Read by QxMD icon Read

Enthesitis ultrasound

Yushiro Endo, Keita Fujikawa, Tomohiro Koga, Akinari Mizokami, Masanobu Mine, Toshiaki Tsukada, Masataka Uetani, Atsushi Kawakami
Spondyloarthritis may be increasingly present in older patients as life expectancy increases. We investigated clinical differences between early-onset and late-onset spondyloarthritis in Japan.We retrospectively reviewed 114 patients consecutively diagnosed with spondyloarthritis. The clinical course of each patient was observed for ≥1 year. We defined early-onset and late-onset spondyloarthritis as <57 or ≥57 years at a median age of this study group, respectively. We compared clinical characteristics between these 2 groups...
February 2019: Medicine (Baltimore)
Basant Elnady, Nashwa K El Shaarawy, Noha Mohammed Dawoud, Tohamy Elkhouly, Dalia El-Sayed Desouky, Eman Nabil ElShafey, Mohamed S El Husseiny, Johannes J Rasker
OBJECTIVE: To evaluate ultrasonographic subclinical inflammatory synovitis and enthesitis in psoriasis patients, without clinical arthritis or enthesitis compared with healthy controls, with a 2-year follow-up to study the associated incidence of psoriatic arthritis (PsA). METHODS: A total of 109 consecutive psoriasis vulgaris patients without clinical signs of PsA and 90 healthy controls were included from two tertiary medical centers. Subjects underwent dermatological examination, PASI score evaluation for severity of psoriasis, musculoskeletal examination using 68/66 joints count for tenderness and swollen joints...
February 12, 2019: Clinical Rheumatology
Cristina Macía Villa, Sandra Falcao, Marwin Gutierrez, Julio Medina, Hilde Berner Hammer, Eugenio De Miguel
OBJECTIVE: To analyse the association between enthesitis, synovitis and peritenon extensor tendon inflammation (PTI) in Psoriatic Arthritis (PsA). METHODS: PsA patients with swelling of metacarpophalangeal joints were included. Grey scale (GS) and power Doppler (PD) were used for synovitis and PTI ultrasound identification. Madrid Sonographic Enthesis Index (MASEI) was used for enthesitis assessment. PD activity was evaluated using PD item of MASEI and PD OMERACT definition...
February 1, 2019: Journal of Rheumatology
Jørgen Guldberg-Møller, Lene Terslev, Sabrina M Nielsen, Merete Juhl Kønig, Søren T Torp-Pedersen, Arendse Torp-Pedersen, Robin Christensen, Henning Bliddal, Karen Ellegaard
OBJECTIVES: Ultrasound (US) examination of the entheses is increasingly used. However, little is known about US findings in the entheses in asymptomatic persons. The aim of this study was to investigate the appearance of US signs in the enthuses of the lower limb in asymptomatic subjects. METHODS: We recruited 64 subjects, eight women and eight men whose ages covered four decades, from 20 to 60 years. None had tendon or joint disease in the lower limbs. Participants were examined by a rheumatologist and blood samples were collected to rule out enthesis pathology...
December 19, 2018: Clinical and Experimental Rheumatology
Christian K Huhn, Franziska Schauer, Christoph M Schempp, Nils Venhoff, Stephanie Finzel
The coincidence of skin and joint inflammation poses a challenge for both dermatologists and rheumatologists. Adequate management of such disorders requires that physicians of both specialties have sound knowledge of the other discipline. In case of suspected joint involvement, familiarity with the diagnostic options available to rheumatologists enables dermatologists to selectively refer their patients for a rheumatology consult. The objective of the present review is to familiarize the reader with the stepwise diagnostic workup performed by rheumatologists today, including laboratory tests, musculoskeletal ultrasound, X-ray studies, and magnetic resonance imaging...
January 2019: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Wolfgang Hartung, Axel Nigg, Johannes Strunk, Björn Wolff
Objectives: The aim of this study was to compare the clinical Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) and an established ultrasound enthesitis score following treatment change in patients with spondyloarthritis and enthesitis with respect to the sensitivity to change and health-related quality of life. Materials and methods: About 145 patients with active ankylosing spondylitis (n=65), psoriatic arthritis without (n=66) or with (n=14) axial involvement undergoing intensification of their treatment were included in this multicenter study...
2018: Open Access Rheumatology: Research and Reviews
Silva Pukšić, Pernille Bolton-King, Joseph Sexton, Brigitte Michelsen, Tore K Kvien, Hilde Berner Hammer
Objectives: Disease Activity index for PSoriatic Arthritis (DAPSA) (sum score 68/66 tender/swollen joint counts (68TJC/66SJC), patient's global assessment, pain and C-reactive protein (CRP)) is recommended for clinical assessment of disease activity in patients with psoriatic arthritis (PsA). Ultrasound (US) (grey scale (GS) and power Doppler (PD)) detects inflammation in joints and extra-articular structures. The present objectives were to explore the longitudinal relationships between DAPSA, clinical assessment as well as patient-reported outcome measures (PROMs) with US in patients with PsA initiating biological DMARDs and the associations between DAPSA and US remission...
