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Sho Shiino, Masayuki Yoshida, Kenjiro Jimbo, Sota Asaga, Shin Takayama, Akiko Maeshima, Hitoshi Tsuda, Takayuki Kinoshita, Nobuyoshi Hiraoka
Benign inclusions, such as endosalpingiosis, in an axillary sentinel lymph node (SLN) can be misdiagnosed as metastatic breast carcinoma. However, endosalpingiosis is rare in lymph nodes above the diaphragm. Among 792 patients with breast carcinoma who underwent sentinel lymph node biopsy at our center, 2 patients have experienced benign glandular inclusions in 3 SLNs, and all of these glandular inclusions were lined with columnar and ciliated epithelial cells. Immunohistochemistry revealed that the epithelial cells were positive for Müllerian markers (e...
February 12, 2019: Virchows Archiv: An International Journal of Pathology
Yanqin Fan, Qian Yang, Yingjie Yang, Zhao Gao, Yiqiong Ma, Lu Zhang, Wei Liang, Guohua Ding
Previous studies have shown that mitochondrial dysfunction plays an important role in high- glucose(HG)-induced podocyte injury and thus contributes to the progression of diabetic nephropathy(DN). The histone deacetylase Sirtuin6 (Sirt6) has been revealed to have an essential role in the regulation of mitochondrial function in skeletal muscle and cardiomyocytes. However, its specific role in mitochondrial homeostasis in podocytes is undetermined. Here, we aimeds to explore the physiological function of Sirt6 in podocyte mitochondria and apoptosis under HG conditions and explore the possible mechanism...
2019: International Journal of Biological Sciences
Xin Guo, Jiro Watanabe, Kenji Takahashi, Tatsuro Hayashi, Nozomu Kurose, Yasuyuki Sasaguri, Hidetaka Uramoto, Hiromi Iwagaki, Kazuki Nabeshima, Sohsuke Yamada
An 80-year-old male with previous workplace exposure to asbestos presented with a history of an increase in the pulmonary-to-hilar mass, measuring more than 50 mm in diameter, likely in the right lower lobe. We first interpreted it as suspicious of primary lung adenocarcinoma with direct invasion to the right hilar lymph node. A right middle and lower lobectomy with partial resection of upper lobe was performed, and gross examination showed a hilar tumor lesion, involving the middle/lower lobe to hilar lymph node and looking whitish to yellow-grayish, partly adjacent to the right pulmonary artery...
2019: SAGE Open Medical Case Reports
Ana P Oliveira, Luan K M Souza, Thiago S L Araújo, Simone de Araújo, Kerolayne M Nogueira, Francisca Beatriz M Sousa, Renan O Silva, Dvison M Pacífico, Conceição S Martins, Gerly Anne de C Brito, Marcellus H L P Souza, Jand Venes R Medeiros
This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluated the effect of supplementing 10⁸ CFU•g body wt-1 •day-1 of DSM on ethanol-induced gastric injury. DSM significantly reduced the ulcer area (1.940 ± 1.121 mm²) with 3 days of pretreatment. The effects of DSM supplementation were reversed by Resiniferatoxin (RTX), TRPV1 agonist (3 nmol/kg p...
January 21, 2019: Nutrients
Adam J Wyness, David M Paterson, Tania Mendo, Emma C Defew, Marc I Stutter, Lisa M Avery
Microbiological water quality monitoring of bathing waters does not account for faecal indicator organisms in sediments. Intertidal deposits are a significant reservoir of FIOs and this indicates there is a substantial risk to bathers through direct contact with the sediment, or through the resuspension of bacteria to the water column. Recent modelling efforts include sediment as a secondary source of contamination, however, little is known about the driving factors behind spatial and temporal variation in FIO abundance...
January 14, 2019: Science of the Total Environment
Qutuba G Karwi, Liyan Zhang, Cory S Wagg, Wang Wang, Manoj Ghandi, Dung Thai, Hai Yan, John R Ussher, Gavin Y Oudit, Gary D Lopaschuk
BACKGROUND: In heart failure the myocardium becomes insulin resistant which negatively influences cardiac energy metabolism and function, while increasing cardiac insulin signalling improves cardiac function and prevents adverse remodelling in the failing heart. Glucagon's action on cardiac glucose and lipid homeostasis counteract that of insulin's action. We hypothesised that pharmacological antagonism of myocardial glucagon action, using a human monoclonal antibody (mAb A) against glucagon receptor (GCGR), a G-protein coupled receptor, will enhance insulin sensitivity and improve cardiac energy metabolism and function post myocardial infarction (MI)...
