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(Epigen* OR (Methyla* OR Methylo*)) AND ((TBI OR Traumatic Brain Injur* OR Concuss*) OR (MDD OR Depress* OR Mood))

Alexander J Watts, Kenneth B Storey
During winter hibernation in mammals, body temperature falls to near-ambient levels, metabolism shifts to favor lipid oxidation, and metabolic rate is strongly suppressed by inhibiting many ATP-expensive processes (e.g., transcription, translation) for animals in order to survive for many months on limited reserves of body fuels. Regulation of such profound changes (i.e., metabolic rate depression) requires rapid and reversible controls provided by protein posttranslational modifications. Protein lysine methylation provides one mechanism by which the functionality, activity, and stability of cellular proteins and enzymes can be modified for the needs of the hibernator...
February 15, 2019: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Gabriel R Fries, Wei Zhang, Deborah Benevenuto, Joao Quevedo
Major depressive disorder (MDD) is a severe and chronic psychiatric disorder with a high prevalence in the population. Although our understanding of its pathophysiological mechanisms has significantly increased over the years, available treatments still present several limitations and are not effective to all MDD patients. Epigenetic mechanisms have recently been suggested to play key roles in MDD pathogenesis and treatment, including the effects of small noncoding RNAs known as microRNAs (miRNAs). miRNAs can modulate gene expression posttranscriptionally by interfering with the stability and translation of messenger RNA molecules and are also known to cross-talk with other epigenetic mechanisms...
2019: Advances in Experimental Medicine and Biology
Hua Tian, Yanyan Li, Panpan Kang, Zhichao Wang, Feng Yue, Peng Jiao, Nana Yang, Shucun Qin, Shutong Yao
This study was designed to explore the inductive effect of glycated high-density lipoprotein (gly-HDL) on endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP)-mediated macrophage apoptosis and its relationship with autophagy. Our results showed that gly-HDL caused macrophage apoptosis with concomitant activation of ER stress pathway, including nuclear translocation of activating transcription factor 6, phosphorylation of protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2α, and CHOP up-regulation, which were inhibited by 4-phenylbutyric acid (PBA, an ER stress inhibitor) and the gene silencing of PERK and CHOP...
February 12, 2019: Journal of Cellular and Molecular Medicine
Muzi Li, Carl D'Arcy, Xintong Li, Tieyuan Zhang, Ridha Joober, Xiangfei Meng
There has been a limited number of systematic reviews conducted to summarize the overview of the relationship between DNA methylation and depression, and to critically appraise the roles of major study characteristics in the accuracy of study findings. This systematic review aims to critically appraise the impact of study characteristics on the association between DNA methylation and depression, and summarize the overview of this association. Electronic databases and gray literatures until December 2017 were searched for English-language studies with standard diagnostic criteria of depression...
February 4, 2019: Translational Psychiatry
Laura S Bleker, Jeannette Milgrom, Alexandra Sexton-Oates, Tessa J Roseboom, Alan W Gemmill, Christopher J Holt, Richard Saffery, Huibert Burger, Susanne R de Rooij
BACKGROUND: Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations. Current evidence is largely based on animal and observational human studies. Therefore, evidence from experimental human studies is needed. In this follow-up of a small randomized controlled trial (RCT), DNA-methylation was compared between children of women who had received cognitive behavioral therapy (CBT) for antenatal depression and children of women who had received treatment as usual (TAU)...
February 4, 2019: Clinical Epigenetics
Jun Shen, Yaqing Li, Chujie Qu, Linling Xu, Huimin Sun, Junjian Zhang
BACKGROUND: Chronic unpredictable mild stress (CUMS) is an important risk factor for depression and cognitive deficits in humans. Enriched environment (EE) showed a beneficial effect on depression and cognition by enhancing brain derived neurotrophic factor (BDNF) expression and synaptic plasticity. However, it is still not clearly understood whether an epigenetic mechanism is involved in the BDNF modulation and synaptic plasticity that occurs after EE treatment for the depressive-like behaviors and cognitive deficits elicited by CUMS...
January 28, 2019: Journal of Affective Disorders
Taylena Maria Teófilo, Gloria Pinto Duarte, Rosivaldo Dos Santos Borges, Armênio Dos Santos Aguiar, Pedro Jorge Caldas Magalhães, Saad Lahlou
Previously, we showed that the synthetic nitroderivative trans-4-methyl-β-nitrostyrene (T4MeN) induced vasorelaxant effects in rat isolated aortic rings. Here, we investigated the mechanisms underlying the cardiovascular effects of T4MeN in normotensive rats. In pentobarbital-anesthetized rats, intravenous (i.v.) injection of T4MeN (0.03-0.5mg/kg) induced a rapid (onset time of 1-2s) and dose-dependent bradycardia and hypotension. These cardiovascular responses to T4MeN were abolished by bilateral cervical vagotomy or selective blockade of neural conduction of vagal C-fibre afferents by perineural treatment of both cervical vagus nerves with capsaicin...
