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breast cytology

Diana Montezuma, Daniela Malheiros, Fernando C Schmitt
OBJECTIVE: Recently the International Academy of Cytology (IAC) proposed a new reporting system for breast fine needle aspiration biopsy (FNAB) cytology. We aimed to categorize our samples according to this classification and to assess the risk of malignancy (ROM) for each category as well as the diagnostic yield of breast FNAB. STUDY DESIGN: Breast FNAB specimens obtained between January 2007 and December 2017 were reclassified according to the newly proposed IAC Yokohama reporting system...
February 15, 2019: Acta Cytologica
Geehyuk Kim, Jemberu Taye, Kwangmin Yu, Sunyoung Park, Jungho Kim, Sunghyun Kim, Dongsup Lee, Hye-Young Wang, Kwang Hwa Park, Hyeyoung Lee
After breast and colon cancer, cervical cancer is the third most common cancer of women worldwide. Since human papillomavirus (HPV) infection is known to be the predominant cause of cervical cancer, molecular HPV screening is currently used along with cytological and histological examination methods for precancer diagnosis. Nevertheless, the sensitivity of the current HPV test is less than 80%; thus, many cervical cancer cases are not able to be diagnosed by HPV screening alone, and likewise, patients with cervical cancer are often determined to be HPV-negative by the current screening methods...
2019: Analytical Cellular Pathology (Amsterdam)
Charu Agarwal, Varsha Chauhan, Mukta Pujani, Kanika Singh, Sujata Raychaudhari, Mitasha Singh
OBJECTIVE: As fine needle aspiration cytology (FNAC) is the primary tool for evaluation of breast lesions, it is essential to segregate lesions with low and high risk of malignancy. To address this, Masood proposed a cytological scoring system for categorization, Masood's Scoring Index (MSI), which was modified later (Modified Masood's Scoring Index [MMSI]). This study analyses the effectiveness of MMSI over MSI and assesses the concordance between cytological scoring and histopathology...
February 13, 2019: Acta Cytologica
Haruhiko Yoshioka, Hiroki Ueno, Souta Oikawa, Masanori Tanaka, Yoshie Hasegawa, Kayo Horie, Jun Watanabe
Aim: The objective of this study was to apply a scoring method to fine needle aspiration cytology on breast duct dilatation and cystic lesions, to set an optimum cut-off value to differentiate between benign and malignant cases, and to identify features useful for cell judgment. Materials and Methods: Samples were 23 preparations of specimens (12 benign and 11 malignant cases) suspected with intraductal lesions or cystic change by ultrasonography or mammography and cytology...
January 2019: Journal of Cytology
Shirin Kord, Maral Mokhtari, Sedigheh Tahmasebi
Background: Among all diagnostic techniques for breast lesions, fine-needle aspiration (FNA) is the simplest, most reliable and cheapest one. Aim: To compare liquid-based and conventional cytology in diagnosis of breast mass. Materials and Methods: About 101 patients with breast mass were enrolled. The aspirated materials were divided into two parts. One was poured into a liquid medium and the other part was directly spread on clean glass slides...
January 2019: Journal of Cytology
Ziba Gandomkar, Patrick C Brennan, Claudia Mello-Thoms
Inter-pathologist agreement for nuclear atypia scoring of breast cancer is poor. To address this problem, previous studies suggested some criteria for describing the variations appearance of tumor cells relative to normal cells. However, these criteria were still assessed subjectively by pathologists. Previous studies used quantitative computer-extracted features for scoring. However, application of these tools is limited as further improvement in their accuracy is required. This study proposes COMPASS (COMputer-assisted analysis combined with Pathologist's ASSessment) for reproducible nuclear atypia scoring...
February 4, 2019: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Anila Kunjulekshmyamma Raveendrannair, Anitha Mathews, Bipin T Varghese, K Jayasree
A 36-year-old female presented with lump in the left breast of 2 months duration. Fine-needle aspiration cytology (FNAC) and trucut biopsy confirmed the diagnosis of carcinoma. Clinically, it was T3N1Mx disease. Computed tomography (CT) of the chest detected bilateral lung metastasis. CT head and neck detected a nodule in the thyroid which on FNAC was suspicious of papillary carcinoma. The patient was started on chemotherapy for breast disease with a good initial response; however, while on-follow up, there was progression of disease at primary site...
