keyword
https://read.qxmd.com/read/38547042/high-reliability-pediatric-heart-centers-always-working-toward-getting-better
#1
JOURNAL ARTICLE
Andrea Torzone, Alexandra Birely
PURPOSE OF REVIEW: The purpose of this review is to examine high reliability through the lens of a contemporary pediatric heart center, noting that continuous improvement, rather than perfection, should be embraced. Aiming to elevate topics with lesser attention, this review elaborates on key concepts and proposed considerations for maintaining a high reliability heart center. RECENT FINDINGS: As provision of care reaches a new complexity, programs are called upon to evaluate how they can bring their teams into the future of pediatric cardiac care...
March 27, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38546172/an-automated-flowchart-for-the-modified-rankin-scale-assessment-a-multicenter-inter-rater-agreement-analysis
#2
JOURNAL ARTICLE
Joao Brainer Clares de Andrade, Terence Joseph Quinn, Leonardo Augusto Carbonera, Vinicius Montanaro, Alexandre Robles, Rafael Padua, Saulo Ribeiro, Gisele Sampaio Silva
BACKGROUND AND OBJECTIVE: The Modified Rankin Scale (mRS) is a widely adopted scale for assessing stroke recovery. Despite limitations, the mRS has been adopted as primary outcome in most recent clinical acute stroke trials. Designed to be used by multidisciplinary clinical staff, the congruency of this scale is not consistent, which may lead to mistakes in clinical or research application. We aimed to develop and validate an interactive and automated digital tool for assessing the mRS - the iRankin...
March 28, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38545949/determining-3d-structure-from-molecular-formula-and-isotopologue-rotational-spectra-in-natural-abundance-with-reflection-equivariant-diffusion
#3
JOURNAL ARTICLE
Austin H Cheng, Alston Lo, Santiago Miret, Brooks H Pate, Alán Aspuru-Guzik
Structure determination is necessary to identify unknown organic molecules, such as those in natural products, forensic samples, the interstellar medium, and laboratory syntheses. Rotational spectroscopy enables structure determination by providing accurate 3D information about small organic molecules via their moments of inertia. Using these moments, Kraitchman analysis determines isotopic substitution coordinates, which are the unsigned |x|, |y|, |z| coordinates of all atoms with natural isotopic abundance, including carbon, nitrogen, and oxygen...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38545631/a-modified-patte-classification-system-for-rotator-cuff-tendon-retraction-to-predict-reparability-and-tendon-healing-in-arthroscopic-rotator-cuff-repair
#4
JOURNAL ARTICLE
Yoshitsugu Takeda, Koji Fujii, Naoto Suzue, Yoshiteru Kawasaki, Junichiro Sumitomo, Keisuke Nishidono, Yugen Fujii, Masashi Kano
PURPOSE: The purpose of this study was to propose a modified Patte classification system for tendon retraction, including the cut-off points for predicting reparability and rotator cuff healing after arthroscopic rotator cuff repair (ARCR) and assess its prediction accuracy and measurement reliability. METHODS: This retrospective study included 463 consecutive patients scheduled to undergo ARCR for full-thickness supraspinatus tears. Receiver operating characteristic (ROC) curve analysis was used to determine the cut-off points for predicting reparability and tendon healing...
March 28, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38545572/influence-of-accuracy-and-precision-of-measurements-of-long-bone-tumors-in-imaging-studies-a-retrospective-study-in-musculoskeletal-oncology
#5
JOURNAL ARTICLE
G K Rangarajan, R Krishnakumar, D Devakumar, M Karthigaiselvi, Anand Raja, Chandrakumar Krishnan
The aim of this study is to evaluate the level of accuracy and precision of bone scan (BS), MRI, and digital radiography (DR) to measure long bone tumors to design custom-made prosthesis (CMP)/modular prosthesis (MP) in limb salvage surgery (LSS) with the help of phantom and patient's study. There are two separate groups: one is the phantom study and another one is the patient's study. The phantom study is done with the Jaszack Phantom for the Gamma camera and the indigenous phantom for the MRI and DR. Three independent imaging professionals (nuclear medicine physicians and radiologists) measured the distance between standardized, preselected points on the Jaszack phantom in the Gamma Camera (GC) and indigenous phantom on the coronal and sagittal view of the MRI scan and in digital radiography...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38544582/complete-removable-denture-retained-by-a-symphyseal-single-implant-a-case-report
#6
Akkar Youness, Nadia Merzouk, Anissa Regragui
Complete denture is a real challenge for any practitioner. The aim of implantology is to optimize prosthetic balance and ensure that prostheses are perfectly integrated from a bio-functional viewpoint, despite an unfavorable anatomophysiological context. Here, we present a case managed in our department concerning a mandibular complete removable denture retained by a medial symphyseal implant. A 61-year-old fully edentulous mandibular patient with a Kennedy Applegate class I edentulous maxilla in good general health consulted for the renewal of his mandibular complete denture, which was deemed unstable and non-retentive...
