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Patient reported outcome measure

Cheng Jingbo, Feng Mingli, Cao Guanglei, Li Zheng, An Shuai, Huang Jiang
The objectives of our study were to evaluate (1) patellar height changes when the knee axis correction was < 15 degrees and (2) the clinical effect after open wedge high tibial osteotomy (OWHTO). Sixty-nine patients (69 knees) undergoing OWHTO between January 2016 and June 2017 were enrolled in this prospective study. All patients underwent OWHTO using a three-dimensional (3D)-printed patient-specific instrument. We used X-ray and lower-limb computed tomography scan to measure the osteotomy angle, patellar height, and other patellofemoral joint indices...
March 15, 2019: Journal of Knee Surgery
Laura S Porter, James W Carson, Maren Olsen, Kimberly M Carson, Linda Sanders, Lee Jones, Kelly Westbrook, Francis J Keefe
PURPOSE: Patients with metastatic breast cancer (MBC) experience high levels of symptoms. Yoga interventions have shown promise for improving cancer symptoms but have rarely been tested in patients with advanced disease. This study examined the acceptability of a comprehensive yoga program for MBC and the feasibility of conducting a randomized trial testing the intervention. METHODS: Sixty-three women with MBC were randomized with a 2:1 allocation to yoga or a support group comparison condition...
March 15, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Jennifer Hong, Laura Aspey, Gaobin Bao, Tamara Haynes, S Sam Lim, Cristina Drenkard
OBJECTIVES: Depression may occur in up to 30% of individuals with cutaneous lupus erythematosus (CLE), many of whom may also have systemic manifestations. Chronic cutaneous lupus erythematosus (CCLE) conditions are less likely to present systemic involvement than acute and subacute conditions but more often cause permanent scarring and dyspigmentation. However, little is known about depression in those who have CCLE confined to the skin (primary CCLE). As African Americans are at high risk for primary CCLE and depression, we aimed to investigate the prevalence of and explore the risk factors for depression in a population-based cohort of predominantly Black patients with primary CCLE...
March 15, 2019: American Journal of Clinical Dermatology
Polyzois Makras, Athanasios D Anastasilakis, George Antypas, Efstathios Chronopoulos, Evangelia G Kaskani, Aikaterini Matsouka, Dimos K Patrikos, Konstantinos D Stathopoulos, Symeon Tournis, George Trovas, Christos Kosmidis
We report the updated guidelines for the management of osteoporosis in Greece, which include guidance on fracture risk assessment, diagnosis-pharmacological treatment-follow-up of osteoporosis based on updated information, and national evidence from Greek clinical practice and the healthcare setting. PURPOSE: The purpose of this report was to update the Guidelines for the Management of Osteoporosis in Greece that was published in 2011. METHODS: In line with the GRADE system, the working group initially defined the main clinical questions that should be addressed when dealing with the diagnosis and management of osteoporosis in clinical practice in Greece...
March 15, 2019: Archives of Osteoporosis
Laura Marciano, Anne-Linda Camerini, Peter J Schulz
BACKGROUND: Empirical evidence on how health literacy affects diabetes outcomes is inconsistent. The purpose of this meta-analysis was to quantitatively summarize the findings on the associations between health literacy and diabetes knowledge, self-care activities, and glycemic control as disease-related outcomes, with specific focus on the type of health literacy assessment. DATA SOURCES: Nine databases (MEDLINE, CINAHL, Communication and Mass Media Complete, PsychInfo, PsychArticles, Psychology and Behavioral Sciences Collection, ERIC, Sociology, Embase) were searched for peer-reviewed original research articles published until 31 March 2018...
March 15, 2019: Journal of General Internal Medicine
Sara Jasionowska, Oliver Brunckhorst, Rowland W Rees, Asif Muneer, Kamran Ahmed
PURPOSE: Redo-urethroplasty is a challenge for any genitourethral surgeon, with a number of techniques previously described. This systematic review aims to identify the surgical techniques described in the literature and evaluate the evidence for their effectiveness in managing recurrent urethral strictures. MATERIALS AND METHODS: A systematic review of the MEDLINE and EMBASE databases from 1945 to July 2018 was performed and the urethroplasty procedures were classified according to the site and surgical technique...
March 15, 2019: World Journal of Urology
Sibel Z Aydin, Joanna C Robson, Antoine G Sreih, Catherine Hill, Fatma Alibaz-Oner, Sarah Mackie, Susan Beard, Gülen Hatemi, Tanaz A Kermani, Alfred Mahr, Alexa Meara, Nataliya Milman, Beverley Shea, Gunnar Tómasson, Peter Tugwell, Haner Direskeneli, Peter A Merkel
OBJECTIVE: The OMERACT Vasculitis Working Group seeks to develop validated outcome measures for use in trials for large-vessel vasculitis (LVV). METHODS: An international Delphi exercise conducted among investigators identified items considered important to measure active disease. In parallel, qualitative research with patients was conducted, including interviews and focus groups. RESULTS: Next steps prioritized by the group for LVV include i) defining disease states (remission, flare, and patient-acceptable symptom state); and ii) selection of patientreported outcome tools...
