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Advanced Wound Dressing

Julie Bitner, Ulka Sachdev, Eric S Hager, Ellen D Dillavou
BACKGROUND: Venous ulcers are painful, recurrent, and difficult to heal. Electronic medical records (EMRs) are often not optimized to track wounds. Specialized wound care programs may not interface with office-based records, creating a need to standardize the process of venous ulcer measurement and dressing documentation within existing systems. This work describes the creation of an EMR protocol to track venous ulcer size, to standardize dressings, to address related health issues, and to improve education of the patient...
February 15, 2019: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Radhika Narayanaswamy, Vladimir P Torchilin
Conventional drug delivery approaches are plagued by issues pertaining to systemic toxicity and repeated dosing. Hydrogels offer convenient drug delivery vehicles to ensure these disadvantages are minimized and the therapeutic benefits from the drug are optimized. With exquisitely tunable physical properties that confer them great controlled drug release features and the merits they offer for labile drug protection from degradation, hydrogels emerge as very efficient drug delivery systems. The versatility and diversity of the hydrogels extend their applications beyond targeted drug delivery also to wound dressings, contact lenses and tissue engineering to name but a few...
February 8, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
I A Placinta, E España-Gregori, A Rodrigo-Hernández, C Martínez-Rubio, J Safont-Albert, M Á Bort-Martí
An 80 year-old woman with no relevant medical history, consulted for worsening of right palpebral itching and pain after an insect bite. Her eyelids had areas of laceration due to scratching, which rapidly progressed to fibrinoid necrosis over the first 24hours. Lesions were cultivated, revealing Streptococcus pyogenes and Staphylococcus aureus. The patient was admitted to hospital with the diagnosis of periorbital necrotising fasciitis, in order to receive treatment with intravenous ceftriaxone, linezolid, and immediate surgical debridement...
February 4, 2019: Archivos de la Sociedad Española de Oftalmología
Daniel V Zurawski, Chad C Black, Yonas A Alamneh, Lionel Biggemann, Jaideep Banerjee, Mitchell G Thompson, Matthew C Wise, Cary L Honnold, Robert K Kim, Chrysanthi Paranavitana, Jonathan P Shearer, Stuart D Tyner, Samandra T Demons
Objective: To better understand Acinetobacter baumannii pathogenesis and to advance drug discovery against this pathogen, we developed a porcine, full-thickness, excisional, monospecies infection wound model. Approach: The research was facilitated with AB5075, a previously characterized, extensively drug-resistant A . baumannii isolate. The model requires cyclophosphamide-induced neutropenia to establish a skin and soft tissue infection (SSTI) that persists beyond 7 days. Multiple, 12-mm-diameter full-thickness wounds were created in the skin overlying the cervical and thoracic dorsum...
January 1, 2019: Advances in Wound Care
Rachael Zoe Murray, Zoe Elizabeth West, Allison June Cowin, Brooke Louise Farrugia
There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.
2019: Burns and Trauma
Lucie Bacakova, Julia Pajorova, Marketa Bacakova, Anne Skogberg, Pasi Kallio, Katerina Kolarova, Vaclav Svorcik
Nanocellulose is cellulose in the form of nanostructures, i.e., features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, found in bacterial cellulose; nanofibers, present particularly in electrospun matrices; and nanowhiskers, nanocrystals, nanorods, and nanoballs. These structures can be further assembled into bigger two-dimensional (2D) and three-dimensional (3D) nano-, micro-, and macro-structures, such as nanoplatelets, membranes, films, microparticles, and porous macroscopic matrices...
January 29, 2019: Nanomaterials
Hsin-Chung Tsai, Caitlin W Lehman, Chuan-Mu Chen
OBJECTIVE: To compare the healing results between platelet-rich plasma (PRP) and platelet-derived patches versus traditional advanced wound dressings in patients with chronic wounds. METHOD: Patients with and without diabetes were divided into two groups, each of which received either PRP patch treatments or the advanced wound dressings. All wounds were cleaned, debrided and assessed by physicians. The data were analysed and represented as mean ± standard deviation (SD)...
