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Early gallbladder cancer

T Mizuno, T Ebata, Y Yokoyama, T Igami, J Yamaguchi, S Onoe, N Watanabe, M Ando, M Nagino
BACKGROUND: The indications for major hepatectomy for gallbladder cancer either with or without pancreatoduodenectomy remain controversial. The clinical value of these extended procedures was evaluated in this study. METHODS: Patients who underwent major hepatectomy for gallbladder cancer between 1996 and 2016 were identified from a prospectively compiled database. Postoperative outcomes and overall survival were compared between patients undergoing major hepatectomy alone or combined with pancreatoduodenectomy (HPD)...
February 14, 2019: British Journal of Surgery
Hyuna Sung, Rebecca L Siegel, Philip S Rosenberg, Ahmedin Jemal
BACKGROUND: Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 obesity-related cancers. METHODS: We obtained incidence data for invasive cancers among people aged 25-84 years diagnosed from Jan 1, 1995, to Dec 31, 2014, for 25 population-based state registries in the USA...
February 1, 2019: Lancet. Public Health
Adil Baskiran, Emrah Sahin, Nese Karadag, Tevfik Tolga Sahin, Bora Barut, Dincer Ozgor, Abuzer Dirican
OBJECTIVE: Gallbladder cancer (GBC) is a rare clinical entity that has a poor prognosis. Radical resection with meticulous lymph node dissection is the only treatment option. The aim of the present study is to evaluate the efficacy of radical resection for GBC in the early postoperative period with the viewpoint of clinicopathological correlation. METHODS: Patients (n=24) who underwent radical resection with lymph node dissection for GBC between 2015 and 2017 were included...
September 2018: Northern Clinics of Istanbul
Tejaswini Subbannayya, Pamela Leal-Rojas, Alex Zhavoronkov, Ivan V Ozerov, Mikhail Korzinkin, Niraj Babu, Aneesha Radhakrishnan, Sandip Chavan, Remya Raja, Sneha M Pinto, Arun H Patil, Mustafa A Barbhuiya, Prashant Kumar, Rafael Guerrero-Preston, Sanjay Navani, Pramod K Tiwari, Rekha Vijay Kumar, T S Keshava Prasad, Juan Carlos Roa, Akhilesh Pandey, David Sidransky, Harsha Gowda, Evgeny Izumchenko, Aditi Chatterjee
Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late presentation of the disease, lack of early diagnostic markers and limited efficacy of therapeutic interventions. Elucidation of molecular events in GBC can contribute to better management of the disease by aiding in the identification of therapeutic targets. To identify aberrantly activated signaling events in GBC, tandem mass tag-based quantitative phosphoproteomic analysis of five GBC cell lines was carried out...
January 21, 2019: Journal of Cell Communication and Signaling
Anne M Horgan, Jennifer J Knox
Biliary tract cancers, including gallbladder cancer, intrahepatic, perihilar, and distal cholangiocarcinomas, although anatomically contiguous, represent a heterogeneous group of cancers with extensive biologic and genetic diversity. With early disease, surgical resection is the preferred option for all subtypes; however, relapse rates remain high, and survival outcomes are poor. Data to guide the use of adjuvant therapy have been limited to retrospective series, population-based studies, and meta-analyses, all with their associated limitations...
December 2018: Journal of Oncology Practice
Ravi Mehrotra, Sonam Tulsyan, Showket Hussain, Balraj Mittal, Sundeep Singh Saluja, Sandeep Singh, Pranay Tanwar, Asiya Khan, Milind Javle, Manal M Hassan, Shubham Pant, Xabier De Aretxabala, Bhawna Sirohi, Preetha Rajaraman, Tanvir Kaur, G K Rath
Gallbladder cancer (GBC) is a rare malignancy of biliary tract cancer (BTC), characterized by late presentation and poor prognosis. It exhibits wide geographical as well as ethnical variations. So, diverse epidemiology along with etiological factors have been discussed in the current article. Present review unravels the germ line polymorphisms contributing to GBC susceptibility through candidate gene approach and GWAS. GBC is enriched with multiple mutations consisting of both passenger and driver mutations...
October 2018: Mutation Research
Krashna Patel, Khaled Dajani, Saranya Vickramarajah, Emmanuel Huguet
BACKGROUND: Gallbladder polyp (GBP) surveillance seeks to identify early neoplasms, but practice varies amongst surgical units. Recent European consensus guidelines have recommended an evidence-based GBP surveillance strategy. In a tertiary centre Hepato-Pancreato-Biliary unit we examine GBP surveillance, malignant yield, and assess cost-effectiveness of the new European consensus guidelines. METHODS: Respective data were collected from all patients with ultrasonography-detected GBPs between January 2008 and January 2013...
