keyword
https://read.qxmd.com/read/37845660/randomized-controlled-phase-iii-trial-to-investigate-superiority-of-robot-assisted-gastrectomy-over-laparoscopic-gastrectomy-for-clinical-stage-t1-4an0-3-gastric-cancer-patients-jcog1907-mona-lisa-study-a-study-protocol
#1
JOURNAL ARTICLE
Rie Makuuchi, Masanori Terashima, Mitsumi Terada, Junki Mizusawa, Ryosuke Kita, Masanori Tokunaga, Takeshi Omori, Toshiyasu Ojima, Kazuhisa Ehara, Masaya Watanabe, Yoshitomo Yanagimoto, Souya Nunobe, Takahiro Kinoshita, Seiji Ito, Yasunori Nishida, Jun Hihara, Narikazu Boku, Yukinori Kurokawa, Takaki Yoshikawa
BACKGROUND: Laparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks, such as motion restriction and difficulties in spatial perception. Robot-assisted gastrectomy (RG) overcomes these drawbacks by using articulated forceps, tremor-filtering capability, and high-resolution three-dimensional imaging, and it is expected to enable more precise and safer procedures than LG for gastric cancer. However, robust evidence based on a large-scale randomized study is lacking...
October 17, 2023: BMC Cancer
https://read.qxmd.com/read/36735243/makuuchi-s-criteria-for-liver-resection-in-the-modern-era-of-functional-liver-remnant-volume-evaluation
#2
EDITORIAL
Kensuke Yamamura, Toru Beppu
No abstract text is available yet for this article.
February 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/36181504/reevaluation-of-makuuchi-s-criteria-for-resecting-hepatocellular-carcinoma-a-japanese-nationwide-survey
#3
JOURNAL ARTICLE
Osamu Aramaki, Tadatoshi Takayama, Yutaka Matsuyama, Shoji Kubo, Norihiro Kokudo, Masayuki Kurosaki, Takamichi Murakami, Shuichiro Shiina, Masatoshi Kudo, Michiie Sakamoto, Osamu Nakashima, Takumi Fukumoto, Hiroko Iijima, Susumu Eguchi, Yuji Soejima, Masatoshi Makuuchi
AIM: Although Makuuchi's criteria are widely used to determine the cutoff for safe liver resection, there have been few reports of concrete data supporting their validity. Here, we verified the utility of Makuuchi's criteria by comparing the operative mortality rates associated with liver resection between hepatocellular carcinoma patients meeting or exceeding the criteria. METHODS: A database was built using data from 15597 patients treated between 2000 and 2007 for whom values for all three variables included in Makuuchi's criteria for liver resection (clinical ascites, serum bilirubin, and indocyanine green clearance) were available...
October 1, 2022: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/35411926/phase-i-ii-study-of-streptozocin-monotherapy-in-japanese-patients-with-unresectable-or-metastatic-gastroenteropancreatic-neuroendocrine-tumors
#4
JOURNAL ARTICLE
Izumi Komoto, Norihiro Kokudo, Taku Aoki, Chigusa Morizane, Tetsuhide Ito, Takuya Hashimoto, Wataru Kimura, Naoya Inoue, Kiyoshi Hasegawa, Shunsuke Kondo, Hideki Ueno, Hisato Igarashi, Takamasa Oono, Masatoshi Makuuchi, Takeshi Takamoto, Ichiro Hirai, Akiko Takeshita, Masayuki Imamura
BACKGROUND: This phase I/II study was conducted to evaluate the efficacy, safety and pharmacokinetics of streptozocin (STZ) in Japanese patients with unresectable or metastatic gastroenteropancreatic neuroendocrine tumors. METHODS: Twenty-two patients received up to 4 cycles of intravenous STZ at either 500 mg/m2 once daily for 5 consecutive days every 6 weeks (daily regimen) or at 1000-1500 mg/m2 once weekly for 6 weeks (weekly regimen). Tumor response was evaluated using the modified RECIST criteria ver...
