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Stem cell hip arthritis

Mohsen Emadedin, Shahedeh Karimi, Aliasghar Karimi, Narges Labibzadeh, Maryam Niknejadi, Hossein Baharvand, Nasser Aghdami
BACKGROUND: Avascular necrosis (AVN) of femoral head is a progressive bone disease due to ischemia of femoral head; patients experience pain and they can not do normal activity. There is not an effective way to treat the cause of this disease. In recent studies, treatment of this disease using pluripotent stem cell-derived mesenchyme is safe and effective, but this method needs more investigation. In this study, the safety and efficacy of CD133+ cells were evaluated as a novel method of stem cell therapy to treat AVN...
November 5, 2018: Cytotherapy
Jim Kennedy, Jacques Noel, Anne O'Meara, Kevin Mulhall, Ellen Crushell, Esmond Fogarty, Paula Kelly
BACKGROUND: After successful hematopoietic stem cell transplantation, maintaining function and mobility have become key goals in the management of patients with Hurler syndrome, (mucopolysaccharoidosis type 1H). The aim of this study was to establish the functional and radiologic outcomes after hip surgery in patients with this condition who had reached skeletal maturity. METHODS: We prospectively followed 13 mucopolysaccharoidosis type 1H patients with closed triradiate cartilages who had undergone hip surgery in a single institution (Our Lady's Children's Hospital, Crumlin) in early childhood, after successful hematopoietic stem cell transplantation...
January 2016: Journal of Pediatric Orthopedics
Emilio Camafeita, José-Ramón Lamas, Enrique Calvo, Pilar Tornero-Esteban, Juan-Antonio López, Benjamín Fernández-Gutiérrez
Osteoarthritis (OA) is considered the most prevalent form of arthritis. The aim of this study was to verify potential protein OA biomarkers by applying Selected Reaction Monitoring (SRM) assays to protein extracts obtained from Bone Marrow-Mesenchymal Stem Cells (BM-MSCs) isolated from OA patients. BM aspirates were obtained from the femoral channel of OA patients at the time of surgery and from the femoral channel of hip fracture subjects without OA during hip joint replacement surgery for the treatment of subcapital fracture...
2014: Clinical Proteomics
R F P Schelbergen, W de Munter, M H J van den Bosch, F P J G Lafeber, A Sloetjes, T Vogl, J Roth, W B van den Berg, P M van der Kraan, A B Blom, P L E M van Lent
OBJECTIVE: Alarmins S100A8 and S100A9 are major products of activated macrophages regulating cartilage damage and synovial activation during murine and human osteoarthritis (OA). In the current study, we investigated whether S100A8 and S100A9 are involved in osteophyte formation during experimental OA and whether S100A8/A9 predicts osteophyte progression in early human OA. METHODS: OA was elicited in S100A9-/- mice in two experimental models that differ in degree of synovial activation...
January 2016: Annals of the Rheumatic Diseases
Hana Chang, Denitsa Docheva, Ulf R Knothe, Melissa L Knothe Tate
The overarching aim of this study is to assess the feasibility of using periosteal tissue from the femoral neck of arthritic hip joints, usually discarded in the normal course of hip replacement surgery, as an autologous source of stem cells. In addition, the study aims to characterize intrinsic differences between periosteum-derived cell (PDC) populations, isolated via either enzymatic digestion or a migration assay, including their proliferative capacity, surface marker expression, and multipotency, relative to commercially available human bone marrow-derived stromal cells (BMSCs) cultured under identical conditions...
March 2014: Stem Cells Translational Medicine
Philippe Hernigou, Steffen Quiennec, Isaac Guissou
In 1939, Frederick R. Thompson of New York and Austin T. Moore of South Carolina separately developed replacements for the entire ball of the hip. These were used to treat hip fractures and also certain arthritis cases. This type of hemiarthroplasty addressed the problem of the arthritic femoral head only. The diseased acetabulum (hip socket) was not replaced. This prosthesis consisted of a metal stem that was placed into the marrow cavity of the femur, connected in one piece with a metal ball fitted into the hip socket...
March 2014: International Orthopaedics
George J Feldman, Javad Parvizi, Mark Levenstien, Kathryn Scott, Jill A Erickson, Paolo Fortina, Marcella Devoto, Christopher L Peters
Developmental dysplasia of the hip (DDH) is a debilitating condition characterized by incomplete formation of the acetabulum leading to dislocation of the femur, suboptimal joint function, and accelerated wear of the articular cartilage resulting in arthritis. DDH affects 1 in 1000 newborns in the United States; there are well-defined "pockets" of high prevalence in Japan, and in Italy and other Mediterranean countries. Although reasonably accurate for detecting gross forms of hip dysplasia, existing techniques fail to find milder forms of dysplasia...
December 2013: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
W Drescher, T Pufe, R Smeets, R V Eisenhart-Rothe, M Jäger, M Tingart
Femoral head necrosis is an ischaemic bone necrosis of traumatic or nontraumatic pathogenesis which can lead to hip joint destruction in young age. It is today the indication for 10 % of all the total hip joint replacements. Known aetiologies of nontraumatic femoral head necrosis are alcoholism, steroids, sickle cell anaemia, caisson, and Gaucher's disease. Further risk factors are chemotherapy, chronic inflammatory bowel disease, systemic lupus erythematosus, and multiple sclerosis, in which also steroids are involved...
April 2011: Zeitschrift Für Orthopädie und Unfallchirurgie
Nicola Dalbeth, Bregina Pool, Timothy Smith, Karen E Callon, Maria Lobo, William J Taylor, Peter B Jones, Jillian Cornish, Fiona M McQueen
INTRODUCTION: Diverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of patients with PsA. METHODS: Patients with PsA (n = 38), with psoriasis (n = 10), and healthy controls (n = 12) were studied. Serum was obtained for testing of Dikkopf-1 (Dkk-1), macrophage-colony stimulating factor (M-CSF), osteoprotegerin (OPG), and receptor activator of nuclear factor-κB ligand (RANKL) with ELISA...
