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M C Van Remmerden, L Hoogland, S E Mous, B Dierckx, M Coesmans, H A Moll, K Lubbers, C R Lincken, A M Van Eeghen
Little is known about care needs of young adults with Fragile X Syndrome (FXS). Patient-driven information is needed to improve understanding and support of young adults with FXS. A qualitative study was performed in 5 young adult patients (aged 18-30), and 33 parents of young adults. Concerns and care needs were categorized using the International Classification of Functioning, Disability, and Health. Results indicated concerns on 14 domains for males, and 13 domains for females, including physical, psychological and socio-economical issues...
March 16, 2019: Journal of Autism and Developmental Disorders
Gary Sacks, Ella Robinson, Adrian J Cameron
PURPOSE OF REVIEW: There is a broad consensus that policies to create healthier food environments are needed to address obesity. However, previous reviews of the relationships between the healthiness of food environments and diet/obesity-related outcomes have typically reported either mixed associations or none at all. This paper aimed to synthesise measurement and interpretation issues in this field, based on findings from previous reviews. RECENT FINDINGS: Key issues, drawn from 14 previous reviews in the last decade, included: (1) the use of measures of the food environments that are too narrow in scope; (2) inadequate measures of the way in which people are exposed to, and interact with, food environments; and (3) large heterogeneity in tools and methods used...
March 16, 2019: Current Obesity Reports
Elisa Rossi, Sonia Poirault-Chassac, Ivan Bieche, Richard Chocron, Anne Schnitzler, Anna Lokajczyk, Pierre Bourdoncle, Blandine Dizier, Nour C Bacha, Nicolas Gendron, Adeline Blandinieres, Coralie L Guerin, Pascale Gaussem, David M Smadja
Stem cells at the origin of endothelial progenitor cells and in particular endothelial colony forming cells (ECFCs) subtype have been largely supposed to be positive for the CD133 antigen, even though no clear correlation has been established between its expression and function in ECFCs. We postulated that CD133 in ECFCs might be expressed intracellularly, and could participate to vasculogenic properties. ECFCs extracted from cord blood were used either fresh (n = 4) or frozen (n = 4), at culture days <30, to investigate the intracellular presence of CD133 by flow cytometry and confocal analysis...
March 16, 2019: Stem Cell Reviews
Lei Ma, Bingzi Zhao, Zhibin Guo, Daozhong Wang, Dandan Li, Jisheng Xu, Zengqiang Li, Jiabao Zhang
Unbalanced fertilization lacking nitrogen (N), phosphorus (P), or potassium (K) is a worldwide phenomenon; however, whether they affect bacterial community composition and intraspecific interactions in a similar pattern and how they affect bacterial activity are not systematically compared. Soils under different kinds of unbalanced fertilization in a 21-year field experiment were collected to investigate the variation in dehydrogenase activity (DHA), bacterial community diversity, structure, composition, and possible interactions...
March 16, 2019: Environmental Science and Pollution Research International
Daqing Piao, Lara A Sypniewski, Danielle Dugat, Christian Bailey, Daniel J Burba, Luis DeTaboada
The target level photobiomodulation (PBM) irradiances along the thoracic to lumbar segment of the interior spinal canal in six cadaver dogs resulting from surface illumination at 980 nm were measured. Following a lateral hemi-laminectomy, a flexible probe fabricated on a plastic tubular substrate of 6.325 mm diameter incorporating nine miniature photodetectors was embedded in the thoracic to lumbar segment of the spinal canal. Intra-spinal irradiances at the nine photodetector sites, spanning an approximate 8 cm length caudal to T13, were measured for various applied powers of continuous wave (CW) surface illumination at 980 nm with a maximal power of 10 W corresponding to a surface irradiance of 3...
March 16, 2019: Lasers in Medical Science
Chenshu Zhang, Judith S Brook, Carl G Leukefeld, David W Brook
This longitudinal study assesses the associations between developmental trajectories of religious service attendance from mean age 14 to mean age 43 and nicotine dependence and alcohol dependence/abuse at mean age 43 (N = 548). Six trajectories of religious service attendance were identified. As compared with belonging to weekly stable trajectory group, a higher probability of belonging to the weekly/none decreasing, occasional stable, and non-attendance trajectory group was significantly associated with a higher likelihood of nicotine dependence...
