keyword
https://read.qxmd.com/read/38534210/construction-of-a-human-immune-library-from-gallbladder-cancer-patients-for-the-single-chain-fragment-variable-scfv-antibody-selection-against-claudin-18-2-via-phage-display
#1
JOURNAL ARTICLE
Brian Effer, Daniel Ulloa, Camila Dappolonnio, Francisca Muñoz, Isabel Iturrieta-González, Loraine Cotes, Claudio Rojas, Pamela Leal
Gallbladder cancer (GBC) is a very aggressive malignant neoplasm of the biliary tract with a poor prognosis. There are no specific therapies for the treatment of GBC or early diagnosis tools; for this reason, the development of strategies and technologies that facilitate or allow an early diagnosis of GBC continues to be decisive. Phage display is a robust technique used for the production of monoclonal antibodies (mAbs) involving (1) the generation of gene libraries, (2) the screening and selection of isoforms related to an immobilized antigen, and (3) the in vitro maturation of the affinity of the antibody for the antigen...
March 12, 2024: Antibodies
https://read.qxmd.com/read/38528196/nonocclusive-mesenteric-ischemia-nomi-on-roux-limb-after-biliary-reconstruction-successfully-treated-by-interventional-radiology-ivr
#2
JOURNAL ARTICLE
Makoto Kawamoto, Yoshihiro Miyasaka, Nobuhiko Koreeda, Yousuke Hirano, Ryotaro Yamamoto, Masato Watanabe
Nonocclusive mesenteric ischemia (NOMI) is a life-threatening disorder. Early diagnosis is challenging because NOMI lacks specific symptoms. A 52-year-old man who received extended cholecystectomy with Roux-en-Y hepaticojejunostomy for gallbladder cancer (GBC) presented to our hospital with nausea and vomiting. Neither tender nor peritoneal irritation sign was present on abdominal examination. Blood test exhibited marked leukocytosis (WBC:19,800/mm3). A contrast-enhanced abdominal computed tomography (CT) scan revealed remarkable wall thickening and lower contrast enhancement effect localized to Roux limb...
March 25, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38514507/early-detection-of-occupational-cholangiocarcinoma-in-a-high-risk-patient-under-intensive-surveillance-a-case-study
#3
JOURNAL ARTICLE
Naoko Kounami, Sakae Maeda, Akihiro Kitagawa, Hideo Tomihara, Yuki Ushimaru, Nobuyoshi Ohara, Tomohira Takeoka, Mitsunobu Imasato, Ryohei Kawabata, Shingo Noura, Yumiko Yasuhara, Atsushi Miyamoto
BACKGROUND: Occupational cholangiocarcinoma is associated with exposure to organic solvents, such as dichloromethane (DCM) and 1,2-dichloropropane (DCP). This report describes a case of occupational cholangiocarcinoma detected through regularly imaging following the discovery of elevated serum γ-glutamyl trans peptidase (γ-GTP) levels revealed during regular checkup. CASE PRESENTATION: A 43-year-old man who had been working in a printing company with 15 years of exposure to organic solvents presented to our hospital owing to abnormalities found during a routine checkup...
March 22, 2024: Surgical Case Reports
https://read.qxmd.com/read/38493667/biliary-tract-cancers-french-national-clinical-practice-guidelines-for-diagnosis-treatments-and-follow-up-tncd-snfge-ffcd-unicancer-gercor-sfcd-sfed-afef-sfro-sfp-sfr-acabi-achbpt
#4
REVIEW
Gael S Roth, Loic Verlingue, Matthieu Sarabi, Jean-Frédéric Blanc, Emmanuel Boleslawski, Karim Boudjema, Anne-Laure Bretagne-Bignon, Marine Camus-Duboc, Romain Coriat, Gilles Créhange, Thierry De Baere, Christelle de la Fouchardière, Clarisse Dromain, Julien Edeline, Maximiliano Gelli, Boris Guiu, Samy Horn, Valérie Laurent-Croise, Côme Lepage, Astrid Lièvre, Anthony Lopez, Sylvain Manfredi, Julie Meilleroux, Cindy Neuzillet, Valérie Paradis, Frédéric Prat, Maxime Ronot, Olivier Rosmorduc, Antonio Sa Cunha, Olivier Soubrane, Anthony Turpin, Christophe Louvet, Olivier Bouché, David Malka
INTRODUCTION: This document is a summary of the French intergroup guidelines of the management of biliary tract cancers (BTC) (intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder carcinomas) published in September 2023, available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org). METHODS: This collaborative work was conducted under the auspices of French medical and surgical societies involved in the management of BTC...
