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Sajjad ahmad

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https://read.qxmd.com/read/30725250/artemisia-amygdalina-upregulates-nrf2-and-protects-neurons-against-oxidative-stress-in-alzheimer-disease
#1
Nasreena Sajjad, Abubakar Wani, Ankita Sharma, Rohaya Ali, Sumaya Hassan, Rabia Hamid, Huma Habib, Bashir Ahmad Ganai
Alzheimer disease is a complex neurodegenerative disorder. It is the common form of dementia in elderly people. The etiology of this disease is multifactorial, pathologically it is accompanied with accumulation of amyloid beta and neurofibrillary tangles. Accumulation of amyloid beta and mitochondrial dysfunction leads to oxidative stress. In this study, neuroprotective effect of Artemisiaamygdalina against H2 O2 -induced death was studied in differentiated N2a and SH-SY5Ycells. Cells were treated with H2 O2 to induce toxicity which was attenuated by Artemisia amygdalina...
February 6, 2019: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/30688407/allogeneic-ex-vivo-expanded-corneal-epithelial-stem-cell-transplantation-a-randomized-controlled-clinical-trial
#2
John D M Campbell, Sajjad Ahmad, Ashish Agrawal, Carol Bienek, Anne Atkinson, Neil W A Mcgowan, Stephen Kaye, Sanjay Mantry, Kanna Ramaesh, Alison Glover, Jane Pelly, Coral MacRury, Margaret MacDonald, Emily Hargreaves, Jacqueline Barry, John Drain, Bruce Cuthbertson, Louis Nerurkar, Ian Downing, Alasdair R Fraser, Marc L Turner, Baljean Dhillon
Limbal stem cell deficiency (LSCD) is a disease resulting from the loss or dysfunction of epithelial stem cells, which seriously impairs sight. Autologous limbal stem cell transplantation is effective in unilateral or partial bilateral disease but not applicable in total bilateral disease. An allogeneic source of transplantable cells for use in total bilateral disease can be obtained from culture of donated cadaveric corneal tissue. We performed a controlled multicenter study to examine the feasibility, safety, and efficacy of allogeneic corneal epithelial stem cells in the treatment of bilateral LSCD...
January 28, 2019: Stem Cells Translational Medicine
https://read.qxmd.com/read/30668370/in-vitro-efficacy-of-eugenol-in-inhibiting-single-and-mixed-biofilms-of-drug-resistant-strains-of-candida-albicans-and-streptococcus-mutans
#3
Huma Jafri, Mohd Sajjad Ahmad Khan, Iqbal Ahmad
BACKGROUND: Candida albicans is frequently associated with mixed infections of Streptococcus mutans in plaque biofilms. These pathogens under chemical interactions resulting in mixed biofilm development have turned it into a prevalent and costly oral disease, which is not successfully being treated by existing chemotherapeutics. HYPOTHESIS: Considering the need for newer drugs to overcome this challenge, the present study was aimed to investigate the efficacy of eugenol in inhibiting single and mixed biofilms of C...
October 9, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30642847/rare-case-of-hashimoto-s-encephalitis-mimicking-grief-reaction
#4
Angeliki Giannopoulou, Sajjad Ahmad, Chandranath Sarkar, Atul Kalhan
A 46-year-old woman was admitted with tonic-clonic seizures. She was noticed to be withdrawn and low in mood for few months. She had reduced level of consciousness with hyper-reflexia and myoclonus. Metabolic, vasculitic, autoimmune, paraneoplastic and septic screen were normal. Lumbar puncture showed raised protein in the cerebrospinal fluid but the cytology, bacterial and viral screens were negative. A CT of the head revealed global brain swelling consistent with encephalitis which was empirically treated with antibiotics and antiviral therapy...
January 14, 2019: BMJ Case Reports
https://read.qxmd.com/read/30630573/evaluation-of-genexpert-mtb-rif-assay-for-detection-of-pulmonary-tuberculosis-on-sputum-samples
#5
Altintas Yasemin, Sajjad Ahmad, Sumera Afzal, Aman Ullah, Anwar Sheed
OBJECTIVE: To analyse the diagnostic performance of MTB/RIF assay for the diagnosis of pulmonary tuberculosis and detection of rifampicin resistance using sputum samples. STUDY DESIGN: Observational cross-sectional study. PLACE AND DURATION OF STUDY: Provincial TB Reference Laboratory (PTRL), Hayatabad Medical Complex, Peshawar, Pakistan, from January to October 2015. METHODOLOGY: A total of 268 participants were consecutively enrolled in the study after meeting the inclusion criteria...