November 8, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Li Tian, Zhengdong Deng, Lei Xu, Tao Yang, Wei Yao, Lei Ji, Yun Lu, Jian Zhang, Yan Liu, Jianming Wang
Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis due to early invasion and metastasis. However, the molecular mechanisms through which GBC cells interact with the tumor microenvironment (TME) remain poorly understood. Here, we examined the role of the tumor suppressor apoptosis-stimulating of p53 protein 2 (ASPP2) in regulating GBC invasion and metastasis and macrophage recruitment. The clinicopathological significance of ASPP2 expression was measured by immunohistochemical analysis in 72 patients with GBC...
November 2, 2018: Cell Death & Disease
Cong-Ya Zhou, Yi-Ping Dong, Xiao Sun, Xin Sui, Hong Zhu, Ya-Qin Zhao, Yuan-Yuan Zhang, Clifford Mason, Qing Zhu, Su-Xia Han
Carbohydrate antigen 19-9 (CA19-9) fails to demonstrate the predictive value for early detection pancreatic ductal adenocarcinoma (PDAC). Glypican-1 (GPC1+) exosomes may serve as a noninvasive diagnostic tool to detect early stages of PDAC. Therefore, it is necessary to explore the serum GPC1 levels and determine whether serum GPC1 serves as a novel biomarker for PDAC patients. Blood samples were collected from 156 patients with PDAC, 199 non-cancer controls, and 240 patients with other cancers. Serological levels of GPC1 were examined by enzyme-linked immunosorbent assay (ELISA)...
November 2018: Cancer Medicine
Prajish Iyer, Shailesh V Shrikhande, Malika Ranjan, Asim Joshi, Nilesh Gardi, Ratnam Prasad, Bhasker Dharavath, Rahul Thorat, Sameer Salunkhe, Bikram Sahoo, Pratik Chandrani, Hitesh Kore, Bhabani Mohanty, Vikram Chaudhari, Anuradha Choughule, Dhananjay Kawle, Pradip Chaudhari, Arvind Ingle, Shripad Banavali, Poonam Gera, Mukta R Ramadwar, Kumar Prabhash, Savio George Barreto, Shilpee Dutt, Amit Dutt
The uncommonness of gallbladder cancer in the developed world has contributed to the generally poor understanding of the disease. Our integrated analysis of whole exome sequencing, copy number alterations, immunohistochemical, and phospho-proteome array profiling indicates ERBB2 alterations in 40% early-stage rare gallbladder tumors, among an ethnically distinct population not studied before, that occurs through overexpression in 24% (n=25) and recurrent mutations in 14% tumors (n=44); along with co-occurring KRAS mutation in 7% tumors (n=44)...
October 10, 2018: International Journal of Cancer. Journal International du Cancer
Xuan Wang, Guang-Yang Yu, Mo Chen, Ran Wei, Jinhong Chen, Zheng Wang
Extrahepatic bile duct cancer (EBDC) is a combined type of malignancy mainly consisting of extrahepatic cholangiocarcinoma and gallbladder cancer. Clinically, it is featured with latent symptoms and early metastasis, leading to a poor prognosis. Therefore, this cohort study aimed to depict the possible metastatic patterns of EBDC of diverse sub-types and evaluate the prognostic significance of diverse metastatic destinations with data from the clinical database. Relevant data of total 4061 confirmed EBDC patients diagnosed between 2010 and 2013 from the Surveillance, Epidemiology and End Results (SEER) database was obtained...
October 2018: Cancer Medicine
Mohammed Y Aldossary, Amal A Alayed, Samir Amr, Mohammed S Alqahtani
INTRODUCTION: Primary squamous cell carcinoma of the gallbladder is extremely rare, and accounts for about 3% of all malignant gallbladder neoplasms. PRESENTATION OF CASE: We report the case of a 58-year-old woman who presented with acute onset epigastric pain radiating to the back. The initial diagnosis, based on radiological images, was an incidental gallbladder mass with multiple gallstones. A staging laparoscopy was performed, followed by exploratory laparotomy with radical cholecystectomy...
2018: International Journal of Surgery Case Reports
Gennaro Clemente, Andrea Tringali, Agostino M De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante
Background: Mirizzi syndrome is a condition difficult to diagnose and treat, representing a particular "challenge" for the biliary surgeon. The disease can mimic cancer of the gallbladder, causing considerable diagnostic difficulties. Furthermore, it increases the risk of intraoperative biliary injury during cholecystectomy. The aim of this study is to point out some particular aspects of diagnosis and treatment of this condition. Methods: The clinical records of patients with Mirizzi syndrome, treated in the last five years, were reviewed...
