Imen Ghzaiel, Samah Maaloul, Mohamed Ksila, Amira Namsi, Aline Yammine, Meriam Debbabi, Asma Badreddine, Wiem Meddeb, Vivien Pires, Thomas Nury, Franck Ménétrier, Laure Avoscan, Amira Zarrouk, Mauhamad Baarine, Olfa Masmoudi-Kouki, Taoufik Ghrairi, Raoudha Abdellaoui, Boubker Nasser, Sonia Hammami, Mohamed Hammami, Mohammad Samadi, Anne Vejux, Gérard Lizard
7-Ketocholesterol and 7β-hydroxycholesterol are most often derived from the autoxidation of cholesterol. Their quantities are often increased in the body fluids and/or diseased organs of patients with age-related diseases such as cardiovascular diseases, Alzheimer's disease, age-related macular degeneration, and sarcopenia which are frequently associated with a rupture of RedOx homeostasis leading to a high oxidative stress contributing to cell and tissue damages. On murine cells from the central nervous system (158N oligodendrocytes, microglial BV-2 cells, and neuronal N2a cells) as well as on C2C12 murine myoblasts, these two oxysterols can induce a mode of cell death which is associated with qualitative, quantitative, and functional modifications of the peroxisome...
2024: Advances in Experimental Medicine and Biology