keyword
https://read.qxmd.com/read/38168617/trends-in-antihypertensive-use-among-privately-insured-hypertensive-clients-in-ghana
#1
JOURNAL ARTICLE
Afia Frimpomaa Asare Marfo, John Serbe Marfo, Jacob Plange-Rhule, Samantha Hollingworth
The objective of the study was to describe the patterns of antihypertensive medicines (AHM) in a selected national population in Ghana. The claims data for all privately insured patients in Ghana over three years to 2018 were analysed. The classes of medicines used, the dose by time, gender and age, and generic status were examined. In addition, the use in Defined Daily Dose (DDD) per 1000 population per day was estimated. Classes of AHM prescribed were CCB, ARB, ACEI, diuretics, and BB. Amlodipine, nifedipine, losartan, lisinopril, and bendroflumethiazide accounted for 74% of all use...
January 2, 2024: Journal of Human Hypertension
https://read.qxmd.com/read/38045916/the-18-year-risk-of-cancer-angioedema-insomnia-depression-and-erectile-dysfunction-in-association-with-antihypertensive-drugs-post-trial-analyses-from-allhat-medicare-linked-data
#2
JOURNAL ARTICLE
Xianglin L Du, Journey Martinez, Jose-Miguel Yamal, Lara M Simpson, Barry R Davis
PURPOSE: This study aimed to determine the 18-year risk of cancer, angioedema, insomnia, depression, and erectile dysfunction in association with antihypertensive drug use. METHODS: This is a post-trial passive follow-up study of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants between 1994 and 1998 that was conducted by linking their follow-up data with Medicare claims data until 2017 of subjects who were free of outcomes at baseline on 1 January 1999...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38022184/a-case-of-angiotensin-converting-enzyme-ace-inhibitor-induced-small-bowel-angioedema
#3
Sarmad Pirzada, Beebarg Raza, Ali Abbas Mankani, Bazigh Naveed
Angioedema is a rare but known side effect of angiotensin-converting enzyme (ACE) inhibitor therapy. The most common presentations of ACE inhibitor-induced angioedema describe swellings in the oropharyngeal and periorbital regions. We describe a rare case of a 58-year-old female with a history of type 2 diabetes and hypertension taking lisinopril for the past three years and presented with recurrent episodes of abdominal pain, nausea, and vomiting around the same time she started taking the drug. Multiple computed tomography (CT) scans were performed, which showed findings consistent with edema in the proximal small bowel...
October 2023: Curēus
https://read.qxmd.com/read/37908932/angioedema-from-triple-therapy-a-case-report
#4
Nicholas Lepore, Taya Carpenter, Alan Wolff
Angioedema is a rare but potentially life-threatening complication associated with angiotensin-converting enzyme (ACE) inhibitors. Although the pathophysiology is well understood, cases involving the concurrent use of other medications are less explored. We present a unique case of ACE inhibitor-induced angioedema in a 57-year-old male, which developed soon after receiving intravenous contrast. The patient's medication list included a dipeptidyl peptidase-IV inhibitor and a calcium channel blocker. Studies have shown an increased risk of angioedema with the combined use of these medications, likely due to alterations in bradykinin metabolism...
September 2023: Curēus
https://read.qxmd.com/read/37829951/hyponatremia-in-a-patient-with-vasodilatory-shock-due-to-overdose-of-antihypertensive-medications-a-case-report
#5
Abdul Hannan A Rasheed, Kavitha Vellanki, Frank Woo, David J Leehey
Vasodilatory shock can be caused by septic shock, neurogenic shock, anaphylaxis, drugs, and toxins. Vasopressin is commonly used for the restoration of vasomotor tone in vasodilatory shock due to sepsis. This agent exerts its vasoconstrictive effect via smooth muscle V1 receptors and has antidiuretic activity via kidney V2 receptors. Stimulation of V2 receptors results in the integration of aquaporin 2 channels into the apical membrane of collecting ducts leading to free water reabsorption. This antidiuretic action of vasopressin predisposes to hyponatremia...
