Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He, Moying Li, Tianzuo Zhan, Abbas Khan, Xiaohui Li, Xiangxiang Zeng, Chaopeng Li, Dongsheng Ouyang, Kelong Ai, Xuan Chen, Dongbo Liu, Zhonghua Liu, Dongqing Wei, Ke Cao
BACKGROUND: Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from Zanthoxylum bungeanum Maxim, has anti-inflammatory and antioxidant biological activity, however, its function and mechanism in DIC remain unclear. METHODS: We established DOX-induced cardiotoxicity models both in vitro and in vivo...
November 17, 2023: Journal of Translational Medicine