Maria Antonietta D'Agostino, Philippe Carron, Corine Gaillez, Philip G Conaghan, Esperanza Naredo, Alejandra López-Rdz, Ladislav Šenolt, Ruben Burgos-Vargas, Petra Hanova, Ilaria Padovano, Tomas Cazenave, Maria S Stoenoiu, Marina Backhaus, Gaël Mouterde, Weibin Bao, Punit Goyanka, Maarten Boers, Georg Schett
OBJECTIVES: In the ULTIMATE study with an open label extension, we assessed the long-term effect of secukinumab at tissue level on synovitis and enthesitis, and across all psoriatic arthritis (PsA) manifestations, using both clinical evaluations and power Doppler ultrasonography (PDUS). METHODS: This randomised, placebo-controlled, Phase 3 study (ULTIMATE) included biologic-naïve patients with PsA with active PDUS synovitis and clinical enthesitis, and inadequate response to conventional synthetic disease-modifying antirheumatic drugs...
August 19, 2023: Seminars in Arthritis and Rheumatism