February 1, 2019: European Journal of Pharmacology
Dan Xiang, Jiawei Xiao, Linyan Fu, Lihua Yao, Qirong Wan, Ling Xiao, Fan Zhu, Gaohua Wang, Zhongchun Liu
Tacr2, the gene encoding the NK2 receptor, belongs to G protein-coupled receptors. Accumulating evidence has indicated that the tachykinin receptors may contribute to the pathophysiology of depression. During the last decade, some studies have shown that Tacr2 activation is involved in the modulation of emotional processes. However, the extent, to which stress impacts Tacr2 expression remains unclear. The molecular mechanisms underlying depression also remain poorly understood. In this study, we subjected adult male Sprague Dawley (SD) rats to chronic unpredictable mild stress (CUMS) to induce a depression-like phenotype...
January 31, 2019: Behavioural Brain Research
Felipe V Gomes, Xiyu Zhu, Anthony A Grace
Schizophrenia is a neurodevelopmental disorder with genetic predisposition, and stress has long been linked to its etiology. While stress affects all stages of the illness, increasing evidence suggests that stress during critical periods of development may be particularly detrimental, increasing individual's vulnerability to psychosis. To thoroughly understand the potential causative role of stress, our group has been focusing on the prenatal methylazoxymethanol acetate (MAM) rodent model, and discovered that MAM offspring display abnormal stress reactivity and heightened anxiety prepubertally, prior to the manifestation of a hyperdopaminergic state...
January 30, 2019: Schizophrenia Research
Aobing Cheng, Yang Lu, Qiaobing Huang, Zhiyi Zuo
Application of the commonly used volatile anesthetic sevoflurane after brain ischemia (sevoflurane postconditioning) attenuates ischemic brain injury. It is not known whether autophagy plays a role in this sevoflurane postconditioning-induced neuroprotection. Human SH-SY5Y cells were induced to become neuron-like cells. These cells were subjected to 1h oxygen-glucose deprivation (OGD) and then exposed to sevoflurane for 1h. Chloroquine, an inhibitor of autolysosomes, rapamycin, an autophagy inducer, or 3-methyladenine (3-MA), an autophagy inhibitor, were incubated with cells during OGD and sevoflurane exposure...
January 30, 2019: European Journal of Pharmacology
Karen Ka Lam Pang, Mahima Sharma, Sreedharan Sajikumar
Various epigenetic modifications, including histone lysine methylation, play an integral role in learning and memory. The importance of the histone lysine methyltransferase complex G9a/GLP and its associated histone H3 lysine K9 dimethylation in memory formation and cognition, has garnered the attention of researchers in the past decade. Recent studies feature G9a/GLP as the 'bidirectional regulator of synaptic plasticity', the neural correlate of memory. As the 'title' suggests, G9a/GLP participates in the maintenance of both long-term potentiation (LTP) and long-term depression (LTD)...
January 28, 2019: Neurobiology of Learning and Memory
Johanna Klinger-König, Johannes Hertel, Sandra Van der Auwera, Stefan Frenzel, Liliane Pfeiffer, Melanie Waldenberger, Janine Golchert, Alexander Teumer, Matthias Nauck, Georg Homuth, Henry Völzke, Hans J Grabe
DNA methylation of the FKBP5 gene is assumed to alter FKBP5 expression and hence the synthesis of the FK506 binding protein 51, a central element of a genomic negative feedback loop for glucocorticoid receptor signaling. The present study aimed to replicate and extend previously reported influences of FKBP5 genotypes, childhood maltreatment and depression on methylation levels of five CpG sites in intron 7 of the FKBP5 gene in a large population-based sample. Besides the single nucleotide polymorphism (SNP) rs1360780, associations of the FKBP5 methylation with 22 other, unlinked FKBP5 SNPs as well as associations between FKBP5 methylation levels and transcription levels were investigated...
January 23, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Brandon C McKinney, Chien-Wei Lin, Tanbin Rahman, Hyunjung Oh, David A Lewis, George Tseng, Etienne Sibille
A consistent gene set undergoes age-associated expression changes in the human cerebral cortex, and our Age-by-Disease Model posits that these changes contribute to psychiatric diseases by "pushing" the expression of disease-associated genes in disease-promoting directions. DNA methylation (DNAm) is an attractive candidate mechanism for age-associated gene expression changes. We used the Illumina HumanMethylation450 array to characterize genome-wide DNAm in the postmortem orbital frontal cortex from 20 younger (<42 years) and 19 older (>60 years) subjects...
January 29, 2019: Translational Psychiatry
Eilis Hannon, Sarah J Marzi, Leonard S Schalkwyk, Jonathan Mill
Most variants associated with complex phenotypes in genome-wide association studies (GWAS) do not directly index coding changes affecting protein structure. Instead they are hypothesized to influence gene regulation, with common variants associated with disease being enriched in regulatory domains including enhancers and regions of open chromatin. There is interest, therefore, in using epigenomic annotation data to identify the specific regulatory mechanisms involved and prioritize risk variants. We quantified lysine H3K27 acetylation (H3K27ac) - a robust mark of active enhancers and promoters that is strongly correlated with gene expression and transcription factor binding - across the genome in entorhinal cortex samples using chromatin immunoprecipitation followed by highly parallel sequencing (ChIP-seq)...