September 2023: Curēus
https://read.qxmd.com/read/37805878/management-of-risks-of-adverse-drug-reactions-according-to-adr-report-form-data-from-lviv-region-healthcare-facilities-in-2022
#6
JOURNAL ARTICLE
N Stepaniuk, O Piniazhko, O Poshyvak, T Bessarab, N Hudz, I Gavriluk
The study aimed to analyse the adverse drug reactions report form data received by the State Expert Center of the Ministry of Health of Ukraine from healthcare professionals in the Lviv region in 2022. Regarding specific types of medicines, the ones with proven cause-and-effect relationships that caused the highest frequency of adverse drug reactions incidents were chemotherapeutic agents (35.5%), medicines affecting the cardiovascular system (20.3%), and non-steroidal anti-inflammatory drugs (8%). Within the penicillin class, amoxicillin potentiated by clavulanate (67%) and amoxicillin (29%) were the dominant drugs showing the highest incidence rate of adverse reactions...
2023: Georgian Medical News
https://read.qxmd.com/read/37354687/the-nitrosamine-contamination-in-beta-blockers-bisoprolol-metoprolol-ace-inhibitors-lisinopril-perindopril-thiazides-diuretics-hct-calcium-channel-blockers-amlodipine-felodipine-sartans-candesartan-and-%C3%B0-he-subsequent-skin-cancer-development-and-progression
#7
JOURNAL ARTICLE
G Tchernev
The problem of contamination of the most commonly used medicines with nitrosamines is worsening worldwide. According to recent literature data, this "contamination" is the cause not only of skin cancer (keratinocytic/melanoma) but also of gastrointestinal neoplasms, brain tumours, neuroblastoma, rectal carcinoma, acute lymphoblastic leukaemia, and many others. It is these clinical manifestations that are associated with/ or already directly linked to the nitrosamine content of drugs and food products used by patients in previous periods...
April 2023: Georgian Medical News
https://read.qxmd.com/read/37240985/therapeutic-drug-monitoring-in-arterial-hypertension
#8
JOURNAL ARTICLE
Sergey Seleznev, Alexey Shchulkin, Pavel Mylnikov, Elena Yakusheva, Natalia Nikulina
(1) Background: This study was planned to assess the concentration of antihypertensive drugs (AHD) in the blood serum in patients with controlled and uncontrolled arterial hypertension (AH). (2) Methods: We assessed 46 patients with AH. Based on the results of 24 h blood pressure monitoring (ABPM), the patients were randomized into two groups. The first group consisted of the patients with controlled AH; the second group consisted of the patients with uncontrolled AH. Venous blood was taken in both groups of patients in the morning before and 2 h after taking drugs to assess the concentration of lisinopril, amlodipine, valsartan, and indapamide...
May 11, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37126923/the-role-of-amiodarone-in-post-operative-hypothyroidism-patient-with-factitious-thyrotoxicosis-and-atrial-fibrillation-a-case-report
#9
Dien Aulia, Deasy Ardiany
INTRODUCTION: Factitious thyrotoxicosis includes all causes of thyrotoxicosis from the short or long-term ingestion of thyroid hormone, of which one of the complications is atrial fibrillation. CASE PRESENTATION: A woman, 71 years old, complained of chest palpitations. She had a medical history of thyroidectomy, hypertension, and dyslipidemia. In addition, she took Levothyroxine, amlodipine and simvastatin regularly. On physical examination, the general status was weak, with vital signs showing blood pressure (BP) of 170/100 mmHg, heart rate (HR) of 130-150 bpm, irregular rhythm, respiratory rate (RR) of 20×/min, axillary temperature of 36...
April 24, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37053203/l-type-calcium-channel-blocker-increases-vegf-concentrations-in-retinal-cells-and-human-serum
#10
JOURNAL ARTICLE
Anmol Kumar, Stefan Mutter, Erika B Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P Hiltunen, Kimmo K Kontula, Per-Henrik Groop
OBJECTIVE: Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). Previously, we have reported an association between mutations in a gene coding for the L-type calcium channel subunit, VEGF and DR. L-type calcium channel blockers (LTCCBs) have been widely used as antihypertensive medication (AHM), but their association with VEGF and DR is still unclear. Therefore, we explored the effect of LTCCBs compared to other AHMs on VEGF concentrations in retinal cells and human serum...
2023: PloS One
https://read.qxmd.com/read/37039792/heterogeneity-in-blood-pressure-response-to-4-antihypertensive-drugs-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Johan Sundström, Lars Lind, Shamim Nowrouzi, Emil Hagström, Claes Held, Per Lytsy, Bruce Neal, Kerstin Marttala, Ollie Östlund
IMPORTANCE: Hypertension is the leading risk factor for premature death worldwide. Multiple blood pressure-lowering therapies are available but the potential for maximizing benefit by personalized targeting of drug classes is unknown. OBJECTIVE: To investigate and quantify the potential for targeting specific drugs to specific individuals to maximize blood pressure effects. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, repeated crossover trial in men and women with grade 1 hypertension at low risk for cardiovascular events at an outpatient research clinic in Sweden...
