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Makuuchi criteria

Yuta Kobayashi, Yoshitaka Kiya, Toshitaka Sugawara, Yujiro Nishioka, Masaji Hashimoto, Junichi Shindoh
BACKGROUND: Recent advances in liver surgery have dramatically improved the safety of hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to compare outcomes for patients fulfilling an extended criteria vs. those fulfilling the conventional criteria based on the bilirubin and indocyanine green (ICG) clearance (Makuuchi's criteria). METHODS: The short term outcomes of patients undergoing hepatectomy for HCC and who fulfilled the expanded criteria (ICG clearance of future remnant liver [ICG-Krem] ≥ 0...
January 30, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Keiichi Fujiya, Masanori Tokunaga, Noriyuki Nishiwaki, Kenichiro Furukawa, Hayato Omori, Sanae Kaji, Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Terashima
BACKGROUND: Randomized controlled trials, including the Japan Clinical Oncology Group (JCOG) 0912 trial, have shown the safety of laparoscopy-assisted distal gastrectomy (LADG) for select healthy patients. It is unclear whether LADG is feasible in patients who do not meet trial eligibility criteria. METHODS: The present study retrospectively reviewed 547 patients with clinical stage I gastric cancer who underwent distal or pylorus-preserving gastrectomy. Of these, 185 were identified as not fulfilling the eligibility criteria of JCOG 0912; the short-term surgical outcomes between LADG and open distal gastrectomy (ODG) were compared in this group before and after propensity score matching...
June 18, 2018: Journal of Gastrointestinal Surgery
Takeshi Takamoto, Takuya Hashimoto, Akihiko Ichida, Kei Shimada, Yoshikazu Maruyama, Masatoshi Makuuchi
BACKGROUND: It remains unclear whether the presence of chemotherapy-induced liver injury (CALI) or impaired liver functional reserve affects the long-term outcome. This study assessed the applicability and long-term effects of using criteria based on the indocyanine green (ICG) test results in selecting the operative procedure among patients with colorectal liver metastases (CRLM) who had a risk of CALI. STUDY DESIGN: CRLM patients who received preoperative chemotherapy including oxaliplatin and/or irinotecan prior to a curative hepatectomy between 2007 and 2017 were included...
June 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Etsuro Bando, Rie Makuuchi, Tomoyuki Irino, Yutaka Tanizawa, Taiichi Kawamura, Masanori Terashima
BACKGROUND: In the 8th edition of the tumor-node-metastasis (TNM) classification, the gastric cancer staging system includes two classifications: the clinical stage (cStage) and the postoperative pathologic stage. However, the correlation between the new cStage and overall survival has not been studied. Moreover, clinical N (cN) grade analysis is not included in the new clinical staging system. This study validated the prognostic value of cStage in the 8th edition of the TNM classification and the significance of N classification for pretreatment staging in gastric cancer...
January 22, 2018: Gastric Cancer
Keiichi Fujiya, Kohei Takizawa, Masanori Tokunaga, Noboru Kawata, Makoto Hikage, Rie Makuuchi, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masaki Tanaka, Naomi Kakushima, Hiroyuki Ono, Masanori Terashima
BACKGROUND: The standard treatment for clinical submucosal invasive (cT1b) early gastric cancer is gastrectomy. However, Japanese gastric cancer treatment guidelines list endoscopic submucosal dissection (ESD) as an option for treating limited early gastric cancer cases. ESD can be curative depending on the pathological characteristics of resected specimens. Thus, we aimed to clarify the benefits and disadvantages of preceding ESD for early gastric cancer. METHODS: We retrospectively analyzed patients who underwent ESD or curative gastrectomy for cT1b gastric cancer with differentiated adenocarcinoma 30 mm or less in diameter...