March 16, 2019: Journal of Religion and Health
Ting Zhang, Wenjia Sun, Jing Xue, Jiaxi Chen, Qifeng Jiang, Lijun Mou, Hengjian Du
Podocytic infolding glomerulopathy (PIG) is a newly proposed disease entity, and only 29 cases have been reported worldwide so far, characterized by microspheres or microtubular structures or both associated with podocytic infolding into the glomerular basement membrane (GBM) on electron microscopy. We present two new cases of PIG with connective tissue disease (CTD), one with primary Sjögren's syndrome and the other with systemic lupus erythematosus (SLE), and make a systemic review of the literature. In the entire 31 patients of PIG, 24 (77...
March 16, 2019: Clinical Rheumatology
Anke Kindermann, Jan Baier, Andreas Simm, Roland Haase, Babett Bartling
The receptor for advanced glycation end-products is mainly expressed in type I alveolar epithelial cells but its importance in lung development and response to neonatal hyperoxia is unclear. Therefore, our study aimed at the analysis of young wildtype and RAGE knockout mice which grew up under normoxic or hyperoxic air conditions for the first 14 days followed by a longer period of normoxic conditions. Lung histology, expression of lung-specific proteins, and respiratory mechanics were analyzed when the mice reached an age of 2 or 4 months...
March 16, 2019: Pflügers Archiv: European Journal of Physiology
Yann Le Mansec, Sylvain Dorel, Antoine Nordez, Marc Jubeau
PURPOSE: Reaction time, classically divided into premotor time and electromechanical delay (EMD), can be determinant in daily life or sport situations. While some previous studies reported a negative impact of both muscle and mental fatigue on reaction time, the respective contributions of premotor time and EMD to the changes of reaction time remains unclear. The aim of the study was, therefore, to assess the effects of both muscle and mental effort on reaction time and its components...
March 16, 2019: European Journal of Applied Physiology
Aurélien Courvoisier, Matthieu Nesme, Julien Gerbelot, Alexandre Moreau-Gaudry, François Faure
PURPOSE: Bracing is the most commonly used treatment for scoliosis. But braces remain predominantly "handcrafted." Our objective was to create a novel brace simulator using a high-fidelity 3D "avatar" of the patient's trunk. METHODS: An observational cross-sectional study was constructed. The inclusion criteria were patients with a moderate idiopathic scoliosis (between 15° and 35° of Cobb angle) aged between 9 and 15 years old with an indication of brace treatment...
March 16, 2019: European Spine Journal
Kayleen Bailey, Neeta Pandit-Taskar, John L Humm, Pat Zanzonico, Stephen Gilheeney, Nai-Kong V Cheung, Kim Kramer
PURPOSE: We explored the use of intraventricular 131 I-Omburtamab targeting B7-H3 in patients with ETMR. METHODS: Patients were enrolled in an IRB approved, phase 1, 3 + 3 dose escalation trial. Patients with CNS disease expressing the antibody target antigen B7-H3 were eligible. We report on a cohort of three patients with ETMR who were enrolled on the study. Three symptomatic children (ages 14 months, 3 and 3.5 years) had large parietal masses confirmed to be B7-H3-reactive ETMR...
March 16, 2019: Journal of Neuro-oncology
Remo H M Furtado, Robert P Giugliano, Talia F Dalcoquio, Flavia B B Arantes, Carlos J D G Barbosa, Paulo R R Genestreti, André Franci, Fernando R Menezes, Carlos A K Nakashima, Marco A Scanavini Filho, Aline G Ferrari, Rocio Salsoso, Luciano M Baracioli, Jose C Nicolau
Recent reports have suggested that aspirin effect might be influenced by bodyweight, with decreased efficacy in heavier individuals. We investigated the influence of bodyweight on aspirin pharmacodynamics in two independent datasets of patients taking non-enteric coated aspirin 100 mg QD for coronary artery disease (CAD). In the first dataset, 368 patients had their platelet aggregation assessed using VerifyNow Aspirin and measured in Aspirin Reaction Units (ARU). In the second dataset, 70 patients had serum thromboxane B2 (TXB2) dosage assessed by an ELISA assay and measured in pg/mL...
March 16, 2019: Journal of Thrombosis and Thrombolysis
Masato Ikeda, Risa Terashima, Taku Yamada, Masahiro Suyama, Shinya Yokote, Masatsugu Nakao, Izumi Yamamoto, Keita Hirano, Hideo Okonogi, Hiroyasu Yamamoto, Takashi Yokoo
BACKGROUND: A decrease in absolute numbers (abs.) of circulating dendritic cells (DCs) and recruitment into target organs has been reported, but whether the level of proteinuria associates with circulating DC abs. has not been clarified. METHODS: We conducted a cross-sectional study of 210 patients with kidney disease aged 21-96 years who were admitted to our hospital for kidney biopsy in 2007-2010. For accuracy, the level of proteinuria was thoroughly measured by 24-h urine collection from patients in their admitted condition...