April 11, 2023: JAMA
https://read.qxmd.com/read/36472269/effectiveness-of-lisinopril-and-amlodipine-combination-at-hypertension-with-comorbidity-of-arteriosclerosis-obliterans-in-general-practice
#12
JOURNAL ARTICLE
Liliya S Babinets, Rostyslav D Levchuk, Iryna M Halabitska, Olga I Kryskiv
OBJECTIVE: The aim: To analyze the dynamics of daily monitoring of blood pressure, intracardiac (according to echocardiography), peripheral hemodynamics (according to ultrasound of the vessels of the lower extremity), the thickness of the intima-media complex (according to carotid sonography) in patients with hypertension the effect of treatment with a combination of lisinopril and amlodipine. PATIENTS AND METHODS: Materials and methods: The study included 40 patients with hypertension with 2 (29 patients) and 3 (11 patients) degrees of hypertension in combination with AOLE with I-III stages of chronic insufficiency of the lower extremity, which revealed hyperkinetic, eukinetic, and hypokinetic types of hypertension with a predominance of the sympathetic nervous system...
2022: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/36027404/vasculitis-and-renovascular-hypertension-a-case-report
#13
JOURNAL ARTICLE
Diana Ferrão, Clara Silva, Mariana Matos, Susana Ferreira, Sofia Tavares, Luís Nogueira-Silva, Maria João Lima, Jorge Almeida
OBJECTIVE: Vasculitides are a group of rare, systemic diseases that induce inflammatory reactions in blood vessels, causing a reduction of blood flow and ischemia. In the kidney, luminal narrowing reduces blood flow and activates the renin-angiotensin-aldosterone system, causing renovascular hypertension. DESIGN AND METHOD: Clinical case report. RESULTS: A 47-year-old male with previous intestinal tuberculosis and hypertension diagnosed two years prior (blood pressure around 220/110 mmHg) was referred to our Hypertension Clinic...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36027086/the-effect-of-dapagliflozin-on-the-level-of-systolic-blood-pressure-and-glycemic-control-in-patients-with-arterial-hypertension-and-type-2-diabetes
#14
JOURNAL ARTICLE
Larysa Zhuravlyova, Tetyana Rogachova, Nelya Sokolnikova, Maryna Filonenko
OBJECTIVE: to determine the influence of dapagliflozin (D) on the level of blood pressure (BP) in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). DESIGN AND METHOD: A total of 57 patients with AH, stage II and concomitant non-severe T2DM were examined (fasting plasma glucose < 9 mmol/L, glycosylated hemoglobin (HbA1c) - 7.45 ± 1.3%, mean age 52.4 ± 2.8, mean BP 162/102 ± 3.5/2.3 mm Hg, BMI 28.3 ± 2.7 kg/m2, disease duration 6...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/36027065/optimization-of-blood-pressure-control-and-angioprotection-with-fixed-combination-of-lisinopril-amlodipine-rosuvastatin-in-patients-after-a-covid-19
#15
JOURNAL ARTICLE
Sergey Nedogoda, Alla Ledyaeva, Elena Chumachek, Vera Tsoma, Alla Salasyuk, Viktoriya Lutova, Ekaterina Popova, Daniil Vlasov, Olga Bychkova, Viktoriya Labaznikova, Konstantin Evdokimov
OBJECTIVE: Evaluation of the capability of a fixed combination of lisinopril + amlodipine + rosuvastatin (ECWAMER) in achieving additional angioprotection in patients with arterial hypertension (AH) and high pulse wave velocity (PWV) in patients after confirmed COVID-19 had 75 - 95% lung involvement, complicated by bilateral polysegmental viral pneumonia, with genetically engineered biological drugs (GIBD) therapy, who had not previously received combined antihypertensive therapy (AHT)...