January 9, 2019: Cardiovascular Diabetology
Peng Ji, Bo Lönnerdal, Kwangwook Kim, Cynthia N Jinno
Background: Iron oversupplementation in healthy term infants may adversely affect growth and cognitive development. Objective: We hypothesized that early-life iron excess causes systemic and central nervous system iron overload, and compromises social behavior. Methods: The nursing pig was used as a translational model in a completely randomized study. On postnatal day (PD) 1, 24 pigs (1.57 ± 0.28 kg mean ± standard deviation body wt) were assigned to the following treatment groups: 1) nonsupplemented iron-deficient group (NON); 2) control group (CON), intramuscularly injected with iron dextran (100 mg Fe) on PD2; 3) moderate iron group (MOD), orally administered ferrous sulfate at 10 mg Fe · kg body wt-1 · d-1; and 4) high iron group (HIG), orally administered ferrous sulfate at 50 mg Fe · kg-1 · d-1...
January 8, 2019: Journal of Nutrition
Sara Cantera, Sergio Bordel, Raquel Lebrero, Juan Gancedo, Pedro A García-Encina, Raúl Muñoz
Despite the environmental relevance of CH4 and forthcoming stricter regulations, the development of cost-efficient and environmentally friendly technologies for CH4 abatement is still limited. To date, one of the most promising solutions for the mitigation of this important GHG consists of the bioconversion of CH4 into bioproducts with a high profit margin. In this context, methanotrophs have been already proven as cell-factories of some of the most expensive products synthesized by microorganisms. In the case of ectoine (1000 $ kg-1 ), already described methanotrophic genera such as Methylomicrobium can accumulate up to 20% (ectoine wt-1 ) using methane as the only carbon source...
January 7, 2019: World Journal of Microbiology & Biotechnology
Kun Ling Ma, Liang Liu, Yang Zhang, Gui Hua Wang, Ze Bo Hu, Pei Pei Chen, Jian Lu, Chen Chen Lu, Tie Kai Gong, Yu Xiang Gong, Bi Cheng Liu
AIM: This study aimed to investigate the effects of aspirin on podocyte injury and its underlying mechanisms in diabetic nephropathy (DN). METHODS: Eight-week-old male Sprague-Dawley rats were divided into three groups: non-diabetic rats (Control), streptozotocin-induced diabetic rats (DM), and diabetic rats treated with aspirin (DM + Aspirin) for 12 weeks. Intracellular lipid accumulation was evaluated by Oil Red O staining and quantitative free cholesterol assays...
January 2, 2019: International Urology and Nephrology
Ping-Chung Tsai, Yi-Chen Yeh, Po-Kuei Hsu, Yu-Chung Wu
Mediastinal Mullerian cyst was first reported by Hattori in 2005. We report a case of a posterior mediastinal paravertebral cyst found incidentally by surveillance chest roentgenogram in a 44-year-old woman. She had a "no drain" uniportal thoracoscopic removal procedure, and histologic examination showed single layer of columnar epithelial lining that stained positive for estrogen receptors (ER), progesterone receptors (PR), paired box gene 8 (PAX8), and Wilms' tumor protein 1 (WT-1), confirming the diagnosis of mediastinal Mullerian cyst...
December 2018: Annals of Translational Medicine
Byung-Kwan Jeong, Chang O Sung, Kyu-Rae Kim
Background: Breast cancer treatment with selective estrogen receptor modulators (SERMs) increases the incidence of uterine malignant mixed Müllerian tumors (uMMMTs). We examine clinicopathologic characteristics and prognosis of SERM-associated uMMMTs (S-uMMMTs) and discuss possible pathogenetic mechanisms. Materials and Methods: Among 28,104 patients with breast cancer, clinicopathologic features and incidence of uMMMT were compared between patients who underwent SERM treatment and those who did not...
December 18, 2018: Journal of Pathology and Translational Medicine
Bei Zhang, Bingyang Bian, Lirong Bi, Zhuo Wang, Yang Zhao, Jiping Wang
RATIONALE: Prostate cancer often metastasizes (most commonly to the pelvic lymph nodes and axial skeleton); however, metastases to the pelvic cavity as a solitary mass are unusual. While metastatic prostate cancer is unconventional in pelvic cavity, cystic pelvic lesions are even more scarce. Accurate identification of cystic metastasis can be helpful in management of prostate cancer. PATIENT CONCERNS: A 64-year-old male was admitted to our hospital due to urethral irritation symptom and dysuria...
December 2018: Medicine (Baltimore)
Ji-Yeong Byeon, Choong-Min Lee, Yea-Jin Lee, Young-Hoon Kim, Se-Hyung Kim, Eui Hyun Jung, Won Ki Chae, Yun Jeong Lee, Choon-Gon Jang, Seok-Yong Lee
Tolterodine is metabolized to an active 5-hydroxymethyl tolterodine (5-HMT) by CYP2D6. This study investigated the relationship between CYP2D6 genotypes and pharmacokinetics of tolterodine and its active metabolite in healthy Korean subjects. All volunteers were genotyped for CYP2D6 and divided into four different genotype groups (CYP2D6*wt/*wt [*wt = *1 or *2], CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10). Each subject received a single oral dose of tolterodine tartrate (2 mg) in single-dose phase of the study...
