Alessia Nisco, Tiago M A Carvalho, Maria Tolomeo, Daria Di Molfetta, Piero Leone, Michele Galluccio, Milagros Medina, Cesare Indiveri, Stephan Joel Reshkin, Rosa Angela Cardone, Maria Barile
FLAD1, along with its FAD synthase (FADS, EC 2.7.7.2) product, is crucial for flavin homeostasis and, due to its role in the mitochondrial respiratory chain and in nuclear epigenetics, is closely related to cellular metabolism. Therefore, it is not surprising that it could be correlated with cancer. To our knowledge, no previous study has investigated FLAD1 prognostic significance in pancreatic ductal adenocarcinoma (PDAC). Thus, in the present work, the FAD synthesis process was evaluated in two PDAC cell lines: (i) PANC-1 and PANC-1 derived cancer stem cells (CSCs), presenting the R273H mutation in the oncosuppressor p53, and (ii) MiaPaca2 and MiaPaca2 derived CSCs, presenting the R248W mutation in p53...
May 31, 2023: FEBS Journal