June 1, 2022: Journal of Hypertension
https://read.qxmd.com/read/35948937/antihypertensive-medicine-use-differs-between-ghana-and-nigeria
#16
JOURNAL ARTICLE
Samantha A Hollingworth, Daniel Ankrah, Benjamin S C Uzochukwu, Chinyere C Okeke, Francis Ruiz, Emily Thacher
BACKGROUND: Non-communicable diseases are a growing burden in many African countries; cardiovascular disease is the main disease. Antihypertensive medicines (AHM) are a common treatment option but we know little about community use in most low- and medium-income countries (LMIC). We aimed to describe the use of antihypertensive medicines (AHM) in Ghana and Nigeria using a novel data source. METHODS: We used data from mPharma-a health and pharmaceutical company which distributes pharmaceuticals to hospital and retail pharmacies...
August 10, 2022: BMC Cardiovascular Disorders
https://read.qxmd.com/read/35794660/bioequivalence-evaluation-and-food-effect-assessment-of-lisinopril-amlodipine-tablets-in-healthy-chinese-subjects-under-fasting-and-fed-conditions
#17
RANDOMIZED CONTROLLED TRIAL
Ting Li, Yan-Ping Liu, Shu-Qin Liu, Ping Shi, Xin Jiang, Ye Tao, Xiao-Meng Gao, Ya-Ping Ma, Yu Cao
PURPOSE: The combination of lisinopril and amlodipine has a marked additional effect on blood pressure and fewer side effects than individual monotherapy. This study was conducted to compare the pharmacokinetic parameters and evaluate the bioequivalence between two Lisinopril/amlodipine tablets in healthy Chinese subjects. METHODS: A single center, randomized, open-label, single-dose, two-period crossover bioequivalence study was designed in healthy Chinese subjects under both fasting and fed conditions...
July 7, 2022: BMC Pharmacology & Toxicology
https://read.qxmd.com/read/35571234/risk-of-developing-alzheimer-s-disease-and-related-dementias-in-allhat-trial-participants-receiving-diuretic-ace-inhibitor-or-calcium-channel-blocker-with-18-years-of-follow-up
#18
JOURNAL ARTICLE
Xianglin L Du, Lara M Simpson, Mikala C Osani, Jose-Miguel Yama, Barry R Davis
Background: There is no any large randomized clinical trial of antihypertensive drug treatment with 18-year passive follow-up to examine the risk of Alzheimer's Disease (AD) or Related Dementias (ADRD). Methods: Post-trial passive follow-up study of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants in 1994-1998 by linking with their Medicare claims data through 2017 among 17,158 subjects in 567 U.S. centers who were free of ADRD at baseline on January 1, 1999...
2022: Journal of Alzheimer's Disease and Parkinsonism
https://read.qxmd.com/read/35146537/genetic-variation-of-pharmacogenomic-vip-variants-in-the-chinese-li-population-an-updated-research
#19
JOURNAL ARTICLE
Shuangyu Yang, Xia Dou, Zhen Wang, Wenjie Zhang, Kefan Ding, Wenting Meng, Haiyue Li, Jianfeng Liu, Yuanwei Liu, Tianbo Jin
Previous studies have shown that the frequency of very important pharmacogenomic (VIP) genes varies in different populations which leads to the diversities in drug efficacy, safety, and the risk associated with adverse drug reactions (ADRs). The purpose of this study was to identify the distribution differences of VIP variants between the Li population and the other 13 populations. Based on the Pharmacogenomics Knowledgebase database (PhamGKB), we successfully genotyped 52 VIP variants within 27 genes in 200 unrelated Li population...
March 2022: Molecular Genetics and Genomics: MGG
https://read.qxmd.com/read/34987247/selected-antihypertensive-agents-and-their-fixed-dose-combinations-effectively-ameliorate-trastuzumab-mediated-cardiac-dysfunction-in-rats
#20
JOURNAL ARTICLE
A A Adeneye, Olufunke Esan Olorundare, Temidayo Olutayo Omobowale, Akinyele Olubiyi Akinsola, Phillip Manma Kolo, Ralph Muehl Albrecht Albrecht, Peter Anthony Crooks
This study evaluates the therapeutic potentials of selected antihypertensive drugs [valsartan, amlodipine, lisinopril and their fixed-dose combinations (amlodipine + lisinopril) and (valsartan + lisinopril)] in ameliorating trastuzumab (TZM)‑induced cardiac dysfunctions in experimental rats. After an ethical clearance for the study was obtained, in-bred young adult female Wistar rats were randomly allotted into 10 groups of 6 rats per group. Group I rats were treated with 10 ml/kg/day sterile water p.o. and 1 ml/kg/day sterile water i...
June 30, 2021: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
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