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JOURNAL ARTICLE
Ruyuan Zhu, Luyao Wang, Ling Zhao, Xiaojing Liu
BACKGROUND: Craniopharyngioma is a common intracranial tumour in children. Clinical manifestations are related to hypothalamic/pituitary deficiencies, visual impairment, and increased intracranial pressure. Defects in pituitary function cause shortages of growth hormone, gonadotropin, corticotropin, thyrotropin, and vasopressin, resulting in short stature, delayed puberty, feebleness, lethargy, polyuria, etc. However, manifestations involving precocious puberty (PP) are rare. CASE REPORT: In both patients, surgical resection was performed after the diagnosis of craniopharyngioma, and breast development occurred postoperatively at one month in one patient and at one year and three months in the other patient...
April 18, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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JOURNAL ARTICLE
Michael G Brandel, Jillian H Plonsker, Robert C Rennert, Gautam Produturi, Megana Saripella, Arvin R Wali, Carson McCann, Vijay M Ravindra, David R Santiago-Dieppa, J Scott Pannell, Jeffrey A Steinberg, Alexander A Khalessi, Michael L Levy
INTRODUCTION: Pediatric intracranial aneurysms (IAs) are rare and have distinct clinical profiles compared to adult IAs. They differ in location, size, morphology, presentation, and treatment strategies. We present our experience with pediatric IAs over an 18-year period using surgical and endovascular treatments and review the literature to identify commonalities in epidemiology, treatment, and outcomes. METHODS: We identified all patients < 20 years old who underwent treatment for IAs at our institution between 2005 and 2020...
April 18, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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JOURNAL ARTICLE
Yujia Yan, Xingwei An, Hecheng Ren, Bin Luo, Song Jin, Li Liu, Yang Di, Tingting Li, Ying Huang
Previous studies have shown that the growth status of intracranial aneurysms (IAs) predisposes to rupture. This study aimed to construct a nomogram for predicting the growth of small IAs based on geometric and hemodynamic parameters. We retrospectively collected the baseline and follow-up angiographic images (CTA/ MRA) of 96 small untreated saccular IAs, created patient-specific vascular models and performed computational fluid dynamics (CFD) simulations. Geometric and hemodynamic parameters were calculated...
April 18, 2024: Neurosurgical Review
#4
JOURNAL ARTICLE
Jun Zhu, Enyu Pan, Lujun Pang, Xiwei Zhou, Yanjun Che, Zhao Liu
Subarachnoid hemorrhage (SAH) is a neurological disorder that severely damages the brain and causes cognitive impairment. MicroRNAs are critical regulators in a variety of neurological diseases. MiR-497-5p has been found to be downregulated in the aneurysm vessel walls obtained from patients with aneurysmal subarachnoid hemorrhage, but its functions and mechanisms in SAH have not been reported. Therefore, this study was designed to investigate the effect of miR-497-5p and its related mechanisms in SAH. We established an in vitro SAH model by exposing PC12 cells to oxyhemoglobin (oxyHb)...
April 18, 2024: Molecular Genetics and Genomics: MGG
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JOURNAL ARTICLE
A Khanafer, P von Gottberg, P Albiña-Palmarola, T Liebig, M Forsting, O Ganslandt, H Henkes
PURPOSE: Recent observational studies have indicated the efficacy of stent retriever devices for the treatment of posthemorrhagic cerebral vasospasm (CVS), both by deployment and on-site withdrawal into the microcatheter (stent angioplasty, SA) and deployment followed by retraction through the target vessel similar to thrombectomy (Stent Retraction to reLieve Arterial Cerebral vaSospasm caused by SAH, Stent-ReLACSS). This article reports the findings with each application of pRESET and pRELAX in the treatment of CVS...