January 2019: Indian Journal of Pathology & Microbiology
Tanzila Saba, Sana Ullah Khan, Naveed Islam, Naveed Abbas, Amjad Rehman, Nadeem Javaid, Adeel Anjum
The advancement of computer- and internet-based technologies has transformed the nature of services in healthcare by using mobile devices in conjunction with cloud computing. The classical phenomenon of patient-doctor diagnostics is extended to a more robust advanced concept of E-health, where remote online/offline treatment and diagnostics can be performed. In this article, we propose a framework which incorporates a cloud-based decision support system for the detection and classification of malignant cells in breast cancer, while using breast cytology images...
January 29, 2019: Microscopy Research and Technique
Nitesh Mohan, Ranjan Agrawal, Parbodh Kumar
Filariasis is a major health problem of the tropical and subtropical regions, but filariae are also found in temperate climates. The disease is endemic all over India and microfilariae have been observed as coincidental findings with inflammatory conditions and neoplastic lesions. We report a rare case of a 40-year-old female from a nonendemic area presenting with lump in the left breast. The skin overlying the mass was fungating and ulcerated. Ipsilateral axillary lymph nodes were palpable. Fine-needle aspiration cytology revealed highly cellular smears having ductal epithelial cells arranged in groups, tight clusters, and scattered singly...
July 2018: Tropical Parasitology
Tomonori Tanei, Ambara R Pradipta, Koji Morimoto, Motoko Fujii, Mayumi Arata, Akihiro Ito, Minoru Yoshida, Elena Saigitbatalova, Almira Kurbangalieva, Jun-Ichiro Ikeda, Eiichi Morii, Shinzaburo Noguchi, Katsunori Tanaka
Clean operating margins in breast cancer surgery are important for preventing recurrence. However, the current methods for determining margins such as intraoperative frozen section analysis or imprint cytology are not satisfactory since they are time-consuming and cause a burden on the patient and on hospitals with a limited accuracy. A "click-to-sense" probe is developed based on the detection of acrolein, which is a substance released by oxidatively stressed cancer cells and can be visualized under fluorescence microscopy...
January 23, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Soulideth Vilayvong, Kiyomi Hando, Masaki Sekine, Thitsamay Luangxay, Phetsamone Arounlangsy, Pheangvilay Xaysomphet, Phetlammone Xayaphet, Hatthakone Thavisouk, Yurie Soejima, Masanobu Kitagawa, Motoji Sawabe
Background: Pathology and laboratory medicine (PALM) services are limited in low-resource countries, such as Lao PDR. Patients with malignant pleural effusion (MPE) are not properly diagnosed and treated in these situations. The purpose of this study is to confirm the usefulness of immunocytochemistry in MPE to identify the histological type and probable primary site of cancer of MPE and to discuss its usefulness in low-resource countries, such as Laos. Methods: We retrospectively reviewed glass slides of pleural effusion sent to the Department of Pathology at the University of Health Sciences from the central hospitals for cytological screening from January 2012 to December 2016...
January 25, 2019: Asian Pacific Journal of Cancer Prevention: APJCP
Charu Agarwal, Kanika Singh, Mukta Pujani, Sujata Raychaudhuri, Nimisha Sharma, Varsha Chauhan
OBJECTIVE: Granulomatous mastitis is a rare inflammatory condition of the breast clinically mimicking breast carcinoma and pyogenic abscess, thereby creating a diagnostic dilemma. Tuberculous mastitis is a rare clinical entity accounting for approximately 3% of all mammary lesions. All cases of granulomatous mastitis diagnosed cytologically over a period of 3 years were evaluated to ascertain the cases with tuberculous etiology. MATERIAL AND METHOD: Fine needle aspiration cytology of the breast lump was performed and all the cytological parameters were evaluated...
January 11, 2019: Türk Patoloji Dergisi
Luis Angel Pérula de Torres, Jose Ignacio Moscosio Cuevas, Cruz Bartolomé Moreno, Pilar Martín-Carrillo, María Martín-Rabadán, Celia Jiménez García
OBJECTIVE: To decide if Primary Care (PC) professionals know the European Code against Cancer (CECC) and if this relates to practice the recommendations with themselves and with their patients. DESIGN: descriptive, observational study. SETTING: Spanish Health Centers. PARTICIPANTS: Health professionals. INTERVENTIONS: self-administered questionnaire. MAIN MEASUREMENTS: cancer protective and risk factors, screening for colorectal, breast, cervix and prostate cancer, level of knowledge of the ECAC...
