Tommaso Schirinzi, Daniela Maftei, Riccardo Maurizi, Maria Albanese, Clara Simonetta, Roberta Bovenzi, Jacopo Bissacco, Davide Mascioli, Laura Boffa, Maria Grazia Di Certo, Francesca Gabanella, Beatrice Francavilla, Stefano Di Girolamo, Nicola Biagio Mercuri, Francesco Maria Passali, Roberta Lattanzi, Cinzia Severini
The biological substrate of persistent post-COVID-19 hyposmia is still unclear. However, as many neurodegenerative diseases present with smell impairment at onset, it may theoretically reflect degeneration within the central olfactory circuits. However, no data still exist regarding the post-COVID-19 patients. As the olfactory neurons (ONs) mirror pathological changes in the brain, allowing for tracking the underlying molecular events, here, we performed a broad analysis of ONs from patients with persistent post-COVID-19 OD to identify traces of potential neurodegeneration...
April 4, 2024: Molecular Neurobiology