March 13, 2024: European Journal of Cancer
https://read.qxmd.com/read/38472947/the-many-hidden-faces-of-gallbladder-carcinoma-on-ct-and-mri-imaging-from-a-to-z
#5
JOURNAL ARTICLE
Damaris Neculoiu, Lavinia Claudia Neculoiu, Ramona Mihaela Popa, Rosana Mihaela Manea
Gallbladder carcinoma represents the most aggressive biliary tract cancer and the sixth most common gastrointestinal malignancy. The diagnosis is a challenging clinical task due to its clinical presentation, which is often non-specific, mimicking a heterogeneous group of diseases, as well as benign processes such as complicated cholecystitis, xanthogranulomatous cholecystitis, adenomyomatosis, porcelain gallbladder or metastasis to the gallbladder (most frequently derived from melanoma, renal cell carcinoma)...
February 22, 2024: Diagnostics
https://read.qxmd.com/read/38432668/-progress-and-controversy-in-minimally-invasive-approach-to-radical-cholecystectomy-for-gallbladder-cancer
#6
JOURNAL ARTICLE
Z Zhou, Y Yang, Z Y Yang, W Gong
Surgical treatment is one of the most important forms of treatment in patients with gallbladder cancer. With the development of minimally invasive technology, the feasibility, safety and efficacy of minimally invasive approaches such as laparoscopic or robotic-assisted radical cholecystectomy for gallbladder cancer have received continuous attention.For patients with an early T-stage (Tis or T1a), laparoscopic simple cholecystectomy is safe and economical, with a good prognosis for postoperative patients, and it has been widely accepted and performed...
March 1, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/38432667/-can-laparoscopic-surgery-be-the-preferred-strategy-for-gallbladder-cancer
#7
JOURNAL ARTICLE
Y Liu, X Ruan, X Wang, W L Yu, Y J Zhang
Gallbladder cancer, notoriously known for its high malignancy, predominantly requires radical surgery as the treatment of choice. Although laparoscopic techniques have become increasingly prevalent in abdominal surgeries in recent years, the progress of laparoscopic techniques in gallbladder cancer is relatively slow. Due to the anatomical complexity, technical difficulty, and biological features of gallbladder cancer that is prone to metastasis and dissemination, traditional open surgery is still the main surgical approach...
March 1, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/38428766/decoding-the-role-of-long-non-coding-rnas-in-gallbladder-cancer-pathogenesis-a-review-focus-on-signaling-pathways-interplay
#8
REVIEW
Ahmed S Doghish, Abdullah F Radwan, Mohamed Bakr Zaki, Nourhan Elfar, Rewan Moussa, Zahraa Walash, Nora A A Alhamshry, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Hanan Elimam
Gallbladder cancer (GBC) is one of the most aggressive types of biliary tree cancers and the commonest despite its rarity. It is infrequently diagnosed at an early stage, further contributing to its poor prognosis and low survival rate. The lethal nature of the disease has underlined a crucial need to discern the underlying mechanisms of GBC carcinogenesis which are still largely unknown. However, with the continual evolution in the research of cancer biology and molecular genetics, studies have found that non-coding RNAs (ncRNAs) play an active role in the molecular pathophysiology of GBC development...
February 28, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38427281/applications-of-artificial-intelligence-in-biliary-tract-cancers
#9
REVIEW
Pankaj Gupta, Soumen Basu, Chetan Arora
Biliary tract cancers are malignant neoplasms arising from bile duct epithelial cells. They include cholangiocarcinomas and gallbladder cancer. Gallbladder cancer has a marked geographical preference and is one of the most common cancers in women in northern India. Biliary tract cancers are usually diagnosed at an advanced, unresectable stage. Hence, the prognosis is extremely dismal. The five-year survival rate in advanced gallbladder cancer is < 5%. Hence, early detection and radical surgery are critical to improving biliary tract cancer prognoses...