April 18, 2024: Clinical Neuroradiology
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JOURNAL ARTICLE
Seung Hyun Lee, Jooyoung Lee, Da-Woon Kim, Dong Hyun Kim, Sung Jae Ahn, Moon Gwan Choi, Sungyang Jo, Chong Hyun Suh, Sun J Chung
OBJECTIVES: This study aimed to identify predictors for the recurrence of spontaneous intracranial hypotension (SIH) after epidural blood patch (EBP). BACKGROUND: Epidural blood patch is the main treatment option for SIH; however, the characteristics of patients who experience relapse after successful EBP treatment for SIH remain understudied. METHODS: In this exploratory, retrospective, case-control study, we included 19 patients with SIH recurrence after EBP and 36 age- and sex-matched patients without recurrence from a single tertiary medical institution...
April 18, 2024: Headache
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JOURNAL ARTICLE
Justin E Vranic, Adam A Dmytriw, Inka K Berglar, Naif M Alotaibi, Nicole M Cancelliere, Christopher J Stapleton, James D Rabinov, Pablo Harker, Rajiv Gupta, Joshua D Bernstock, Matthew J Koch, Scott B Raymond, Justin R Mascitelli, T Tyler Patterson, Joshua Seinfeld, Andrew White, David Case, Christopher Roark, Chirag D Gandhi, Fawaz Al-Mufti, Jared Cooper, Charles Matouk, Nanthiya Sujijantarat, Diego A Devia, Maria I Ocampo-Navia, Daniel E Villamizar-Torres, Juan C Puentes, Mohamed M Salem, Ammad Baig, Kareem El Namaani, Anna Luisa Kühn, Bryan Pukenas, Brian T Jankowitz, Jan Karl Burkhardt, Adnan Siddiqui, Pascal Jabbour, Jasmeet Singh, Ajit S Puri, Robert W Regenhardt, Vitor Mendes Pereira, Aman B Patel
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using pipeline embolization device (PED). We aimed to assess the impact of platelet function testing (PFT) on reducing periprocedural thromboembolic complications associated with PED flow diversion in patients receiving aspirin and clopidogrel. METHODS: Patients with unruptured intracranial aneurysms requiring PED flow diversion were identified from 13 centers for retrospective evaluation...
April 18, 2024: Neurosurgery
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JOURNAL ARTICLE
David R Peters, Joe Bernard, Robert Morgan, Vincent Rossi
Spontaneous intracranial hypotension is a rare but serious condition characterized by orthostatic headaches and a variety of neurological symptoms. 1,2 Spontaneous intracranial hypotension should be considered in all patients with new onset, daily, persistent headaches, and orthostatic symptoms. It is typically caused by spontaneous spinal cerebrospinal fluid (CSF) leaks. 1,2 Traditional first-line treatments include hydration, bedrest, epidural blood patches, and fibrin glue injections. However, refractory cases often require surgical intervention, especially those caused by a small ventral osteophyte, which is classified as a type 1 leak...
April 18, 2024: Operative Neurosurgery (Hagerstown, Md.)
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JOURNAL ARTICLE
Sara Mazzucco, Linxin Li, Maria Assuncao Tuna, Peter M Rothwell
INTRODUCTION: Cerebral blood flow (CBF) declines with age and abnormalities in CBF are associated with age-related cerebrovascular disease and neurodegeneration. Women have higher CBF than men, although this sex-difference diminishes to some extent with age in healthy subjects. The physiological drivers of these age/sex differences are uncertain, but might be secondary to age and sex-differences in haemoglobin (Hb) level. Hb levels are inversely correlated with CBF, are lower in women, and decline with age in men, but the interrelations between these factors have not been explored systematically either in healthy subjects or across the full age-range in patients with vascular risk factors...
