Zhengfei Guo, Xiaoyu Wang, Yan Li, Aiming Xing, Chengyun Wu, Daojun Li, Chunfei Wang, Anne de Bures, Yonghong Zhang, Siyi Guo, Julio Sáez-Vasquez, Zhenguo Shen, Zhubing Hu
Ribosome biogenesis is a process of making ribosomes that is tightly linked with plant growth and development. Here, through a suppressor screen for the smo2 mutant, we found that lack of a ribosomal stress response mediator, ANAC082 partially restored growth defects of the smo2 mutant, indicating SMO2 is required for the repression of nucleolar stress. Consistently, the smo2 knock-out mutant exhibited typical phenotypes characteristic of ribosome biogenesis mutants, such as pointed leaves, aberrant leaf venation, disrupted nucleolar structure, abnormal distribution of rRNA precursors, and enhanced tolerance to aminoglycoside antibiotics that target ribosomes...
April 2023: Plant Journal