2010: Arthritis Research & Therapy
Hisako Ishizuka, Verónica García-Palacios, Ganwei Lu, Mark A Subler, Heju Zhang, Christina S Boykin, Sun Jin Choi, Liena Zhao, Kenneth Patrene, Deborah L Galson, Harry C Blair, Tamer M Hadi, Jolene J Windle, Noriyoshi Kurihara, G David Roodman
ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis, but its potential role in these processes is unclear. ADAM8 stimulates osteoclast (OCL) formation, but the effects of overexpression or loss of expression of ADAM8 in vivo and the mechanisms responsible for the effects of ADAM8 on osteoclastogenesis are unknown. Therefore, to determine the effects of modulating ADAM expression, we generated tartrate-resistant acid phosphatase (TRAP)-ADAM8 transgenic mice that overexpress ADAM8 in the OCL lineage and ADAM8 knockout (ADAM8 KO) mice...
January 2011: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Nan-Hua Chang, Robert D Inman, John E Dick, Joan E Wither
OBJECTIVE: Studies of human inflammatory arthritis would be significantly aided by the development of better animal models. Our hypothesis is that it is possible to develop humanized arthritis models through novel techniques of hematopoietic stem and progenitor cell (HSPC) delivery. METHODS: Bone marrow was obtained from patients with osteoarthritis who were undergoing total hip replacement. HSPC were enriched by negative selection and injected into the femur of irradiated anti-CD122 treated nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice...
March 2010: Journal of Rheumatology
Jochen Ringe, Thomas Häupl, Michael Sittinger
Chronic inflammation during rheumatoid arthritis and degenerative processes during osteoarthritis eventually result in joint destruction. Anti-inflammatory therapies facilitate the inhibition or delay of progressing joint cartilage and bone loss, but do not regenerate these tissues. Surgical procedures are quite unsatisfactory in long-term evaluation and often lead to endoprothetic joint replacement. Present tissue engineering technologies offer new strategies for the treatment of cartilage and bone defects...
March 2007: Expert Opinion on Biological Therapy
I Espigado, A García, J M Rodríguez, A Valenzuela, A Marín-Niebla, M Carmona
Hemopoietic stem cell transplantation (HCST) is an experimental therapy that may produce prolonged remissions in patients with rheumatoid arthritis (RA) resistant to other treatments. Prosthetic articular replacement is often required in severe long-lasting disease. There is a well-founded concern regarding the feasibility and safety of reconstructive surgery after HSCT and as yet no published data on the subject. We report a patient with RA of 9 years' duration resistant to conventional treatments plus femoral head necrosis, who underwent prosthetic hip replacement with no post-surgical complications one year after HSCT, with a sustained response...
September 2003: Clinical and Experimental Rheumatology
F Launay, J L Jouve, J M Guillaume, E Viehweger, M Jacquemier, G Bollini
PURPOSE OF THE STUDY: Hip disease can produce major pain and functional disorders in children who should benefit from total hip arthroplasty. We report our experience with total hip prostheses implanted without cement in children. MATERIAL AND METHODS: We performed 17 total hip arthroplasties in 13 children who had various conditions, mainly chronic juvenile osteoarthritis and aseptic osteonecrosis secondary to sickle cell anemia. The acetabular inserts were not cemented...
September 2002: Revue de Chirurgie Orthopédique et Réparatrice de L'appareil Moteur
Shunsei Hirohata, Tamiko Yanagida, Tetsuya Tomita, Hideki Yoshikawa, Takahiro Ochi
Recent studies have suggested the involvement of bone marrow in the pathogenesis of rheumatoid arthritis (RA), in which proliferation of monocyte-lineage cells (MLC) as well as local B cell activation in the synovium play an important role. Here, we show that bone marrow-derived MLC have the capacity to activate human peripheral blood IgD- B cells. Bone marrow CD34+ cells from RA patients that had been stimulated with stem cell factor and GM-CSF for 3-4 weeks (>90% CD14+ HLA-DR+ cells, <0.5% CD19+ B cells, and <0...
June 2002: Journal of Leukocyte Biology
M H Sy, A Toure-Fall, N Diop-Sall, J M Dangou, S I Seye
Skeletal fluorosis typically manifests as a diffuse increase in bone density, whereas avascular necrosis of the epiphyses and diaphyseal marrow are the main skeletal manifestations of sickle cell disease. The diagnostic and therapeutic challenges raised when both disorders are present are illustrated by two cases in Senegalese patients from an area characterized by high fluoride contents in the water and soil. Both had SS sickle cell disease. Skeletal fluorosis was diagnosed during evaluation for avascular necrosis in one patient and in the wake of septic arthritis in the other...
2000: Joint, Bone, Spine: Revue du Rhumatisme
R Rogalski, J Huebner, J Goulet, H Kaufer
Forty-seven bipolar hemiarthroplasties were performed from January 1985 to December 1986. Twenty-three patients (24 hips) returned for a history, physical, and repeat radiographs. Ten primary press-fit and two cemented primary bipolar hemiarthroplasties were performed. Four patients underwent cemented and eight received press-fit revision bipolar hemiarthroplasties. Fourteen patients had simultaneous cancellous, reamed femoral head autograft, or allograft acetabular bone augmentation. Omitting one patient who had replacement for Lévi's pleonosteosis, the average acetabular migration among the remaining 23 patients was 4 mm of superior and 1...
July 1993: Orthopedics
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