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https://read.qxmd.com/read/30760409/cytoreductive-surgery-and-heated-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis-from-rare-etiologies
#1
Matthew Mah, Lloyd A Mack, Scott Hurton, Antoine Bouchard-Fortier
BACKGROUND: Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS/HIPEC) are commonly used in the treatment of peritoneal carcinomatosis (PC) originating from colorectal, appendiceal and ovarian cancers. It is unclear what benefit CRS/HIPEC might have for PC from uncommon etiologies, therefore we sought to describe local practice patterns and evaluate overall survival (OS). METHODS: All patients who had CRS/HIPEC between 2000 and 2016 were identified using our institutional cancer database...
January 25, 2019: American Journal of Surgery
https://read.qxmd.com/read/30753790/concentrations-of-interleukin-6-8-10-and-tumour-necrosis-factor-%C3%AE-in-the-faeces-of-dogs-with-acute-diarrhoea
#2
N Prakash, P Stumbles, C S Mansfield
AIM: To compare the concentration of faecal cytokines interleukin (IL)-6, -8, -10, and tumour necrosis factor (TNF)-α in dogs with acute diarrhoea with clinically normal (non-diarrhoeic) dogs. METHODS: A total of 14 dogs presenting with acute diarrhoea, and 25 dogs with no history of gastrointestinal signs in the 2 months prior to enrolment, were recruited from two veterinary hospitals in Melbourne, Australia. IL-6, -8, -10, and TNF-α were measured in faecal samples using canine-specific ELISA...
February 12, 2019: New Zealand Veterinary Journal
https://read.qxmd.com/read/30737053/intracorporeal-versus-extracorporeal-anastomosis-after-laparoscopic-gastrectomy-for-gastric-cancer-a-systematic-review-with-meta-analysis
#3
M Milone, M Manigrasso, M Burati, U Elmore, N Gennarelli, M Cesare Giglio, F Maione, M Musella, V Lo Conte, F Milone, G Domenico De Palma
AIM: To perform a systematic review and meta-analyses of studies comparing the totally laparoscopic procedures with intracorporeal anastomosis (IA) to laparoscopic-assisted surgery with extracorporeal anastomosis (EA) in gastric resections. METHODS: We performed a systematic search in the electronic databases. Outcomes analysed were: intraoperative (operative time and intraoperative blood loss), oncologic (harvested nodes, distance of the tumour from proximal and distal margin), postoperative complications (gastric stasis, intraluminal and extraluminal bleeding, leakage and wound infection) recovery (time to first flatus, time to first oral intake and hospital stay)...
February 5, 2019: Journal of Visceral Surgery
https://read.qxmd.com/read/30734017/international-benchmarking-in-oesophageal-and-gastric-cancer-surgery
#4
L A D Busweiler, M Jeremiasen, B P L Wijnhoven, M Lindblad, L Lundell, C J H van de Velde, R A E M Tollenaar, M W J M Wouters, J W van Sandick, J Johansson, J L Dikken
Background: Benchmarking on an international level might lead to improved outcomes at a national level. The aim of this study was to compare treatment and surgical outcome data from the Swedish National Register for Oesophageal and Gastric Cancer (NREV) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA). Methods: All patients with primary oesophageal or gastric cancer who underwent a resection and were registered in NREV or DUCA between 2012 and 2014 were included...
February 2019: BJS open
https://read.qxmd.com/read/30719067/antiproliferative-and-proapoptotic-effects-of-a-protein-component-purified-from-aspongopus-chinensis-dallas-on-cancer-cells-in-vitro-and-in-vivo
#5
Jun Tan, Ying Tian, Renlian Cai, Tianci Yi, Daochao Jin, Jianjun Guo
Aspongopus chinensis Dallas is used as a traditional Chinese medicine. In China, clinical evidence suggests that it has anticancer activity. However, the anticancer active components are not fully elucidated. In the present study, we purified an anticancer active component (named CHP) from A. chinensis. To gain a comprehensive insight into the protein components, shotgun proteomic analysis was conducted. The anticancer active protein band was cut from the sodium dodecyl sulphate-polyacrylamide gel electrophoresis gel and digested with trypsin to generate peptide mixture...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30717751/circular-rna-circnrip1-acts-as-a-microrna-149-5p-sponge-to-promote-gastric-cancer-progression-via-the-akt1-mtor-pathway
#6
Xing Zhang, Sen Wang, Haixiao Wang, Jiacheng Cao, Xiaoxu Huang, Zheng Chen, Penghui Xu, Guangli Sun, Jianghao Xu, Jialun Lv, Zekuan Xu
BACKGROUND: CircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation and development. 'MiRNA sponge' is the most reported role played by circRNAs in many tumours. The AKT/mTOR axis is a classic signalling pathway in cancers that sustains energy homeostasis through energy production activities, such as the Warburg effect, and blocks catabolic activities, such as autophagy. Additionally, the AKT/mTOR axis exerts a positive effect on EMT, which promotes tumour metastasis...
