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Huiming Cheng

Lan Cheng, Huiming Huang, Jingyou Zeng, Zulan Liu, Xiaoling Tong, Zhi Li, Hongping Zhao, Fangyin Dai
In this study, eight types of materials including nanoparticles (Cu and CaCO₃), metallic ions (Ca2+ and Cu2+ ), and amino acid substances (serine, tyrosine, sericin amino acid, and fibroin amino acid) were used as additives in silkworm diets to obtain in-situ modified silk fiber composites. The results indicate that tyrosine and fibroin amino acids significantly increase potassium content in silk fibers and induce the transformation of α-helices and random coils to β -sheet structures, resulting in higher crystallinities and better mechanical properties...
December 20, 2018: Materials
Jun Liu, Yuhui Zhao, Zhonghua Cheng, Huiming Zhang
Based on panel data on 285 Chinese cities from 2003 to 2012, we use a dynamic spatial panel model to empirically analyze the effect of manufacturing agglomeration on haze pollution. The results show that when economic development levels, population, technological levels, industrial structure, transportation, foreign direct investment, and greening levels are stable, manufacturing agglomeration significantly aggravates haze pollution. However, region-specific analysis reveals that the effects of manufacturing agglomeration on inter-regional haze pollution depends on the region: the effect of manufacturing agglomeration on haze pollution is the largest in the Western region, followed by the Central region, and is the least in the Eastern region...
November 8, 2018: International Journal of Environmental Research and Public Health
Xiang'zi Leng, Xin Qian, Meng Yang, Cheng Wang, Huiming Li, Jinhua Wang
The aim of this study was to establish a method for predicting heavy metal concentrations in PM2.5 (particulate matter with a diameter of less than 2.5 μm) using support vector machine (SVM) models combined with magnetic properties of leaves. In this study, PM2.5 samples and the leaves of three common evergreen tree species were collected simultaneously during four different seasons in Nanjing, China. A SVM algorithm was used to establish models for the prediction of airborne heavy metal concentrations based on leaf magnetic properties, with or without meteorological factors and pollutant concentrations as input variables...
November 2018: Environmental Pollution
Dong-Lei Yang, Guiping Zhang, Lili Wang, Jingwen Li, Dachao Xu, Cuiru Di, Kai Tang, Lan Yang, Liang Zeng, Daisuke Miki, Cheng-Guo Duan, Huiming Zhang, Jian-Kang Zhu
DNA methylation is a conserved epigenetic mark that is critical for many biological processes in plants and mammals. In Arabidopsis, the antagonistic activities of RNA-directed DNA methylation (RdDM) and ROS1-dependent active DNA demethylation are key for the dynamic regulation of locus-specific DNA methylation. However, the molecular factors that coordinate RdDM and active demethylation are largely unknown. Here we report that CLSY4 and its three paralogous SWI2/SNF2-type chromatin-remodeling proteins function in both RdDM and DNA demethylation in Arabidopsis...
2018: Cell Discovery
Xiaofeng Su, Guoqing Lu, Latifur Rehman, Xiaokang Li, Lu Sun, Huiming Guo, Hongmei Cheng
Verticillium dahliae is a soil-borne phytopathogenic fungus that causes a destructive vascular wilt, but details of the molecular mechanism behind its pathogenicity are not very clear. Here, we generated a red fluorescent isolate of V. dahliae by protoplast transformation to explore its pathogenicity mechanism, including colonization, invasion, and extension in Nicotiana benthamiana , using confocal microscopy. The nucleotide sequences of mCherry were optimized for fungal expression and cloned into pCT-HM plasmid, which was inserted into V...
October 18, 2018: Genes
Xiaofeng Su, Guoqing Lu, Huiming Guo, Kaixuan Zhang, Xiaokang Li, Hongmei Cheng
Verticillium wilt caused by the soil-borne fungus Verticillium dahliae is a common, devastating plant vascular disease notorious for causing economic losses. Despite considerable research on plant resistance genes, there has been little progress in modeling the effects of this fungus owing to its complicated pathogenesis. Here, we analyzed the transcriptional and metabolic responses of Arabidopsis thaliana to V. dahliae inoculation by Illumina-based RNA sequencing (RNA-seq) and nuclear magnetic resonance (NMR) spectroscopy...
October 18, 2018: Scientific Reports
Weihua Long, Maolong Hu, Jianqin Gao, Song Chen, Jiefu Zhang, Li Cheng, Huiming Pu
Rapeseed ( Brassica napus L.) is a vital oil crop worldwide. High oleic acid content is a desirable quality trait for rapeseed oil, which makes it more beneficial to human health. However, many germplasm resources with high oleic acid content in rapeseed have not been evaluated with regard to their genotypes, making it difficult to select the best strains with this trait for the breeding of high oleic acid rapeseed variety. This work was to explore the gene-regulation mechanism of this trait using a new super-high oleic acid content (∼85%) line N1379T as genetic material...