July 8, 2022: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/35047336/impact-of-preoperative-endoscopy-for-predicting-treatment-response-and-prognosis-in-patients-with-gastric-cancer-after-neoadjuvant-chemotherapy
#5
JOURNAL ARTICLE
Yoshiaki Shoji, Souya Nunobe, Naoki Nishie, Shusuke Yagi, Rie Makuuchi, Satoshi Ida, Koshi Kumagai, Manabu Ohashi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Junko Fujisaki, Takeshi Sano
Background and study aims  Response evaluation criteria in solid tumors (RECIST) have been the gold standard to preoperatively predict treatment response and prognosis in patients with gastric cancer (GC) after neoadjuvant chemotherapy (NAC); however, methods for patients without evaluable lesions by RECIST are not yet confirmed. The aim of this study was to assess the utility of preoperative endoscopy for predicting treatment response and prognosis in patients with GC after NAC. Patients and methods  This retrospective study included 105 patients with initially resectable GC who underwent NAC followed by surgical treatment...
January 2022: Endoscopy International Open
https://read.qxmd.com/read/31788120/development-of-new-software-enabling-automatic-identification-of-the-optimal-anatomical-liver-resectable-region-incorporating-preoperative-liver-function
#6
JOURNAL ARTICLE
Mitsugi Shimoda, Masanori Hariyama, Yukio Oshiro, Shuji Suzuki
Determining the resectable region and volume of the liver prior to anatomical resection is important. The synapse Vincent (SV) system is the current method for surgical liver resection that relies on the surgeon's individual experience and skill. Additionally, in cases involving abnormal liver function, the resectable region is limited due to deteriorating liver function, thus making the determination of the hepatectomy region challenging. The current study outlines a novel 3D Hariyama-Shimoda Soft (HSS) simulation software that can be used to automatically simulate the optimal hepatectomy region under a limited resectable liver volume...
December 2019: Oncology Letters
https://read.qxmd.com/read/31570478/risk-factors-for-deterioration-of-remnant-liver-function-after-hepatic-resection-for-hepatocellular-carcinoma
#7
JOURNAL ARTICLE
Rui Marukuchi, Kenei Furukawa, Ryota Iwase, Jungo Yasuda, Hironori Shiozaki, Shinji Onda, Takeshi Gocho, Hiroaki Shiba, Katsuhiko Yanaga
BACKGROUND/AIM: After primary resection of hepatocellular carcinoma (HCC), the impact of patient's characteristics at the initial hepatectomy, on long-term remnant liver function has not been reported. The aim of this study was to identify factors associated with the deterioration of remnant liver function among patients who developed recurrent HCC. PATIENTS AND METHODS: A total of 51 patients with intrahepatic recurrence after initial hepatic resection for HCC were included...
October 2019: Anticancer Research
https://read.qxmd.com/read/31535301/efficacy-of-postoperative-chemotherapy-after-resection-that-leaves-no-macroscopically-visible-disease-of-gastric-cancer-with-positive-peritoneal-lavage-cytology-cy1-or-localized-peritoneum-metastasis-p1a-a-multicenter-retrospective-study
#8
MULTICENTER STUDY
Toshifumi Yamaguchi, Atsuo Takashima, Kengo Nagashima, Rie Makuuchi, Masaki Aizawa, Manabu Ohashi, Keitaro Tashiro, Tatsuya Yamada, Takahiro Kinoshita, Hiroaki Hata, Yasuyuki Kawachi, Ryohei Kawabata, Toshikatsu Tsuji, Jun Hihara, Takeshi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Kazuhide Higuchi, Narikazu Boku
BACKGROUND: Gastric cancer (GC) patients with positive peritoneal lavage cytology (CY1) and/or localized peritoneum metastasis (P1a) are defined as stage IV in the 15th edition of the Japanese Classification of Gastric Cancer. In Japan, the most common treatment for patients with CY1 and/or P1a is gastrectomy followed by postoperative chemotherapy. PATIENTS AND METHODS: Subjects in this multi-institutional retrospective study were GC patients with CY1 and/or P1a who received surgical resection that leaves no macroscopically visible disease...
