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Endocrinology, Diabetes,Obesity

Ray Rodgers, Jodie Avery, Vivienne Moore, Michael Davies, Ricardo Azziz, Elisabeth Stener-Victorin, Lisa Moran, Sarah Robertson, Nigel Stepto, Rob Norman, Helena J Teede
OBJECTIVE: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19-28% of women of reproductive age...
February 1, 2019: Endocrine Connections
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
February 6, 2019: Lancet Diabetes & Endocrinology
Jorge Sapunar, Alex Escalona, A Verónica Araya, Carmen Gloria Aylwin, María Juliana Bastías, Camilo Boza, Carlos Cárcamo, Attila Csendes A, Patricio Davidof F, Ricardo Funke, Patricia Gómez, María Isabel González, Rodolfo Lahsen, Enrique Lanzarini, Alberto Maíz, Verónica Mujica, Rodrigo Muñoz, Gustavo Pérez, Félix Raimann, Patricio Salman, Matías Sepúlveda, Néstor Soto, Rodrigo Villagrán
Diabetes Mellitus (DM) and obesity are a public health problem in Chile. Bariatric surgery is the most effective treatment alternative to achieve a significant and sustained weight reduction in patients with morbid obesity. The results of controlled clinical trials indicate that, compared to medical treatment, surgery for obese patients with DM2 allows a better control of blood glucose and cardiovascular risk factors, reduces the need for medications and increases the likelihood for remission. Consensus conferences and clinical practice guidelines support bariatric surgery as an option to treat DM2 in Class III Obesity (Body Mass Index (BMI) > 40) regardless of the glycemic control and the complexity of pharmacological treatment and in Class II Obesity (BMI 35-39,9) with inadequate glycemic control despite optimal pharmacological treatment and lifestyle...
December 2018: Revista Médica de Chile
Guy I Sydney, Kalliopi J Ioakim, Stavroula A Paschou
An adrenal incidentaloma (AI) is an adrenal mass incidentally found via a radiological modality, independent of an endocrinological investigation. In this review, we aimed to investigate the possible reasons behind the increased frequency in AI detection, especially in ageing populations. The pathophysiological effects of insulin resistance (IR), hyperinsulinemia and various anabolic pathways are analyzed. In addition, we review data from studies indicating an increased incidence of adrenal adenomas and carcinomas in patients with type 2 diabetes mellitus (T2DM)...
March 2019: Maturitas
Lara Mroueh, Dana Ayoub, Maya El-Hajj, Sanaa Awada, Samar Rachidi, Salam Zein, Amal Al-Hajje
Background: Diabetes type 2 is considered one of the main public health concerns. Lack of adherence to treatment leads to poor therapeutic outcome, poor glycemic control, and high risk for developing diabetes complications. Objectives: The aim of this study is to evaluate adherence to oral antidiabetic medication in Diabetes type 2 Lebanese patients, and to evaluate factors leading to low adherence. Methods: A cross-sectional study was conducted in outpatients endocrinology clinics of two hospitals and four private clinics located in Beirut-Lebanon...
October 2018: Pharmacy Practice
Naglaa Fathy Barseem, Soheir S Abou El Ella, Maha A Tawfik, Rasha R El-Nehrawy
BACKGROUND: Genetic variations of the FTO gene were associated with obesity and type 2 diabetes determinants in the European population, notably raised blood levels of insulin and glucose. OBJECTIVE: The aim of this study was to test the association of FTOrs17817449with obesity/BMI and type 2 diabetes risk among obese Egyptian population. MATERIALS AND METHODS: In this case-control study,(PCR-RFLP assay) was used for genotyping FTOrs17817449polymorphism (SNP) in 120 obese children and 120 controls conducted from attendants of genetic & endocrinology Unit and outpatient clinics, Pediatric Department, Faculty of Medicine, Menoufia University Hospitals...
January 1, 2019: Endocrine, Metabolic & Immune Disorders Drug Targets
Ramona F Stroescu, Otilia Mărginean, Teofana Bizerea, Mihai Gafencu, Adrian Voicu, Gabriela Doroș
Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population. Methods A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology...
December 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
B Lin, Q B Yang, Y C Yu, Y F Wang, S Y Li, C Jin
Objective: To study the effect of nutrition intervention on the body composition and blood glucose in newly diagnosed patients with type 2 diabetes mellitus complicated with overweight and obesity. Methods: A total of 84 newly diagnosed patients with type 2 diabetes mellitus complicated with overweight and obesity were selected from the department of endocrinology in China-Japan Friendship Hospital from April 2015 to December 2016. Basic information and body composition of these patients were collected and measured...