January 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/30606171/bio-guided-profiling-and-hplc-dad-finger-printing-of-atriplex-lasiantha-boiss
#6
Tanzeel Zohra, Muhammad Ovais, Ali Talha Khalil, Muhammad Qasim, Muhammad Ayaz, Zabta Khan Shinwari, Sajjad Ahmad, Mohammad Zahoor
BACKGROUND: Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of various ailments. The current study has been aimed to validate the therapeutic potential of ethnomedicinally significant plant Atriplex lasiantha Boiss. METHODS: The polarity based extraction process was carried out using fourteen solvents to figure out best extraction solvent and bioactive fractions. Total phenolic-flavonoids contents were quantified colorimetrically and polyphenolics were measured using HPLC-DAD analysis...
January 3, 2019: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/30591791/role-of-diagnostic-factors-associated-with-antioxidative-status-and-expression-of-matrix-metalloproteinases-mmps-in-patients-with-cancer-therapy-induced-ocular-disorders
#7
Mahmood Rasool, Arif Malik, Muhammad Abdul Basit Ashraf, Mahwish Arooj, Asia Kiran, Sulayman Waquar, Ujala Ayyaz, Ayesha Zahid, Ahmad Zaheer, Abdul Jabbar, Maryam Zain, Amir Raza, Asim Mehmood, Tahira Batool Qaisrani, Zeenat Mirza, Mohammed Hussein Al-Qahtani, Sajjad Karim, Absarul Haque
Background: Cancer patients when treated with different chemotherapeutic drugs often develop mild to severe sight threatening diseases during or after chemotherapy. The mechanism involved in the pathogenesis of ocular toxicities is poorly understood. Oxidative stress, inflammation and MMPs (angiogenic factor) are involved in the progression of chemotherapy related ocular disorders. Materials and methods: The concentration of oxidative stress markers such as MDA, NO and levels of different antioxidant molecules such as SOD, CAT, GSH, GPx, GPr, VIT A, VIT E and VIT C present in the serum of chemotherapy treated patients ( n  = 50) and in normal persons ( n  = 20) were estimated by the direct spectrophotometric method while the concentration of TNF-α and MMP-9 activity were determined using human TNF-α and MMP-9 ELISA kits...
December 2018: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/30469056/insecticide-toxic-effects-and-blood-biochemical-alterations-in-occupationally-exposed-individuals-in-punjab-pakistan
#8
Khizar Hayat, Muhammad Afzal, Muhammad Anjum Aqueel, Sajjad Ali, Muhammad Farhan Saeed, Ahmad Kaleem Qureshi, Muhammad Irfan Ullah, Qaiser M Khan, Muhammad Tayyib Naseem, Umair Ashfaq, Christos A Damalas
Biomonitoring of people exposed to hazardous materials provides opportunities for early identification of several diseases, particularly in those individuals who are constantly exposed to pesticides, such as pesticide operators and workers in pesticide manufacturing industry. However, data on this hot topic are limited in Pakistan. In this study, insecticide toxic effects and biochemical alterations (i.e., damage in DNA and enzyme activity) were studied in blood samples of occupationally exposed individuals from Punjab, Pakistan...
November 13, 2018: Science of the Total Environment
https://read.qxmd.com/read/30465389/chondroectodermal-syndrome
#9
Asad Ullah Jan, Sajjad Ahmad, Tehseen Ahmad Cheema, Farman Ullah, Muhammad Waqar, Baqir Hussain
Chondroectodermal syndrome or Ellis Van Creveld (EVC) is a rare autosomal recessive congenital disorder. It was first described by Richard W.B.Ellis and Simon Van Creveld in 1940. Parental consanguinity is present in about 30% of the cases. A large number of cases were reported in Amish population of Lancaster County, Pennsylvania USA and also in Aboriginal community of Australia in 1964. The incidence in Amish population is 1/5000 live births and in general population 7/1,000,000. There are only 150 cases reported worldwide...
July 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://read.qxmd.com/read/30410128/effectiveness-of-intralesional-steroid-injections-with-dilatation-in-corrosive-oesophageal-strictures-a-randomized-control-trial
#10
Fawad Ahmad Randhawa, Nasir Farooq Butt, Syed Osama Talat, Sajjad Hussain Sabir, Muhammad Adeel Qamar
OBJECTIVE: To compare the improvement of dilatation among patients receiving intralesional steroid injection with dilatation versus dilatation alone for the management of corrosive ooesophageal strictures. METHODS: The randomized controlled trial was conducted at Mayo Hospital, Lahore, Pakistan, from November 10, 2014, to November 10, 2015, and comprised patients of either gender aged 15-50years who had corrosive ooesophageal stricture. They were randomised into 2 groups by using the lottery method...