April 18, 2024: European Stroke Journal
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REVIEW
Coralie Mignot, Susanne Weise, Dino Podlesek, Georg Leonhardt, Moustafa Bensafi, Thomas Hummel
Brain activity may manifest itself as oscillations which are repetitive rhythms of neuronal firing. These local field potentials can be measured via intracranial electroencephalography (iEEG). This review focuses on iEEG used to map human brain structures involved in olfaction. After presenting the methodology of the review, a summary of the brain structures involved in olfaction is given, followed by a review of the literature on human olfactory oscillations in different contexts. A single case is provided as an illustration of the olfactory oscillations...
April 2024: Journal of Neuroscience Research
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Tarik Belokda, Hajar Hamadi, Yassine Ait M'Barek, Lamia Benantar, Khalid Aniba
Cryptococcal meningitis (CM) is the third most common neurological complication in immunocompromised patients and is usually associated with high rates of morbidity and mortality. The most common complication of CM is intracranial hypertension (ICH), and it constitutes a poor prognosis factor. This case report describes a case of subacute onset hydrocephalus revealing a human immunodeficiency virus (HIV)-associated CM in a seven-year-old girl requiring cerebrospinal fluid diversion and fungal treatment with a favorable outcome...
March 2024: Curēus
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JOURNAL ARTICLE
Lulu Xi, Xiaohui Liu, Hongchen Shi, Wenbiao Han, Liqin Gao, Li Wang, Junpeng Liu, Yue Ren, Yuanyuan Du, Guangzhao Liu
PURPOSE: There are several ways to treat trigeminal neuralgia (TN); however, TN may recur after treatment. This study investigated the efficacy and safety of computed tomography (CT)-guided percutaneous balloon compression (PBC) under local anesthesia for treatment of recurrent trigeminal neuralgia. Patients and Methods . This is a prospective and nonrandomized controlled clinical study. Forty-eight patients with classical TN were scheduled to undergo PBC surgery at the pain department of our institution between January 2021 and June 2021...
2024: Pain Research & Management
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Mengmeng Wang, Jing Li, Lingyu Zhang, Nana Li, Xuemei Li, Pengfei Wang
INTRODUCTION: Tirofiban is a non-peptide selective glycoprotein IIb/IIIa receptor inhibitor with a short half-life. The research assesses the efficacy and safety of continuous intravenous tirofiban in patients with acute ischemic stroke (AIS) undergoing endovascular therapy (ET). METHODS: A systematic search of Pubmed, Embase, Web of Science, and Cochrane Library databases is conducted from inception until January 26, 2024. Eligible studies are included based on predefined selection criteria...
2024: Frontiers in Neurology
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Chengye Hou, Yuanqin Liu, Feng Li, Qinglu Zhang
RATIONALE: Intracranial ependymal cysts are relatively rare. The current case report focuses on a patient who was diagnosed with an ependymal cyst and underwent surgical treatment. Postoperative pathological examination confirmed the presence of this lesion in the cerebellum. CHIEF COMPLAINT: A 32-year-old female patient presented with a chief complaint of dizziness and headache with no triggers for the past 1 year. She also reported an increase in the frequency and intensity of symptoms in the past 2 weeks...
2024: Frontiers in Neuroscience
#15
JOURNAL ARTICLE
Frederik Boxberg, Mohammad Al-Tibi, Katharina Schulz, Heinrich Lanfermann, Martin Schlunz-Hendann, Dominik Grieb
PURPOSE: We report our initial experience with endovascular embolization of intracranial aneurysms using this new self-expanding open-cell stent system (pEGASUS stent system) with the antithrombogenic hydrophilic polymer coating. MATERIALS AND METHODS: We retrospectively reviewed all patients treated with stent-assisted coiling or the Woven EndoBridge device using the pEGASUS stent system between September 2022 and June 2023. Demographic, clinical, and angiographic data were analyzed as well as short-term follow-up, including procedural complication rates and aneurysmal occlusion rates using the Raymond-Roy occlusion classification (RROC)...
April 18, 2024: Neurointervention
#16
JOURNAL ARTICLE
A core-lab adjudicated analysis of single-stent assisted coiling of wide-neck bifurcation aneurysms.