2018: RMD Open
Laura Savage, Mark Goodfield, Laura Horton, Abdulla Watad, Elizabeth Hensor, Paul Emery, Richard Wakefield, Miriam Wittmann, Dennis McGonagle
OBJECTIVE: This study investigated whether sonographically determined subclinical enthesopathy in patients with moderate-to-severe psoriasis regressed under therapy with ustekinumab, initiated for skin disease. METHODS: Seventy-three systemic therapy-naïve patients with moderate-to-severe psoriasis and without symptoms of PsA, and 23 healthy volunteers, were screened using ultrasound for subclinical enthesitis. Subsequently, 23 psoriasis patients with "inflammatory changes" on ultrasound were treated with ustekinumab for 52 weeks...
November 22, 2018: Arthritis & Rheumatology
Daniel Wadsack, Horst Sattler, Marcus E Kleber, Katharina Eirich, Hubert Scharnagl, Günter Fauler, Winfried März, Tanja B Grammer
A 33-year-old female had suffered from spontaneously recurrent bursitis and tendosynovitis/enthesitis of the patellar and Achilles tendons for about 10 years. The episodes of immobilization increased. Ultrasound imaging of the swollen and painful tendons showed chronic inflammation with neoangiogenesis within the tendons and hypoechoic lesions. Clinical and laboratory tests did not provide evidence for a rheumatic disease. Low density lipoprotein cholesterol was elevated. Biopsies of skin lesions did not confirm the suspicion of cutaneous xanthomas...
October 24, 2018: Journal of Clinical Lipidology
Stephanie Tom, Yujie Zhong, Richard Cook, Sibel Zehra Aydin, Gurjit Kaeley, Lihi Eder
OBJECTIVE: To assess the performance of various sonographic elemental entheseal lesions in distinguishing between psoriatic arthritis (PsA) and controls to inform the development of a novel sonographic enthesitis score for PsA. METHODS: A total of 100 age- and sex-matched individuals (50 PsA and 50 controls) were evaluated. Eleven entheseal sites were scanned bilaterally according to a standardized protocol by 2 sonographers. Based on the Outcome Measures in Rheumatology (OMERACT) definition of sonographic enthesitis, the following lesions were assessed: structural entheseal changes (hypoechogenicity), thickening, bone erosion, enthesophytes, calcification, and Doppler signal, in addition to bursitis and bone irregularities...
October 15, 2018: Journal of Rheumatology
Tugba Ozsoy-Unubol, Ilker Yagci
The aim of this study is to evaluate the diagnostic utility of ultrasonographic enthesitis assessment in patients with non-radiographic axial spondyloarthritis (nr-axSpA) and to compare different sonographic scoring methods. Patients with nr-axSpA (n = 30) and mechanical back pain (MBP) (n = 30) were enrolled in the study with standardized clinical criteria. For both of the groups, a total of 18 entheses were evaluated in each patient with B mode ultrasound and power Doppler by a sonographer who is blinded to initial clinical and radiological assessments...
November 2018: Rheumatology International
Maria-Antonietta D'Agostino
Over the last 25 years, ultrasound has been used to evaluate involvement at the entheses in spondyloarthritis (SpA) and psoriatic arthritis (PsA). Several studies have been reported indicating its value in detecting active inflammation at entheseal sites using both gray scale and Doppler findings. This review explores the recent literature and appraises the current knowledge and the unmet needs of enthesitis detection by ultrasound in the management of both SpA and PsA.
September 2018: Clinical and Experimental Rheumatology
Fatima Arslan Alhussain, Esen Kasapoglu Gunal, Esra Kurum, Sibel Bakirci, Ayse Bilge Ozturk, Dennis McGonagle, Sibel Zehra Aydin
Objectives: AS and PsA share clinical and immunological features centred on enthesitis. However, a strong association between PsA and preceding injury has been recognized. The aim of this study was to test the hypothesis that the entheseal damage seen by US is commoner in PsA patients than in AS patients. Methods: Seventy-nine AS and 85 PsA patients had US scans of 1640 entheses to calculate entheseal inflammation (hypoechogenicity, thickening and Doppler) and damage scores (calcifications, enthesophytes and erosions)...
September 26, 2018: Rheumatology
Antonio Marchesoni, Roberto Caporali, Ennio Lubrano
While the destructive changes of peripheral articular damage of psoriatic arthritis (PsA) are extensively studied, the productive modifications have been somewhat neglected. This literature-based study focuses on the clinically relevant aspects of peripheral bone proliferation in PsA. New bone proliferation frequently occurs as juxta-articular and entheseal apposition in PsA patients but also in psoriatic patients without arthritis, the Psoriatic Arthritis Ratingen Score is the only radiographic method to evaluate peri-articular new bone formation, numerous ultrasound systems to score entheseal changes have been proposed, several serum biomarkers of bone-turnover have been associated with PsA and psoriasis but they do not have clinical relevance...
