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Membraneous Glomerulonephritis

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https://read.qxmd.com/read/30762802/dual-anti-neutrophil-cytoplasmic-antibody-and-anti-glomerular-basement-membrane-antibody-positive-crescent-glomerulonephritis-in-a-patient-with-monoclonal-gammopathy-of-undetermined-significance-a-case-report
#1
Xiaoli Li, Yunfei Hao, Rong Xue, Xueting Qi, Zhigang Ma
RATIONALE: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion. PATIENT CONCERNS: Here, we describe a patient with half-year fatigue and 40-day nausea and vomiting...
February 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30734164/podocyte-penetration-of-the-glomerular-basement-membrane-to-contact-on-the-mesangial-cell-at-the-lesion-of-mesangial-interposition-in-lupus-nephritis-a-three-dimensional-analysis-by-serial-block-face-scanning-electron-microscopy
#2
Takashi Takaki, Nobuhiko Ohno, Sei Saitoh, Masaaki Nagai, Kensuke Joh
BACKGROUND: The interaction among the glomerular components plays an important role in the development of glomerular lesions; thus, investigation of the ultrastructural three-dimensional (3D) configuration of the human glomerular cells and extracellular matrix (ECM) is important for understanding the pathogenesis of glomerulosclerosis, especially glomerulonephritis. METHODS: We applied a new technique of serial block-face scanning electron microscopy (SBF-SEM), which helps to acquire serial electron microscopic images to reconstruct a 3D ultrastructure, to a human kidney biopsy specimen obtained from a 25-year-old woman with lupus nephritis...
February 8, 2019: Clinical and Experimental Nephrology
https://read.qxmd.com/read/30704432/a-case-of-aggressive-atypical-anti-gbm-disease-complicated-by-cmv-pneumonitis
#3
Barbora Sporinova, Susanna A McRae, Daniel A Muruve, Marvin J Fritzler, Samih H Nasr, Alex C Chin, Hallgrimur Benediktsson
BACKGROUND: Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30-60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-GBM antibodies...
January 31, 2019: BMC Nephrology
https://read.qxmd.com/read/30701916/atypical-goodpasture-s-disease-a-clinical-case-report-and-literature-review
#4
REVIEW
M L Bulanova, D V Potapov, N M Bulanov, L V Lysenko Kozlovskaya
Goodpasture's disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria...
June 20, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30701911/the-role-of-podocytes-dysfunction-in-chronic-glomerulonephritis-progression
#5
REVIEW
N V Chebotareva, I N Bobkova, L V Lysenko
In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine...
June 20, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30683055/development-of-anti-glomerular-basement-membrane-glomerulonephritis-during-the-course-of-iga-nephropathy-a-case-report
#6
Tadasu Kojima, Go Hirose, Shuuhei Komatsu, Taito Oshima, Kentaro Sugisaki, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada, Takashi Oda
BACKGROUND: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months. CASE PRESENTATION: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years...
January 25, 2019: BMC Nephrology
https://read.qxmd.com/read/30673815/infliximab-associated-focal-segmental-glomerulosclerosis-in-a-patient-with-ankylosing-spondylitis
#7
REVIEW
Handan Yarkan Tuğsal, Berrin Zengin, Gökçe Kenar, Gerçek Can, Mehtat Ünlü, Fatoş Önen, Merih Birlik
The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria...
January 23, 2019: Rheumatology International
https://read.qxmd.com/read/30663975/changes-in-primary-glomerulonephritis-in-singapore-over-four-decades
#8
Keng-Thye Woo, Choong-Meng Chan, Cynthia Lim, Jason Choo, Yoke Mooi Chin, Wei Ling Teng, Alwin H L Loh, Hui-Lin Choong, Han-Kim Tan, Kok-Seng Wong, Grace S L Lee, Evan J C Lee, Stephanie Fook-Chong, Puay Hoon Tan, Marjorie Foo
This review of 3,289 native kidney biopsies over the past four decades in Singapore documents the changing pattern of biopsy-proven glomerulonephritis (GN)from that of a third world country to that of a developed nation. In the 1st decade, mesangial proliferative GN was the most common form of primary GN, similar to the Asian region. In the 2nd decade, the percentage of mesangial proliferative GN decreased, but membranous GN became more common, as was seen in China and Thailand. In the 3rd decade, focal segmental glomerulosclerosis (FSGS) and membranous nephropathy continued to rise, but it was only recently, in the 4th decade, that FSGS prevalence increased dramatically, although membranous nephropathy continues to increase in some Asian countries...