Aliya Siddiqui, Kyle M Fargen, Justin E Vranic, Aman B Patel, Christopher S Ogilvy, Ajith J Thomas, Justin R Mascitelli, Johanna T Fifi, J Mocco, Reade Andrew De Leacy
BACKGROUND AND PURPOSE: Core-lab adjudicated data regarding the efficacy of the single-stent assisted aneurysm coiling technique 'L-stenting' are lacking. We present a multicenter, core-lab adjudicated study evaluating the safety and effectiveness of single-stent assisted coiling in the treatment of wide-neck bifurcation aneurysms (WNBAs). METHODS: Consecutive patients who underwent L-stenting for WNBAs at three academic institutions between 2015 and 2019 were included in this retrospective study...
April 17, 2024: Journal of Neurointerventional Surgery
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JOURNAL ARTICLE
Galadu Subah, Sabrina Zeller, Nitesh Damodara, Michael Fortunato, Jenna Garrett, Shoaib Syed, Anaz Uddin, Issac Pak, Eric Feldstein, Stephan Mayer, Chirag D Gandhi, Fawaz Al-Mufti
BACKGROUND: Despite the widespread use of heparin during and following endovascular procedures in the management of aneurysmal subarachnoid hemorrhage (SAH) patients, limited research has explored the incidence and impact of heparin-induced thrombocytopenia (HIT) on SAH. METHODS: Descriptive statistics, multivariate regressions, and propensity score-matching were employed to compare clinical characteristics, comorbidities, interventions, complications, and outcomes of HIT in SAH patients identified within the US National Inpatient Sample database from 2010 to 2019...
April 17, 2024: Journal of Neurointerventional Surgery
#18
JOURNAL ARTICLE
Andreu Arinyo-I-Prats, Víctor J López-Madrona, Milan Paluš
Applications of causal techniques to neural time series have increased extensively over last decades, including a wide and diverse family of methods focusing on electroencephalogram (EEG) analysis. Besides connectivity inferred in defined frequency bands, there is a growing interest in the analysis of cross-frequency interactions, in particular phase and amplitude coupling and directionality. Some studies show contradicting results of coupling directionality from high frequency to low frequency signal components, in spite of generally considered modulation of a high-frequency amplitude by a low-frequency phase...
April 15, 2024: NeuroImage
#19
JOURNAL ARTICLE
Ewa Galaj, Guo-Hua Bi, Zheng-Xiong Xi
A growing body of research indicates that β-caryophyllene (BCP), a constituent present in a large number of plants, possesses significant therapeutic properties against CNS disorders, including alcohol and psychostimulant use disorders. However, it is unknown whether BCP has similar therapeutic potential for opioid use disorders. In this study, we found that systemic administration of BCP dose-dependently reduced heroin self-administration in rats under an FR2 schedule of reinforcement and partially blocked heroin-enhanced brain stimulation reward in DAT-cre mice, maintained by optical stimulation of midbrain dopamine neurons at high frequencies...
April 15, 2024: Neuropharmacology
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JOURNAL ARTICLE
Jeong Woo Choi, Mahsa Malekmohammadi, Soroush Niketeghad, Katy A Cross, Hamasa Ebadi, Amirreza Alijanpourotaghsara, Adam Aron, Ueli Rutishauser, Nader Pouratian
While medial frontal cortex (MFC) and subthalamic nucleus (STN) have been implicated in conflict monitoring and action inhibition, respectively, an integrated understanding of the spatiotemporal and spectral interaction of these nodes and how they interact with motor cortex (M1) to definitively modify motor behavior during conflict is lacking. We recorded neural signals intracranially across presupplementary motor area (preSMA), M1, STN, and globus pallidus internus (GPi), during a flanker task in 20 patients undergoing deep brain stimulation implantation surgery for Parkinson disease or dystonia...
April 15, 2024: Progress in Neurobiology
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