August 29, 2018: Clinical and Experimental Rheumatology
Mihaela Spârchez, Daniela Fodor
Musculoskeletal ultrasound (MSUS) has become almost indispensable in the rheumatology settings nowadays, allowing early diagnosis, careful guidance during procedures such as joint injections and therapy monitoring. Nonetheless, the applicability of MSUS in pediatric population is still limited. Recently, a standardized MSUS examination procedure in pediatric patients with rheumatic diseases, definitions for synovitis and the sonographic features of joints in healthy children has been developed. Also, important data on age-related  vascularization and ossification of joints in children have been published...
August 30, 2018: Medical Ultrasonography
Cecile Poulain, Maria Antonietta D'Agostino, Severine Thibault, Jean Pierre Daures, Salah Ferkal, Philippe Le Corvoisier, Alain Rahmouni, Damien Loeuille, Maxime Dougados, Pascal Claudepierre
Early diagnosis of axial spondyloarthritis (axSpA) remains a challenge due to the lack of specificity of clinical symptoms and variable prevalence of axial imaging findings permitting a definite diagnosis. Power Doppler ultrasonography (PDUS) of the entheses has demonstrated to be a potential useful tool for the classification and diagnostic management of early SpA independently of the phenotype. Objectives: To assess the classification value (sensitivity and specificity) of PDUS-defined enthesitis for identifying patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA (ASAS+) in patients with recent inflammatory back pain (IBP) (the DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort)...
2018: RMD Open
Jerry Bagel, Sergio Schwartzman
Psoriatic arthritis (PsA) is an inflammatory arthritis that is estimated to affect approximately 30% of patients with psoriasis. Enthesitis and dactylitis, two hallmarks of PsA, are associated with radiographic peripheral/axial joint damage and severe disease. Clinical symptoms of enthesitis include tenderness, soreness, and pain at entheses on palpation, whereas dactylitis is recognized by swelling of an entire digit that is different from adjacent digits. Both ultrasound and magnetic resonance imaging can be used to diagnose enthesitis and dactylitis, especially in patients in whom symptoms may be difficult to discern...
December 2018: American Journal of Clinical Dermatology
Peter V Balint, Lene Terslev, Philippe Aegerter, George Arthur Willem Bruyn, Isabelle Chary-Valckenaere, Frederique Gandjbakhch, Annamaria Iagnocco, Sandrine Jousse-Joulin, Ingrid Möller, Esperanza Naredo, Wolfgang A Schmidt, Richard J Wakefield, Maria-Antonietta D'Agostino
OBJECTIVES: To evaluate the reliability of consensus-based ultrasound (US) definitions of elementary components of enthesitis in spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to evaluate which of them had the highest contribution to defining and scoring enthesitis. METHODS: Eleven sonographers evaluated 40 entheses from five patients with SpA/PsA at four bilateral sites. Nine US elementary lesions were binary-scored: hypoechogenicity, thickened insertion, enthesophytes, calcifications, erosions, bone irregularities, bursitis and Doppler signal inside and around enthesis...
December 2018: Annals of the Rheumatic Diseases
Ofir Elalouf, Sibel Bakirci Ureyen, Zahi Touma, Melanie Anderson, Gurjit S Kaeley, Sibel Z Aydin, Lihi Eder
OBJECTIVE: As part of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) ultrasound working group, we performed a systematic review of the literature to assess the evidence and knowledge gaps in scoring instruments of enthesitis in psoriatic arthritis (PsA). METHODS: A systematic search of PubMed, EMBase, and Cochrane databases was performed. The search strategy was constructed to find original publications containing terms related to ultrasound, enthesitis, spondyloarthritis (SpA) or PsA...
January 2019: Journal of Rheumatology
Marco Canzoni, Matteo Piga, Alen Zabotti, Carlo Alberto Scirè, Greta Carrara, Ignazio Olivieri, Annamaria Iagnocco
INTRODUCTION: Psoriatic arthritis (PsA) occurs in 10%-15% of people with psoriasis and accounts for 10%-20% of early arthritis clinics referral. Only a few prognostic factors of therapeutic response in patients with PsA have been identified. In the last years, the role of imaging has grown up and the European League Against Rheumatism recognised that ultrasound (US) has higher sensitivity than clinical examination to detect inflammatory disease activity. The aims of the Ultrasound in PSoriatic arthritis TREAtMent (UPSTREAM) study are to integrate clinic and US in order to inform whether US has provide an added prognostic value in PsA...
July 10, 2018: BMJ Open
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"