to evaluate the antimicrobial resistance patterns of toxigenic C. difficile isolates cultured from diarrhoeal stool samples of hospitalised patients with suspected CDI in three tertiary care hospitals in Tehran, Iran...
January 28, 2019: Journal of Global Antimicrobial Resistance
Muna Salah, Issa Shtayeh, Raed Ghneim, Randa Al-Qass, Ali Sabateen, Hiyam Marzouqa, Musa Hindiyeh
Azithromycin has been recommended by the American Academy of Pediatrics for treatment of shigellosis in children. In this study 502 Shigella species isolated between 2004-2014 were tested for azithromycin epidemiological cutoff values (ECV) by disk diffusion. Azithromycin MIC and the presence of the macrolide resistance genes [ erm(A), erm(B), erm(C), ere(A), ere(B), mph(A), mph(B), mph(D), mef(A), msr(A )] were determined on all 56 (11.1%) isolates with azithromycin ≤15mm disk diffusion diameter. The distribution of azithromycin ECV MIC's was also determined on 186 Shigella isolates with disk diffusion diameter ≥16 mm...
January 30, 2019: Journal of Clinical Microbiology
Lok Bahadur Shrestha, Ratna Baral, Prakash Poudel, Basudha Khanal
BACKGROUND: Urinary tract infection (UTI) is one of most common pediatric infections. The study was designed to assess the clinical profile, common bacterial microorganisms causing UTI and their antimicrobial susceptibility patterns at B. P. Koirala Institute of Health Sciences (BPKIHS) hospital. METHODS: This is a prospective cross-sectional study conducted at Department of Microbiology and Infectious Diseases for 6 months (January to June 2018). A total of 1962 non-repetitive urine specimens (midstream, nappy pad, catheter aspirated) of pediatric patients (0-14 years age) suspected of UTI were obtained in the Microbiology laboratory...
January 29, 2019: BMC Pediatrics
Pham Hong Nhung, Vu Ho Van, Nguyen Quoc Anh, Doan Mai Phuong
OBJECTIVES: Antimicrobial suceptibility pattern of clinical Burkholderia pseudomallei in Vietnam has not reported since the first publication in 2008. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary referral center in Hanoi from January 2012 to December 2017. METHODS: A total of 312 B. pseudomallei isolates obtained from meliodiosis patients admited in 2000-bed general hospital were analyzed by Etest method...
January 24, 2019: Journal of Global Antimicrobial Resistance
Özlem Akışoğlu, Doruk Engin, Seyyide Sarıçam, Hamit Kaan Müştak, Burçin Şener, Gülşen Hasçelik
Burkholderia spp. emerged as important pathogens in the airways of immunocompromised humans, especially those with cystic fibrosis (CF). Failure of identification with conventional techniques, high intrinsic resistance to most antibiotics and biofilm formation can cause difficulties in the treatment of these infections. The aim of this study was to identify Burkholderia spp. strains isolated from CF and non-CF patients with with routine microbiological methods, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and multilocus sequence analysis (MLSA), to determine of the antibiotic susceptibility and synergies, and to evaluate biofilm formation of these isolates...
January 2019: Mikrobiyoloji Bülteni
Vaishali A Kongre, Sae S Pol, Renu S Bharadwaj, Yogesh K Gurav, Mandeep S Chadha, Babasaheb V Tandale, Avinash R Deoshatwar
Influenza-like illness (ILI) and acute respiratory infection (ARI) are common presentations during winter, and indiscriminate antibiotic use contributes significantly to the emerging post-antibiotic era. Although viral agents causing ILI are predominant, they are indistinguishable from the bacterial agents based on the clinical features alone. The present study was aimed at determining the bacterial agents associated with ILI and their susceptibility pattern during a study done in a community setting in Pune during a surveillance of ILI between March 2013 to November 2016...
November 16, 2018: Curēus
Ing-Moi Hii, Chun-Eng Liu, Yu-Lin Lee, Wei-Lun Liu, Ping-Feng Wu, Min-Han Hsieh, Mao-Wang Ho, Yen-Hsu Chen, Fu-Der Wang
Purpose: In 2012, the Clinical and Laboratory Standards Institute (CLSI) revised its breakpoints for drugs and species because of the increase in non- albicans Candida infections and their drug resistance. Following global trends, the non- albicans candidemia resistance rate has increased in Taiwan as well. To update the antifungal susceptibility of non- albicans candidemia isolates, we conducted a multicenter study using the revised break points. Patients and methods: Patients with non- albicans candidemia infections were identified at five tertiary hospitals in Taiwan from July 1, 2011, to June 30, 2014...
2019: Infection and Drug Resistance
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