January 2018: Gastric Cancer
Masanobu Enomoto, Tomoya Tago, Kenta Kasahara, Takahiro Wada, Takaaki Matsudo, Yusuke Murakoshi, Tetsuo Ishizaki, Kazuhiko Kasuya, Kenji Katsumata, Akihiko Tsuchida
OBJECTIVE: We evaluated hepatectomy combined with radiofrequency ablation(RFA)in patients with liver metastases from colorectal cancer for which curative resection is difficult. METHODS: This study included 13 patients who underwent hepatectomy combined with RFA for liver metastases from colorectal cancer in or before 2015. RESULTS: In 11 patients who were determined to have achieved a complete curative resection, the 50%survival time was 35...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Satoshi Kitai, Masatoshi Kudo, Naoshi Nishida, Namiki Izumi, Michiie Sakamoto, Yutaka Matsuyama, Takafumi Ichida, Osamu Nakashima, Osamu Matsui, Yonson Ku, Norihiro Kokudo, Masatoshi Makuuchi
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) with decompensated liver cirrhosis (LC) is a life-threatening condition, which is amenable to liver transplantation (LT) as the standard first-line treatment. However, the application of LT can be limited due to a shortage of donor livers. This study aimed to clarify the effect of non-surgical therapy on the survival of patients with HCC and decompensated LC. METHODS: Of the 58,886 patients with HCC registered in the nationwide survey of the Liver Cancer Study Group of Japan (January 2000-December 2005), we included 1,344 patients with primary HCC and Child-Pugh (C-P) grade C for analysis in this retrospective study...
July 2016: Liver Cancer
Guido Torzilli, Matteo Donadon, Jacques Belghiti, Norihiro Kokudo, Tadatoshi Takayama, Alessandro Ferrero, Gennaro Nuzzo, Jean-Nicolas Vauthey, Michael A Choti, Eduardo De Santibanes, Masatoshi Makuuchi
INTRODUCTIONS: Different staging systems have been devised for patients undergoing resection for hepatocellular carcinoma (HCC) with disparate results. The aim of this study was to create a new nomogram to predict individual survival after hepatectomy for HCC. METHODS: Based on the "Hepatocellular Carcinoma: Eastern & Western Experiences Network," data from 2046 patients who underwent HCC resections at ten centers were reviewed. Patient survival was analyzed with Cox-regression analysis to construct a unique nomogram and contour plots to predict survival...
June 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Xian-Qiang Wang, Zhe Liu, Wen-Ping Lv, Ying Luo, Guang-Yun Yang, Chong-Hui Li, Xiang-Fei Meng, Yang Liu, Ke-Sen Xu, Jia-Hong Dong
AIM: To evaluate a different decision tree for safe liver resection and verify its efficiency. METHODS: A total of 2457 patients underwent hepatic resection between January 2004 and December 2010 at the Chinese PLA General Hospital, and 634 hepatocellular carcinoma (HCC) patients were eligible for the final analyses. Post-hepatectomy liver failure (PHLF) was identified by the association of prothrombin time < 50% and serum bilirubin > 50 μmol/L (the "50-50" criteria), which were assessed at day 5 postoperatively or later...
August 21, 2015: World Journal of Gastroenterology: WJG
Kohta Iguchi, Etsuro Hatano, Kenya Yamanaka, Shiro Tanaka, Kojiro Taura, Shinji Uemoto
BACKGROUND/AIMS: Resection criteria in hepatocellular carcinoma (HCC) should be established based on the risk of posthepatectomy liver failure (PHLF) and the survival benefit from hepatectomy. This study aimed at verifying the validity of the conventional criteria regarding the incidence of PHLF and the long-term prognosis of HCC patients. METHODS: A retrospective study was performed on 265 patients who underwent major hepatectomy. Makuuchi's criteria and the future liver remnant plasma clearance rate of indocyanine green (ICGK-rem) ≥0...
