Bright Agbodzi, Francine Berlange Sado Yousseu, Fredy Brice Nemg Simo, Selassie Kumordjie, Clara Yeboah, Mba-Tihssommah Mosore, Ronald E Bentil, Heather G Coatsworth, Naiki Attram, Shirley Nimo-Paintsil, Anne T Fox, Joseph H K Bonney, William Ampofo, Rhoel R Dinglasan, Terrel Sanders, Michael R Wiley, Maurice Demanou, Andrew G Letizia
Dengue fever is expanding as a global public health threat including countries within Africa. For the past few decades, Cameroon has experienced sporadic cases of arboviral infections including dengue fever. Here, we conducted genomic analyses to investigate the origin and phylogenetic profile of Cameroon DENV-1 outbreak strains and predict the impact of emerging therapeutics on these strains. Bayesian and maximum-likelihood phylogenetic inference approaches were employed in virus evolutionary analyses. An in-silico analysis was performed to assess the divergence in immunotherapeutic and vaccine targets in the new genomes...
November 7, 2023: Emerging Microbes & Infections