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Oxygen post seizure

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https://read.qxmd.com/read/30890997/incidence-recurrence-and-risk-factors-for-peri-ictal-central-apnea-and-sudden-unexpected-death-in-epilepsy
#1
Laura Vilella, Nuria Lacuey, Johnson P Hampson, M R Sandhya Rani, Kenneth Loparo, Rup K Sainju, Daniel Friedman, Maromi Nei, Kingman Strohl, Luke Allen, Catherine Scott, Brian K Gehlbach, Bilal Zonjy, Norma J Hupp, Anita Zaremba, Nassim Shafiabadi, Xiuhe Zhao, Victoria Reick-Mitrisin, Stephan Schuele, Jennifer Ogren, Ronald M Harper, Beate Diehl, Lisa M Bateman, Orrin Devinsky, George B Richerson, Adriana Tanner, Curtis Tatsuoka, Samden D Lhatoo
Introduction: Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e., post-ictal generalized EEG suppression (PGES) and recurrence. Methods: Prospective, multi-center seizure monitoring study of autonomic, and breathing biomarkers of SUDEP in adults with intractable epilepsy and monitored seizures. Video EEG, thoraco-abdominal excursions, capillary oxygen saturation, and electrocardiography were analyzed...
2019: Frontiers in Neurology
https://read.qxmd.com/read/30623786/information-needs-for-designing-a-home-monitoring-system-for-children-with-medical-complexity
#2
Flory L Nkoy, Michelle G Hofmann, Bryan L Stone, Justin Poll, Lauren Clark, Bernhard A Fassl, Nancy A Murphy
Background Children with medical complexity (CMC) are a growing population of medically fragile children with unique healthcare needs, who have recurrent emergency department (ED) and hospital admissions due to frequent acute escalations of their chronic conditions. Mobile health (mHealth) tools have been suggested to support CMC home monitoring and prevent admissions. No mHealth tool has ever been developed for CMC and challenges exist. Objective To: 1) assess information needs for operationalizing CMC home monitoring, and 2) determine technology design functionalities needed for building a mHealth application for CMC...
February 2019: International Journal of Medical Informatics
https://read.qxmd.com/read/30604923/delaying-latency-to-hyperbaric-oxygen-induced-cns-oxygen-toxicity-seizures-by-combinations-of-exogenous-ketone-supplements
#3
Csilla Ari, Andrew P Koutnik, Janine DeBlasi, Carol Landon, Christopher Q Rogers, John Vallas, Sahil Bharwani, Michelle Puchowicz, Ilya Bederman, David M Diamond, Mark S Kindy, Jay B Dean, Dominic P D Agostino
Central nervous system oxygen toxicity (CNS-OT) manifests as tonic-clonic seizures and is a limitation of hyperbaric oxygen therapy (HBOT), as well as of recreational and technical diving associated with elevated partial pressure of oxygen. A previous study showed that ketone ester (1,3-butanediol acetoacetate diester, KE) administration delayed latency to seizures (LS) in 3-month-old Sprague-Dawley (SD) rats. This study explores the effect of exogenous ketone supplements in additional dosages and formulations on CNS-OT seizures in 18 months old SD rats, an age group correlating to human middle age...
January 2019: Physiological Reports
https://read.qxmd.com/read/30593160/sudden-seizure-during-cesarean-section-a-case-report
#4
Wenqin Zhou, Qing Zhu
RATIONALE: A first seizure can range from a fleeting subjective experience or a twitch (myoclonic jerk) through to a tonic-clonic convulsion. A first seizure occurred in a parturient during cesarean section is very rare. We describe the case of a parturient who suffered seizure when the fetus was delivered. PATIENT CONCERNS: Our patient is a 31-year-old parturient with a first seizure during cesarean section. DIAGNOSES: Seizure. INTERVENTIONS: The patient received supportive therapy to maintain oxygen supply and propofol was administered to terminate seizure during cesarean section...