2018: Frontiers in Genetics
Tong Han, Yan Wang, Mingying Wang, Xu Li, Keguang Cheng, Xiang Gao, Zhanlin Li, Jiao Bai, Huiming Hua, Dahong Li
To explore antitumor agents with potent efficacy and low toxicity, scutellarein derivatives with benzoic acid mustard (10a-c, 11a-c and 13a-c) were designed and synthesized. The antiproliferative activities of the target derivatives against A549, MCF-7 and Bel-7402 cancer cell lines were tested. Compound 10a showed the strongest potency with an IC50 value of 1.50 μM against MCF-7 cell line, and displayed low toxicity against human liver L-O2 normal cells (IC50  > 50 μM), showing specificity between normal and malignant cells...
October 5, 2018: European Journal of Medicinal Chemistry
Ningbo Qin, Tatsunori Sasaki, Wei Li, Jian Wang, Xiangyu Zhang, Dahong Li, Zhanlin Li, Maosheng Cheng, Huiming Hua, Kazuo Koike
Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7), dehydrosilychristin A (8), and silydianin (11) were identified as a novel class of natural PTP1B inhibitors (IC50 1.3 7-23.87 µM). Analysis of structure-activity relationship suggested that the absolute configurations at C-7" and C-8" greatly affected the PTP1B inhibitory activity...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
Meng He, Xiaoyi Chen, Kui Cheng, Lingqing Dong, Wenjian Weng, Huiming Wang
Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO2 nanorod film incorporated with Zn-containing bioactive glass (TiO2 /Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO2 /Zn-BG film were significantly upregulated compared to that of the film without TiO2 nanorod nanostructure (Zn-BG) or without Zn (TiO2 /BG)...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Qi Yan, Yuan Song, Lu Zhang, Zhaowei Chen, Cheng Yang, Shan Liu, Xiaohan Yuan, Hongyu Gao, Guohua Ding, Huiming Wang
Sustained activation of autophagy and lipid accumulation in tubular epithelial cells (TECs) are both associated with the kidney fibrosis progression. Autophagy has been found involved in the lipid metabolism regulation through a bi-directional mechanism of inducing lipolysis as well as promoting lipid droplet formation. However, whether and how autophagy influences lipid accumulation in kidney fibrosis remain unclear. In the current study, we show that UUO-induced lipid accumulation in tubular cells was significantly reduced when the pharmacological inhibitor 3-MA or CQ was administrated both in vivo and in vitro...
2018: Cell Death Discovery
Huiming Zhu, Hang Xia, Yawei Guo, Cheng Peng
This paper empirically examines the effects of urbanization and income inequality on CO2 emissions in the BRICS economies (i.e., Brazil, Russia, India, China, and South Africa) during the periods 1994-2013. The method we used is the panel quantile regression, which takes into account the unobserved individual heterogeneity and distributional heterogeneity. Our empirical results indicate that urbanization has a significant and negative impact on carbon emissions, except in the 80th , 90th , and 95th quantiles...
June 2018: Environmental Science and Pollution Research International
Huiming Wang, Yujuan Wang, Jili Zhu, Xinghua Chen, Cheng Chen, Cuizhi Xiang, Houjun Jia, Guohua Ding
Percutaneous insertion of peritoneal dialysis catheters is theoretically most preferred by nephrologists because of the advantages of bedside performing, surgery independence, and minimal injury over other procedures of catheter placement such as open surgical dissection or laparoscopic operation. However, blindly placing catheters in the percutaneous procedure brings the risk of catheter malposition or bowel perforation; this largely retarded it's implementation. We had previously developed a novel technique termed "Wang's forceps-assisted catheter insertion and fixation," which had been successfully applied in the open surgical catheter insertion and displaced catheter reposition in our center...
July 2018: Artificial Organs
Xiaozhao Wang, Zun Chen, Beibei Zhou, Xiyue Duan, Wenjian Weng, Kui Cheng, Huiming Wang, Jun Lin
Extracellular matrix (ECM) provides a dynamic and complex environment to determine the fate of stem cells. In this work, light harvested cell sheets were treated with paraformaldehyde or ethanol, which eventually become ECM. Such ECM was then immobilized on titanium substrates via polydopamine chemistry. Their effects on bone marrow mesenchymal stromal cells (BMSCs) behaviors were investigated. It was found that paraformaldehyde-treated ECM coating (PT-ECM) showed a well-maintained microstructure, whereas that of ethanol-treated (ET-ECM) was completely changed...