March 1, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38389867/outcomes-of-self-expandable-metal-stents-in-patients-with-unresectable-gallbladder-cancer-undergoing-percutaneous-biliary-drainage
#10
JOURNAL ARTICLE
Pavithra Subramanian, Mukul Morya, Pankaj Gupta, Ruby Siddiqui, Anupam Singh, Vaneet Jearth, Jimil Shah, Santosh Irrinki, Jayanta Samanta, Harshal Mandavdhare, Vishal Sharma, Harjeet Singh, Saroj K Sinha, Thakur D Yadav, Vikas Gupta, Lileswar Kaman, Gaurav Prakash, Usha Dutta
BACKGROUND: Biliary obstruction in gallbladder cancer (GBC) is associated with worse prognosis and needs drainage. In patients with biliary confluence involvement, percutaneous biliary drainage (PBD) is preferred over endoscopic drainage. However, PBD catheters are associated with higher complications compared to endoscopic drainage. PBD with self-expandable metal stents (SEMS) is desirable for palliation. However, the data in patients with unresectable GBC is lacking. MATERIALS AND METHODS: This retrospective study comprised consecutive patients with proven GBC who underwent PBD-SEMS insertion between January 2021 and December 2022...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38380191/phase-ii-trial-of-folfirinox-in-advanced-biliary-tract-cancer
#11
JOURNAL ARTICLE
Shouki Bazarbashi, Mohamed Aseafan, Mahmoud Elshenawy, Ahmed Alzahrani, Ali H Aljubran, Fahad Almugbel, Noura Alzannan, Tusneem Elhassan
INTRODUCTION: Biliary tract cancers (BTCs), characterized by poor prognosis and limited treatment options, are increasingly prevalent malignancies with a five-year survival rate of less than 20% for advanced-stage disease. The standard first-line chemotherapy combining gemcitabine and cisplatin offers modest survival benefits, necessitating the exploration of more effective therapies. This study reports the results of a single-arm, open-label, phase 2 trial assessing the efficacy and safety of fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) as a first-line treatment for metastatic or locally advanced unresectable BTC...
January 2024: Curēus
https://read.qxmd.com/read/38348696/neuroendocrine-neoplasms-of-the-gallbladder-a-single-institute-analysis-of-outcomes-and-prognostic-factors
#12
JOURNAL ARTICLE
Kunal Nandy, Shraddha Patkar, Subhash Yadav, Vikas Ostwal, Anant Ramaswamy, Prabhat Bhargav, Mahesh Goel
INTRODUCTION: Neuroendocrine neoplasms (NENs) are classified as neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and mixed neuroendocrine and nonneuroendocrine neoplasms (MiNENs) according to World Health Organization classification. We present our experience of NENs of the gallbladder (GB) from a high-volume cancer hospital. MATERIALS AND METHODS: The present study is a retrospective analysis of all patients with GB NENs who presented between January 2015 and June 2023...
February 13, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38340624/synchronous-tumors-of-gastric-carcinoma-combined-gallbladder-cancer-and-pseudotumor-chronic-pancreatitis
#13
Minh Thao Nguyen, Cong Thuan Dang, Thi Huyen Thuong Nguyen, Quy Tran Ngo, Anh Vu Pham
INTRODUCTION AND IMPORTANCE: Synchronous primary cancers in the stomach and gallbladder were not previously reported in the medical literature. Pseudotumor pancreatitis was also described many years ago. It was misdiagnosed and required surgery for pancreatic head neoplasms. PRESENTATION OF CASE: A 57-year-old male patient went to our hospital for abdominal pain. He was indicated for gastroduodenal endoscopy, and the result was adenocarcinoma. Abdominal ultrasound and Ctscan detected the gallbladder fundus's localized thickening structure and the pancreatic head's hyperechoic structure...
February 8, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38310406/primary-biliary-tract-cancers-in-golestan-iran-13-year-experience-of-golestan-population-based-cancer-registry
#14
JOURNAL ARTICLE
Ali Ashkbari, Fazel Isapanah Amlashi, Sima Besharat, Mostafa Mofidi, Taghi Amiriani, Abdolreza Fazel, Mehdi Alimadadi, Faezeh Salamat, Seyyed Mehdi Sedaghat, Somayeh Livani, Ali Bagheri, Shahriyar Semnani, Alireza Norouzi, Gholamreza Roshandel
BACKGROUND: Epidemiological research on the high-risk population might be helpful in early detection and prevention of biliary tract malignancies. This study assesses the prevalence of biliary tract cancer (BTC) in the Golestan province, northeastern Iran, between 2004 and 2016. METHODS: The current study used information from the Golestan Population-based Cancer Registry (GPCR) to access the epidemiology of BTC across a 13-year period while taking into account temporal and geographic differences...
September 1, 2023: Archives of Iranian Medicine
https://read.qxmd.com/read/38280752/dysplasia-and-early-carcinoma-of-the-gallbladder-and-bile-ducts-terminology-classification-and-significance
#15
REVIEW
N Volkan Adsay, Olca Basturk
Most precursor lesions and early cancerous changes in the gallbladder and bile ducts present as clinically/grossly inapparent lesions. Low-grade dysplasia is difficult to define and clinically inconsequential by itself; however, extra sampling is required to exclude accompanying significant lesions. For high-grade dysplasia ('carcinoma in situ'), a complete sampling is necessary to rule out invasion. Tumoral intramucosal neoplasms (ie, intracholecystic and intraductal neoplasia) form radiologically/grossly visible masses, and they account for (present in the background of) about 5% to 10% of invasive cancers of the region...
