keyword
https://read.qxmd.com/read/36203163/optimized-diagnosis-based-comorbidity-measures-for-all-cause-mortality-prediction-in-a-national-population-based-icu-population
#21
JOURNAL ARTICLE
Anna Aronsson Dannewitz, Bodil Svennblad, Karl Michaëlsson, Miklos Lipcsey, Rolf Gedeborg
BACKGROUND: We aimed to optimize prediction of long-term all-cause mortality of intensive care unit (ICU) patients, using quantitative register-based comorbidity information assessed from hospital discharge diagnoses prior to intensive care treatment. MATERIAL AND METHODS: Adult ICU admissions during 2006 to 2012 in the Swedish intensive care register were followed for at least 4 years. The performance of quantitative comorbidity measures based on the 5-year history of number of hospital admissions, length of stay, and time since latest admission in 36 comorbidity categories was compared in time-to-event analyses with the Charlson comorbidity index (CCI) and the Simplified Acute Physiology Score (SAPS3)...
October 6, 2022: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/35915513/postoperative-fasting-is-associated-with-longer-icu-stay-in-oncologic-patients-undergoing-elective-surgery
#22
JOURNAL ARTICLE
Caroline Fachini, Claudio Z Alan, Luciana V Viana
BACKGROUND: Cancer patients present nutritional and complications risks during the postoperative period. Fasting contributes to surgical catabolic damage. This study evaluates the consequence of fasting time on the surgical outcomes of cancer patients undergoing elective surgeries. METHODS: Prospective cohort, evaluating two categories of patients according to postoperative fasting: less than or greater than 24 h. OUTCOMES: Hospitalization time, 28-day mortality, ICU stay and infection rates...
August 2, 2022: Perioperative Medicine
https://read.qxmd.com/read/35743491/impaired-antibody-response-is-associated-with-histone-release-organ-dysfunction-and-mortality-in-critically-ill-covid-19-patients
#23
JOURNAL ARTICLE
Rickard Lagedal, Oskar Eriksson, Anna Sörman, Joram B Huckriede, Bjarne Kristensen, Stephanie Franzén, Anders Larsson, Anders Bergqvist, Kjell Alving, Anders Forslund, Barbro Persson, Kristina N Ekdahl, Pablo Garcia de Frutos, Bo Nilsson, Gerry A F Nicolaes, Miklos Lipcsey, Michael Hultström, Robert Frithiof
PURPOSE: the pathophysiologic mechanisms explaining differences in clinical outcomes following COVID-19 are not completely described. This study aims to investigate antibody responses in critically ill patients with COVID-19 in relation to inflammation, organ failure and 30-day survival. METHODS: All patients with PCR-verified COVID-19 and gave consent, and who were admitted to a tertiary Intensive care unit (ICU) in Sweden during March-September 2020 were included...
June 14, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35638173/a-nationwide-evaluation-of-antibiotics-consumption-in-swedish-intensive-care-units
#24
JOURNAL ARTICLE
Fredrik Sjövall, Morgan Edström, Sten Walther, Håkan Hanberger
BACKGROUND: Around 70% of all ICU patients are treated with antibiotics whereas up to 30% are suggested as unnecessary. Measuring antibiotic consumption is a prerequisite to improving its use and the purpose of the present investigation was to explore the use of antibiotics in Swedish ICUs. MATERIAL AND METHODS: Daily Defined Doses (DDDs) of antimicrobials delivered to Swedish ICUs, 2016-2018, were retrieved from Swedish pharmacies. From the Swedish Intensive Care Registry, we extracted data on a number of patient admissions, occupied bed days and Simplified Acute Physiology Score (SAPS)3...