2015: Digestive Surgery
Chia-Yu Lai, Cheng-Chung Wu, John Wang, Cheng-Chan Yu, Shao-Bin Cheng, Dar-Cherng Yeh, Fang-Ku Peng
BACKGROUND/AIMS: High operative mortality has been reported after liver resection for hepatocellular carcinoma (HCC) in cirrhotic patients with high preoperative serum alanine aminotransferase (sALT) level. Their long-term prognosis has never been investigated. The aim of this study is to evaluate the benefit of liver resection for HCC in this subgroup of patients. METHODOLOGY: A retrospective review of the medical records of 978 cirrhotic patients who underwent curative liver resection for HCC between 2000 and 2012 was conducted...
October 2014: Hepato-gastroenterology
Tohru Utsunomiya, Mitsuo Shimada, Masatoshi Kudo, Takafumi Ichida, Osamu Matsui, Namiki Izumi, Yutaka Matsuyama, Michiie Sakamoto, Osamu Nakashima, Yonson Ku, Norihiro Kokudo, Masatoshi Makuuchi
OBJECTIVE: To examine the prognostic factors and outcomes after several types of treatments in patients with hepatocellular carcinoma (HCC) negative for hepatitis B surface antigen and hepatitis C antibody, so-called "non-B non-C HCC" using the data of a nationwide survey. BACKGROUND: The proportion of non-B non-C HCC is rapidly increasing in Japan. METHODS: A total of 4741 patients with non-B non-C HCC, who underwent hepatic resection (HR, n = 2872), radiofrequency ablation (RFA, n = 432), and transcatheter arterial chemoembolization (TACE, n = 1437) as the initial treatment, were enrolled in this study...
February 2014: Annals of Surgery
Eisuke Ito, Soji Ozawa, Hiroshi Kijima, Akihito Kazuno, Takayuki Nishi, Osamu Chino, Hideo Shimada, Makiko Tanaka, Shigeaki Inoue, Sadaki Inokuchi, Hiroyasu Makuuchi
BACKGROUND: Prognostic factors for superficial esophageal cancer cannot be limited to such factors as lymph node metastasis (N factor), depth of tumor invasion (T factor), and genetic alterations. The purpose of this study was to examine whether invasive growth patterns of tumors, such as infiltrative growth pattern c (INFc) and budding, represent new useful prognostic factors for superficial esophageal cancer. METHODS: We investigated 87 cases of superficial esophageal cancer in patients treated with radical surgery...
December 2012: Journal of Gastroenterology
Shigeru Marubashi, Koji Umeshita, Toshimasa Asahara, Kenji Fujiwara, Hironori Haga, Takashi Hashimoto, Katsuyoshi Hatakeyama, Takafumi Ichida, Takashi Kanematsu, Masaki Kitajima, Kendo Kiyosawa, Masatoshi Makuuchi, Shinichi Miyagawa, Susumu Satomi, Yuji Soejima, Yasutsugu Takada, Noriaki Tanaka, Satoshi Teraoka, Morito Monden
This prospective, non-randomized, multicenter cohort study analyzed the safety and efficacy of a steroid-free immunosuppressive (IS) protocol for hepatitis C virus (HCV)-positive living donor liver transplant (LDLT) recipients in Japan. Of 68 patients enrolled from 13 transplant centers, 56 fulfilled the inclusion/exclusion criteria; 27 were assigned the steroid-free IS protocol (Fr group) and 29 the traditional steroid-containing IS protocol (St group). Serum HCV RNA levels increased over time and were higher in the St group until postoperative day 90 (POD 14, p=0...
November 2012: Clinical Transplantation
Kenichi Takayasu, Shigeki Arii, Masatoshi Kudo, Takafumi Ichida, Osamu Matsui, Namiki Izumi, Yutaka Matsuyama, Michiie Sakamoto, Osamu Nakashima, Yonson Ku, Norihiro Kokudo, Masatoshi Makuuchi
BACKGROUND & AIMS: Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ≥4 tumors in a treatment algorithm proposed by Japanese guidelines. However, the best indication and appropriateness of the algorithm for TACE are still unclear. METHODS: In 4966 HCC patients who underwent TACE, survival was evaluated based on tumor number, size and liver function; and the adequacy of the algorithm for TACE was validated...