January 2020: Annals of Surgical Oncology
https://read.qxmd.com/read/31326264/indocyanine-green-clearance-of-remnant-liver-icg-krem-predicts-postoperative-subclinical-hepatic-insufficiency-after-resection-of-colorectal-liver-metastasis-theoretical-validation-for-safe-expansion-of-makuuchi-s-criteria
#9
JOURNAL ARTICLE
Yuta Kobayashi, Yoshitaka Kiya, Yujiro Nishioka, Masaji Hashimoto, Junichi Shindoh
BACKGROUND: Multidisciplinary treatment for colorectal liver metastases (CLMs) often includes major hepatectomy for preoperative chemotherapy-related hepatic injury, although the safety limit for resection extent is unclear. We investigated this parameter using the estimated indocyanine green clearance rate (ICG-K) of liver remnants, focusing on postoperative subclinical hepatic insufficiency (PHI). METHODS: Altogether, 225 patients who underwent resection of CLMs were studied...
February 2020: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/31211911/use-of-the-national-clinical-database-to-evaluate-the-association-between-preoperative-liver-function-and-postoperative-complications-among-patients-undergoing-hepatectomy
#10
JOURNAL ARTICLE
Keiichi Kubota, Taku Aoki, Hiraku Kumamaru, Takayuki Shiraki, Hiroaki Miyata, Yasuyuki Seto, Yoshihiro Kakeji, Masakazu Yamamoto
BACKGROUND/PURPOSE: The aim of the present study was to clarify the association between preoperative liver function and complications after hepatectomy. METHODS: The study included 11,686 patients registered in the National Clinical Database for 2015 for whom data on ICG15 and hepatectomy were available. The patients were divided into four groups: group A (ICG15 <10%; n=5661), group B (ICG15 10% - <20%; n=4381), group C (ICG15 20% - <30%; n=1173) and group D (ICG15 >30%; n=463)...
June 18, 2019: Journal of Hepato-biliary-pancreatic Sciences
https://read.qxmd.com/read/30711244/expanded-makuuchi-s-criteria-using-estimated-indocyanine-green-clearance-rate-of-future-liver-remnant-as-a-safety-limit-for-maximum-extent-of-liver-resection
#11
COMPARATIVE STUDY
Yuta Kobayashi, Yoshitaka Kiya, Toshitaka Sugawara, Yujiro Nishioka, Masaji Hashimoto, Junichi Shindoh
BACKGROUND: Recent advances in liver surgery have dramatically improved the safety of hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to compare outcomes for patients fulfilling an extended criteria vs. those fulfilling the conventional criteria based on the bilirubin and indocyanine green (ICG) clearance (Makuuchi's criteria). METHODS: The short term outcomes of patients undergoing hepatectomy for HCC and who fulfilled the expanded criteria (ICG clearance of future remnant liver [ICG-Krem] ≥ 0...
August 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/29916107/feasibility-of-laparoscopic-distal-gastrectomy-for-stage-i-gastric-cancer-in-patients-outside-of-clinical-trials
#12
JOURNAL ARTICLE
Keiichi Fujiya, Masanori Tokunaga, Noriyuki Nishiwaki, Kenichiro Furukawa, Hayato Omori, Sanae Kaji, Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: Randomized controlled trials, including the Japan Clinical Oncology Group (JCOG) 0912 trial, have shown the safety of laparoscopy-assisted distal gastrectomy (LADG) for select healthy patients. It is unclear whether LADG is feasible in patients who do not meet trial eligibility criteria. METHODS: The present study retrospectively reviewed 547 patients with clinical stage I gastric cancer who underwent distal or pylorus-preserving gastrectomy. Of these, 185 were identified as not fulfilling the eligibility criteria of JCOG 0912; the short-term surgical outcomes between LADG and open distal gastrectomy (ODG) were compared in this group before and after propensity score matching...