December 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Zeynep Erdogan, Mehmet Kashif Kurcer, Meltem Kurtuncu, Safiye Catalcam
OBJECTIVE: To test the validity and reliability of the Turkish version of the Weight Self-Stigma Questionnaire. METHODS: The methodological, descriptive study was conducted at the Bulent Ecevit University, Zonguldak, Turkey, from January to June, 2016, and comprised obese patients presenting at the Endocrinology and Diabetes polyclinic tied to the university. Data was collected using patient identification form and Weight Self-Stigma Questionnaire. SPSS 18 was used for statistical analysis...
December 2018: JPMA. the Journal of the Pakistan Medical Association
Sofien Regaieg, Faten Hadjkacem, Nadia Charfi, Dorra Ghorbel, Rim Marrakchi, Sourour Yaich, Jamel Dammak, Kamel Jamoussi, Mohamed Abid
AIM: To describe the prevalence of metabolic syndrome and to study the association of physical activity measured by pedometer with the metabolic syndrome components, in a sample of overweight and obese adolescents from Sfax City. METHODS: This study concerned 51 obese and overweight adolescents (28 girls and 23 boys), between the ages of 15 and 18 years, recruited by the unit of obesity and metabolic syndrome department of endocrinology, Hedi Chaker Hospital, University of Sfax, between december 2012 and october 2013...
June 2018: La Tunisie Médicale
Inka Miñambres, Miguel Angel Rubio, Ana de Hollanda, Irene Breton, Nuria Vilarrasa, Silvia Pellitero, Marta Bueno, Albert Lecube, Clara Marcuello, Albert Goday, Maria D Ballesteros, German Soriano, Assumpta Caixàs
CONTEXT: Information concerning the risk-benefit profile of bariatric surgery in subjects with liver cirrhosis is scarce. Our aim was to describe the long-term outcomes of bariatric surgery in a cohort of patients with liver cirrhosis submitted to bariatric surgery. METHODS: This was a multicenter, retrospective observational study performed by the Obesity Group of the Spanish Society of Endocrinology and Nutrition (GOSEEN), with a review of patients with cirrhosis who had undergone bariatric surgery during the period from April 2004 to March 2017 in ten public reference hospitals in Spain...
November 5, 2018: Obesity Surgery
Assaf Buch, Lital Keinan-Boker, Ofer Kis, Eli Carmeli, Elena Izkhakov, Maya Ish-Shalom, Yitshal Berner, Gabi Shefer, Yonit Marcus, Naftali Stern
Purpose: Unwanted weight loss is one of the established criteria for the diagnosis of frailty. However, the relevance of this criterion to detect frailty in obese older adults has not been assessed. In particular, with the exception of malignancy, unwanted weight loss is not commonly seen in older obese subjects. Therefore, we tested the possibility that some obesity phenotypes and/or diabetes might be more useful in the detection of frailty in this setting. Patients and methods: A preliminary cross-sectional study of 50 consecutive subjects was conducted at The Institute of Endocrinology, Metabolism and Hypertension, Tel-Aviv Sourasky Medical Center...
2018: Clinical Interventions in Aging
Kathryn E Kyler, Rachel B Kadakia, Hannah L Palac, Soyang Kwon, Adolfo J Ariza, Helen J Binns
Use of metformin for weight loss for children in a clinical setting has not been well described; therefore, we aimed to identify characteristics of obese patients prescribed metformin in a clinical setting and evaluate changes in anthropometric measures. Records of obese patients aged 10 to 18 years without diabetes attending an academic endocrinology practice from 2009 to 2013 were reviewed. Analyses assessed changes in anthropometric measures (weight, body mass index [BMI], and BMI z-score) over 12 months between those prescribed metformin (n = 49) and those not prescribed metformin (n = 142)...
December 2018: Clinical Pediatrics
Alfonso Galderisi, Cosimo Giannini, Ram Weiss, Grace Kim, Veronika Shabanova, Nicola Santoro, Bridget Pierpont, Mary Savoye, Sonia Caprio
BACKGROUND: Type 2 diabetes is preceded by a prediabetic stage of impaired glucose tolerance that affects 10-23% of youth and is expected to double over the next decade. The natural history of impaired glucose tolerance and the determinants of β-cell dynamic response have never been investigated longitudinally in young people. We aimed to investigate the clinical and metabolic determinants of longitudinal glucose tolerance changes and β-cell function in a multiethnic cohort of obese youth...
