Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Jiayue Liu, Maelle Batardiere, H Carlo Maurer, Celina Copeland, Jahg Wong, Olivia Ben-Levy, Sabrina M Torbit, Brenda Jarvis, Frank Revetta, Sergey Ivanov, Nidhi Jyotsana, Yuki Makino, Amanda M Ruelas, Anna L Means, Anirban Maitra, Marcus C B Tan, Kathleen E DelGiorno
OBJECTIVE: Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recently, we showed that acinar to ductal metaplasia, an injury repair program, is characterized by a transcriptomic program similar to gastric spasmolytic polypeptide expressing metaplasia (SPEM), suggesting common mechanisms of reprogramming between the stomach and pancreas. The aims of this study were to assay IPMN for pyloric markers and to identify molecular drivers of this program...
February 28, 2024: bioRxiv