October 2022: Infectious Diseases
https://read.qxmd.com/read/35623857/overhydration-in-acute-kidney-injury-is-it-always-a-menace-to-critically-ill-patients-a-survival-study-using-bioimpedance-spectroscopy
#25
JOURNAL ARTICLE
Marcelo Vargas Gonçalves, Larissa Ribas Ribeiro, Jennifer Aquino, Rafaela Catto, Rony Kafer Nobre, Raíra Marodin Freitas, Rafael Lazaro Barros, Maristela Böhlke
INTRODUCTION: The hydration status is a predictor of survival in critically ill patients. However, it is unclear whether this association depends on the patient clinical condition. This study was designed to analyze the impact of hydration status on survival of critically ill patients with acute kidney injury (AKI) with or without sepsis. METHODS: A prospective cohort study following critically ill patients with AKI consecutively admitted over a one-year period to a teaching hospital intensive care unit (ICU)...
June 2022: Clinical Nutrition ESPEN
https://read.qxmd.com/read/35613193/impact-of-high-cardiovascular-risk-on-hospital-mortality-in-intensive-care-patients-hospitalized-for-covid-19
#26
JOURNAL ARTICLE
Bruno Ferraz de Oliveira Gomes, João Luiz Fernandes Petriz, Iliana Regina Ribeiro Menezes, Anny de Sousa Azevedo, Thiago Moreira Bastos da Silva, Valdilene Lima Silva, Leticia de Sousa Peres, David Fernandes Pedro Pereira, Giovanni Possamai Dutra, Suzanna Andressa Morais de Paula, Bárbara Ferreira da Silva Mendes, Plinio Resende do Carmo Junior, Basilio de Bragança Pereira, Gláucia Maria Moraes de Oliveira
BACKGROUND: Some studies have shown a higher prevalence of deaths in patients with cardiovascular risk factors (CRF) during hospitalization for COVID-19. OBJECTIVES: To assess the impact of high cardiovascular risk in patients hospitalized in intensive care for COVID-19. METHODS: Retrospective study with patients admitted to an intensive care unit, with a diagnosis of COVID-19 confirmed by RT-PCR, and with at least one troponin measurement during hospitalization...
May 2022: Arquivos Brasileiros de Cardiologia
https://read.qxmd.com/read/35573266/the-impact-of-body-mass-index-on-the-prognostic-performance-of-the-simplified-acute-physiology-score-3-a-prospective-cohort-study
#27
JOURNAL ARTICLE
Isabella B B Ferreira, Rodrigo C Menezes, Matheus L Otero, Thomas A Carmo, Gabriel A Agareno, Gabriel P Telles, Bruno V B Fahel, María B Arriaga, Kiyoshi F Fukutani, Licurgo Pamplona Neto, Sydney Agareno, Kevan M Akrami, Nivaldo M Filgueiras Filho, Bruno B Andrade
Objective: To assess the Simplified Acute Physiology Score 3 (SAPS3) prognostic score performance across different body mass index categories. Methods: A retrospective cohort study in a general ICU in Brazil. A secondary analysis of medical records was performed with clinical and epidemiological data. Patients were stratified according to their body mass index (BMI) category, and a binary logistic regression was then performed to identify factors independently associated with mortality...
