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Sajjad ahmad ocular

John D M Campbell, Sajjad Ahmad, Ashish Agrawal, Carol Bienek, Anne Atkinson, Neil W A Mcgowan, Stephen Kaye, Sanjay Mantry, Kanna Ramaesh, Alison Glover, Jane Pelly, Coral MacRury, Margaret MacDonald, Emily Hargreaves, Jacqueline Barry, John Drain, Bruce Cuthbertson, Louis Nerurkar, Ian Downing, Alasdair R Fraser, Marc L Turner, Baljean Dhillon
Limbal stem cell deficiency (LSCD) is a disease resulting from the loss or dysfunction of epithelial stem cells, which seriously impairs sight. Autologous limbal stem cell transplantation is effective in unilateral or partial bilateral disease but not applicable in total bilateral disease. An allogeneic source of transplantable cells for use in total bilateral disease can be obtained from culture of donated cadaveric corneal tissue. We performed a controlled multicenter study to examine the feasibility, safety, and efficacy of allogeneic corneal epithelial stem cells in the treatment of bilateral LSCD...
January 28, 2019: Stem Cells Translational Medicine
Mahmood Rasool, Arif Malik, Muhammad Abdul Basit Ashraf, Mahwish Arooj, Asia Kiran, Sulayman Waquar, Ujala Ayyaz, Ayesha Zahid, Ahmad Zaheer, Abdul Jabbar, Maryam Zain, Amir Raza, Asim Mehmood, Tahira Batool Qaisrani, Zeenat Mirza, Mohammed Hussein Al-Qahtani, Sajjad Karim, Absarul Haque
Background: Cancer patients when treated with different chemotherapeutic drugs often develop mild to severe sight threatening diseases during or after chemotherapy. The mechanism involved in the pathogenesis of ocular toxicities is poorly understood. Oxidative stress, inflammation and MMPs (angiogenic factor) are involved in the progression of chemotherapy related ocular disorders. Materials and methods: The concentration of oxidative stress markers such as MDA, NO and levels of different antioxidant molecules such as SOD, CAT, GSH, GPx, GPr, VIT A, VIT E and VIT C present in the serum of chemotherapy treated patients ( n  = 50) and in normal persons ( n  = 20) were estimated by the direct spectrophotometric method while the concentration of TNF-α and MMP-9 activity were determined using human TNF-α and MMP-9 ELISA kits...
December 2018: Saudi Journal of Biological Sciences
Shafi Balal, Arit Udoh, Yannis Pappas, Erica Cook, Garry Barton, Ali Hassan, Karen Hayden, Rupert Richard Alexander Bourne, Sajjad Ahmad, Shahina Pardhan, Michael Harrison, Benjamin Sharma, Mohammad Wasil, Anant Sharma
INTRODUCTION: Patients with severe dry eye disease (DED) often have limited treatment options with standard non-surgical management focused on the use of artificial tears for lubrication and anti-inflammatory drugs. However, artificial tears do not address the extraordinary complexity of human tears. Crudely, human tears with its vast constituents is essentially filtered blood. Blood and several blood-derived products including autologous serum, have been studied as tear substitutes. This study proposes to test the use of whole, fresh, autologous blood obtained from a finger prick for treatment of severe DED...
October 31, 2018: BMJ Open
Davide Borroni, Bogumil Wowra, Vito Romano, Maria Boyadzhieva, Diego Ponzin, Stefano Ferrari, Sajjad Ahmad, Mohit Parekh
Simple limbal epithelial transplantation is a recently developed technique for treating limbal stem cell deficiency caused by ocular burns. A small limbal biopsy from the donor eye, usually from the patient's healthy eye, is excised and dissected into multiple pieces. An amniotic membrane is atttached using fibrin glue on the diseased eye after removing the conjunctivalized pannus from the corneal surface. The limbal biopsy pieces are placed onto the amniotic membrane, fixed with fibrin glue, followed by bandaging of the ocular surface with a contact lens...