December 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30568003/postconvulsive-central-apnea-as-a-biomarker-for-sudden-unexpected-death-in-epilepsy-sudep
#5
Laura Vilella, Nuria Lacuey, Johnson P Hampson, M R Sandhya Rani, Rup K Sainju, Daniel Friedman, Maromi Nei, Kingman Strohl, Catherine Scott, Brian K Gehlbach, Bilal Zonjy, Norma J Hupp, Anita Zaremba, Nassim Shafiabadi, Xiuhe Zhao, Victoria Reick-Mitrisin, Stephan Schuele, Jennifer Ogren, Ronald M Harper, Beate Diehl, Lisa Bateman, Orrin Devinsky, George B Richerson, Philippe Ryvlin, Samden D Lhatoo
OBJECTIVE: To characterize peri-ictal apnea and postictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy. METHODS: This was a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of sudden unexpected death in epilepsy (SUDEP) in patients ≥18 years old with intractable epilepsy and monitored GCS. Video-EEG, thoracoabdominal excursions, nasal airflow, capillary oxygen saturation, and ECG were analyzed...
December 19, 2018: Neurology
https://read.qxmd.com/read/30319527/post-ictal-modulation-of-baroreflex-sensitivity-in-patients-with-intractable-epilepsy
#6
Behnaz Esmaeili, Farhad Kaffashi, Wanchat Theeranaew, Aman Dabir, Samden D Lhatoo, Kenneth A Loparo
Objective: Seizure-related autonomic dysregulation occurs in epilepsy patients and may contribute to Sudden Unexpected Death in Epilepsy (SUDEP). We tested how different types of seizures affect baroreflex sensitivity (BRS) and heart rate variability (HRV). We hypothesized that BRS and HRV would be reduced after bilateral convulsive seizures (BCS). Methods: We recorded blood pressure (BP), electrocardiogram (ECG) and oxygen saturation continuously in patients ( n = 18) with intractable epilepsy undergoing video-EEG monitoring...
2018: Frontiers in Neurology
https://read.qxmd.com/read/30142618/two-predictors-of-postictal-generalized-eeg-suppression-tonic-phase-duration-and-postictal-immobility-period
#7
Marjan Asadollahi, Mahyar Noorbakhsh, Leila Simani, Mahtab Ramezani, Kurosh Gharagozli
PURPOSE: To determine the effect of different seizure characteristics on the occurrence of postictal generalized EEG suppression (PGES). PGES is considered as a potential risk factor of sudden unexpected death in epilepsy (SUDEP) by several studies. METHODS: In this retrospective cross-sectional study, episodes of generalized convulsive seizures (GCS) were reviewed in regard to state at seizure-onset, the seizure and tonic phase durations, postictal immobility (PI) duration and whether the patient received oxygen (O2) mask during the post-ictal phase...
October 2018: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/30112701/inhibition-of-myd88-signaling-skews-microglia-macrophage-polarization-and-attenuates-neuronal-apoptosis-in-the-hippocampus-after-status-epilepticus-in-mice
#8
Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuang
Inflammation is implicated in epileptogenesis. Activated microglia and macrophages (MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal models of epilepsy. It is not yet known how the MG/MΦ activation phenotype affects pathological changes in the brain after a single seizure. In this study, we had 2 main purposes: first, to characterize post-status epilepticus (SE) inflammation by tracking MG/MΦ polarization, and, second, to explore the role of an innate immune receptor adaptor protein, namely, myeloid differentiation primary response gene 88 (MyD88), in the induction of SE in a mouse model...
August 15, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/30019618/detection-of-hyperexcitability-by-functional-magnetic-resonance-imaging-after-experimental-traumatic-brain-injury
#9
Joanna K Huttunen, Antti M Airaksinen, Carmen Barba, Gabriella Colicchio, Juha-Pekka Niskanen, Artem Shatillo, Alejandra Sierra Lopez, Xavier Ekolle Ndode-Ekane, Asla Pitkänen, Olli H Gröhn
Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. Given that increased neuronal activity in the brain triggers a blood oxygenation level-dependent (BOLD) response in functional magnetic resonance imaging (fMRI), we hypothesized that fMRI could be used to identify the brain area(s) with hyperexcitability during post-injury epileptogenesis. We applied fMRI to detect onset and spread of BOLD activation after pentylenetetrazol (PTZ)-induced seizures (PTZ, 30 mg/kg, intraperitoneally) in 16 adult male rats at 2 months after lateral fluid percussion (FPI)-induced traumatic brain injury (TBI)...