March 2022: Heliyon
https://read.qxmd.com/read/35560774/genesis-of-antibiotic-resistance-ar-lxxviii-turbulence-modeling-of-hemodynamics-in-simplified-severe-sepsis-protocol-2-sssp-2-nct01663701-erp-egdt-correlation-of-time-fluid-bolus-dependent-pressure-drop-in-boundary-layer-separation-with-adverse-pressure-gradient
#28
JOURNAL ARTICLE
Natalie Padilla, Dania Alvizo, Subburaj Kannan
The objective is to identify the underlying hemodynamic alteration in usual care group registered with 5 patients @ 100% ihm; vs the sepsis protocol cohort registered with 11 patients @ 90.05% ihmwith a median hospital stay of 5 days; GCS 3-8(SAPS3≥56, (Ref: Fig 3) NCT01663701(PMID: 28973227). Cause for Concern: The pivotal clinical indices such as, i. antibiogram, ii.drug resistance index(DRI), iii.resistance map(RM), iv.antibiotic resistance footprint (ARF), v.AR stewardship data, and vi. Global Antimicrobial Resistance and Use Surveillance System (GLASS) data, for the entire patients' cohorts before and after admitting to ED as a part of baseline characteristics, not presented...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35552786/genesis-of-antibiotic-resistance-ar-lxxvi-turbulence-modeling-of-hemodynamics-in-simplified-severe-sepsis-protocol-2-sssp-2-nct01663701-erp-egdt-mechanism-s-time-dependent-fluid-volume-overload-elicit-adverse-pressure-gradient-apg-in-metarteriole
#29
JOURNAL ARTICLE
Raul Puente, Natalie Padilla, Subburaj Kannan
NCT01663701(PMID: 28973227) observed that usual care group, 5 patients @ 100% in-hospital mortality (ihm); and the sepsis protocol cohort with 11 patients @ 90.05% ihm with a median hospital stay of 5 days (Usual Care: BP: 96/61mmHg, PP: 35mmHg; MAP: 72mmHg; Sepsis Protocol: BP: 95/61 mmHg; PP: 34 mmHg; MAP: 73mmHg; SAPS3≥56, JVP, > -2 cm H2O @ implicit hypovolemia (JVP: 6 to 8 cm above the right atrium; elevated: JVP > 9 cm, (Ref: Fig 3. p1239). OBJECTIVE: to determine the effect(s) of fluid resuscitation on hemodynamic parameters in usual care cohort vs sepsis protocol cohort...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35448960/airway-management-procedures-in-swedish-emergency-department-patients-a-national-retrospective-study
#30
JOURNAL ARTICLE
Susanne B Wilhelms, Daniel B Wilhelms
BACKGROUND: With the on-going debate about which specialty should be responsible for intubations in the emergency department in mind, the aim of this study was to describe the prevalence of endotracheal intubation and other airway management procedures in emergency department patients in Sweden. METHODS: All patients registered in the Swedish Intensive Care Registry with admission date from January 1 2013 until June 7 2018 and reported admission type "from the emergency department" or "emergency department" reported in the SAPS3 scoring were included...
April 21, 2022: BMC Emergency Medicine
https://read.qxmd.com/read/35052684/plasma-leptin-is-increased-in-intensive-care-patients-with-covid-19-an-investigation-performed-in-the-pronmed-cohort
#31
JOURNAL ARTICLE
Anders Larsson, Miklós Lipcsey, Michael Hultström, Robert Frithiof, Mats Eriksson
COVID-19 has shaken the world and intensive care units (ICU) have been challenged by numerous patients suffering from a previously unknown disease. Leptin is a polypeptide pleiotropic hormone, mainly expressed by adipocytes. It acts as a proinflammatory cytokine and is associated with several conditions, known to increase the risk of severe COVID-19. Very little is known about leptin in severe viral disorders. Plasma leptin was analyzed in 222 out of 229 patients with severe COVID-19 on admission to an ICU at Uppsala University Hospital, a tertiary care hospital in Sweden, and compared to plasma leptin in 25 healthy blood donors...
December 21, 2021: Biomedicines
https://read.qxmd.com/read/34829832/a-comparison-between-endostatin-and-conventional-biomarkers-on-30-day-mortality-and-renal-replacement-therapy-in-unselected-intensive-care-patients
#32
JOURNAL ARTICLE
Toralph Ruge, Anders Larsson, Miklós Lipcsey, Jonas Tydén, Joakim Johansson, Mats Eriksson
Endostatin may predict mortality and kidney impairment in general populations as well as in critically ill patients. We decided to explore the possible role of endostatin as a predictor of 30-day mortality, acute kidney injury (AKI), and renal replacement therapy (RRT) in a cohort of unselected intensive care unit (ICU) patients. Endostatin and creatinine in plasma were analyzed and SAPS3 was determined in 278 patients on ICU arrival at admission to a Swedish medium-sized hospital. SAPS3 had the highest predictive value, 0...
