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Keywords Neurostimulation AND Neuropath...

Neurostimulation AND Neuropathic Pain

https://read.qxmd.com/read/38510888/sustained-relief-of-complex-regional-pain-syndrome-crps-pain-following-a-60-day-peripheral-nerve-stimulation-a-report-of-three-cases
#1
Genaro J Gutierrez, Claire A Zurn, Nathan D Crosby
Patients who present to pain clinics with complex regional pain syndrome (CRPS) typically have debilitating pain, including hyperalgesia and allodynia, and additional substantial quality-of-life concerns related to the motor and autonomic-related symptoms of CRPS. Present treatments for CRPS such as neuropathic pain medications and sympathetic blocks are often unsatisfactory for managing symptoms. The present cases highlight the use of a 60-day percutaneous peripheral nerve stimulation (PNS) treatment for three patients with CRPS Type I affecting the foot...
February 2024: Curēus
https://read.qxmd.com/read/38483366/five-year-longitudinal-follow-up-of-restorative-neurostimulation-shows-durability-of-effectiveness-in-patients-with-refractory-chronic-low-back-pain-associated-with-multifidus-muscle-dysfunction
#2
JOURNAL ARTICLE
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Dawood Sayed, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology. MATERIALS AND METHODS: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38470666/transcranial-magnetic-stimulation-to-treat-neuropathic-pain-a-bibliometric-analysis
#3
REVIEW
Bruno Daniel Carneiro, Isaura Tavares
Neuropathic pain is caused by a lesion or disease of the somatosensory system and is one of the most incapacitating pain types, representing a significant non-met medical need. Due to the increase in research in the field and since innovative therapeutic strategies are required, namely in intractable neuropathic pain, neurostimulation has been used. Within this approach, transcranial magnetic stimulation (TMS) that uses a transient magnetic field to produce electrical currents over the cortex emerges as a popular method in the literature...
February 28, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38398392/improved-outcomes-and-therapy-longevity-after-salvage-using-a-novel-spinal-cord-stimulation-system-for-chronic-pain-multicenter-observational-european-case-series
#4
JOURNAL ARTICLE
Philippe Rigoard, Maxime Billot, Renaud Bougeard, Jose Emilio Llopis, Sylvie Raoul, Georgios Matis, Jan Vesper, Hayat Belaïd
Spinal cord stimulation (SCS) is proven to effectively relieve chronic neuropathic pain. However, some implanted patients may face loss of efficacy (LoE) over time, and conversion to more recent devices may rescue SCS therapy. Recent SCS systems offer novel stimulation capabilities, such as temporal modulation and spatial neural targeting, and can be used to replace previous neurostimulators without changing existing leads. Our multicenter, observational, consecutive case series investigated real-world clinical outcomes in previously implanted SCS patients who were converted to a new implantable pulse generator...
February 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38274409/treating-chronic-intractable-pain-with-a-miniaturized-spinal-cord-stimulation-system-1-year-outcomes-from-the-aus-npower-study-during-the-covid-19-pandemic
#5
John Salmon, Daniel Bates, Neels Du Toit, Paul Verrills, James Yu, Murray G Taverner, Vahid Mohabbati, Matthew Green, Gary Heit, Robert Levy, Peter Staats, Shilpa Kottalgi, James Makous, Bruce Mitchell
PURPOSE: Spinal cord stimulation (SCS) is a highly effective treatment for chronic neuropathic pain. Despite recent advances in technology, treatment gaps remain. A small SCS system with a miniaturized implantable pulse generator (micro-IPG; <1.5 cm3 in volume) and an externally worn power source may be preferred by patients who do not want a large, implanted battery. We report here the long-term outcomes from the first-in-human study evaluating the safety and performance of a new neurostimulation system...