November 2018: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/30406854/performance-assessment-of-artificial-neural-networks-and-support-vector-regression-models-for-stream-flow-predictions
#11
Ateeq-Ur-Rauf, Abdul Razzaq Ghumman, Sajjad Ahmad, Hashim Nisar Hashmi
Water resources planning, development, and management need reliable forecasts of river flows. In past few decades, an important dimension has been introduced in the prediction of the hydrologic phenomenon through artificial intelligence-based modeling. In this paper, the performance of three artificial neural network (ANN) and four support vector regression (SVR) models was investigated to predict streamflows in the Upper Indus River. Results from ANN models using three different optimization techniques, namely Broyden-Fletcher-Goldfarb-Shannon, Conjugate Gradient, and Back Propagation algorithms, were compared with one another...
November 8, 2018: Environmental Monitoring and Assessment
https://read.qxmd.com/read/30405995/anomalous-origin-of-left-anterior-descending-artery-and-left-circumflex-artery-from-right-coronary-sinus-with-malignant-left-anterior-descending-artery-course-role-of-coronary-ct-angiography-derived-fractional-flow-reserve-in-decision-making
#12
Hassan Tahir, Sajjad Ahmad, Muhammad U Awan, Bassam Omar, Joey Glass, Jason Cole
Congenital coronary anomalies are uncommon and are mostly asymptomatic; however, patients may have symptoms depending on the origin and course of anomalous artery. Very rarely, coronary anomalies can also lead to life-threatening complications especially in young athletes. A malignant course of the left main (LM) or left anterior descending (LAD) artery between aorta and pulmonary artery is considered the most significant risk factor for such complications. Various noninvasive tests are available to evaluate myocardial ischemia due to anomalous coronary artery...
August 28, 2018: Curēus
https://read.qxmd.com/read/30385451/the-feasibility-of-finger-prick-autologous-blood-fab-as-a-novel-treatment-for-severe-dry-eye-disease-ded-protocol-for-a-randomised-controlled-trial
#13
Shafi Balal, Arit Udoh, Yannis Pappas, Erica Cook, Garry Barton, Ali Hassan, Karen Hayden, Rupert Richard Alexander Bourne, Sajjad Ahmad, Shahina Pardhan, Michael Harrison, Benjamin Sharma, Mohammad Wasil, Anant Sharma
INTRODUCTION: Patients with severe dry eye disease (DED) often have limited treatment options with standard non-surgical management focused on the use of artificial tears for lubrication and anti-inflammatory drugs. However, artificial tears do not address the extraordinary complexity of human tears. Crudely, human tears with its vast constituents is essentially filtered blood. Blood and several blood-derived products including autologous serum, have been studied as tear substitutes. This study proposes to test the use of whole, fresh, autologous blood obtained from a finger prick for treatment of severe DED...
October 31, 2018: BMJ Open
https://read.qxmd.com/read/30317274/severe-haemolysis-and-renal-failure-precipitated-by-hepatitis-e-virus-in-g6pd-deficient-patient-a-case-report
#14
Baseer Sultan Ahmad, Adeel Ahmad, Sajjad Jamil, Saiyed Abdullah Abubakar Mohsin Ehsanullah, Abeera Munir
Hepatitis E virus is the etiological agent for Hepatitis E infection, which is congruent to Hepatitis A infection. The clinical spectrum of the disease range from asymptomatic self-limiting disease which requires no treatment to life threatening fulminant liver disease in pregnancy, G6PD deficient and post-liver transplant patients, which necessitate urgent treatment. Similarly we are reporting a case of a 28 year old male with no previous known comorbids, who presented in emergency department with low grade fever, yellow discolouration of eyes and upper abdominal pain for last 5-6 days...
September 2018: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/30306508/antiproliferative-antioxidant-and-binding-mechanism-analysis-of-prodigiosin-from-newly-isolated-radio-resistant-streptomyces-sp-strain-wma-lm31
#15
Wasim Sajjad, Sajjad Ahmad, Iffat Aziz, Syed Sikander Azam, Fariha Hasan, Aamer Ali Shah
Streptomyces genus are filamentous Gram positive bacteria, of great intrest, producing biologically active compounds. Recent market and consumer curiosity in natural products have forced scientist and industry for the development of new products with therapeutic potential. This study focuses on evaluation of antioxidant and anticancerous properties of prodigiosin from radio-resistant Streptomyces sp. strain WMA-LM31. A molecular docking approach was adopted to understand theoretical binding mechanism and affinity for anticancer targets...