March 15, 2019: Journal of Rheumatology
Anita Tollisen, Anne Marit Selvaag, Astrid Aasland, Anners Lerdal, Berit Flatø
OBJECTIVE: To describe the longitudinal health status from childhood to adulthood in patients with juvenile idiopathic arthritis (JIA), compare outcomes after 19 years with those of controls and identify early predictors of physical functioning, pain and physical health-related quality of life (HRQOL). METHODS: Between 1995-2003, 96 JIA patients (mean 6.1±4.0 years ,67% female) were assessed within 18 months of diagnosis and every 6 months for the next 3 years with measures of JIA disease activity, physical functioning, pain, fatigue and wellbeing...
March 15, 2019: Journal of Rheumatology
Miso Krsticevic, Svjetlana Dosenovic, Daiana-Anne-Marie Dimcea, Dominika Jedrzejewska, Ana Catarina Marques Lameirão, Eliana Santos Almeida, Antonia Jelicic Kadic, Milka Jeric, Krste Boric, Livia Puljak
OBJECTIVE: Core outcome set (COS) is the minimum set of outcome domains that should be measured and reported in clinical trials. We analyzed outcome domains, prevalence of use of COS published by Outcome Measures in Rheumatology (OMERACT) initiative, outcome measures for outcome domains recommended by OMERACT COS, duration and size of randomized controlled trials (RCTs) testing non-surgical interventions for OA. METHODS: We searched PubMed and analyzed RCTs about non-surgical interventions for OA published from June 2012 to June 2017...
March 15, 2019: Journal of Rheumatology
Natasha B Leighl, Matthew D Hellmann, Rina Hui, Enric Carcereny, Enriqueta Felip, Myung-Ju Ahn, Joseph Paul Eder, Ani S Balmanoukian, Charu Aggarwal, Leora Horn, Amita Patnaik, Matthew Gubens, Suresh S Ramalingam, Gregory M Lubiniecki, Jin Zhang, Bilal Piperdi, Edward B Garon
BACKGROUND: The anti-programmed death 1 monoclonal antibody pembrolizumab has shown antitumour activity and is a first-line and second-line treatment option for patients with programmed death ligand 1 (PD-L1)-expressing advanced non-small-cell lung cancer. We report updated 3-year safety and efficacy outcomes from the phase 1 study, KEYNOTE-001. METHODS: KEYNOTE-001 is a multicohort, open-label, phase 1 study of pembrolizumab (2 mg/kg every 3 weeks or 10 mg/kg every 2 or 3 weeks) in treatment naive or previously treated patients with locally advanced or metastatic non-small-cell lung cancer with measurable disease at baseline...
March 12, 2019: Lancet Respiratory Medicine
Gregory M Gressel, Shayan M Dioun, Michael Richley, David W Lounsbury, Bruce D Rapkin, Sara Isani, Nicole S Nevadunsky, D Y S Kuo, Akiva P Novetsky
OBJECTIVE: The Patient-Reported Outcomes Measurement Information System (PROMIS®) Network has developed a comprehensive repository of electronic patient reported outcomes measures (ePROs) of major symptom domains that have been validated in cancer patients. Their use for patients with gynecologic cancer has been understudied. Our objective was to establish feasibility and acceptability of PROMIS ePRO integration in a gynecologic oncology outpatient clinic and assess if it can help identify severely symptomatic patients and increase referral to supportive services...
March 2019: Gynecologic Oncology
Xin Shelley Wang, Qiuling Shi, Loretta A Williams, Charles S Cleeland, Araceli Garcia-Gonzalez, Ting-Yu Chen, Denita R Shahid, Pedro T Ramirez, Maria D Iniesta, Ashley M Siverand, Larissa A Meyer
OBJECTIVE: Using patient-reported outcomes (PROs) in perioperative care is increasingly common. We report the development, validation, and application of an MD Anderson Symptom Inventory version for use in patients undergoing surgery for gynecologic cancer or benign conditions (MDASI-PeriOp-GYN). METHODS: Our process included: (1) generating PeriOp-GYN-specific candidate items from qualitative interviews with patients, followed by input from an expert panel; (2) dropping items that lacked independent clinical relevance; (3) validating psychometric properties (reliability, validity) of the resulting MDASI-PeriOp-GYN; and (4) conducting cognitive debriefing interviews with patients to confirm ease of comprehension, relevance, and acceptability...
March 2019: Gynecologic Oncology
Thijs Landman, Yvonne Schoon, Michiel Warlé, Frank-Erik De Leeuw, Dick Thijssen
BACKGROUND: Remote ischemic postconditioning (rIPostC) refers to the observation that repeated, short periods of ischemia protect remote areas against tissue damage during and after prolonged ischemia. Based on previous observations of a potential neuroprotective effect of rIPostC, the aim of this study is to evaluate whether repeated rIPostC after an ischemic stroke can reduce infarct size, which could be translated to an improvement in clinical outcomes. METHODS/DESIGN: We will enroll 200 ischemic stroke patients to daily rIPostC or sham conditioning during hospitalization into a randomized single-blind placebo-controlled trial...