2018: Canadian Journal of Gastroenterology & Hepatology
Ashish Gupta, Amit Gupta, Sweety Gupta, Udit Chauhan, Lokavarapu Manoj Joshua
Gallbladder cancer (GBC) is a rare gastrointestinal tumour. It occurs in women with pre-existing cholelithiasis. These tumours pose therapeutic as well as diagnostic challenges to treating clinicians. Early suspicion and optimal surgery for suspected GBC results in the best outcome. We describe two cases of metastatic GBC initially treated by simple cholecystectomy for gallstone despite disease pointers towards a malignant pathology. Subsequent presentation was with histopathologically proven metastatic GBC...
August 8, 2018: Tropical Doctor
Shraddha Patkar, Rajesh S Shinde, Sagar R Kurunkar, Devayani Niyogi, Nitin S Shetty, Mukta Ramadwar, Mahesh Goel
BACKGROUND: Incidental gallbladder cancer (iGBC) is on the rise world over. This may be a good scenario as we get to treat GBC in early stages. However, there is a practice of diagnosing patients based on clinicoradiological findings alone and subjecting them to a radical surgical procedure. This approach over-treats patient and has important implications for resource utilization. METHODS: We performed a retrospective analysis of 284 consecutive patients undergoing upfront surgery for suspected GBC from January 2010 to December 2016...
October 2017: Indian Journal of Cancer
Carl Kilander, Jesper Lagergren, Rickard Ljung, Omid Sadr-Azodi
BACKGROUND: The incidence trends of biliary tract cancer need to be established. This study investigated the incidence and mortality of biliary tract cancer in Sweden in 1970-2010. METHODS: Sex-specific biliary tract cancer incidence and mortality rates were evaluated using data from the Swedish Cancer Register, Patient Register and Causes of Death Register. Case registration was separate for each register. Gallbladder cancer and cancers of the extra-hepatic bile ducts were analyzed separately...
October 2018: Cancer Epidemiology
Masakuni Fujii, Hiroaki Saito, Junji Shiode
There are no neuroectodermal cells in the gallbladder mucosa. Therefore, gallbladder neuroendocrine carcinoma (NEC) is extremely rare and has a poor prognosis. We report a case of a Japanese man in his 60s with this disease. The patient visited a family doctor for epigastralgia. Blood tests showed no abnormalities, including tumor markers, such as CEA and CA19-9. Abdominal ultrasonography (US) showed a low-echoic mass, 39 × 30 mm, with clear boundaries to the liver from the fundus of the gallbladder. Contrast-enhanced computed tomography showed that the tumor was enhanced early and washed out...
July 12, 2018: Clinical Journal of Gastroenterology
Xiwei Cui, Sha Zhu, Zhihang Tao, Xinghao Deng, Yexiao Wang, Yuanjing Gao, Yue Liao, Weijun Ma, Yiwen Zhang, Xuelei Ma
Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients with gallbladder cancer patients.We performed a retrospective study of 159 patients received different therapies in West China Hospital from 2009 to 2014. The preoperative biomarker data, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lactate dehydrogenase, and alkaline phosphatase, as well as other clinical information, were obtained from electronic record...
July 2018: Medicine (Baltimore)
Jacklyn M Nemunaitis, Ursa Brown-Glabeman, Heloisa Soares, Jessica Belmonte, Ben Liem, Itzhak Nir, Victor Phuoc, Rama R Gullapalli
Gallbladder cancer is a rare malignancy of the biliary tract with a poor prognosis, frequently presenting at an advanced stage. While rare in the United States overall, gallbladder cancer has an elevated incidence in geographically distinct locations of the globe including Chile, North India, Korea, Japan and the state of New Mexico in the United States. People with Native American ancestry have a much elevated incidence of gallbladder cancer compared to Hispanic and non-Hispanic white populations of New Mexico...
June 18, 2018: BMC Cancer
Nastassja Köhn, Johannes Maubach, Rene Warschkow, Catherine Tsai, Daniel P Nussbaum, Daniel Candinas, Beat Gloor, Bruno M Schmied, Dan G Blazer, Mathias Worni
BACKGROUND: Current consensus guidelines suggest that gallbladder cancer (GBC) patients with resected T1a disease can be observed while patients with T1b or greater lesions should undergo lymphadenectomy (LNE). The primary aim of this study was to critically explore the impact of LNE in early-stage GBC on overall survival (OS) on a population-based level. METHOD: The 2004-2014 National Cancer Database was reviewed to identify non-metastatic GBC patients with T1a, T1b, or T2 disease and grouped whether a dedicated LNE was performed...
November 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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