February 2024: Curēus
https://read.qxmd.com/read/38543417/extraction-of-mechanical-parameters-via-molecular-dynamics-simulation-application-to-polyimides
#7
JOURNAL ARTICLE
Philipp Rosenauer, Christoph Kratzer, Silvia Larisegger, Stefan Radl
Polyimides feature a vast number of industrial applications due to their high thermal stability and insulation properties. These polymers exhibit an exceptional combination of thermal stability and mechanical toughness, which allows the semiconductor industry to use them as a mechanical stress buffer. Here, we perform all-atom molecular dynamics (MD) simulations for such materials to assess their predictive capability with respect to their mechanical properties. Specifically, we demonstrate that the OPLS-AA force field can be used to successfully describe an often-used polyimide (i...
March 14, 2024: Polymers
https://read.qxmd.com/read/38543362/rhodamine-b-containing-chitosan-based-films-preparation-luminescent-antibacterial-and-antioxidant-properties
#8
JOURNAL ARTICLE
Omar M Khubiev, Anton R Egorov, Daria I Semenkova, Darina S Salokho, Roman A Golubev, Nkumbu D Sikaona, Nikolai N Lobanov, Ilya S Kritchenkov, Alexander G Tskhovrebov, Anatoly A Kirichuk, Victor N Khrustalev, Andreii S Kritchenkov
In this study, Rhodamine B-containing chitosan-based films were prepared and characterized using their mechanical, photophysical, and antibacterial properties. The films were synthesized using the casting method and their mechanical properties, such as tensile strength and elongation at break, were found to be dependent on the chemical composition and drying process. Infrared spectroscopy and X-ray diffraction analysis were used to examine the chemical structure and degree of structural perfection of the films...
March 9, 2024: Polymers
https://read.qxmd.com/read/38543247/a-novel-pbm-for-nanomilling-of-drugs-in-a-recirculating-wet-stirred-media-mill-impacts-of-batch-size-flow-rate-and-back-mixing
#9
JOURNAL ARTICLE
Hamidreza Heidari, Nontawat Muanpaopong, Gulenay Guner, Helen F Yao, Donald J Clancy, Ecevit Bilgili
We examined the evolution of fenofibrate (FNB, drug) particle size distribution (PSD) during the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based population balance model (PBM). Our objective was to elucidate the potential impacts of batch size, suspension volumetric flow rate, and imperfect mixing in a recirculating WSMM. Various specific breakage rate functions were fitted to experimental PSD data at baseline conditions assuming perfect mixing. Then, the best function was used to simulate the PSD evolution at various batch sizes and flow rates to validate the model...
March 2, 2024: Pharmaceutics
https://read.qxmd.com/read/38543232/categorical-analysis-of-database-consistency-in-reporting-drug-drug-interactions-for-cardiovascular-diseases
#10
JOURNAL ARTICLE
Liana Suciu, Sebastian Mihai Ardelean, Mihai Udrescu, Florina-Diana Goldiş, Daiana Hânda, Maria-Medana Tuică, Sabina-Oana Vasii, Lucreţia Udrescu
Drug-drug interactions (DDIs) can either enhance or diminish the positive or negative effects of the associated drugs. Multiple drug combinations create difficulties in identifying clinically relevant drug interactions; this is why electronic drug interaction checkers frequently report DDI results inconsistently. Our paper aims to analyze drug interactions in cardiovascular diseases by selecting drugs from pharmacotherapeutic subcategories of interest according to Level 2 of the Anatomical Therapeutic Chemical (ATC) classification system...