November 3, 2021: Biomedicines
https://read.qxmd.com/read/34819230/predicting-mortality-for-critically-ill-burns-patients-using-the-abbreviated-burn-severity-index-and-simplified-acute-physiology-score-3
#33
JOURNAL ARTICLE
Florence de Lucca Melo, Alfredo Gragnani, Andrea Fernandes de Oliveira, Lydia Masako Ferreira
INTRODUCTION: Reviewing the profile of patients admitted at the Burns Intensive Care Unit at São Paulo Hospital - UNIFESP, as well as the available literature, it becomes evident the need for tools able to predict those patients' outcomes. Distinct score models are used in different health centers, not only as prognostic models, but also as research and quality control tools. Amongst these prognostic scores, there are two strands, the burns specific scores - which consider the injury's characteristics - and the general critical patient's scores...
November 15, 2021: Injury
https://read.qxmd.com/read/34644316/impact-of-obesity-on-intensive-care-outcomes-in-patients-with-covid-19-in-sweden-a-cohort-study
#34
JOURNAL ARTICLE
Lovisa Sjögren, Erik Stenberg, Meena Thuccani, Jari Martikainen, Christian Rylander, Ville Wallenius, Torsten Olbers, Jenny M Kindblom
BACKGROUND: Previous studies have shown that a high body mass index (BMI) is a risk factor for severe COVID-19. The aim of the present study was to assess whether a high BMI affects the risk of death or prolonged length of stay (LOS) in patients with COVID-19 during intensive care in Sweden. METHODS AND FINDINGS: In this observational, register-based study, we included patients with COVID-19 from the Swedish Intensive Care Registry admitted to intensive care units (ICUs) in Sweden...
2021: PloS One
https://read.qxmd.com/read/34620363/protein-provision-and-lower-mortality-in-critically-ill-patients-with-covid-19
#35
JOURNAL ARTICLE
Jose Henrique Silvah, Cristiane Maria Martires de Lima, Carolina Ferreira Nicoletti, Ana Carolina Barbosa, Gizela Pedroso Junqueira, Selma Freire de Carvalho da Cunha, Julio Sergio Marchini
BACKGROUND AND AIMS: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severely impacted the management of critically ill patients, including nutritional therapy. This study aimed to verify an association between mortality and the energy and protein provided to critically ill patients affected by the SARS-CoV-2 and receiving enteral nutrition support. METHODS: Patients with confirmed COVID-19, with >7 days of stay in the ICU, on enteral nutrition were followed from the moment of hospitalization until discharge from the ICU or death...
October 2021: Clinical Nutrition ESPEN
https://read.qxmd.com/read/34601646/long-term-survival-of-mechanically-ventilated-patients-with-severe-covid-19-an-observational-cohort-study
#36
JOURNAL ARTICLE
Oscar Peñuelas, Laura Del Campo-Albendea, Amanda Lesmes González de Aledo, José Manuel Añón, Carmen Rodríguez-Solís, Jordi Mancebo, Paula Vera, Daniel Ballesteros, Jorge Jiménez, Emilio Maseda, Juan Carlos Figueira, Nieves Franco, Ángela Algaba, Juan Pablo Avilés, Ricardo Díaz, Beatriz Abad, Alfonso Canabal, Ana Abella, Federico Gordo, Javier García, Jessica García Suarez, Jamil Cedeño, Basilia Martínez-Palacios, Eva Manteiga, Óscar Martínez, Rafael Blancas, Tommaso Bardi, David Pestaña, José Ángel Lorente, Alfonso Muriel, Andrés Esteban, Fernando Frutos-Vivar
BACKGROUND: Information is lacking regarding long-term survival and predictive factors for mortality in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) and undergoing invasive mechanical ventilation. We aimed to estimate 180-day mortality of patients with COVID-19 requiring invasive ventilation, and to develop a predictive model for long-term mortality. METHODS: Retrospective, multicentre, national cohort study between March 8 and April 30, 2020 in 16 intensive care units (ICU) in Spain...