March 2024: Gastroenterology Clinics of North America
https://read.qxmd.com/read/38261906/the-global-burden-of-early-onset-biliary-tract-cancer-insight-from-the-global-burden-of-disease-study-2019
#16
JOURNAL ARTICLE
Pojsakorn Danpanichkul, Cheng H Ng, Darren J H Tan, Mark D Muthiah, Siwanart Kongarin, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Daniel Q Huang, Hiroyuki Suzuki, Denise M Harnois, Ju D Yang, Mazen Noureddin, Karn Wijarnpreecha
BACKGROUNDS/OBJECTIVES: The escalating incidence of early-onset gastrointestinal cancers is becoming a primary global health concern. Biliary tract cancer (BTC) has been relatively understudied in this regard. We conducted an epidemiological study regarding the burden of this condition. METHODS: We utilized data from the Global Burden of Disease Study 2019 to investigate the temporal trends in early-onset BTC (EOBTC), encompassing the estimation of frequencies and age-standardized rates (ASRs) of EOBTC incidence, mortality, and disability-adjusted life-years (DALYs), from 2010 to 2019...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38251805/clinical-implication-of-the-geometric-location-fundal-end-versus-cystic-ductal-end-of-gallbladder-cancer
#17
JOURNAL ARTICLE
Daegwang Yoo, Seong-Ryong Kim, Eunsung Jun, Yejong Park, Bong Jun Kwak, Woohyung Lee, Jae Hoon Lee, Dae Wook Hwang, Song Cheol Kim, Ki Byung Song
BACKGROUND: Management of early-stage gallbladder cancer is becoming more important as the rate of early detection is increasing. Although there have been many studies about the clinical implication of the invasion depth or peritoneal/hepatic location of gallbladder cancers, there is no study on the clinical implication of the geometric location of cancer along the longitudinal length of the gallbladder. METHODS: The location of gallbladder cancer was defined as the geometric center of the primary site of a tumour, which lies on the longitudinal diameter of the surgical specimens...
January 22, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38214149/brightline-2-a-phase-iia-iib-trial-of-brigimadlin-bi-907828-in-advanced-biliary-tract-cancer-pancreatic-ductal-adenocarcinoma-or-other-solid-tumors
#18
REVIEW
Changhoon Yoo, Angela Lamarca, Hye Jin Choi, Arndt Vogel, Michael J Pishvaian, Lipika Goyal, Makoto Ueno, Angela Märten, Michael Teufel, Lijiang Geng, Chigusa Morizane
Mouse double minute 2 homolog (MDM2) is a key negative regulator of the tumor suppressor p53. Blocking the MDM2-p53 interaction, and restoring p53 function, is therefore a potential therapeutic strategy in MDM2 -amplified, TP53 wild-type tumors. MDM2 is amplified in several tumor types, including biliary tract cancer (BTC), pancreatic ductal adenocarcinoma (PDAC), lung adenocarcinoma and bladder cancer, all of which have limited treatment options and poor patient outcomes. Brigimadlin (BI 907828) is a highly potent MDM2-p53 antagonist that has shown promising activity in preclinical and early-phase clinical studies...
January 12, 2024: Future Oncology
https://read.qxmd.com/read/38137427/an-integrative-pancreatic-cancer-risk-prediction-model-in-the-uk-biobank
#19
JOURNAL ARTICLE
Te-Min Ke, Artitaya Lophatananon, Kenneth R Muir
Pancreatic cancer (PaCa) is a lethal cancer with an increasing incidence, highlighting the need for early prevention strategies. There is a lack of a comprehensive PaCa predictive model derived from large prospective cohorts. Therefore, we have developed an integrated PaCa risk prediction model for PaCa using data from the UK Biobank, incorporating lifestyle-related, genetic-related, and medical history-related variables for application in healthcare settings. We used a machine learning-based random forest approach and a traditional multivariable logistic regression method to develop a PaCa predictive model for different purposes...
December 1, 2023: Biomedicines
https://read.qxmd.com/read/38135812/clinical-significance-of-frequently-down-regulated-phosphatidylethanolamine-binding-protein-1-in-gallbladder-cancer
#20
JOURNAL ARTICLE
Amisha Bharti, Mumtaz Ahmad Ansari, Mallika Tewari, Gopeshwar Narayan, Sunita Singh
BACKGROUND: Promoter hypermethylation of tumor suppressor genes has been demonstrated to be one of the major mechanisms of their epigenetic regulation in various reports. We have studied the promoter methylation status of PEBP1 and evaluated its correlation with gallbladder carcinogenesis. AIMS: PEBP1, an endogenous inhibitor of Raf/MEK/ERK signaling pathway, is a tumor suppressor gene. We aimed to study the expression profile of PEBP1 and understand the mechanism and significance of its deregulation in gallbladder cancer...
December 22, 2023: Digestive Diseases and Sciences
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