February 28, 2024: Pharmaceutics
https://read.qxmd.com/read/38543037/enhancing-the-luminescence-of-la-3-mg-2-nbo-9-mn-4-phosphor-through-h-3-bo-3-and-charge-compensator-co-doping-for-use-in-plant-growth-lamps
#11
JOURNAL ARTICLE
Zaifa Yang, Ruoxuan Wang, Shuyu Yang, Hongxia Bu, Jingfen Zhao
Mn4+ -doped red-light-emitting phosphors have become a research hotspot that can effectively enhance photosynthesis and promote morphogenesis in plants. Herein, the red phosphor La3 Mg2 NbO9 :Mn4+ was synthesized through the solid-state reaction method. The effects of adding H3 BO3 and a charge compensator R+ (R = Li, Na, K) on the crystal structure, morphology, quantum efficiency, and luminous performance of the La3 Mg2 NbO9 :Mn4+ phosphor were systematically analyzed, respectively. The results showed that adding H3 BO3 flux and a charge compensator improved the quantum efficiency and luminescence intensity...
March 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38543029/detection-of-adulterated-naodesheng-tablet-naodesheng-pian-via-in-depth-chemical-analysis-and-subsequent-reconstruction-of-its-pharmacopoeia-q-markers
#12
JOURNAL ARTICLE
Chunhou Li, Xican Li, Jingyuan Zeng, Rongxin Cai, Shaoman Chen, Ban Chen, Xiaojun Zhao
Naodesheng Tablet ( Naodesheng Pian ), a traditional Chinese medicine formula for stroke treatment, is made up of five herbal medicines, i.e., Sanqi , Gegen , Honghua , Shanzha , and Chuanxiong. However, the current Pharmacopoeia quality-marker (Q-marker) system cannot detect possible adulteration. Our study tried to use a new strategy, i.e., standards-library-dependent ultra-high-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS/MS) putative identification, to reconstruct the Q-marker system...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38543012/ethylene-alt-%C3%AE-olefin-copolymers-by-hydrogenation-of-highly-stereoregular-cis-1-4-polydienes-synthesis-and-structural-characterization
#13
JOURNAL ARTICLE
Giovanni Ricci, Antonella Caterina Boccia, Ivana Pierro, Claudio De Rosa, Miriam Scoti
The homogeneous non-catalytic hydrogenation of several types of iso- and syndiotactic cis -1,4 poly(1,3-diene)s with diimide, formed by thermal decomposition of p -toluene-sulfonyl-hydrazide, was examined. Perfectly alternating ethylene/1-alkene copolymers having different tacticity (i.e., isotactic and syndiotactic), which in some cases are difficult to synthesize by simple stereospecific co-polymerization of the corresponding monomers, were obtained. All the copolymers synthesized were fully characterized from a structural, morphological, and rheological point of view through different analytical techniques (FT-IR, NMR, GPC, DSC, RX)...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542892/towards-the-eldorado-of-pka-determination-a-reliable-and-rapid-dft-model
#14
JOURNAL ARTICLE
Silvia Pezzola, Mariano Venanzi, Pierluca Galloni, Valeria Conte, Federica Sabuzi
The selection of a "perfect tool" for the theoretical determination of acid-base dissociation constants (Ka) is still puzzling. Recently, we developed a user-friendly model exploiting CAM-B3LYP for determining pKa with impressive reliability. Herein, a new challenge is faced, examining a panel of functionals belonging to different rungs of the "Jacob's ladder" organization, which classifies functionals according to their level of theory. Specifically, meta-generalized gradient approximations (GGAs), hybrid-GGAs, and the more complex range-separated hybrid (RSH)-GGAs were investigated in predicting the pKa of differently substituted carboxylic acids...
March 12, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542554/pachnoc-packet-and-circuit-hybrid-switching-noc-for-real-time-parallel-stream-signal-processing
#15
JOURNAL ARTICLE
Peng Hao, Shengbing Zhang, Xinbing Zhou, Yi Man, Dake Liu
Real-time heterogeneous parallel embedded digital signal processor (DSP) systems process multiple data streams in parallel in a stringent time interval. This type of system on chip (SoC) requires the network on chip (NoC) to establish multiple symbiotic parallel data transmission paths with ultra-low transmission latency in real time. Our early NoC research PCCNOC meets this need. The PCCNOC uses packet routing to establish and lock a transmission circuit, so that PCCNOC is perfectly suitable for ultra-low latency and high-bandwidth transmission of long data packets...
February 23, 2024: Micromachines
https://read.qxmd.com/read/38542106/two-photon-absorbing-dendrimers-and-their-properties-an-overview
#16
REVIEW
Valérie Maraval, Anne-Marie Caminade
This review describes the two-photon absorption properties of dendrimers, which are arborescent three-dimensional macromolecules differing from polymers by their perfectly defined structure. The two-photon absorption process is a third order non-linear optical property that is attractive because it can be used in a wide range of applications. In this review, dendrimers that were studied for their two-photon absorption properties are first described. Then, the use of dendritic TPA chromophores for light harvesting, photopolymerization, optical power limitation, cell imaging, singlet oxygen generation, and photodynamic therapy is described...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541799/unlocking-diagnostic-precision-fate-protocol-integration-with-blue-and-efast-protocols-for-enhanced-pre-hospital-differential-diagnosis-of-pleural-effusion-manifested-as-dyspnea-in-adults-a-pilot-study
#17
JOURNAL ARTICLE
Damian Kowalczyk, Miłosz Turkowiak, Wojciech Jerzy Piotrowski, Oskar Rosiak, Adam Jerzy Białas
Background : Dyspnea commonly stems from combined myocardial and pulmonary dysfunction, posing challenges for accurate pre-hospital diagnosis. Limited diagnostic capabilities hinder the differentiation of cardiac and pulmonary issues. This study assesses the efficacy of combined cardiac and pulmonary ultrasound using the BLUE, eFAST, and FATE protocols. Methods : Participants were consecutively enrolled from dyspnea-related emergency calls in Warsaw, Poland, from 4 April 2022, to 15 June 2023. Patients with pleural effusion were identified through pre-hospital and in-hospital radiological assessments...
March 9, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541751/long-term-outcome-of-metal-on-metal-total-hip-arthroplasty-with-modular-neck-stem
#18
JOURNAL ARTICLE
Hiroki Wakabayashi, Masahiro Hasegawa, Yohei Naito, Shine Tone, Akihiro Sudo
Background : This study aimed to report the long-term outcomes of total hip arthroplasty (THA) using a Conserve Plus (Wright Medical, Japan) metal-on-metal (MoM) acetabular prosthesis with a modular neck stem. Methods : This study enrolled 50 patients (10 men and 40 women; mean age, 65.8 (39-87) years) who underwent primary THA using a Conserve Plus MoM acetabular prosthesis with a modular neck stem. The preoperative diagnosis in most patients was osteoarthritis. Clinical function of hip joint outcomes was investigated using the Japanese Orthopedic Association (JOA) hip score preoperatively and at the final follow-up...
March 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541606/what-is-life-rethinking-biology-in-light-of-fundamental-parameters
#19
REVIEW
Jacques Fantini, Mélanie Matveeva, Marine Lefebvre, Henri Chahinian
Defining life is an arduous task that has puzzled philosophers and scientists for centuries. Yet biology suffers from a lack of clear definition, putting biologists in a paradoxical situation where one can describe at the atomic level complex objects that remain globally poorly defined. One could assume that such descriptions make it possible to perfectly characterize living systems. However, many cases of misinterpretation put this assumption into perspective. In this article, we focus on critical parameters such as time, water, entropy, space, quantum properties, and electrostatic potential to redefine the nature of living matter, with special emphasis on biological coding...
February 20, 2024: Life
https://read.qxmd.com/read/38541577/nano-innovations-in-cancer-therapy-the-unparalleled-potential-of-mxene-conjugates
#20
REVIEW
Sanjay Kulkarni, Soji Soman, Prerana D Navti, Amrita Arup Roy, Ajinkya Nitin Nikam, P Vineeth, Jahnavi Kulkarni, Krishnaraj Somayaji Shirur, Abhijeet Pandey, Sajan D George, Srinivas Mutalik
MXenes are two-dimensional transition metal carbides, nitrides, and carbonitrides that have become important materials in nanotechnology because of their remarkable mechanical, electrical, and thermal characteristics. This review emphasizes how crucial MXene conjugates are for several biomedical applications, especially in the field of cancer. These two-dimensional (2D) nanoconjugates with photothermal, chemotherapeutic, and photodynamic activities have demonstrated promise for highly effective and noninvasive anticancer therapy...
March 20, 2024: Materials
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