October 2, 2021: Annals of Intensive Care
https://read.qxmd.com/read/34562689/a-dynamic-online-nomogram-predicting-severe-vitamin-d-deficiency-at-icu-admission
#37
JOURNAL ARTICLE
George Bou Kheir, Amina Khaldi, Aya Karam, Louis Duquenne, Jean-Charles Preiser
INTRODUCTION: Although prevalent and associated with worsened outcomes, vitamin D severe deficiency is not systematically searched among intensive care unit (ICU) admissions and waiting time for measurement results range from hours to few days. Hence, we developed and internally validated a simple nomogram for predicting severe vitamin D deficiency at ICU admission. PATIENTS AND METHODS: Data of 3338 ICU admissions from an observational prospective cohort registered between January 2017 and December 2019 were analyzed...
September 4, 2021: Clinical Nutrition
https://read.qxmd.com/read/34449310/mmp-2-and-mmp-9-levels-in-plasma-are-altered-and-associated-with-mortality-in-covid-19-patients
#38
JOURNAL ARTICLE
Carolina D Avila-Mesquita, Ariel E S Couto, Ligia C B Campos, Tauana F Vasconcelos, Jessyca Michelon-Barbosa, Carlos A C Corsi, Fabiola Mestriner, Bruno C Petroski-Moraes, Maria J Garbellini-Diab, Daniel M S Couto, Maria C Jordani, Denise Ferro, Lourenço Sbragia, Edwaldo E Joviliano, Paulo R Evora, Rodrigo de Carvalho Santana, Olindo Assis Martins-Filho, Katarzyna Polonis, Mayra G Menegueti, Mauricio S Ribeiro, Maria Auxiliadora-Martins, Christiane Becari
Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography...
August 20, 2021: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/34150790/acute-kidney-injury-due-to-covid-19-in-intensive-care-unit-an-analysis-from-a-latin-american-center
#39
JOURNAL ARTICLE
Precil Diego Miranda de Menezes Neves, Victor Augusto Hamamoto Sato, Sara Mohrbacher, Bernadete Maria Coelho Ferreira, Érico Souza Oliveira, Leonardo Victor Barbosa Pereira, Alessandra Martins Bales, Luciana Loureiro Nardotto, Jéssica Nogueira Ferreira, David José Machado, Estêvão Bassi, Amilton Silva-Júnior, Pedro Renato Chocair, Américo Lourenço Cuvello-Neto
Introduction: The kidney may be affected by coronavirus (COVID-19) in the setting of acute kidney injury (AKI). Data about AKI in intensive care unit (ICU) patients in Latin America are scarce. We aimed to evaluate the risk of AKI, dialysis (HD), and death in ICU COVID-19 patients in a Brazilian center. Methods: Analysis from medical records of COVID-19 patients in a Brazilian center. Results: A total of 95 patients were analyzed. There was male predominance (64.2%), median age: 64.9 years, and previous history of hypertension and diabetes in 51...
2021: Frontiers in Medicine
https://read.qxmd.com/read/33632273/long-term-outcome-after-intensive-care-for-covid-19-differences-between-men-and-women-a-nationwide-cohort-study
#40
JOURNAL ARTICLE
Erik Zettersten, Lars Engerström, Max Bell, Gabriella Jäderling, Johan Mårtensson, Linda Block, Emma Larsson
BACKGROUND: Questions remain about long-term outcome for COVID-19 patients in general, and differences between men and women in particular given the fact that men seem to suffer a more dramatic course of the disease. We therefore analysed outcome beyond 90 days in ICU patients with COVID-19, with special focus on differences between men and women. METHODS: We identified all patient ≥ 18 years with COVID-19 admitted between March 6 and June 30, 2020, in the Swedish Intensive Care Registry...
February 25, 2021: Critical Care: the Official Journal of the Critical Care Forum
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