January 2, 2019: Journal of Wound Care
Kersten Reider, Elizabeth McElroy, Stormy Lemay
The human body is a complex, multisystem organism that can manifest disease processes in a multitude of ways. Over the decades, technological advancements have allowed us to make precise diagnoses so that clinicians can thoroughly treat the underlying cause. Frequently these disease processes require surgical intervention to eliminate the progression and provide the patient with positive outcomes. When surgical intervention is required, the patient is often left with large complex wounds. Just like medical advancements, wound care modalities have made vast technological improvements...
October 29, 2018: Curēus
Linda L Benskin
Objective: Wound management recommendations usually group dressings by base substrate material or reimbursement codes, even when functional differences are vast ( e.g ., honey-containing alginates, super-absorbent hydrogels). Polymeric membrane dressings (PMDs) diverge dramatically from conventional foam dressings in functional attributes, indications, and patient results, providing an opportunity to demonstrate the evidence for categorizing dressings based upon functional differences. Approach: A search of ALL published literature describing the use of PMDs, with no date or language limits, was conducted...
December 1, 2018: Advances in Wound Care
Allen Gabriel, Subhas Gupta, Dennis P Orgill
Postoperative complications such as surgical site infections, dehiscence, seromas, and hematomas prolong wound care and impose significant cost increases to patients and healthcare providers. Clinicians aiming to reduce the incidence of these complications should be aware of risk factors associated with surgical type, procedures used, patient characteristics, and postoperative care. Today, improved guidelines and general practices for managing surgical incisions have reduced the incidence of complications to historic lows...
January 2019: Plastic and Reconstructive Surgery
C M Han, M R Yu, X G Wang
Wound healing is a complex and sequential biological process involving various cells and factors under body's regulation. Appropriate interventions play positive roles in promoting effective wound healing and improving healing quality. In the clinical practice, there are many new instruments, dressings, and drugs developed for wound care, including antibacterial dressings, wet dressings, precise debridement, negative pressure wound therapy, cytokines/growth factors, and dermal substitutes, which provide revolutionary means for wound treatment...
December 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Ilaria Zollino, Diana Campioni, Maria Grazia Sibilla, Mirko Tessari, Anna Maria Malagoni, Paolo Zamboni
BACKGROUND AIMS: Preclinical and observational reports indicate that adipose tissue (AT) is a safe and promising tool to treat non-healing venous leg ulcers (VLUs). METHODS: From an initial cohort of 38 patients, 16 patients affected by non-healing VLUs were randomly allocated to the experimental arm (5 men and 3 women) and control arm (5 men and 3 women). In the experimental arm, wounds were treated by debridement, centrifuged adipose tissue (CAT), advanced dressings and compression...
December 21, 2018: Cytotherapy
Brindha J, Kaushik Chanda, Balamurali M M
Utilization of protein-protein interactions or protein-peptide interactions has led to new crosslinking chemistries, resulting into protein hydrogels. Enzyme catalyzed crosslinking of specific amino acids has also been used to generate crosslinked protein hydrogels. Weak, temporary, reversible or non-covalently crosslinked protein gels as well as strong, permanent, irreversible or covalently crosslinked protein gels with mechanical strengths of varying degrees are generated by means of various crosslinking strategies...
February 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
Pierluigi Bonomo, Isacco Desideri, Mauro Loi, Lucia Pia Ciccone, Monica Lo Russo, Carlotta Becherini, Daniela Greto, Gabriele Simontacchi, Nicola Pimpinelli, Lorenzo Livi
PURPOSE: Severe bio-radiation dermatitis may develop in patients treated with concurrent radiotherapy and cetuximab for head and neck squamous cell carcinoma. The aim of our work was to report on the impact of a grade-specific management approach on treatment tolerability. METHODS: Concomitant radiotherapy and cetuximab was prescribed for patients deemed ineligible for cisplatin-based chemoradiation. Since 2014, an advanced wound care nursing team was established in our clinic to implement a standardized policy for skin toxicity...