February 4, 2019: Molecular Cancer
https://read.qxmd.com/read/30717106/preventive-effect-of-blueberry-extract-on-liver-injury-induced-by-carbon-tetrachloride-in-mice
#7
Bihui Liu, Yuan Fang, Ruokun Yi, Xin Zhao
The blueberry is a common fruit that is rich in nutritional value and polyphenol substances. In this study, the blueberry polyphenol content in extract was analysed by spectrophotometry. The results showed that the blueberry polyphenol content in the extract reached 52.7%. A mouse model of liver injury induced by carbon tetrachloride (CCl₄) was established to study the preventive effect of blueberry extract (BE) on liver injury in mice and the experimental animals were examined using biochemical and molecular biological methods...
February 1, 2019: Foods (Basel, Switzerland)
https://read.qxmd.com/read/30714150/rn181-is-a-tumour-suppressor-in-gastric-cancer-by-regulation-of-the-erk-mapk-cyclin-d1-cdk4-pathway
#8
Suihai Wang, Xiaobo Wang, Yanjun Gao, Yingxia Peng, Ningning Dong, Qian Xie, Xian Zhang, Yingsong Wu, Ming Li, Ji-Liang Li
RN181, a RING finger domain-containing protein, is an E3 ubiquitin ligase. However, its biological function and clinical significance in cancer biology are obscure. Here, we report that RN181 expression is significantly down-regulated in 165 tumour tissues of gastric carcinoma (GC) versus adjacent non-tumour tissues, and inversely-associated with tumour differentiation, tumour size, clinical stage and patient's overall survival. Alterations of RN181 expression in GC cells by retrovirus-transduced up-regulation and down-regulation demonstrated that RN181 functions as a tumour suppressor to inhibit growth of GC in both in vitro culture and in vivo animal models by decreasing tumour cell proliferation and increasing tumour cell apoptosis...
February 3, 2019: Journal of Pathology
https://read.qxmd.com/read/30711967/the-effect-of-supplementary-omegaven%C3%A2-on-the-clinical-outcome-of-patients-with-advanced-esophagogastric-adenocarcinoma-receiving-palliative-epirubicin-oxaliplatin-and-capecitabine-chemotherapy-a-phase-ii-clinical-trial
#9
Amar M Eltweri, Anne L Thomas, Wen Y Chung, Bruno Morgan, John Thompson, Ashley R Dennison, David J Bowrey
BACKGROUND/AIM: Previous studies have shown anti-proliferative and anti-apoptotic effects of omega-3 fatty acids (Omegaven®) in vitro and in vivo. Whether this effect can be exploited in patients with advanced esophago-gastric adenocarcinoma is unknown. The present study intended to determine the tumour radiological response and toxicity profile of intravenous omega-3 fish oil infusion when combined with standard palliative chemotherapy, and present the effects of this treatment on plasma cytokine biomarkers...
February 2019: Anticancer Research
https://read.qxmd.com/read/30679589/huaier-n-butanol-extract-suppresses-proliferation-and-metastasis-of-gastric-cancer-via-c-myc-bmi1-axis
#10
Yiping Wang, Hang Lv, Zhiyuan Xu, Jiancheng Sun, Yixiu Ni, Zhe Chen, Xiangdong Cheng
Gastric cancer (GC) ranks as the third leading cause of cancer-related mortality worldwide, and approximately 42% of all cases diagnosed each year worldwide are diagnosed in China. A large number of clinical applications have revealed that Trametes robiniophila Μurr. (Huaier) exhibits an anti-tumour effect. However, loss of the bioactive components of Huaier during the extraction procedure with water is unavoidable, and the underlying mechanism of the anti-cancer effect of Huaier remains poorly understood...