March 16, 2019: Clinical and Experimental Nephrology
S Arun Kumar, Bhagavatula Indira Devi, Madhusudan Reddy, Dhaval Shukla
INTRODUCTION: There are no comparative studies available for hyperosmolar therapy in children. The present study is a prospective open label randomized control trial to compare the effect of equiosmolar doses of mannitol and hypertonic saline in reducing intracranial pressure in children who sustained severe traumatic brain injury. METHODS: This is a prospective open-label randomized controlled trial. Thirty children aged less than or equal to 16 years with severe traumatic brain injury and raised intracranial pressure as measured by ventricular catheter insertion were enrolled...
March 16, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Victor M Lu, John P Welby, Anita Mahajan, Nadia N Laack, David J Daniels
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a pediatric brain tumor with dismal prognosis despite initial radiation therapy (RT). The clinical consequences of attempting reirradiation (reRT) in these patients to alleviate both symptomatology and improve prognosis are currently unclear. Thus, the aim of this systematic review and meta-analysis was to clarify the efficacy and safety of reRT in DIPG. METHODS: Searches of seven electronic databases from inception to January 2019 were conducted following the appropriate guidelines...
March 16, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
A O Adeniji, O O Okoh, A I Okoh
The incidence and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) in the Buffalo River Estuary in the Eastern Cape Province of South Africa were assessed in this study. A total of 60 surface water and 19 sediment samples were collected from 5 sites of the estuary over a period of 6 months (December 2015 to May 2016). Extraction of PAHs from the water and sediment samples was achieved by using liquid-liquid and soxhlet extraction methods respectively, followed by column clean up with silica gel and quantification by gas chromatography-flame ionization detection...
March 16, 2019: Archives of Environmental Contamination and Toxicology
Ankush Mittal, Motaz Elmahdy Hassan, Joht Singh Chandan, Brian H Willis, Krishnarajah Nirantharakumar, Kesvapilla Subramonian
PURPOSE: Urolithiasis is a common condition that poses significant morbidity to patients. There are similarities in the development of certain cancers and urinary tract calculi (UTC), however, little is known about their temporal relationship. This study aims to identify if cancer is a risk factor for the development of UTC. METHODS: A population-based retrospective cohort study was conducted for the period 1st January 1990 to 1st May 2016. 124,901 exposed patients identified using clinical codes with newly diagnosed cancer were matched to 476,203 unexposed controls by age, gender, BMI, and general practice...
March 16, 2019: Urolithiasis
Willem-Maarten P F Bosman, Benjamin L Emmink, Abhiram R Bhashyam, R Marijn Houwert, Jort Keizer
PURPOSE: Olecranon fractures are common and typically require surgical fixation due to displacement generated by the pull of the triceps muscle. The most common techniques for repairing olecranon fractures are tension-band wiring or plate fixation, but these methods are associated with high rates of implant-related soft-tissue irritation. Another treatment option is fixation with an intramedullary screw, but less is known about surgical results using this strategy. Thus, the purpose of this study was to report the clinical and functional outcomes of olecranon fractures treated with an intramedullary cannulated screw...
March 16, 2019: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Outi Huttala, Jertta-Riina Sarkanen, Tuula Heinonen, Timo Ylikomi
Besides being an energy storage, adipose tissue is an endocrine organ closely associated with vascular system. Human relevant in vitro models are needed to study adipose tissue and related diseases. Vasculature plays a central role in the development and inhibition of adipose tissue related diseases. Here, adipocyte culture was established from hASC (human adipose stromal cells), and a vascularized adipose tissue model was established from hASC and HUVEC (human umbilical cord vein endothelial cell) co-culture, utilizing the same differentiation procedure...
March 11, 2019: ALTEX
Stephanie M Toth-Manikowski, Tammy L Sirich, Timothy W Meyer, Thomas H Hostetter, Seungyoung Hwang, Natalie S Plummer, Xin Hai, Josef Coresh, Neil R Powe, Tariq Shafi
BACKGROUND: Residual kidney function (RKF) is thought to exert beneficial effects through clearance of uremic toxins. However, the level of native kidney function where clearance becomes negligible is not known. METHODS: We aimed to assess whether levels of nonurea solutes differed among patients with 'clinically negligible' RKF compared with those with no RKF. The hemodialysis study excluded patients with urinary urea clearance >1.5 mL/min, below which RKF was considered to be 'clinically negligible'...
March 15, 2019: Nephrology, Dialysis, Transplantation
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