October 2018: The lancet child & adolescent health
Martin B Whyte, Fariba Shojaee-Moradie, Sharaf E Sharaf, Nicola C Jackson, Barbara Fielding, Roman Hovorka, Jeewaka Mendis, David Russell-Jones, A Margot Umpleby
Context: GLP-1 agonists control postprandial glucose and lipid excursion in type 2 diabetes; however the mechanism(s) are unclear. Objective: To determine the mechanism(s) of postprandial lipid and glucose control with lixisenatide (GLP-1 analogue) in type 2 diabetes. Design: Randomised, double-blind, cross-over study. Setting: Centre for Diabetes, Endocrinology, and Research, Royal Surrey County Hospital, Guildford, UK...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
Charlotte Marsot, Philippe Chanson, Françoise Borson-Chazot
Bone is now considered as a particular endocrine organ. Its endocrine function is not yet fully understood and has been the subject of several conferences at the European Society of Endocrinology Congress 2018. Bone regulates phosphate metabolism by secreting fibroblast growth factor 23; it also regulates glucose metabolism via osteocalcin and energy metabolism, thanks to lipocalin 2, a new hormone acting on the brain. In addition, the incidence of diabetes continues to grow, and its impact on bone has been demonstrated, with an increased risk of fractures regardless the type of diabetes...
September 2018: Annales D'endocrinologie
Reem Sami Alquoqa, Violet Kasabri, Randa Naffa, Amal Akour, Yasser Bustanji
Background: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are associated with obesity, which triggers the release of inflammatory substances. Myeloperoxidase (MPO), a peroxidase enzyme, and alpha-1-acid glycoprotein (AGP), an acute-phase protein, are known to be released in patients with inflammatory conditions and cardiovascular disease (CVD). Methods: In this study, we investigated the correlation between MPO and AGP levels in pre/diabetic and MetS patients by conducting a cross-sectional study at The University of Jordan Hospital (UoJH) at the diabetes and endocrinology outpatient clinics...
September 2018: Therapeutic Advances in Endocrinology and Metabolism
Suzanne V Arnold, Darren K McGuire, Silvio E Inzucchi, Fengming Tang, Sanjeev N Mehta, Carolyn S P Lam, Abhinav Goyal, Laurence S Sperling, Nathan D Wong, Niklas Hammar, Peter Fenici, Mikhail Kosiborod
BACKGROUND: Although practice guidelines stress individualization of glucose management in patients with type 2 diabetes (T2D), the extent to which providers take patient factors into account when selecting medications is not well known. METHODS: Diabetes Collaborative Registry (DCR) is an outpatient diabetes registry including primary care, cardiology, and endocrinology practices. T2D medications were grouped as those which may be suboptimal for key patient subgroups, and we examined patient factors associated with use of these agents using hierarchical, multivariable Poisson models...
November 2018: Journal of Diabetes and its Complications
Marijke De Keukelaere, Steffen Fieuws, Nele Reynaert, Eva Vandoorne, Kristel Vande Kerckhove, Willeke Asscherickx, Kristina Casteels
The prevalence of childhood overweight and obesity has risen during the last 30 years, not only in children with type 2 diabetes, but also those with type 1 (T1D) and this is linked with an increased cardiovascular risk. A better understanding of weight patterns in the years after diagnosis of T1D is important to identify those children with a risk for excess weight gain and strategies to decrease this. We retrospectively analyzed data of all children with T1D followed at the department of Pediatric Endocrinology Leuven and diagnosed between 1991 and 2015...
November 2018: European Journal of Pediatrics
Dr KhushBakht, Saadon Mazhar, Amanullah Bhalli, Aqeela Rashid, Khurshid Khan, Uzma Jahanzaib
Introduction Due to normal physiological changes in various anthropometric indices during pregnancy, the routine measurements of body weight, height, waist circumference, and waist-to-hip ratio are deemed inappropriate in predicting obesity and risk of gestational diabetes mellitus in pregnancy. Neck circumference is a novel marker to determine the risk of gestational diabetes in pregnancy. We conducted this study to determine the correlation between neck circumference and gestational diabetes mellitus and its associated risk factors...
May 28, 2018: Curēus
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