June 18, 2018: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/29488125/surgical-strategy-based-on-indocyanine-green-test-for-chemotherapy-associated-liver-injury-and-long-term-outcome-in-colorectal-liver-metastases
#13
JOURNAL ARTICLE
Takeshi Takamoto, Takuya Hashimoto, Akihiko Ichida, Kei Shimada, Yoshikazu Maruyama, Masatoshi Makuuchi
BACKGROUND: It remains unclear whether the presence of chemotherapy-induced liver injury (CALI) or impaired liver functional reserve affects the long-term outcome. This study assessed the applicability and long-term effects of using criteria based on the indocyanine green (ICG) test results in selecting the operative procedure among patients with colorectal liver metastases (CRLM) who had a risk of CALI. STUDY DESIGN: CRLM patients who received preoperative chemotherapy including oxaliplatin and/or irinotecan prior to a curative hepatectomy between 2007 and 2017 were included...
June 2018: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/29357013/validation-of-the-prognostic-impact-of-the-new-tumor-node-metastasis-clinical-staging-in-patients-with-gastric-cancer
#14
JOURNAL ARTICLE
Etsuro Bando, Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Taiichi Kawamura, Masanori Terashima
BACKGROUND: In the 8th edition of the tumor-node-metastasis (TNM) classification, the gastric cancer staging system includes two classifications: the clinical stage (cStage) and the postoperative pathologic stage. However, the correlation between the new cStage and overall survival has not been studied. Moreover, clinical N (cN) grade analysis is not included in the new clinical staging system. This study validated the prognostic value of cStage in the 8th edition of the TNM classification and the significance of N classification for pretreatment staging in gastric cancer...
January 22, 2018: Gastric Cancer
https://read.qxmd.com/read/28484889/the-value-of-diagnostic-endoscopic-submucosal-dissection-for-patients-with-clinical-submucosal-invasive-early-gastric-cancer
#15
JOURNAL ARTICLE
Keiichi Fujiya, Kohei Takizawa, Masanori Tokunaga, Noboru Kawata, Makoto Hikage, Rie Makuuchi, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masaki Tanaka, Naomi Kakushima, Hiroyuki Ono, Masanori Terashima
BACKGROUND: The standard treatment for clinical submucosal invasive (cT1b) early gastric cancer is gastrectomy. However, Japanese gastric cancer treatment guidelines list endoscopic submucosal dissection (ESD) as an option for treating limited early gastric cancer cases. ESD can be curative depending on the pathological characteristics of resected specimens. Thus, we aimed to clarify the benefits and disadvantages of preceding ESD for early gastric cancer. METHODS: We retrospectively analyzed patients who underwent ESD or curative gastrectomy for cT1b gastric cancer with differentiated adenocarcinoma 30 mm or less in diameter...