2024: Journal of Pain Research
https://read.qxmd.com/read/38261232/trigeminal-postherpetic-neuralgia-from-pathophysiology-to-treatment
#6
REVIEW
Christy S Niemeyer, Michael Harlander-Locke, Andrew N Bubak, Rachael Rzasa-Lynn, Marius Birlea
PURPOSE OF REVIEW: Trigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the trigeminal nerve. It poses significant challenges due to its persistent and debilitating nature. This review explores the clinical characteristics of TG-PHN, analyzes its pathophysiological underpinnings, and addresses existent and potential therapies. RECENT FINDINGS: TG-PHN is one of the most common and complex PHN locations...
January 23, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38255308/a-literature-review-the-mechanisms-and-treatment-of-neuropathic-pain-a-brief-discussion
#7
REVIEW
Renira Rugnath, Casey Orzechowicz, Clayton Newell, Veronica Carullo, Anesh Rugnath
Classically, neuropathic pain is described as a pain caused by a lesion or disease of the somatosensory system. However, one must note that the presence of somatosensory pathology alone does not guarantee a progression to neuropathic pain. This is due, in part, to the fact that neuropathic pain is a notoriously complex disease process, involving sensitization of both the central and peripheral nervous systems. Its causes are also numerous and varied, including trauma, the compression of a nerve, autoimmune disorders, diabetes, and infections...
January 17, 2024: Biomedicines
https://read.qxmd.com/read/38245324/spinal-cord-stimulation-in-painful-diabetic-neuropathy-an-overview
#8
RANDOMIZED CONTROLLED TRIAL
Erika A Petersen
Up to 25% of people with diabetes develop painful diabetic neuropathy (PDN). The standard of care pharmacotherapies for PDN have limited efficacy with a considerable side effect profile. Spinal cord stimulation (SCS) is a form of electrical neurostimulation that modulates neural function via electrodes implanted into the spinal epidural space. While low frequency SCS has been shown to be potentially effective for treating pain associated with neuropathies, it masks pain perception by inducing paresthesia. Compared to low frequency SCS, high frequency (10 kHz) SCS delivers paresthesia-free therapy...
December 2023: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38220575/modulations-in-high-density-eeg-during-the-suppression-of-phantom-limb-pain-with-neurostimulation-in-upper-limb-amputees
#9
JOURNAL ARTICLE
Daria Kleeva, Gurgen Soghoyan, Artur Biktimirov, Nikita Piliugin, Yury Matvienko, Mikhail Sintsov, Mikhail Lebedev
Phantom limb pain (PLP) is a distressing and persistent sensation that occurs after the amputation of a limb. While medication-based treatments have limitations and adverse effects, neurostimulation is a promising alternative approach whose mechanism of action needs research, including electroencephalographic (EEG) recordings for the assessment of cortical manifestation of PLP relieving effects. Here we collected and analyzed high-density EEG data in 3 patients (P01, P02, and P03). Peripheral nerve stimulation suppressed PLP in P01 but was ineffective in P02...
January 13, 2024: Cerebral Cortex
https://read.qxmd.com/read/37976486/results-from-a-prospective-clinical-study-us-npower-evaluating-a-miniature-spinal-cord-stimulator-for-the-management-of-chronic-intractable-pain
#10
JOURNAL ARTICLE
Mehul J Desai, Tejal Raju, Chheany Ung, Sailesh Arulkumar, Leo Kapural, Mayank Gupta, Kasra Amirdelfan, David Rosenfeld, Aaron Calodney, Dawood Sayed, Ajay Antony, Sean Li, Ramana Naidu, Joel Ackerman, Robert Ball, Michael Fishman, Peter Staats, Gary Heit, Shilpa Kottalgi, James Makous
BACKGROUND: Chronic, intractable, neuropathic pain is readily treatable with spinal cord stimulation (SCS). Technological advancements, including device miniaturization, are advancing the field of neuromodulation. OBJECTIVES: We report here the results of an SCS clinical trial to treat chronic, low back and leg pain, with a micro-implantable pulse generator (micro-IPG). STUDY DESIGN: This was a single-arm, prospective, multicenter, postmarket, observational study...
