Jean Ikanga, Sarah D Patrick, Megan Schwinne, Saranya Sundaram Patel, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Kevin E Yarasheski, Charlotte E Teunissen, Anthony Stringer, Allan Levey, Julio C Rojas, Brandon Chan, Argentina Lario Lago, Joel H Kramer, Adam L Boxer, Andreas Jeromin, Alvaro Alonso, Robert J Spencer
BACKGROUND: The current study examined the sensitivity of two memory subtests and their corresponding learning slope metrics derived from the African Neuropsychology Battery (ANB) to detect amyloid pathology and APOEε4 status in adults from Kinshasa, the Democratic Republic of the Congo. METHODS: 85 participants were classified for the presence of β-amyloid pathology and based on allelic presence of APOEε4 using Simoa. All participants were screened using CSID and AQ, underwent verbal and visuospatial memory testing from ANB, and provided blood samples for plasma Aβ42 , Aβ40 , and APOE proteotype...
2024: Frontiers in Neurology