Vinit Upasani, Katie Townsend, Mary Y Wu, Edward J Carr, Agnieszka Hobbs, Giulia Dowgier, Martina Ragno, Lou S Herman, Sonal Sharma, Devesh Shah, Simon F K Lee, Neil Chauhan, Julie M Glanville, Lucy Neave, Steven Hanson, Sriram Ravichandran, Aoife Tynan, Mary O'Sullivan, Fernando Moreira, Sarita Workman, Andrew Symes, Siobhan O Burns, Susan Tadros, Jennifer C L Hart, Rupert C L Beale, Sonia Gandhi, Emma C Wall, Laura McCoy, David M Lowe
BACKGROUND: Patients with antibody deficiency respond poorly to COVID-19 vaccination and are at risk of severe or prolonged infection. They are given long-term immunoglobulin replacement therapy (IRT) prepared from healthy donor plasma to confer passive immunity against infection. Following widespread COVID-19 vaccination alongside natural exposure, we hypothesised that immunoglobulin preparations will now contain neutralising SARS-CoV-2 spike antibodies which confer protection against COVID-19 disease and may help to treat chronic infection...
June 20, 2023: Clinical Infectious Diseases