January 24, 2019: Scientific Reports
https://read.qxmd.com/read/30679193/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-correlation-with-adverse-clinicopathological-features-and-patient-outcome
#11
Anjelica Hodgson, Ekaterina Olkhov-Mitsel, Brooke E Howitt, Marisa R Nucci, Carlos Parra-Herran
AIMS: The International Endocervical Adenocarcinoma Criteria and Classification (IECC) was recently proposed as an improved method for categorising endocervical adenocarcinoma (EA) into human papillomavirus (HPV)-associated adenocarcinomas (HPVAs) and non-HPV-associated adenocarcinomas (NHPVAs). Such categorisation correlates with patient age and tumour size; however, its association with patient outcome remains to be established. METHODS: Institutional cases of EA with histological material available were selected...
January 24, 2019: Journal of Clinical Pathology
https://read.qxmd.com/read/30677863/a-review-of-gastric-cancer-research-in-malaysia
#12
Kean Ghee Lim, Kandasami Palayan
Incidence rates of gastric cancer in Malaysia has declined by 48% among males and 31% among females in the latest reporting period of 13 years. Malays used to have age-standardized-rates only a fifth of those in Chinese and Indians, but the incidence among them is slightly rising even as the rates drop in the other races. Besides ethnicity, a low level of education, high intake of salted fish and vegetables, H pylori infection and smoking are risk factors. Consumption of fresh fruit and vegetable is protective...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/30677853/florid-cutaneous-papillomatosis-as-a-marker-of-neoplastic-recurrence
#13
M Esteves, I Antunes, F Azevedo
Florid cutaneous papillomatosis is a rare paraneoplastic dermatosis, most commonly associated with gastric adenocarcinoma. It is characterized by a sudden onset of hyperkeratotic papules, clinically indistinguishable from viral warts. We report an 80-year-old man who presented to our department with a two-month history of multiple verrucous lesions affecting the face, perioral region, and hands. Two years before, he was treated for a gastric adenocarcinoma with a subtotal gastrectomy, but showed no evidence of residual disease or recurrence...
August 15, 2018: Dermatology Online Journal
https://read.qxmd.com/read/30675305/plastin3-is-associated-with-epithelial-mesenchymal-transition-and-poor-prognosis-in-gastric-cancer
#14
Junji Kurashige, Takehiro Yokobori, Kosuke Mima, Genta Sawada, Yusuke Takahashi, Hiroki Ueo, Yuki Takano, Tae Matsumura, Ryutaro Uchi, Hidetoshi Eguchi, Tomoya Sudo, Keishi Sugimachi, Masaki Mori, Hideo Baba, Koshi Mimori
The plastin3 ( PLS3 ) gene, which encodes an actin bundling protein known to inhibit cofilin-mediated depolymerization of actin fiber, has been previously reported to serve an important role in the epithelial-mesenchymal transition (EMT) in cancer. The aim of the present study was to determine the clinical significance of PLS3 and its role in regulating EMT, as well as in promoting cell invasion and migration in gastric cancer. The expression of plastin3 mRNA was measured in 163 resected gastric cancer specimens, in order to determine the clinicopathological significance...
February 2019: Oncology Letters
https://read.qxmd.com/read/30661291/rps15a-promotes-gastric-cancer-progression-via-activation-of-the-akt-ikk-%C3%AE-nf-%C3%AE%C2%BAb-signalling-pathway
#15
Chenchen Liu, Xigan He, Xiaowen Liu, Jian Yu, Meng Zhang, Fudong Yu, Yanong Wang
This study aimed to investigate the clinical significance, potential biological function and underlying mechanism of RPS15A in gastric cancer (GC) progression. RPS15A expression was detected in 40 pairs of GC tissues and matched normal gastric mucosae (MNGM) using qRT-PCR analysis. Immunohistochemistry assay was conducted using a tissue microarray including 186 primary GC samples to characterize the clinical significance of RPS15A. A series of in vitro and in vivo assays were performed to elucidate the biological function of RPS15A in GC development and underlying molecular mechanisms...