January 7, 2019: Atencion Primaria
Ellis Barbé, Mintsje de Boer, Daphne de Jong
The role of cytopathology in malignant lymphoma is largely restricted to primary screening in patients with lymphadenopathy of unknown causes and evaluation of relapse and transformation during follow-up of patients with known and fully classified malignant lymphoma. Few lymphoma diagnoses fully rely on cytology, however, of which breast-implant associated anaplastic large cell lymphoma (BIA-ALCL) is currently in the center of clinical attention. Due to the major attention both in the medical and lay media for the recently substantiated high lymphoma risk in women with breast implants, cytopathology departments now frequently receive seroma fluid aspirates with this specific differential diagnostic consideration...
January 9, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
Chiyembekezo Kachimanga, Atupere Phiri, Fatsani Manase, Katie Cundale, George Talama, Steve Kamiza, Lawrence Nazimera, Arnold Jumbe, Noel Kalanga, Nedson Fosiko, Leo Masamba, Emily B Wroe
Introduction: Limited data exists on histologically confirmed cancers and tuberculosis in rural Malawi, despite the high burden of both conditions. One of the main reasons for the limited data is the lack of access to pathology services for diagnosis. We reviewed histopathology results of patients in Neno District, one of the poorest rural districts in Malawi, from May 2011 to July 2017, with an emphasis on cancers and tuberculosis. Methods: This is a retrospective descriptive study reviewing pathology results of samples collected at Neno health facilities and processed at Kamiza Pathology Laboratory...
September 2018: Malawi Medical Journal: the Journal of Medical Association of Malawi
Alexandra Kang, Alina Miranda, Bastiaan de Boer
Whilst cytological smears are still the basis of cytodiagnosis, there is an increasing role for ancillary testing. Specimens obtained are not always optimal, often with limited material for ancillary studies. Several reports have described the utility of scraping material from cytological smears to manufacture cell blocks to provide material for ancillary studies. Our objective was a retrospective review of the PathWest (QE2) experience with manufactured cell blocks (mCB) over the last 10 years. A total of 178 fine-needle aspiration cases with mCB were extracted from the PathWest database...
January 4, 2019: Acta Cytologica
Hee Jun Choi, Jae-Myung Kim, Jai Min Ryu, Isaac Kim, Seok Jin Nam, Jonghan Yu, Se Kyung Lee, Jeong Eon Lee, Seok Won Kim
Purpose: The recent trend in breast cancer treatment is to minimize axillary dissection. However, no pattern of axillary metastasis has been precisely established. The purpose of this study was to evaluate the metastatic lymphatic pattern using near-infrared fluorescence imaging with indocyanine green (ICG) in breast cancer with cytologically proven axillary metastasis. Methods: This was a prospective single-center study. We evaluated 147 patients with breast cancer involving cytologically proven axillary metastasis, and compared physiological and nonphysiological lymphatic metastasis...
December 2018: Journal of Breast Cancer
Hee Jun Choi, Isaac Kim, Emad Alsharif, Sungmin Park, Jae-Myung Kim, Jai Min Ryu, Seok Jin Nam, Seok Won Kim, Jonghan Yu, Se Kyung Lee, Jeong Eon Lee
Purpose: This study aimed to evaluate the effects of sentinel lymph node biopsy (SLNB) on recurrence and survival after neoadjuvant chemotherapy (NAC) in breast cancer patients with cytology-proven axillary node metastasis. Methods: We selected patients who were diagnosed with invasive breast cancer and axillary lymph node metastasis and were treated with NAC followed by curative surgery between January 2007 and December 2014. We classified patients into three groups: group A, negative sentinel lymph node (SLN) status and no further dissection; group B, negative SLN status with backup axillary lymph node dissection (ALND); and group C, no residual axillary metastasis on pathology with standard ALND...
December 2018: Journal of Breast Cancer
Sumana Pillay, Shalen Cheddie, Yoshan Moodley
Background: The triple assessment of clinical breast exam (CBE), fine needle aspirate cytology (FNAC) and breast ultrasonography (US) is used in many settings for the diagnosis of fibroadenoma (FA). The diagnostic accuracy of FNAC and US for FA in South African (SA) women with palpable breast masses (PBM) is unknown. Objective: To report the diagnostic accuracy of FNAC/US for FA in SA women with PBM. Methods: We conducted a retrospective pilot diagnostic study of 91 women who presented with PBM to a SA regional academic hospital...
June 2018: African Health Sciences
Young Ah Kim, Jae Won Joung, Sun-Jae Lee, Hoon-Kyu Oh, Chang Ho Cho, Woo Jung Sung
Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-year-old male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions...
December 28, 2018: Journal of Pathology and Translational Medicine
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