October 10, 2018: Molecular Biology Reports
https://read.qxmd.com/read/30280040/biosorption-potential-of-natural-pyrolysed-and-acid-assisted-pyrolysed-sugarcane-bagasse-for-the-removal-of-lead-from-contaminated-water
#16
Ghulam Mustafa Shah, Muhammad Nasir, Muhammad Imran, Hafiz Faiq Bakhat, Faiz Rabbani, Muhammad Sajjad, Abu Bakr Umer Farooq, Sajjad Ahmad, Lifen Song
Lead (Pb) is a ubiquitous pollutant which poses serious threats to plants, animals and humans once entered into the food chain via contaminated industrial effluents on their discharge into the surface of water bodies and/or geological materials. This study aimed to examine and compare the biosorption potential of natural sugarcane bagasse (NB), pyrolysed sugarcane bagasse (PB) and acid assisted pyrolysed sugarcane bagasse (APB) for the removal of Pb from contaminated water. To explore this objective, a series of batch experiments were conducted at various adsorbent mass (0...
2018: PeerJ
https://read.qxmd.com/read/30273644/subtractive-proteomics-and-immunoinformatics-revealed-novel-b-cell-derived-t-cell-epitopes-against-yersinia-enterocolitica-an-etiological-agent-of-yersiniosis
#17
Qurat Ul Ain, Sajjad Ahmad, Syed Sikander Azam
Yersinia enterocolitica is the third most common cause of gastrointestinal manifestations in Europe. Statistically, every year the pathogen accounts for 640 hospitalizations, 117,000 illnesses, and 35 deaths in the United States. The associated mortality rate of the pathogen is 50% and is virtually resistant to penicillin G, ampicillin and cephalotin. The development of new and effective therapeutic procedures is urgently needed to counter the multi-drug-resistant phenotypes imposed by the said pathogen. Based on subtractive reverse vaccinology and immunoinformatics approaches, we have successfully predicted novel antigenic peptide vaccine candidates against Y...
September 28, 2018: Microbial Pathogenesis
https://read.qxmd.com/read/30218800/the-identification-of-factors-that-influence-the-quality-of-bypass-anastomosis-and-an-evaluation-of-the-usefulness-of-an-experimental-practical-scale-in-this-regard
#18
Ahmad Hafez, Justiina Huhtakangas, Sajjad Muhammad, Michael T Lawton, Rokuya Tanikawa, Mika Niemelä
BACKGROUND: Several factors associated with interrupted and continuous suturing techniques affect the quality of bypass anastomosis. It is difficult to determine the impact of these factors during surgery. The primary objective of this study was to evaluate factors with the potential to influence the quality of bypass anastomosis using either interrupted or continuous suturing. A secondary objective was to evaluate the usefulness of a practical scale when comparing interrupted and continuous suturing techniques to improve bypass anastomosis...
September 12, 2018: World Neurosurgery
https://read.qxmd.com/read/30140674/corrigendum-ursolic-acid-hydrazide-based-organometallic-complexes-synthesis-characterization-antibacterial-antioxidant-and-docking-studies
#19
Muafia Jabeen, Sajjad Ahmad, Khadija Shahid, Abdul Sadiq, Umer Rashid
[This corrects the article DOI: 10.3389/fchem.2018.00055.].
2018: Frontiers in Chemistry
https://read.qxmd.com/read/30133634/dengue-seroprevalence-and-its-socioeconomic-determinants-in-faisalabad-pakistan-a-cross-sectional-study
#20
Faiz Ahmed Raza, Sajjad Ashraf, Shahida Hasnain, Jameel Ahmad, Mazhar Iqbal
INTRODUCTION: Socioeconomic disparities in the community make some groups more vulnerable to dengue infection. METHODS: Fourteen dengue cases (IgM positive) served as index cases for the positive geographic cluster investigations. RESULTS: Of 292 individuals, the overall dengue seroprevalence was 22.9% (IgM positive 4.8%; IgG positive 18.1%). The highest (45%) seroprevalence was reported in the most socioeconomically vulnerable lower class, followed by the middle class (39%)...
July 2018: Revista da Sociedade Brasileira de Medicina Tropical
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