January 28, 2019: Molecular Brain
C R Mccoy, M E Glover, L T Flynn, R K Simmons, J L Cohen, T Ptacek, E J Lefkowitz, N L Jackson, H Akil, X Wu, S M Clinton
There is growing evidence of abnormal epigenetic processes playing a role in the neurobiology of psychiatric disorders, although the precise nature of these anomalies remains largely unknown. To study neurobiological (including epigenetic) factors that influence emotionality, we use rats bred for distinct behavioral responses to novelty. Rats bred for low novelty response (Low Responder; LR) exhibit high levels of anxiety- and depressive-like behavior compared to high novelty responder (HR) rats. Prior work revealed distinct limbic brain development in HR versus LR rats, including altered expression of genes involved in DNA methylation...
January 25, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Kaiyi Zhu, Tai-Hsien Ou Yang, Vincent Dorie, Tian Zheng, Dimitris Anastassiou
Similar environmental risk factors have been implicated in different neuropsychiatric disorders (including major psychiatric and neurodegenerative diseases), indicating the existence of common epigenetic mechanisms underlying the pathogenesis shared by different illnesses. To investigate such commonality, we applied an unsupervised computational approach identifying several consensus co-expression and co-methylation signatures from a data cohort of postmortem prefrontal cortex (PFC) samples from individuals with six different neuropsychiatric disorders-schizophrenia, bipolar disorder, major depression, alcoholism, Alzheimer's and Parkinson's-as well as healthy controls...
January 22, 2019: Translational Psychiatry
Yongqing Liu, Minghua Li, Minghua Fan, Yan Song, Huajing Yu, Xiaojie Zhi, Kuo Xiao, Shirong Lai, Jingliang Zhang, Xueqin Jin, Yongfeng Shang, Jing Liang, Zhuo Huang
BACKGROUND: Major depressive disorder is a prevalent and life-threatening illness in modern society. The susceptibility to major depressive disorder is profoundly influenced by environmental factors, such as stressful lifestyle or traumatic events, which could impose maladaptive transcriptional program through epigenetic regulation. However, the underlying molecular mechanisms remain elusive. Here, we examined the role of histone crotonylation, a novel type of histone modification, and chromodomain Y-like protein (CDYL), a crotonyl-coenzyme A hydratase and histone methyllysine reader, in this process...
December 5, 2018: Biological Psychiatry
Nina K Popova, Vladimir S Naumenko
Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are known as principal players in different kinds of plasticity. The 5-HT-BDNF interaction in early ontogeny and in adult brain is an intriguing problem. Area covered: This paper concentrates on the interaction between 5-HT and BDNF systems and its implication in different plasticity levels, from neurons to behavior. This review describes: 1. different 5-HT functioning in the embryonic (as neurotrophin) and adult brain (as a neurotransmitter) 2. BDNF as a modulator of 5-HT system and vice versa 3 the prolonged positive effect of BDNF on genetically- and epigenetically-defined CNS disorders; 4...
January 21, 2019: Expert Opinion on Therapeutic Targets
Yu Fu, Barry Zorman, Pavel Sumazin, Pietro Paolo Sanna, Vez Repunte-Canonigo
Internal RNA modifications have been known for decades, however their roles in mRNA regulation have only recently started to be elucidated. Here we investigated the most abundant mRNA modification, N6-methyladenosine (m6A) in transcripts from the hippocampus of HIV transgenic (Tg) rats. The distribution of m6A peaks within HIV transcripts in HIV Tg rats largely corresponded to the ones observed for HIV transcripts in cell lines and T cells. Host transcripts were found to be differentially m6A methylated in HIV Tg rats...
2019: PloS One
Ming Li, Yi Tang, Qingshu Li, Ming Xiao, Yaying Yang, Yalan Wang
Recently, nuclear poly-ADP-ribosylation had aroused research interest in epigenetics, but little attempt to explore functions of mono-ADP-ribosylation of histone, the major formation of histone ADP-ribosylated modification. We have previously reported a novel mono-ADP-ribosylation of H3R117, which promoted proliferation of LoVo cells. Here we showed that mono-ADP-ribosylated H3R117 of LoVo cells depressed demethylation of tumor suppressor TFPI2 promoter by suppressing TET1 expression and adjusting H3K9me3 enrichment of TFPI2 promoter to attenuate affinity of TET1, besides, since high H3K27me3 level was associated with hypermethylation, mono-ADP-ribosylated-H3R117-depended-H3K27me3 of TFPI2 promoter may contribute to hypermethylation of TFPI2...
January 16, 2019: Oncogene
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