Dorota Wieczorek, Ewa Kaczorowska, Marta Wiśniewska, Izabela D Madura, Magdalena Leśniak, Jacek Lipok, Agnieszka Adamczyk-Woźniak
Benzoxaboroles emerged recently as molecules of high medicinal potential with Kerydin® (Tavaborole) and Eucrisa® (Crisaborole) currently in clinical practice as antifungal and anti-inflammatory drugs, respectively. Over a dozen of 3-amino benzoxaboroles, including Tavaborole's derivatives, have been synthetized and characterized in terms of their activity against Candida albicans as a model pathogenic fungus. The studied compounds broaden considerably the structural diversity of reported benzoxaboroles, enabling determination of the influence of the introduction of a heterocyclic amine, a fluorine substituent as well as the formyl group on antifungal activity of those compounds...
December 18, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry