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https://read.qxmd.com/read/30879148/clinical-assessment-of-the-gnas-mutation-status-in-patients-with-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#1
REVIEW
Takao Ohtsuka, Takahiro Tomosugi, Ryuichiro Kimura, So Nakamura, Yoshihiro Miyasaka, Kohei Nakata, Yasuhisa Mori, Makiko Morita, Nobuhiro Torata, Koji Shindo, Kenoki Ohuchida, Masafumi Nakamura
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is characterized by cystic dilation of the pancreatic duct, caused by mucin hypersecretion, with slow progression via the adenoma-carcinoma sequence mechanism. Mutation of GNAS at codon 201 is found exclusively in IPMNs, occurring at a rate of 41-75%. Recent advances in molecular biological techniques have demonstrated that GNAS mutation might play a role in the transformation of IPMNs after the appearance of neoplastic cells, rather than in the tumorigenesis of IPMNs...
March 16, 2019: Surgery Today
https://read.qxmd.com/read/30863816/laparoscopic-cystectomy-for-pancreatic-echinococcosis-a-case-report-and-literature-review
#2
Ashraf Imam, Tawfik Khoury, Dani Weis, Harbi Khalayleh, Muhammad Adeleh, Abed Khalaileh
Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with the Echinococcus granulosus tapeworm. Following ingestion of eggs, hydatid cysts develop, most frequently in the liver and lungs, but occasionally in other organs. Infection of the pancreas by hydatid cysts is very rare, even in endemic areas. Most cases of pancreatic hydatid cysts reported in the literature were treated surgically using traditional open laparotomy. There are only few case reports describing laparoscopic treatment for this disease...
February 2019: Annals of Hepato-Biliary-Pancreatic Surgery
https://read.qxmd.com/read/30860020/case-report-rare-presentation-of-multivisceral-echinococcosis
#3
Xiao Cai, Huixia Cai, Qing Gan, Wenxu Chang, Fang Yuan, Wei Luo, Jie Sun, Jing An
Cystic echinococcosis (CE) is a common, chronic, and endemic zoonotic disease usually localized in a single organ; multivisceral cases are rare, especially outside the liver or lung. Here, we describe an unusual case of a 43-year-old Tibetan man with echinococcosis of the infratemporal fossa, heart, liver, pancreas, abdomen, and pelvic cavity. He only presented with diminished vision of the left eye, especially when chewing. Computed tomography and magnetic resonance imaging revealed multivisceral CE. The patient underwent surgery for the excision of a cyst in the infratemporal fossa, as well as chemotherapy, and the diagnosis was confirmed by histopathological examination...
March 11, 2019: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/30852373/solid-pseudopapillary-tumor-of-the-pancreas-in-a-17-year-old-girl
#4
Ayad Ahmad Mohammed, Ferhad Mohammed Rasheed, Sardar Hassan Arif, Abdulwahid M Salih, Fahmi H Kakamad, Shvan H Mohammed
INTRODUCTION: Solid pseudopapillary tumor of the pancreas is a rare tumor of low malignant potential. The aim of this paper is to present and discuss a case of solid pseudopapillary tumor of the pancreas occurring in a 17-year-old female. A 17-year-old girl presented with dull aching poorly localized left hypochondrial pain for two years, she had no clinical findings on physical examination. Ultrasound of the abdomen showed well-defined 9 cm * 7 cm heterogeneous lesion with cystic contents in the region of the tail of the pancreas...
February 27, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30807572/genetic-association-and-transcriptome-integration-identify-contributing-genes-and-tissues-at-cystic-fibrosis-modifier-loci
#5
Jiafen Gong, Fan Wang, Bowei Xiao, Naim Panjwani, Fan Lin, Katherine Keenan, Julie Avolio, Mohsen Esmaeili, Lin Zhang, Gengming He, David Soave, Scott Mastromatteo, Zeynep Baskurt, Sangook Kim, Wanda K O'Neal, Deepika Polineni, Scott M Blackman, Harriet Corvol, Garry R Cutting, Mitchell Drumm, Michael R Knowles, Johanna M Rommens, Lei Sun, Lisa J Strug
Cystic Fibrosis (CF) exhibits morbidity in several organs, including progressive lung disease in all patients and intestinal obstruction at birth (meconium ileus) in ~15%. Individuals with the same causal CFTR mutations show variable disease presentation which is partly attributed to modifier genes. With >6,500 participants from the International CF Gene Modifier Consortium, genome-wide association investigation identified a new modifier locus for meconium ileus encompassing ATP12A on chromosome 13 (min p = 3...
February 2019: PLoS Genetics
https://read.qxmd.com/read/30803366/computer-aided-diagnosis-of-pancreas-serous-cystic-neoplasms-a-radiomics-method-on-preoperative-mdct-images
#6
Ran Wei, Kanru Lin, Wenjun Yan, Yi Guo, Yuanyuan Wang, Ji Li, Jianqing Zhu
OBJECTIVE: Our aim was to propose a preoperative computer-aided diagnosis scheme to differentiate pancreatic serous cystic neoplasms from other pancreatic cystic neoplasms, providing supportive opinions for clinicians and avoiding overtreatment. MATERIALS AND METHODS: In this retrospective study, 260 patients with pancreatic cystic neoplasm were included. Each patient underwent a multidetector row computed tomography scan and pancreatic resection. In all, 200 patients constituted a cross-validation cohort, and 60 patients formed an independent validation cohort...
January 1, 2019: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/30798329/invasive-ductal-carcinoma-arising-in-mucinous-cystic-neoplasm-of-pancreas-a-case-report
#7
Hirozumi Sawai, Masaaki Kurimoto, Shuji Koide, Yuka Kiriyama, Shin Haba, Yoichi Matsuo, Mamoru Morimoto, Hajime Koide, Atsushi Kamiya, Kenji Yamao
BACKGROUND Mucinous cystic neoplasm (MCN) of the pancreas is a rare mucin-producing cystic neoplasm that has a characteristic histological feature referred to as ovarian-type stroma (OS) underlying the epithelium. Pancreatic ductal carcinoma arises from MCN as a precursor lesion, but data on progression pathways are limited. CASE REPORT A 40-year-old female was referred to our hospital for further investigation of a pancreatic cyst. Further examination showed a 7.0 cm multilocular cyst in the pancreatic tail and a solid mass in the thick septum of the cystic tumor...
February 24, 2019: American Journal of Case Reports
https://read.qxmd.com/read/30790046/radical-antegrade-modular-pancreatosplenectomy-for-all-pancreatic-body-and-tail-tumors-rationale-and-results
#8
Masillamany Sivasanker, Ashwin Desouza, Manish Bhandare, Vikram Chaudhari, Mahesh Goel, Shailesh V Shrikhande
BACKGROUND: Radical antegrade modular pancreatosplenectomy (RAMPS) has been propagated as the standard of care for pancreatic cancers involving the body and tail of the pancreas. This procedure has been shown to have promising results in enhancing the microscopically negative tangential resection margins as well as the lymph node yield. METHODS: This is a retrospective analysis of prospectively maintained database on the resections performed for all pancreatic body and tail tumors at Tata Memorial Centre...
February 21, 2019: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/30788092/extra-gastrointestinal-stromal-tumor-with-a-large-cyst
#9
Daichi Nakamura, Yasushi Adachi, Yousuke Kinjo, Shigeki Uchida, Tomohiro Sugiyama, Noriko Sakaida, Michihiko Tsubono, Susumu Ikehara
Gastrointestinal stromal tumors (GISTs) arising at sites other than the alimentary tract are rare, and they are called extra-GISTs (EGISTs). We report a case of a large EGIST forming a cyst, probably arising in the mesentery of the transverse colon. A 64-year-old Japanese man presented to a hospital with an abdominal tumor forming a large cyst. Intraoperatively, the tumor was neither present in nor in contact with the alimentary tract. It was present in the mesentery of the transverse colon and was attached to the greater omentum and peritoneum, immediately anterior to the body of the pancreas...
February 2019: Journal of Surgical Case Reports
https://read.qxmd.com/read/30785528/surgical-management-of-cystic-lesions-of-the-pancreas-a-single-centre-experience
#10
Gabriela Beatriz Sia, Pedro França da Costa Soares, Martinho Antonio Gestic, Elinton Adami Chaim, Francisco Callejas-Neto, Everton Cazzo
BACKGROUND: Cystic lesions of the pancreas represent a group of pancreatic diseases with great histological heterogeneity, varying from benign lesions, some of them with malignant potential, to overt malignant lesions. OBJECTIVE: To describe the cases of cystic lesions of the pancreas which underwent surgical intervention at a tertiary university hospital. METHODS: This is a retrospective population-based study (historical cohort) which was carried out enrolling individuals attended at the Outpatient service of Pancreas Surgery of the Hospital de Clínicas of Unicamp...
October 2018: Arquivos de Gastroenterologia
https://read.qxmd.com/read/30785006/malignant-peripheral-nerve-sheath-tumor-of-the-pancreas-a-case-report
#11
Pradeep Balineni, Rekha Arcot, Kannan Devygounder, Khalilur Rahaman, Bharath Narayansamy, Manoj Prabhu, Shantini Vaitheeswaran
INTRODUCTION: Nerve sheath tumors are tumors arising from nerve sheaths or which show nerve sheath differentiation. They are divided as benign and malignant. They are associated with Von Recklinghausen syndrome. Characterised by café-au-lait spots, lisch nodules, acoustic neuromas, pheochromocytomas. PRESENTATION OF CASE: A 62 year old gentleman came with complaints of Abdominal discomfort for 1month. He also had Left sided abdominal pain, Anorexia, Vomiting, No history of dyspepsia, fever, bowel disturbance...
February 13, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30765652/-a-case-of-solid-pseudopapillary-neoplasm-of-the-pancreas-in-a-male-patient
#12
Yasushi Suganuma, Tatsuro Nishida, Rumi Osawa, Atsushi Matsumura, Shuichi Kin
The patient was a 50-year-old man. Abdominal ultrasound performed as part of a regular check-up suggested the presence of a tumor in the left kidney, and he was referred to our hospital for further examination. Computed tomography(CT) and magnetic resonance imaging(MRI)revealed the presence of a cystic neoplasm of the pancreas with partial calcification. The tumor had a maximum diameter of approximately 12 cm. Based on these findings, the patient was diagnosed with solid pseudopapillary neoplasm(SPN)and underwent distal pancreatectomy and splenectomy...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/30763861/lymphoepithelial-cyst-of-the-pancreas-a-case-report-and-summary-of-imaging-features-of-pancreatic-cysts
#13
Yosuke Namba, Akihiko Oshita, Takashi Nishisaka, Maiko Namba, Tamito Sasaki, Yasuhiro Matsugu, Toshiyuki Itamoto
INTRODUCTION: A lymphoepithelial cyst (LEC) of the pancreas is a benign and rare lesion that is difficult to diagnose preoperatively based on imaging studies. PRESENTATION OF CASE: We report a case of a 49-year-old man who presented with weight loss and diarrhea. The serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were slightly elevated to 6.7 ng/mL (reference value <5.0 ng/mL) and 45 U/mL (reference value <37 U/mL), respectively...
January 30, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30762824/concurrent-pancreatic-metastasis-from-lung-adenocarcinoma-and-primary-cholangiocarcinoma-on-fdg-pet-ct-imaging
#14
Wei Wang, Ying Kan, Xu Yang, Jie Liu, Jigang Yang
A 67-year-old man with a history of left upper lobe resection of poorly differentiated adenocarcinoma 1 year ago underwent FDG PET/CT for restaging. The images demonstrated a round cystic lesion with peripheral FDG uptake and centrally photopenic region. Additional focus of increased activity was detected in the left lobe of the liver. The patient underwent the Whipple and partial hepatectomy. The surgical pathology demonstrated concurrently the metastasis to the pancreas from the lung adenocarcinoma and a primary moderately differentiated cholangiocarcinoma...
February 8, 2019: Clinical Nuclear Medicine
https://read.qxmd.com/read/30758533/a-case-of-human-pancreatic-eurytremiasis
#15
Hiroshi Ogawa, Yasuo Takehara, Shinji Naganawa, Junpei Yamaguchi, Masato Nakaguro
This study provides the first comprehensive imaging report of human pancreatic eurytremiasis. A 43-year-old man with obstructive jaundice and a pancreatic tumor was referred for diagnosis and treatment. Serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were elevated. Computed tomography (CT) revealed a multilocular cystic lesion with delayed enhanced area in the pancreas head. On magnetic resonance imaging, the tumor was hyperintense on diffusion-weighted image, and the apparent diffusion coefficient value of the tumor was lower than that of the normal pancreatic parenchyma...
February 13, 2019: Abdominal Radiology
https://read.qxmd.com/read/30746958/safe-surgery-for-cystic-tumors-of-the-pancreas
#16
Carlos Fernández Del Castillo
Cystic tumors of the pancreas are a common indication for pancreatic surgery, and many of them are incidentally-discovered. Some of these tumors are malignant, and many others are pre-malignant. Less than two generations ago, pancreatic surgery was risky business. Surgical mortality, even in some of the best institutions in the world, was about 25%. Complications were very common and not infrequently patients required reoperations and had to remain in the hospital for weeks or even months. They emerged from this highly debilitated, and often went on to have a very poor quality of life...
February 2019: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/30746953/intraductal-papillary-mucinous-neoplasm-of-the-main-duct-in-a-patient-with-pancreas-divisum
#17
Pablo Sánchez Acedo, Guillermo Viteri Ramírez, Javier Herrera Cabezón, Antonio Tarifa Castilla
Pancreas divisum is a congenital anomaly present in 5-10% of the population and is usually asymptomatic. Pancreatic intraductal papillary mucinous neoplasms (IPMN) are mucinous cystic tumors that have malignant potential and are classified according to their location as IPMN of the main duct, branch duct or mixed type. Larger lesions and those originating in the main duct have an increased risk of malignancy. The real incidence is unknown as most lesions are asymptomatic.
February 11, 2019: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/30741591/clinicopathological-features-and-treatment-outcomes-of-solid-pseudopapillary-neoplasms-of-the-pancreas-a-10-year-case-series-from-a-single-center
#18
Hanxiang Zhan, Yugang Cheng, Lei Wang, Peng Su, Ning Zhong, Zongli Zhang, Xuting Zhi, Sanyuan Hu
BACKGROUND: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare pancreatic tumors. This study summarizes the clinicopathological characteristics and treatment outcomes of SPN patients through a 10-year single-center case series. MATERIALS AND METHODS: Medical records of patients diagnosed with SPNs and who underwent surgery between August 2007 and July 2017 at Qilu Hospital, Shandong University, were retrospectively analyzed. RESULTS: This study included 91 patients: 13 males/78 females, mean age 28...
February 11, 2019: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/30706376/natural-history-and-treatment-trends-in-pancreatic-cancer-subtypes
#19
Courtney J Pokrzywa, Daniel E Abbott, Kristina A Matkowskyj, Sean M Ronnekleiv-Kelly, Emily R Winslow, Sharon M Weber, Alexander V Fisher
BACKGROUND: While pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer, many other histologic forms of pancreatic cancer are also recognized. These histologic variants portray unique characteristics in terms of patient demographics, tumor behavior, survival, and responsiveness to treatments. MATERIALS AND METHODS: Patients who underwent surgical resection of the pancreas for non-metastatic, invasive pancreatic cancer between 2004 and 2014 were selected from the National Cancer Data Base and categorized by histologic variant according to WHO classification guidelines...
January 31, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://read.qxmd.com/read/30705944/eus-guided-pancreatic-radiofrequency-ablation-preclinical-comparison-of-two-currently-available-devices-in-a-pig-model
#20
Maximilien Barret, Sarah Leblanc, Alexandre Rouquette, Stanislas Chaussade, Benoit Terris, Frédéric Prat
Introduction  Two devices are currently available to perform pancreatic radiofrequency ablation (P-RFA). Potential clinical indications might extend from the treatment of pancreatic cystic lesions to ablation of small pancreatic solid lesions or cytoreduction of advanced pancreatic adenocarcinomas, but more preclinical data from animal models are needed to optimize P-RFA operation. Methods  P-RFA was performed under laparotomy and under endoscopic ultrasonographic guidance on the liver and pancreatic parenchyma of four live swine using the Habib EUS RFA (EMcision Ltd, London, UK) probe and the EUS-RA needle (Taewoong Medical, Gyeonggi-do, South Korea)...
February 2019: Endoscopy International Open
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