April 11, 2018: ACS Applied Materials & Interfaces
Xiliang Qi, Xiaokang Li, Huiming Guo, Ning Guo, Hongmei Cheng
The soil-borne ascomycete fungus Verticillium dahliae causes vascular wilt disease and can seriously diminish the yield and quality of important crops. Functional analysis of growth- and pathogenicity-related genes is essential for revealing the pathogenic molecular mechanism of V. dahliae . Phospholipase is an important virulence factor in fungi that hydrolyzes phospholipids into fatty acid and other lipophilic substances and is involved in hyphal development. Thus far, only a few V. dahliae phospholipases have been identified, and their involvement in V...
March 13, 2018: Genes
Shihong Yan, Jing Zhao, Deqiong Xie, Xiuying Huang, Jinlong Cheng, Ye Guo, Changqing Liu, Zhijun Ma, Huiming Yang, Guozhong Zhang
Avian infectious bronchitis (IB) is a highly contagious disease caused by avian infectious bronchitis virus (IBV), which is a considerable economic threat to the poultry industry. QX-like IBV strains have increasingly emerged in China in recent years. Hence, development of a specific vaccine to guard against their potential threat is important. In this study, we sought to develop an attenuated vaccine strain. First, attenuated QX-like IBV strain SZ130 was created by continuous passage in chicken embryos for 130 generations, and then its safety was tested...
March 27, 2018: Vaccine
Shayuan Weng, Huiming Ning, Tao Fu, Ning Hu, Yinbo Zhao, Cheng Huang, Xianghe Peng
Molecular dynamics simulations of nanolaminated graphene/Cu (NGCu) and pure Cu under compression are conducted to investigate the underlying strengthening mechanism of graphene and the effect of lamella thickness. It is found that the stress-strain curves of NGCu undergo 3 regimes i.e. the elastic regime I, plastic strengthening regime II and plastic flow regime III. Incorporating graphene monolayer is proved to simultaneously contribute to the strength and ductility of the composites and the lamella thickness has a great effect on the mechanical properties of NGCu composites...
February 15, 2018: Scientific Reports
Xiaohui Yu, Jinlong Cheng, Zirong He, Chuang Li, Yang Song, Jia Xue, Huiming Yang, Rui Zhang, Guozhong Zhang
The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene significantly influenced viral replication. Here, we investigated the roles of certain amino acid residues in the NP C-terminus in viral replication and virulence. Results showed that the glutamic acid residue at position 402 (E402) in the C-terminus of the NP is critical for RNA synthesis in the NDV mini-genome system...
December 12, 2017: Scientific Reports
Latifur Rehman, Xiaofeng Su, Xiaokang Li, Xiliang Qi, Huiming Guo, Hongmei Cheng
Ferric reductases are integral membrane proteins involved in the reduction of environmental ferric iron into the biologically available ferrous iron. In the most overwhelming phytopathogenic fungus, Verticillium dahliae, these ferric reductase are not studied in details. In this study we explored the role of FreB gene (VDAG_06616) in the ferric reduction and virulence of V. dahliae by generating the knockout mutants (ΔFreB) and complementary strains (ΔFreB-C) using protoplast transformation. When cultured on media supplemented with FeSO4 , FeCl3 and no iron, ΔFreB exhibited significantly reduced growth and spore production especially on media with no iron...
June 2018: Current Genetics
Viktor A Adalsteinsson, Gavin Ha, Samuel S Freeman, Atish D Choudhury, Daniel G Stover, Heather A Parsons, Gregory Gydush, Sarah C Reed, Denisse Rotem, Justin Rhoades, Denis Loginov, Dimitri Livitz, Daniel Rosebrock, Ignaty Leshchiner, Jaegil Kim, Chip Stewart, Mara Rosenberg, Joshua M Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, Paz Polak, Max Lloyd, Sairah Mahmud, Karla Helvie, Margaret S Merrill, Rebecca A Santiago, Edward P O'Connor, Seong H Jeong, Rachel Leeson, Rachel M Barry, Joseph F Kramkowski, Zhenwei Zhang, Laura Polacek, Jens G Lohr, Molly Schleicher, Emily Lipscomb, Andrea Saltzman, Nelly M Oliver, Lori Marini, Adrienne G Waks, Lauren C Harshman, Sara M Tolaney, Eliezer M Van Allen, Eric P Winer, Nancy U Lin, Mari Nakabayashi, Mary-Ellen Taplin, Cory M Johannessen, Levi A Garraway, Todd R Golub, Jesse S Boehm, Nikhil Wagle, Gad Getz, J Christopher Love, Matthew Meyerson
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate or breast cancers. In the earliest tested sample for each patient, 34% of patients have ≥10% tumor-derived cfDNA, sufficient for standard coverage whole-exome sequencing...
November 6, 2017: Nature Communications
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