Harald M Nagy, Margret Paar, Christoph Heier, Tarek Moustafa, Peter Hofer, Guenter Haemmerle, Achim Lass, Rudolf Zechner, Monika Oberer, Robert Zimmermann
Adipose triglyceride lipase (ATGL) is required for efficient mobilization of triglyceride (TG) stores in adipose tissue and non-adipose tissues. Therefore, ATGL strongly determines the availability of fatty acids for metabolic reactions. ATGL activity is regulated by a complex network of lipolytic and anti-lipolytic hormones. These signals control enzyme expression and the interaction of ATGL with the regulatory proteins CGI-58 and G0S2. Up to date, it was unknown whether ATGL activity is also controlled by lipid intermediates generated during lipolysis...
April 4, 2014: Biochimica et Biophysica Acta