November 15, 2018: Journal of Neurotrauma
https://read.qxmd.com/read/29882580/hyperbaric-oxygen-therapy-for-spinal-cord-ischaemia-after-complex-aortic-repair-a-retrospective-review
#10
Matteo Parotto, Maral Ouzounian, Ludwik Fedorko, George Oreopoulos, Thomas Lindsay, Rita Katznelson
BACKGROUND: Complex aortic repair (CAR) carries high rates of debilitating postoperative complications, including spinal cord injury. The rate of spinal cord deficits post-CAR is approximately 10%, with permanent paraplegia in 2.9% and paraparesis in 2.4% of patients. Treatment options are limited. Rescue therapies include optimization of spinal cord perfusion and oxygen delivery by mean arterial pressure augmentation (> 90 mm Hg), cerebrospinal fluid drainage, and preservation of adequate haemoglobin concentration (> 100 g L⁻¹)...
2018: Anaesthesiology Intensive Therapy
https://read.qxmd.com/read/29876334/pneumocephalus-after-tympanomastoidectomy-a-case-presentation
#11
Mohammadhossein Baradaranfar, Sedighe Vaziribozorg, Mojtaba Mirzade, Mostafa Salari
Introduction: Pneumocephalus is the presence of air or gas within the cranial cavity. It can occur following otorhinolaryngological procedures. A small pneumocephalus spontaneously heals without any treatment. In severe cases, conservative therapy includes a 30-degree head elevation, avoidance of the Valsalva maneuver, analgesics, osmotic diuretics, and oxygen therapy. Case Report: A 56-year-old woman was referred to the emergency department due to a severe headache in the frontal area for 2 days before admission...
May 2018: Iranian Journal of Otorhinolaryngology
https://read.qxmd.com/read/29651419/management-of-glioblastoma-multiforme-in-a-patient-treated-with-ketogenic-metabolic-therapy-and-modified-standard-of-care-a-24-month-follow-up
#12
Ahmed M A Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N Seyfried
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic lesion in the right partial space suggesting GBM. Serum testing revealed vitamin D deficiency and elevated levels of insulin and triglycerides. Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast...
2018: Frontiers in Nutrition
https://read.qxmd.com/read/29511115/measurement-of-oxygen-extraction-fraction-by-blood-sampling-to-estimate-severe-cerebral-hemodynamic-failure-and-anticipate-cerebral-hyperperfusion-syndrome-following-carotid-artery-stenting
#13
Tomonori Iwata, Takahisa Mori, Yuhei Tanno, Shigen Kasakura, Kazuhiro Yoshioka
BACKGROUND: Cerebral hyperperfusion syndrome (CHS) is likely to occur after carotid revascularization in patients with stage 2 hemodynamic failure (st2HF), in whom the oxygen extraction fraction (OEF) increases. OBJECTIVE: The purpose of our study was to investigate whether measurement of the global cerebral OEF (gcOEF) by blood sampling can be used to estimate st2HF and anticipate CHS following carotid artery stenting (CAS). METHODS: The OEF was calculated by blood sampling just before and after elective CAS...
March 6, 2018: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/29180981/cerebral-microdialysis-monitoring-to-improve-individualized-neurointensive-care-therapy-an-update-of-recent-clinical-data
#14
REVIEW
Laurent Carteron, Pierre Bouzat, Mauro Oddo
Cerebral microdialysis (CMD) allows bedside semicontinuous monitoring of patient brain extracellular fluid. Clinical indications of CMD monitoring are focused on the management of secondary cerebral and systemic insults in acute brain injury (ABI) patients [mainly, traumatic brain injury (TBI), subarachnoid hemorrhage, and intracerebral hemorrhage (ICH)], specifically to tailor several routine interventions-such as optimization of cerebral perfusion pressure, blood transfusion, glycemic control and oxygen therapy-in the individual patient...
2017: Frontiers in Neurology
https://read.qxmd.com/read/28886474/functional-connectivity-of-the-hippocampus-to-the-thalamocortical-circuitry-in-an-animal-model-of-absence-seizures
#15
Seyed Reza Mousavi, Justin A Arcaro, L Stan Leung, Jeffrey R Tenney, Seyed M Mirsattari
OBJECTIVE: Using the gamma-butyrolactone (GBL) rat model of absence seizures, this study investigated the functional connectivity of the hippocampus, thalamus and cerebral cortex before and during absence seizures. METHODS: Functional connectivity between the hippocampus, thalamus and sensory and motor cortecies, were examined by the temporal correlations of the resting state blood-oxygen-level-dependent (BOLD) signal. Functional connectivity between these regions was calculated at baseline, 5min after saline injection, and at 5, 20 and 52min after GBL injection...