January 21, 2019: Clinical Nephrology
https://read.qxmd.com/read/30648909/the-role-of-regulatory-t-cells-in-experimental-autoimmune-glomerulonephritis
#9
Stefanie Klinge, Karsten Yan, Daniel Reimers, Karen-Maria Brede, Joanna Schmid, Hans-Joachim Paust, Christian F Krebs, Ulf Panzer, Helmut Hopfer, Hans-Willi Mittrücker
Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen α3(IV)NC1 of the GBM. Consequences are the deposition of autoantibodies along the GBM and the development of crescentic glomerulonephritis (GN) with rapid loss of renal function. Foxp3+ regulatory T cells (Treg cells) are crucial for the maintenance of peripheral tolerance to self-antigens and the prevention of immunopathology. Here we use the mouse model of experimental autoimmune glomerulonephritis (EAG) to characterize the role of Treg cells in anti-GBM disease...
January 16, 2019: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/30647501/hepatitis-c-virus-associated-membranoproliferative-glomerulonephritis-treated-with-directly-acting-antiviral-therapy
#10
S Nayak, A Kataria, M K Sharma, A Rastogi, E Gupta, A Singh, S C Tiwari
Hepatitis C virus (HCV) infection has been shown to affect kidneys with various histopathological pattern on the kidney biopsy. These commonly include a membranoproliferative glomerulonephritis (MPGN) pattern with mixed cryoglobulinemia (CG), thrombotic microangiopathy, membranous nephropathy, and vasculitis affecting medium and small vessels of the kidneys causing polyarteritis nodosa. It has been rarely associated with MPGN without detectable CG. We present one such patient who presented to us with HCV-associated MPGN without detectable CG, who recovered completely with directly acting antiviral therapy without any immunosuppression...
November 2018: Indian Journal of Nephrology
https://read.qxmd.com/read/30621605/recurrence-of-goodpasture-syndrome-without-circulating-anti-glomerular-basement-membrane-antibodies-after-kidney-transplant-a-case-report
#11
V Thibaud, N Rioux-Leclercq, C Vigneau, S Morice
BACKGROUND: Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against the Glomerular Basement Membrane (GBM). Linear deposit of immunoglobulins G on the GBM detected by immunofluorescence analysis of renal biopsies is a GS pathognomonic finding. GS is commonly monophasic and its incidence is 1.6 case per million per year. CASE PRESENTATION: This report describes and discusses the case of a 40-year-old woman who one year after allograft kidney transplant, presented with acute pulmonary and renal symptoms of GS, leading to acute graft dysfunction, without circulating anti-GBM antibody detection in laboratory assays...
January 8, 2019: BMC Nephrology
https://read.qxmd.com/read/30612580/nephrotoxicity-of-immune-checkpoint-inhibitors-beyond-tubulointerstitial-nephritis-single-center-experience
#12
Omar Mamlouk, Umut Selamet, Shana Machado, Maen Abdelrahim, William F Glass, Amanda Tchakarov, Lillian Gaber, Amit Lahoti, Biruh Workeneh, Sheldon Chen, Jamie Lin, Noha Abdel-Wahab, Jean Tayar, Huifang Lu, Maria Suarez-Almazor, Nizar Tannir, Cassian Yee, Adi Diab, Ala Abudayyeh
RATIONALE & OBJECTIVE: The approved therapeutic indication for immune checkpoint inhibitors (CPIs) are rapidly expanding including treatment in the adjuvant setting, the immune related toxicities associated with CPI can limit the efficacy of these agents. The literature on the nephrotoxicity of CPI is limited. Here, we present cases of biopsy proven acute tubulointerstitial nephritis (ATIN) and glomerulonephritis (GN) induced by CPIs and discuss potential mechanisms of these adverse effects...