December 12, 2018: Archives of Pharmacal Research
Risako Kawata, Tatsuhito Ii, Tatsuya Hori, Yukino Machida, Kazuhiko Ochiai, Daigo Azakami, Toshiyuki Ishiwata, Masaki Michishita
A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4.5 cm. The cut surface was mottled dark red to reddish brown in color. Microscopically, the enlarged left testis comprised round or polygonal neoplastic cells arranged in a diffuse sheet pattern. These neoplastic cells had a hyperchromatic nucleus and an abundant eosinophilic cytoplasm. Immunohistochemically, these neoplastic cells were positive for vimentin, chromogranin A, synaptophysin, melan-A, inhibin-α, and S100 and negative for desmin and WT-1...
December 12, 2018: Journal of Veterinary Medical Science
Chao Wang, Xiao-Xia Hou, Hong-Liang Rui, Li-Jing Li, Jing Zhao, Min Yang, Li-Jun Sun, Hong-Rui Dong, Hong Cheng, Yi-Pu Chen
Background/Aims: It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated Ophiocordyceps sinensis (ACOS). Methods: A rat model of DN caused by high-fat-diet feeding and low-dose streptozotocin injection and a mouse podocyte injury model induced by high-glucose (HG) stimulation were established, and the intervention effects of ACOS on them were observed...
2018: Journal of Diabetes Research
Laurence Gariépy-Assal, Rodney D Gilbert, Aleksas Žiaugra, Bethany Joy Foster
Denys-Drash syndrome (DDS), a condition caused by mutations in the tumor-suppressor gene WT-1, is associated with a triad of disorders: ambiguous genitalia, nephrotic syndrome leading to end-stage renal disease (ESRD), and Wilms' tumor. Given the variable disease course, management is challenging. We aimed to describe the evolution of DDS and the range of management strategies by summarizing the clinical courses of cases collected from a questionnaire sent to the international pediatric nephrology community...
2018: Clinical Nephrology. Case Studies
Luigi Della Corte, Pierluigi Giampaolino, Annamaria Fabozzi, Miriam Cieri, Brunella Zizolfi, Ilaria Morra, Giuseppe Bifulco
Ovarian cancer is considered the leading cause of death among gynecologic neoplasias. Breast metastases from primary ovarian cancer have been reported in only 0.03-0.6% of all breast cancers. A 38-year-old female, multipara, affected by advanced ovarian cancer and undergone a total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and pelvic peritonectomy two years earlier, was discovered to have a breast metastasis. She underwent a quadrantectomy (QSI) with an open biopsy of nodularity attached to the pectoral muscle fascia: on definitive histological characterization the breast lesions showed a high-grade invasive carcinoma, with papillary serum differentiation, and the immunohistochemistry study of breast lesion showed positivity for cytokeratin 7 and an extensive positivity for Wilm's tumor (WT)-1 and paired box 8 (PAX8)...
November 19, 2018: Gynecological Endocrinology
Toshiaki Takahashi, Florian Friedmacher, Julia Zimmer, Prem Puri
PURPOSE: Congenital diaphragmatic hernia (CDH) and associated pulmonary hypoplasia (PH) are thought to be caused by a malformation of the diaphragmatic and pulmonary mesenchyme. Dispatched RND transporter family member 1 (Disp-1) encodes a transmembrane protein that regulates the release of cholesterol and palmitoyl, which is critical for normal diaphragmatic and airway development. Disp-1 is strongly expressed in mesenchymal compartments of fetal diaphragms and lungs. Recently, Disp-1 mutations have been identified in patients with CDH...
October 31, 2018: Pediatric Surgery International
Sotaro Kayano, Hiroshi Sasaki, Takahiro Kimura, Shin Egawa
Metanephric adenoma is a rare benign renal epithelial tumor. We have experienced two cases of metanephric adenoma. The first case was a left renal tumor found by ultrasonography in a 26-year-old woman. The abdominal computed tomography (CT) revealed a 90 mm mass that was enhanced slightly in the early phase, and enhanced further in the late phase. Laparoscopic radical nephrectomy was performed with suspicion of renal cell carcinoma. The second case was a right renal tumor found by CT imaging for heart disease in a 64-year-old man...
August 2018: Hinyokika Kiyo. Acta Urologica Japonica
M Tecilla, M Bielli, F C Origgi
A 14-year-old red-ear slider turtle (Trachemys scripta elegans) with no history of pre-existing clinical disease died and was referred for necropsy examination. Grossly, oesophageal prolapse, bilateral renal cysts and a paraduodenal cystic mass were detected. Tissues were processed routinely for histology and immunohistochemistry (IHC) with primary antibodies specific for Wilm's tumour suppressor gene-1 (WT-1), insulin, glucagon and pancytokeratins. Microscopically, renal medullary cysts and medullary atrophy resembled the changes associated with polycystic kidney disease (PKD)...
October 2018: Journal of Comparative Pathology
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