November 2017: Epilepsy Research
https://read.qxmd.com/read/28268486/identifying-stereotypic-evolving-micro-scale-seizures-sems-in-the-hypoxic-ischemic-eeg-of-the-pre-term-fetal-sheep-with-a-wavelet-type-ii-fuzzy-classifier
#16
Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth
Perinatal hypoxic-ischemic encephalopathy (HIE) around the time of birth due to lack of oxygen can lead to debilitating neurological conditions such as epilepsy and cerebral palsy. Experimental data have shown that brain injury evolves over time, but during the first 6-8 hours after HIE the brain has recovered oxidative metabolism in a latent phase, and brain injury is reversible. Treatments such as therapeutic cerebral hypothermia (brain cooling) are effective when started during the latent phase, and continued for several days...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/28226660/identifying-stereotypic-evolving-micro-scale-seizures-sems-in-the-hypoxic-ischemic-eeg-of-the-pre-term-fetal-sheep-with-a-wavelet-type-ii-fuzzy-classifier
#17
Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth, Hamid Abbasi, Laura Bennet, Alistair J Gunn, Charles P Unsworth, Charles P Unsworth, Laura Bennet, Hamid Abbasi, Alistair J Gunn
Perinatal hypoxic-ischemic encephalopathy (HIE) around the time of birth due to lack of oxygen can lead to debilitating neurological conditions such as epilepsy and cerebral palsy. Experimental data have shown that brain injury evolves over time, but during the first 6-8 hours after HIE the brain has recovered oxidative metabolism in a latent phase, and brain injury is reversible. Treatments such as therapeutic cerebral hypothermia (brain cooling) are effective when started during the latent phase, and continued for several days...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/28203222/unexpected-death-of-a-child-with-complex-febrile-seizures-pathophysiology-similar-to-sudden-unexpected-death-in-epilepsy
#18
Brian J Dlouhy, Michael A Ciliberto, Christina L Cifra, Patricia A Kirby, Devin L Shrock, Marcus Nashelsky, George B Richerson
Febrile seizures are usually considered relatively benign. Although some cases of sudden unexplained death in childhood have a history of febrile seizures, no documented case of febrile seizure-induced death has been reported. Here, we describe a child with complex febrile seizures who died suddenly and unexpectedly after a suspected seizure while in bed at night during the beginning phases of sleep. She was resuscitated and pronounced brain dead 2 days later at our regional medical center. Autopsy revealed multiorgan effects of hypoperfusion and did not reveal an underlying (precipitating) disease, injury, or toxicological cause of death...
2017: Frontiers in Neurology
https://read.qxmd.com/read/28011391/pathophysiology-of-status-epilepticus
#19
REVIEW
Matthew C Walker
Status epilepticus (SE) is the maximal expression of epilepsy with a high morbidity and mortality. It occurs due to the failure of mechanisms that terminate seizures. Both human and animal data indicate that the longer a seizure lasts, the less likely it is to stop. Recent evidence suggests that there is a critical transition from an ictal to a post-ictal state, associated with a transition from a spatio-temporally desynchronized state to a highly synchronized state, respectively. As SE continues, it becomes progressively resistant to drugs, in particular benzodiazepines due partly to NMDA receptor-dependent internalization of GABA(A) receptors...
February 22, 2018: Neuroscience Letters
https://read.qxmd.com/read/27800071/neonatal-transport-practices-in-ibadan-nigeria
#20
Muhydeen Abiodun Abdulraheem, Olukemi Oluwatoyin Tongo, Adebola Emmanuel Orimadegun, Olukayode Felix Akinbami
INTRODUCTION: Neonatal transport involves moving sick neonates in optimal conditions to ensure good outcomes. It is well organized in most developed countries but receives little attention in developing countries where the highest burden of neonatal mortality exists and a large number of newborns require referrals daily for better medical care. This study sought to evaluate the modes of transport, pre- and intra-transport care of neonates referred to the University College Hospital (UCH), Ibadan, Nigeria...
2016: Pan African Medical Journal
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