Yue Long, Jie Ren, FuChao Cheng, YuMei Duan, BaoFeng Wang, Yuhao Sun, QingFang Sun, LiuGuan Bian, JunChen Yi, Ying Qin, RongBing Huang, WeiTong Guo, Hong Jiang, Chang Liu, Xiao Feng, Ling Qin
BACKGROUND: Cushing's Disease (CD) is a rare clinical syndrome characterized by excessive secretion of adrenocorticotrophic hormone, leading to significant functional and structural brain alterations as observed in Magnetic Resonance Imaging (MRI). While traditional statistical analysis has been widely employed to investigate these MRI changes in CD, it has lacked the ability to predict individual-level outcomes. PURPOSE: To address this problem, this paper has proposed an interpretable machine learning (ML) framework, including model-level assessment, feature-level assessment, and biology-level assessment to ensure a comprehensive analysis based on structural MRI of CD...
April 1, 2024: Medical Physics