December 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Makram E Aljghami, Sundas Saboor, Saeid Amini-Nik
The skin provides a protective barrier to the body against the environment. Ineffective healing of damaged skin can cause a chronic wound which would increase the risk of infection and associated complications. The use of wound dressings to protect the wound and provide an optimal environment for wound repair is a common practice in the burn clinic. While traditional wound healing dressings have substantially changed the wound outcome, wound healing complications are still a challenge to healthcare. Advancements in tissue engineering, biomaterial sciences, and stem cell biology led to the development of novel dressings that not only dress the wounds but also actively contribute to the process of healing...
December 12, 2018: Annals of Biomedical Engineering
G Conzatti, S Cavalie, F Gayet, J Torrisani, N Carrère, A Tourrette
Alginate and chitosan are polysaccharides that are widely used in the biomedical field, especially as wound dressings. Controlled bioadhesion is an advanced functionality that offers the potential to reduce injuries due to the stripping-off of the biomaterial. Herein, we report the efficient grafting of poly-N(isopropylacryamide) (PNIPAM), a thermosensitive polymer that exhibits a lower critical solution temperature (LCST) at 32 °C on the alginate/chitosan polyelectrolyte complex (PEC) surface. In vitro studies did not exhibit a cytotoxic effect, and cells adhered preferentially on the LCST on PNIPAM grafted surfaces, as reported in the literature...
November 30, 2018: Colloids and Surfaces. B, Biointerfaces
Polly E Kintzel, Jared D Knol, Gretchen Roe
INTRODUCTION: Intravenous lidocaine is an option for intractable pain caused by advancing cancer and wound care. We report a case of intractable cancer pain and wound care pain managed with concurrent use of lidocaine administered as a twice daily intravenous bolus in addition to continuous intravenous infusion. CASE DESCRIPTION: A 31-year-old male with rapidly progressing locally advanced squamous cell cancer affecting the gluteal area developed extensive painful and purulent ulcerating wounds affecting the coccyx, superior gluteal cleft, and buttocks...
December 1, 2018: Journal of Palliative Medicine
Deepak Nanda, Shamendra Anand Sahu, Durga Karki, Sanjay Kumar, Amrita Mandal
Background: Despite advances in surgical skills, adipofascial flaps are still less preferred option for coverage of leg defect. We evaluate the use of perforator-based adipofascial flap in small-to-medium-sized soft-tissue defects in the lower limb. Patients and Methods: After localisation of perforators along the major axial vessels in the lower limb using handheld Doppler, adipofascial flap based on the nearest best perforator of anterior tibial artery, posterior tibial artery and peroneal artery was raised to cover soft-tissue defect in 21 patients...
May 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Lindsey Blalock
INTRODUCTION: Current wound treatment options for complex wounds include advanced wound therapies. One such treatment, negative pressure wound therapy (NPWT), has evolved to include automated instillation of topical wound solutions with a user-specified dwell time (NPWTi-d). A novel reticulated open-cell foam dressing with through holes (ROCF-CC) was developed to assist wound cleansing by removing thick wound exudate and infectious material. OBJECTIVE: The author's experience using NPWTi-d with ROCF-CC on complex wounds is presented...
November 22, 2018: Wounds: a Compendium of Clinical Research and Practice
Sun Young Wang, Hyosuk Kim, Gijung Kwak, Hong Yeol Yoon, Sung Duk Jo, Ji Eun Lee, Daeho Cho, Ick Chan Kwon, Sun Hwa Kim
In the past few years, there have been many efforts underway to develop effective wound healing treatments for traumatic injuries. In particular, wound-healing peptides (WHPs) and peptide-grafted dressings hold great promise for novel therapeutic strategies for wound management. This study reports a topical formulation of a new synthetic WHP (REGRT, REG) embedded in a hyaluronic acid (HA)-based hydrogel dressing for the enhancement of acute excisional wound repair. The copper-free click chemistry is utilized to form biocompatible HA hydrogels by cross-linking dibenzocyclooctyl-functionalized HA with 4-arm poly(ethylene glycol) (PEG) azide...
November 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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