November 2023: Pain Physician
https://read.qxmd.com/read/37832728/neuropathic-pain-from-actual-pharmacological-treatments-to-new-therapeutic-horizons
#11
REVIEW
Maxime Thouaye, Ipek Yalcin
Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects between 3 and 17% of the general population. The treatment of neuropathic pain is challenging due to its heterogeneous etiologies, lack of objective diagnostic tools and resistance to classical analgesic drugs. First-line treatments recommended by the Special Interest Group on Neuropathic Pain (NeuPSIG) and European Federation of Neurological Societies (EFNS) include gabapentinoids, tricyclic antidepressants (TCAs) and selective serotonin noradrenaline reuptake inhibitors (SNRIs)...
November 2023: Pharmacology & Therapeutics
https://read.qxmd.com/read/37800281/combining-alginate-pvpi-based-film-with-frequency-rhythmic-electrical-modulation-system-frems%C3%A2-technology-as-an-advanced-strategy-for-diabetic-wounds
#12
JOURNAL ARTICLE
Marco Contardi, Maria Summa, Martina Lenzuni, Luigi Miracoli, Franco Bertora, Maurizio Diaz Mendez, Athanassia Athanassiou, Rosalia Bertorelli
Diabetes is rising as one of the most diffused diseases of our century with the related urgent necessity to face its systemic and local effects on the patients, such as cardiovascular problems, degeneration of limbs, and dysfunction of the wound healing process. The diffusion of leg ulcers has been estimated to be 1.51 for 1,000 population, and these non-resolved wounds can produce several social, economic, and mental health issues in diabetic patients. At the same time, these people experience neuropathic pain that causes morbidity and a further decrease in their quality of life...
October 6, 2023: Macromolecular Bioscience
https://read.qxmd.com/read/37725136/effect-of-electrical-and-chemical-activation-versus-inactivation-stimulation-of-the-infralimbic-division-of-the-medial-prefrontal-cortex-in-rats-with-chronic-neuropathic-pain
#13
JOURNAL ARTICLE
Thais Lohanny Moura-Pacheco, Renata Cristina Martins-Pereira, Priscila Medeiros, Lourenço Sbragia, Christie Ramos Andrade Leite-Panissi, Hélio Rubens Machado, Norberto Cysne Coimbra, Renato Leonardo de Freitas
Neuropathic pain (NP) represents a complex disorder with sensory, cognitive, and emotional symptoms. The medial prefrontal cortex (mPFC) takes critical regulatory roles and may change functionally and morphologically during chronic NP. There needs to be a complete understanding of the neurophysiological and psychopharmacological bases of the NP phenomenon. This study aimed to investigate the participation of the infralimbic division (IFL) of the mPFC in chronic NP, as well as the role of the N-methyl-D-aspartic acid receptor (NMDAr) in the elaboration of chronic NP...
September 19, 2023: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/37708012/fully-implantable-neurostimulation-system-for-long-term-behavioral-animal-study
#14
JOURNAL ARTICLE
Wonok Kang, Jinseung Lee, Wonsuk Choi, Jinseok Kim, Junesun Kim, Sung-Min Park
Spinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI). Numerous studies on pain relief effects with SCS have been conducted and demonstrated promising results while the mechanisms of analgesic effect during SCS remain unclear. However, an experimental system that enables large-scale long-term animal studies is still an unmet need for those mechanistic studies. This study proposed a fully wireless neurostimulation system that can efficiently support a long-term animal study for neuropathic pain relief...
September 14, 2023: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/37619765/right-posterior-insular-epidural-stimulation-in-rats-with-neuropathic-pain-induces-a-frequency-dependent-and-opioid-system-mediated-reduction-of-pain-and-its-comorbid-anxiety-and-depression
#15
JOURNAL ARTICLE
Zeinab Mehsein, Sandra Kobaïter-Maarrawi, Hady Samaha, Mohamad El Shami, Sylvana Albeaini, Joseph Maarrawi
Neuropathic pain (NP) is a sensory, emotional, and persistent disturbing experience caused by a lesion or disease of the somatosensory system which can lead when chronic to comorbidities such as anxiety and depression. Available treatments (pharmacotherapy, neurostimulation) have partial and unpredictable response; therefore, it seems necessary to find a new therapeutical approach that could alleviate most related symptoms and improve patients 'emotional state'. Posterior Insula seems to be a potential target of neurostimulation for pain relief...