April 2012: Journal of Hepatology
Shintaro Yamazaki, Tadatoshi Takayama, Yuki Kimura, Masamichi Moriguchi, Tokio Higaki, Hisashi Nakayama, Masashi Fujii, Masatoshi Makuuchi
OBJECTIVE: To establish transfusion criteria for use of fresh frozen plasma (FFP) in liver resection. BACKGROUND: Fresh frozen plasma has been transfused in liver resection without adequate supporting evidence, leading to unnecessary use. DESIGN: Prospective study using a phase 1 dose-escalation, 3 + 3 cohort expansion design, modified for FFP transfusion. We designated a serum albumin level of 3.0 g/dL (step 1) as the starting limit for no transfusion and reduced the level in 0...
November 2011: Archives of Surgery
Y Mise, K Hasegawa, S Satou, T Aoki, Y Beck, Y Sugawara, M Makuuchi, N Kokudo
BACKGROUND: Hepatic vein (HV) reconstruction may prevent venous congestion following resection of liver tumours that encroach on major HVs. This study aimed to identify criteria for venous reconstruction based on preoperative evaluation of venous congestion. METHODS: A volumetric analysis using image-processing software was performed in selected patients with liver tumours suspected on preoperative imaging of major HV invasion. The size of the non-congested liver remnant (NCLR) was calculated by subtracting the congested area from the liver remnant...
December 2011: British Journal of Surgery
Yasuhiko Sugawara, Sumihito Tamura, Junichi Kaneko, Takuya Iida, Makoto Mihara, Masatoshi Makuuchi, Isao Koshima, Norihiro Kokudo
BACKGROUND: A left liver graft in living donor liver transplantation often has 2 arterial stumps. The indication for multiple arterial reconstructions remains controversial. The aim of this retrospective study was to investigate whether single anastomosis of a left liver graft affects the outcome of living donor liver transplantation. METHODS: When a hepatic graft had 2 arterial stumps, the thicker (dominant) stump was reconstructed first. After the initial reconstruction, another reconstruction was performed only if no pulsating flow was observed from the remnant stump...
June 2011: Surgery
Yoshinori Inagaki, Wei Tang, Masatoshi Makuuchi, Kiyoshi Hasegawa, Yasuhiko Sugawara, Norihiro Kokudo
Des-γ-carboxyprothrombin (DCP) is known as a tumour marker for hepatocellular carcinoma (HCC). Various tumour markers have been developed for serological diagnosis of cancers, including HCC, in order to increase the survival rate of cancer patients. The currently recommended combined testing of DCP and α-fetoprotein (AFP) or Lens culinaris agglutinin-reactive fraction of α-fetoprotein has been established to diagnose HCC. This combined testing using several tumour markers helps to increase the sensitivity of diagnosis of HCC, thus significantly increasing the clinical usefulness of DCP...
January 2011: Liver International: Official Journal of the International Association for the Study of the Liver
Masatoshi Kudo, Shouji Kubo, Kenichi Takayasu, Michiie Sakamoto, Masatoshi Tanaka, Iwao Ikai, Junji Furuse, Kenji Nakamura, Masatoshi Makuuchi
The World Health Organization (WHO) criteria and Response Evaluation Criteria in Solid Tumors (RECIST) are inappropriate to assess the direct effects of treatment on the hepatocellular carcinoma (HCC) by locoreginal therapies such as radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE). Therefore, establishment of response evaluation criteria solely devoted for HCC is needed urgently in the clinical practice as well as in the clinical trials of HCC treatment, such as molecular targeted therapies, which cause necrosis of the tumor...
July 2010: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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