January 2018: Gastric Cancer
https://read.qxmd.com/read/28133019/-radiofrequency-ablation-combined-with-hepatectomy-for-the-treatment-of-liver-metastases-from-colorectal-cancer
#16
JOURNAL ARTICLE
Masanobu Enomoto, Tomoya Tago, Kenta Kasahara, Takahiro Wada, Takaaki Matsudo, Yusuke Murakoshi, Tetsuo Ishizaki, Kazuhiko Kasuya, Kenji Katsumata, Akihiko Tsuchida
OBJECTIVE: We evaluated hepatectomy combined with radiofrequency ablation(RFA)in patients with liver metastases from colorectal cancer for which curative resection is difficult. METHODS: This study included 13 patients who underwent hepatectomy combined with RFA for liver metastases from colorectal cancer in or before 2015. RESULTS: In 11 patients who were determined to have achieved a complete curative resection, the 50%survival time was 35...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/27493893/survival-benefit-of-locoregional-treatment-for-hepatocellular-carcinoma-with-advanced-liver-cirrhosis
#17
JOURNAL ARTICLE
Satoshi Kitai, Masatoshi Kudo, Naoshi Nishida, Namiki Izumi, Michiie Sakamoto, Yutaka Matsuyama, Takafumi Ichida, Osamu Nakashima, Osamu Matsui, Yonson Ku, Norihiro Kokudo, Masatoshi Makuuchi
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) with decompensated liver cirrhosis (LC) is a life-threatening condition, which is amenable to liver transplantation (LT) as the standard first-line treatment. However, the application of LT can be limited due to a shortage of donor livers. This study aimed to clarify the effect of non-surgical therapy on the survival of patients with HCC and decompensated LC. METHODS: Of the 58,886 patients with HCC registered in the nationwide survey of the Liver Cancer Study Group of Japan (January 2000-December 2005), we included 1,344 patients with primary HCC and Child-Pugh (C-P) grade C for analysis in this retrospective study...
July 2016: Liver Cancer
https://read.qxmd.com/read/27003271/predicting-individual-survival-after-hepatectomy-for-hepatocellular-carcinoma-a-novel-nomogram-from-the-hcc-east-west-study-group
#18
MULTICENTER STUDY
Guido Torzilli, Matteo Donadon, Jacques Belghiti, Norihiro Kokudo, Tadatoshi Takayama, Alessandro Ferrero, Gennaro Nuzzo, Jean-Nicolas Vauthey, Michael A Choti, Eduardo De Santibanes, Masatoshi Makuuchi
INTRODUCTIONS: Different staging systems have been devised for patients undergoing resection for hepatocellular carcinoma (HCC) with disparate results. The aim of this study was to create a new nomogram to predict individual survival after hepatectomy for HCC. METHODS: Based on the "Hepatocellular Carcinoma: Eastern & Western Experiences Network," data from 2046 patients who underwent HCC resections at ten centers were reviewed. Patient survival was analyzed with Cox-regression analysis to construct a unique nomogram and contour plots to predict survival...
June 2016: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/26309366/safety-validation-of-decision-trees-for-hepatocellular-carcinoma
#19
COMPARATIVE STUDY
Xian-Qiang Wang, Zhe Liu, Wen-Ping Lv, Ying Luo, Guang-Yun Yang, Chong-Hui Li, Xiang-Fei Meng, Yang Liu, Ke-Sen Xu, Jia-Hong Dong
AIM: To evaluate a different decision tree for safe liver resection and verify its efficiency. METHODS: A total of 2457 patients underwent hepatic resection between January 2004 and December 2010 at the Chinese PLA General Hospital, and 634 hepatocellular carcinoma (HCC) patients were eligible for the final analyses. Post-hepatectomy liver failure (PHLF) was identified by the association of prothrombin time < 50% and serum bilirubin > 50 μmol/L (the "50-50" criteria), which were assessed at day 5 postoperatively or later...
August 21, 2015: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/26227974/validation-of-the-conventional-resection-criteria-in-patients-with-hepatocellular-carcinoma-in-terms-of-the-incidence-of-posthepatectomy-liver-failure-and-long-term-prognosis
#20
JOURNAL ARTICLE
Kohta Iguchi, Etsuro Hatano, Kenya Yamanaka, Shiro Tanaka, Kojiro Taura, Shinji Uemoto
BACKGROUND/AIMS: Resection criteria in hepatocellular carcinoma (HCC) should be established based on the risk of posthepatectomy liver failure (PHLF) and the survival benefit from hepatectomy. This study aimed at verifying the validity of the conventional criteria regarding the incidence of PHLF and the long-term prognosis of HCC patients. METHODS: A retrospective study was performed on 265 patients who underwent major hepatectomy. Makuuchi's criteria and the future liver remnant plasma clearance rate of indocyanine green (ICGK-rem) ≥0...
2015: Digestive Surgery
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