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Live vaccines after IVIG

J Bartolomé, F Porta, A Lafranchi, J J Rodríguez-Molina, E Cela, A Cantalejo, E Fernández-Cruz, A Gómez-Pineda, A G Ugazio, L D Notarangelo, J Gil
An in utero paternal CD34(+) cell transplant was performed in a T-B+NK+ SCID fetus. We report here the results of the 3-year humoral immune reconstitution study. The methods used were ApoB VNTR typing, flow cytometry, nephelometry, hemagglutination, ELISA, ELISPOT and lymphoproliferative assays. The T cells were of donor origin whereas monocytes, B and NK cells were of host origin. Peripheral B cell counts and IgM levels were normal since birth. IVIG therapy was required at 5 months of age until 2 years old...
April 2002: Bone Marrow Transplantation
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