March 15, 2019: Trials
Janaina Andressa de Souza, João Carlos Ferrari Corrêa, Letizzia Dall' Agnol, Filipe Ribeiro Dos Santos, Márcia Rafaella Pereira Gomes, Fernanda Ishida Corrêa
BACKGROUND: Shoulder pain is reported to be one of the major challenges faced in the functional recovery of patients in rehabilitation following a stroke. In such cases, transcranial direct current stimulation (tDCS) has been used as an additional therapeutic tool for improvements in central and peripheral pain. The aim of the proposed study is to evaluate the effect of tDCS when combined with upper limb physical therapy on pain intensity and functional improvement in stroke survivors with shoulder pain in the hemiplegic limb...
March 15, 2019: Trials
Zachary R Kachian, Shira Cohen-Zimerman, Danny Bega, Barry Gordon, Jordan Grafman
BACKGROUND: An increased risk of suicide in Huntington's disease (HD) patients is well documented, with rates significantly higher than those of the general population as well as other neurodegenerative diseases. However, despite its prevalence, the magnitude of this phenomenon as well as its predictors and etiology are still poorly understood. METHODS: We performed the first systematic review of all the studies published between March 1993 and December 2018 which investigated HD patients and gene carriers that reported suicidal ideation, suicide attempt, or suicide as an outcome...
March 5, 2019: Journal of Affective Disorders
Kateir Mariel Contreras Villamizar, Diana Carolina Afanador Rubio, Camilo Alberto González González, Paola Karina García Padilla, Martha Patricia Rodríguez Sánchez
INTRODUCTION: Morbid obesity in chronic kidney disease patients on hemodialysis limits access to renal transplantation. We report here a case of a surgical procedure for weight reduction in a hemodialysis patient and adjustment of dry weight through bioelectrical impedance. CASE PRESENTATION: A 44-year-old male with CKD on hemodialysis for 26 years. After 3 years on dialysis, he underwent a cadaveric kidney transplant. However, after 8 years of transplant, he loses the kidney graft and returns to dialysis treatment...
March 5, 2019: International Journal of Surgery Case Reports
Themistoklis Mikos, Dimitrios Tsolakidis, Grigoris F Grimbizis
The aim of this study is to investigate clinical behavior of Atypical Polypoid Adenomyomas (APAs) and to describe the rates of (i) recurrences, (ii) their association with endometrial hyperplasia and (iii) with endometrial cancer. All studies that reported the outcome of the clinical management of patients with histologically proven APAs were included. A review of the English literature since 1970 was systematically performed (PROSPERO No CRD42018080003). A quality assessment tool was used to assess the scientific value of all the studies...
March 2, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Samuel J Tingle, Rodrigo S Figueiredo, John Ag Moir, Michael Goodfellow, David Talbot, Colin H Wilson
BACKGROUND: Kidney transplantation is the optimal treatment for end-stage kidney disease. Retrieval, transport and transplant of kidney grafts causes ischaemia reperfusion injury. The current accepted standard is static cold storage (SCS) whereby the kidney is stored on ice after removal from the donor and then removed from the ice box at the time of implantation. However, technology is now available to perfuse or "pump" the kidney during the transport phase or at the recipient centre...
March 15, 2019: Cochrane Database of Systematic Reviews
Johann Christoph Geller, Thorsten Lewalter, Niels Eske Bruun, Milos Taborsky, Frank Bode, Jens Cosedis Nielsen, Christoph Stellbrink, Steffen Schön, Holger Mühling, Hanno Oswald, Sebastian Reif, Stefan Kääb, Peter Illes, Jochen Proff, Nikolaos Dagres, Gerhard Hindricks
AIMS: In the IN-TIME trial, automatic daily implant-based multiparameter telemonitoring significantly improved clinical outcomes in patients with chronic systolic heart failure and implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D). We compared IN-TIME results for ICD and CRT-D subgroups. METHODS: Patients with LVEF ≤ 35%, NYHA class II/III, optimized drug treatment, no permanent atrial fibrillation, and a dual-chamber ICD (n = 274) or CRT-D (n = 390) were randomized 1:1 to telemonitoring or no telemonitoring for 12 months...
March 14, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Valerie J Block, Riley Bove, Chao Zhao, Priya Garcha, Jennifer Graves, Andrew R Romeo, Ari J Green, Diane D Allen, Jill A Hollenbach, Jeffrey E Olgin, Gregory M Marcus, Mark J Pletcher, Bruce A C Cree, Jeffrey M Gelfand
Importance: Disability measures in multiple sclerosis (MS) fail to capture potentially important variability in walking behavior. More sensitive and ecologically valid outcome measures are needed to advance MS research. Objectives: To assess continuous step count activity remotely among individuals with MS for 1 year and determine how average daily step count is associated with other measures of MS disability. Design, Setting, and Participants: In a prospective longitudinal observational cohort study, 95 adults with relapsing or progressive MS who were able to walk more than 2 minutes with or without an assistive device were recruited between June 15, 2015, and August 8, 2016, and remotely monitored in their natural environment for 1 year...
March 1, 2019: JAMA Network Open
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