August 22, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/37560573/pruritus-and-urticaria-induced-by-neurostimulation-a-case-report-and-review-of-literature
#16
Chirag Goel, Anusha Manjunath, Olivia A Kozel, Archit Bharathwaj Baskaran, William Gibson, Michael R Jones, Joshua M Rosenow
BACKGROUND: Spinal cord stimulation (SCS) consists of the implantation of neuromodulatory devices in the spinal cord to treat refractory neuropathic pain. Although SCS technology has been proven of immense clinical benefit, complications remain including refractory pain, infection risk, and electrode migration or displacement. Till date, there are minimal reports of allergic side effects following SCS implantation. CASE DESCRIPTION: In the first case, a 36-year-old male with chronic axial and radicular neuropathic pain in underwent implantation of an open paddle lead and generator...
2023: Surgical Neurology International
https://read.qxmd.com/read/37560564/spinal-cord-stimulation-induced-gastroparesis-a-case-report
#17
Anusha Manjunath, Chirag Goel, Archit Bharathwaj Baskaran, Olivia A Kozel, William Gibson, Michael Jones, Joshua M Rosenow
BACKGROUND: Spinal cord stimulation (SCS) involves the utilization of an implantable neurostimulation device, stereotypically used in the treatment of patients with chronic neuropathic pain. While these devices have been shown to have significant clinical benefits, there have also been documented potential complications, including the risk of infection, fractured electrodes, electrode migration, and lack of symptom improvement. In addition, there has been minimal documentation on gastrointestinal (GI) side effects after SCS implantation...
2023: Surgical Neurology International
https://read.qxmd.com/read/37554798/twiddler-s-syndrome-after-dorsal-root-ganglion-stimulation-a-case-report
#18
Maarten Vanloon, Vincent Raymaekers, Sacha Meeuws, Mark Plazier
Dorsal root ganglion stimulation (DRG-S) is a promising therapy for chronic neuropathic pain, but complications of this therapy are poorly understood. Twiddler's syndrome, a rare complication characterized by lead displacement and coiling of wires, has been reported in other neuromodulation devices, but has not been described in the context of DRG-S. Here, we present a first-of-a-kind case report of Twiddler's syndrome occurring after 8 months of DRG-S. This case report highlights the importance of considering Twiddler's syndrome as a potential complication in patients undergoing DRG-S, especially in those with significant weight loss history...
August 2023: Heliyon
https://read.qxmd.com/read/37436342/neurostimulation-for-chronic-pain-a-systematic-review-of-high-quality-randomized-controlled-trials-with-long-term-follow-up
#19
REVIEW
Yilong Zheng, Christopher Weiyang Liu, Diana Xin Hui Chan, Damian Wen Kai Ong, Justin Rui Xin Ker, Wai Hoe Ng, Kai Rui Wan
OBJECTIVE: This study aimed to review the best evidence on the long-term efficacy of neurostimulation for chronic pain. MATERIALS AND METHODS: We systematically reviewed PubMed, CENTRAL, and WikiStim for studies published between the inception of the data bases and July 21, 2022. Randomized controlled trials (RCTs) with a minimum of one-year follow-up that were of high methodologic quality as ascertained using the Delphi list criteria were included in the evidence synthesis...
October 2023: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/37249006/differential-target-multiplexed-spinal-cord-stimulator-a-review-of-preclinical-clinical-data-and-hardware-advancement
#20
REVIEW
Melissa Z Murphy, Michael A Fishman
Spinal cord stimulation (SCS) is an effective neuromodulation technique for treating chronic neuropathic pain. Recent rapid growth in understanding its mechanism has led to the development of glial cell-based differential target multiplexed (DTM) stimulation and its derivative algorithm. Both preclinical research and clinical trials in humans showed superior pain relief using DTM SCS compared with traditional SCS. Another multicenter prospective clinical trial showed significant pain score reduction and energy saving using the DTM derivative algorithm...
April 2023: Pain Management
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