November 2018: Survey of Ophthalmology
Bernhard Steger, Savitha Madhusudan, Stephen B Kaye, Amira Stylianides, Vito Romano, Sundas E Maqsood, Janice Harper, Sajjad Ahmad
PURPOSE: Despite the availability of systemic immunosuppressants, cicatricial conjunctivitis (CC) remains a potentially blinding ocular surface disease. We aim to describe the combined use of rituximab (RTX) and intravenous immunoglobulin (IVIg) for severe recalcitrant autoimmune CC. METHODS: In this single-center retrospective interventional case series with follow-up between 32 and 65 months, 3 cases with mucous membrane pemphigoid (patients 1-3) and 1 case with linear IgA disease (patient 4) were included...
December 2016: Cornea
Tiago Ramos, Deborah Scott, Sajjad Ahmad
The human ocular surface (front surface of the eye) is formed by two different types of epithelia: the corneal epithelium centrally and the conjunctival epithelium that surrounds this. These two epithelia are maintained by different stem cell populations (limbal stem cells for the corneal epithelium and the conjunctival epithelial stem cells). In this review, we provide an update on our understanding of these epithelia and their stem cells systems, including embryology, new markers, and controversy around the location of these stem cells...
2015: Stem Cells International
Shivani A Kasbekar, Mark N A Jones, Sajjad Ahmad, Daniel F P Larkin, Stephen B Kaye
PURPOSE: To investigate graft survival and surgical experience on clinical outcome following deep anterior lamellar keratoplasty (DALK). DESIGN: Multicenter cohort study. METHODS: The United Kingdom Transplant Database was used to identify patients who had undergone a first DALK or penetrating keratoplasty (PKP) for keratoconus. Data were collected at the time of surgery and at 1, 2, and 5 years postoperatively. Graft survival, best-corrected visual acuity, and refractive error were analyzed for 3 consecutive time periods...
December 2014: American Journal of Ophthalmology
Maryam Parvini, Leila Satarian, Kazem Parivar, Mohammad Javan, Mahdi Tondar, Sajjad Ahmad, Hossein Baharvand
The generation of retinal pigment epithelial (RPE) cells from pluripotent stem cells is a topic of interest over the past few years as dysfunctional RPE cells are a primary cause of ocular diseases. However, a number of obstacles need to be overcome before these cells can be used in clinical trials. This review aims to provide an overview of the latest reports on the generation of RPE cells from human pluripotent stem cells. Challenges that need to be addressed in future studies for their therapeutic applications are discussed...
October 2014: Molecular Neurobiology
Hamid Fesharaki, Ahmad Azizzadeh, Seyyed Mohamad Ghoreishi, Mohamad Fasihi, Sajjad Badiei, Leila Rezaei
BACKGROUND: Compensatory ocular counter-torsion (COCT) is supposed to maintain the eyes aligned with the visual environment following head tilt. Because of some recent controversies the functional capacity of this phenomenon was defined according to the extent of induced astigmatic axis error following head tilt. MATERIALS AND METHODS: Objective autorefractometry was performed on 70 eyes with a regular astigmatism of ≥2D at vertical, right head tilt and left head tilt positions of 5°, 10°, 15°, 20° and 25°...
2014: Advanced Biomedical Research
Sai Kolli, Sajjad Ahmad, Hardeep Singh Mudhar, Adam Meeny, Majlinda Lako, Francisco C Figueiredo
Ocular surface reconstruction with ex vivo expanded limbal stem cells (LSCs) is a widely used clinical treatment for patients with limbal stem cell deficiency (LSCD). This is not applicable to patients with bilateral LSCD where there are no remaining LSCs. Cultivated oral mucosa epithelium (OME) has been used as an alternative source of autologous epithelial stem cells for ocular reconstruction in few clinical trials. However, successful generation of stratified OME epithelium has only been achieved in the presence of animal feeder cells and/or animal-derived products in the culture media, likely to contribute to increased risk of pathogen transmission and graft rejection...
