Huma Q Rana, Jill E Stopfer, Michelle Weitz, Lindsay Kipnis, Diane R Koeller, Samantha Culver, Joanna Mercado, Rebecca Sue Gelman, Meghan Underhill-Blazey, Bradley A McGregor, Christopher J Sweeney, Nancie Petrucelli, Courtney Kokenakes, Sara Pirzadeh-Miller, Brian Reys, Arthur Frazier, Andrew Knechtl, Salman Fateh, Donna Rachel Vatnick, Rebecca Silver, Kerry E Kilbridge, Mark M Pomerantz, Xiao X Wei, Atish D Choudhury, Guru P Sonpavde, Olga Kozyreva, Christopher Lathan, Carrie Horton, Jill S Dolinsky, Elisabeth I Heath, Theodora Suzanne Ross, Kevin Dale Courtney, Judy E Garber, Mary-Ellen Taplin
PURPOSE: Germline genetic testing (GT) is recommended for men with prostate cancer (PC), but testing through traditional models is limited. The ProGen study examined a novel model aimed at providing access to GT while promoting education and informed consent. METHODS: Men with potentially lethal PC (metastatic, localized with a Gleason score of ≥8, persistent prostate-specific antigen after local therapy), diagnosis age ≤55 years, previous malignancy, and family history suggestive of a pathogenic variant (PV) and/or at oncologist's discretion were randomly assigned 3:1 to video education (VE) or in-person genetic counseling (GC)...
September 21, 2023: JCO oncology practice