January 19, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30661053/tumour-associated-macrophages-derived-cxcl8-determines-immune-evasion-through-autonomous-pd-l1-expression-in-gastric-cancer
#16
Chao Lin, Hongyong He, Hao Liu, Ruochen Li, Yifan Chen, Yangyang Qi, Qi Jiang, Lingli Chen, Peipei Zhang, Heng Zhang, He Li, Weijuan Zhang, Yihong Sun, Jiejie Xu
OBJECTIVE: Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, the regulatory effect of CXCL8 on immune surveillance in gastric cancer remains obscure. DESIGN: Flow cytometry analyses were performed to examine major source of CXCL8 and phenotypes of immune cells in fresh tumour tissues from 76 patients with gastric cancer. Real-time PCR was performed to analyse CXCL8 mRNA level in gastric cancer tissues...
January 19, 2019: Gut
https://read.qxmd.com/read/30661051/clinical-spectrum-and-pleiotropic-nature-of-cdh1-germline-mutations
#17
Joana Figueiredo, Soraia Melo, Patrícia Carneiro, Ana Margarida Moreira, Maria Sofia Fernandes, Ana Sofia Ribeiro, Parry Guilford, Joana Paredes, Raquel Seruca
CDH1 encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of function. E-cadherin is recognised as a tumour suppressor gene, and it is well established that CDH1 genetic alterations cause diffuse gastric cancer and lobular breast cancer-the foremost manifestations of the hereditary diffuse gastric cancer syndrome. However, in the last decade, evidence has emerged demonstrating that CDH1 mutations can be associated with lobular breast cancer and/or several congenital abnormalities, without any personal or family history of diffuse gastric cancer...
January 19, 2019: Journal of Medical Genetics
https://read.qxmd.com/read/30655459/totally-laparoscopic-versus-open-gastrectomy-for-advanced-gastric-cancer-a-matched-retrospective-cohort-study
#18
B Yo Chan, K Kw Yau, C Ko Chan
INTRODUCTION: Laparoscopic gastrectomy revolutionised the management of gastric cancer, yet its oncologic equivalency and safety in treating advanced gastric cancer (especially that in smaller centres) has remained controversial because of the extensive lymphadenectomy and learning curve involved. This study aimed to compare outcomes following laparoscopic versus open gastrectomy for advanced gastric cancer at a regional institution in Hong Kong. METHODS: Fifty-four patients who underwent laparoscopic gastrectomy from January 2009 to March 2017 were compared with 167 patients who underwent open gastrectomy during the same period...
January 18, 2019: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://read.qxmd.com/read/30638808/survival-outcomes-following-adrenalectomy-for-isolated-metastases-to-the-adrenal-gland
#19
Jason Ramsingh, Patrick O'Dwyer, Carol Watson
BACKGROUND: Adrenal metastases can arise from different primary sites. Surgical resection of the adrenal gland in patients with isolated metastases may offer improved survival in many of these patients. However, the benefit of surgery in this heterogenous group is often disputed. The aim of this study was to identify patients undergoing adrenalectomy for isolated metastases and to describe survival outcomes based on origin of the primary malignancy. METHODS: Patients undergoing surgery for isolated adrenal metastases were retrospectively analysed from a prospectively kept database...
January 4, 2019: European Journal of Surgical Oncology
https://read.qxmd.com/read/30632400/knockdown-of-linc02465-suppresses-gastric-cancer-cell-growth-and-metastasis-via-pi3k-akt-pathway
#20
Liang Han, Yanping Hao, Jianhua Wang, Zhengjiang Wang, Hongmei Yang, Xudong Wu
Gastric cancer (GC) is the second primary cause of cancer-associated mortality around the world. Long non-coding RNAs (lncRNAs) are critical modulators of multiple cellular processes, and their abnormal expression and/or function are related to a variety of diseases, including cancer. Nowadays, various lncRNAs have been unveiled to exert a functional role in GC, but more still remain to be identified since the therapies for GC patients are limited. Herein, we discover LINC02465, a novel recognized lncRNA, is upregulated and correlated with tumour size, tumour stage, lymph node metastasis and differentiation in gastric cancer...
January 11, 2019: Human Gene Therapy. Clinical Development
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