January 6, 2019: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/30592438/overexpression-of-toll-like-receptor-9-correlates-with-podocyte-injury-in-a-murine-model-of-autoimmune-membranoproliferative-glomerulonephritis
#13
Md Abdul Masum, Osamu Ichii, Yaser Hosny Ali Elewa, Teppei Nakamura, Yuki Otani, Marina Hosotani, Yasuhiro Kon
Toll-like receptors (Tlrs) are sensors of danger signals which promote the activation of immune cells and intrinsic renal cells. Podocytes, the intrinsic cells of glomerulus, are continuously exposed to various plasma solutes and danger signals due to their unique location in the glomerulus. Herein, we show that Tlr9 is overexpressed in podocytes and the mechanisms which cause its injury and development of membranoproliferative glomerulonephritis (MPGN) in model BXSB/MpJ-Yaa (Yaa) mice. Yaa mice developed typical lesions of MPGN and showed strong expression of Tlr9 mRNA throughout the glomerulus particularly toward the periphery of the glomerulus...
December 28, 2018: Autoimmunity
https://read.qxmd.com/read/30588955/spectrum-of-glomerular-diseases-in-arab-countries-a-systematic-review
#14
REVIEW
Nasar Yousuf Alwahaibi, Halima Khalfan Al Issaei, Buthaina Saif Al Dhahli
According to the best of our knowledge, there is no review compiling incidence of glomerular disease in all Arab countries. Most of the Arab countries do not have a national renal biopsy registry. In addition, there is scanty data available on the epidemiology of glomerular diseases in Arab countries. In this review, we performed a systematic review analyzing the incidence of glomerular disease in all Arab countries. Relevant manuscripts in all 22 Arab countries found through searches of Medline, Science Direct, Embase, and Google Scholar were evaluated...
November 2018: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/30509213/recurrent-glomerulonephritis-following-renal-transplantation-and-impact-on-graft-survival
#15
S H Jiang, A L Kennard, G D Walters
BACKGROUND: Recurrence of primary glomerulonephritis in the post-transplant period has been described in the literature but the risk remains poorly quantified and its impact on allograft outcomes and implications for subsequent transplants remain under-examined. Here we describe the rates and timing of post-transplant glomerulonephritis recurrence for IgA nephropathy, focal segmental glomerulosclerosis, mesangiocapillary GN and membranous GN based on 28 years of ANZDATA registry transplant data...
December 3, 2018: BMC Nephrology
https://read.qxmd.com/read/30509047/membranous-glomerulonephritis-a-common-unspecific-pattern-of-glomerular-injury
#16
Aleksandra Starzyńska-Kubicka, Agnieszka Perkowska-Ptasińska, Barbara Górnicka
Membranous nephropathy (MN) is a chronic form of glomerulonephritis, associated with the presence of immune complexes beneath the podocytes on the subepithelial region of glomerular capillaries. MN is not a disease entity but one of relatively common patterns of glomerular injury that may be a manifestation of primary renal autoimmunological reaction or may evolve as a phenomenon secondary to wide spectrum of systemic processes.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/30499730/igg4-related-kidney-disease-and-retroperitoneal-fibrosis-an-update
#17
Mitsuhiro Kawano, Takako Saeki, Hitoshi Nakashima
The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter...
November 30, 2018: Modern Rheumatology
https://read.qxmd.com/read/30484732/changes-in-the-diagnosis-of-glomerular-diseases-in-east-china-a-15-year-renal-biopsy-study
#18
Qin Zhou, Xin Yang, Meifang Wang, Huiping Wang, Jie Zhao, Yan Bi, Xiayue Wang, Jihong Yao, Ying Chen, Chuan Lin, Xishao Xie, Hong Jiang, Jianghua Chen
BACKGROUND: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years. METHODS AND RESULTS: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled...
November 2018: Renal Failure
https://read.qxmd.com/read/30458823/expression-of-dendrin-in-several-glomerular-diseases-and-correlation-to-pathological-parameters-and-renal-failure-preliminary-study
#19
Maja Mizdrak, Katarina Vukojević, Natalija Filipović, Vesna Čapkun, Benjamin Benzon, Merica Glavina Durdov
BACKGROUND: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up. METHODS: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study...
November 20, 2018: Diagnostic Pathology
https://read.qxmd.com/read/30455920/membranous-or-membranous-like-gn-a-case-report-of-massive-proteinuria-positive-serum-with-negative-pla2r-on-biopsy
#20
Gurwant Kaur, Guoli Chen
This case report represents primary membranous glomerulonephritis (MGN) with positive serum anti-PLA2R antibodies, 2+ positivity for IgG4 on immunofluorescence with routine fresh-frozen sections and negative PLA2R stain on biopsy. He was treated as primary MGN based on positive serum PLA2R and the absence of clinical symptoms or signs suggestive of any secondary MGN.
November 2018: Clinical Case Reports
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