August 2014: Stem Cells
Bakiah Shaharuddin, Sajjad Ahmad, Annette Meeson, Simi Ali
Cornea transplantation has been considered to be different from other solid organ transplantation because of the assumed immune-privileged state of the anterior chamber of the eye. Three major lines of thought regarding the molecular mechanisms of immune privilege in the eye are as follows: (a) anatomical, cellular, and molecular barriers in the eye; (b) anterior chamber-associated immune deviation; and (c) immunosuppressive microenvironment in the eye. However, cornea transplants suffer allograft rejection when breached by vascularization...
August 2013: Stem Cells Translational Medicine
Bakiah Shaharuddin, Sajjad Ahmad, Simi Ali, Annette Meeson
Corneal blindness carries a morbidity that affects quality of life and is often associated with an increased economic burden. In this review, we focus on the severe and painful condition of limbal stem cell deficiency, an important cause of corneal blindness. Conventional corneal transplantation usually results in graft failure and is contraindicated in this condition. Ex vivo-expanded limbal epithelial transplantation has been used as a cellular-based therapy to regenerate and reconstruct the ocular surface as a mode of treatment...
May 2013: Regenerative Medicine
Gustavo S Figueiredo, Sai S P Kolli, Sajjad Ahmad, Kevin Gales, Francisco C Figueiredo
BACKGROUND: Urrets-Zavalia syndrome (UZS) consists of a fixed dilated pupil associated with iris atrophy. It is a poorly understood complication following penetrating keratoplasty (PKP) for keratoconus (KC). In this work, we aim to establish the incidence, visual outcomes, and an understanding of UZS. METHODS: This was a retrospective single-center study in a tertiary eye service in the United Kingdom of consecutive patients with UZS following PKP for KC in a 10-year period...
March 2013: Graefe's Archive for Clinical and Experimental Ophthalmology
Medi Eslani, Alireza Baradaran-Rafii, Sajjad Ahmad
Stem cells located at the limbus are the ultimate source for regeneration of the corneal epithelium in normal and traumatized states. When limbal stem cells are dysfunctional or deficient, limbal stem cell deficiency (LSCD) develops. Its surgical management depends on laterality and severity of corneal-limbal involvement. Conventional methods of stem cell transplantation are conjunctival-limbal autograft (CLAU), conjunctival-limbal allograft (CLAL), and kerato-limbal allograft (KLAL) surgeries. Cultivated limbal epithelial transplantation (CLET) and cultivated oral mucosal epithelial transplantation (COMET) on a carrier such as amniotic membrane are current surgical alternatives...
May 2012: Seminars in Ophthalmology
Ruby Shalom-Feuerstein, Laura Serror, Stephanie De La Forest Divonne, Isabelle Petit, Edith Aberdam, Livia Camargo, Odile Damour, Clotilde Vigouroux, Abraham Solomon, Cédric Gaggioli, Joseph Itskovitz-Eldor, Sajjad Ahmad, Daniel Aberdam
Approximately 6 million people worldwide are suffering from severe visual impairments or blindness due to corneal diseases. Corneal allogeneic transplantation is often required to restore vision; however, shortage in corneal grafts and immunorejections remain major challenges. The molecular basis of corneal diseases is poorly understood largely due to lack of appropriate cellular models. Here, we described a robust differentiation of human-induced pluripotent stem cells (hiPSCs) derived from hair follicles or skin fibroblasts into corneal epithelial-like cells...
May 2012: Stem Cells
Sajjad Ahmad, Sai Kolli, Majlinda Lako, Francisco Figueiredo, Julie T Daniels
Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.
April 2010: Drug Discovery Today
Sai Kolli, Sajjad Ahmad, Majlinda Lako, Francisco Figueiredo
The corneal epithelium is maintained by a population of stem cells known as limbal stem cells (LSCs) due to their location in the basal layer of the outer border of the cornea known as the limbus. Treatment of limbal stem cell deficiency (LSCD) has been achieved with transplantation of ex vivo expanded LSCs taken from a small biopsy of limbus. This is a relatively new technique, and as such, specific national or international guidance has yet to be established. Because of the lack of such specific guidance, our group has sought to minimize any risk to the patient by adopting certain modifications to the research methodologies in use at present...
March 31, 2010: Stem Cells
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