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Steroid AND Respiratory

Sean J Callahan, Andrew Vranic, Lucia Flors, Michael Hanley, Mark H Stoler, Borna Mehrad
Objective: To describe the clinical characteristics and outcomes of patients diagnosed with obliterative bronchiolitis (OB) not associated with transplantation or point-source exposures to inhaled toxins. Patients and Methods: We compiled all confirmed diagnoses of OB at our institution and analyzed their demographic characteristics, treatments, and outcomes as defined by pulmonary function tests (PFTs) and transplant-free mortality. The study period ranged from July 2007 to August 2017...
March 2019: Mayo Clinic Proceedings. Innovations, Quality & Outcomes
Christopher Nnaoma, Ogechukwu Chika-Nwosuh, Christian Engell
BACKGROUND Strongyloides stercoralis is an intestinal helminth. Parasitism is caused by penetration of the larvae through the skin. It is endemic in tropical and subtropical regions of the world and in the United States occurs in the southeastern region. It has a tendency to remain dormant or progress to a state of hyper-infection during immunosuppression. CASE REPORT We present the case of a 70-year-old Nigerian who developed fatal ARDS secondary to Strongyloides infection after been treated with steroids for treatment of autoimmune necrotizing myopathy...
March 22, 2019: American Journal of Case Reports
J M Pearson, E A Pajor, J R Campbell, N A Caulkett, M Levy, C Dorin, M C Windeyer
Assisted calves are often born weak, injured, or oxygen deprived and have a higher risk of morbidity and mortality. The objective was to investigate the impact of using pain mitigation at birth in assisted beef calves on physiological indicators of pain and inflammation, passive immunity, health, and growth. Thirty-three primiparous cows and their calves requiring assistance at birth on 2 ranches located in southern Alberta were enrolled. Data collected at birth included: date and time of calving, calf sex, meconium staining, presentation of calf, and calving difficulty (easy assist: 1 person manually delivered the calf; difficult assist: delivery by 2 or more people, or mechanical assistance)...
March 21, 2019: Journal of Animal Science
Melahat Uzel Şener, Ali Demir, Alp Şener
Lightning strike is an environmental electrical injury with high rates of morbidity and mortality. Lightning strike injuries are also considered to be high-voltage injuries. Respiratory injuries associated with lightning strikes include pulmonary edema, pulmonary contusion, acute respiratory distress syndrome, and pulmonary hemorrhage. In addition to direct damage, the affected patients are also exposed to secondary trauma; similarly, many other mechanisms associated with lightning injury have the same risk...
March 2019: Turkish Journal of Trauma & Emergency Surgery: TJTES
Ruth Waldron, Dympna Waldron, Eileen McMahon, Leona Reilly, Una Ni Riain, Catherine Fleming, Anthony O'Regan
Background: Mycobacterium goodii is a rapidly growing nontuberculous mycobacterium which has been associated with several infections including cellulitis, osteomyelitis, lymphadenitis, infected pacemakers and bursitis but it is a rare cause of respiratory infection. Case presentation: In this case report we describe a 51-year-old woman who presented with a 6-week history of non-productive cough, pleuritic chest pain and weight loss. She had a history of gastric adenocarcinoma managed with a distal oesophagectomy and total gastrectomy and consequentially suffered severe post-operative gastric reflux...
2019: Respiratory Medicine Case Reports
Michelle Cancel, Mingchen Song
Objective: Antisynthetase syndrome is a condition that includes interstitial lung disease and inflammatory myositis in its definition. The interstitial lung disease of this syndrome can vary in severity and if not identified soon enough, can lead to severe respiratory failure. Here we present a patient who had a working diagnosis of acute eosinophilic pneumonia. He initially improved after prolonged hospitalization and course of high dose steroids. CT chest revealed interval improvement in his bilateral ground glass and reticular opacities but residual fibrotic interstitial lung disease...
2019: Respiratory Medicine Case Reports
Randhall B Carteri, Afonso Kopzynski, Lizia Nardi Menegassi, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Luis Valmor Portela
We hypothesized that supraphysiological administration of the anabolic-androgenic steroids (AAS) like testosterone (TEST) and nandrolone decanoate (NAND) might differentially affect synaptic and extrasynaptic components of mitochondrial bioenergetics, thereby resulting in memory impairment. Oil (VEH), NAND or TEST (15 mg/Kg) were daily administered to male CF-1 albino mice for 19-days. We evaluated in the synaptosomes and extrasynaptic mitochondria, Ca2+ influx/efflux, membrane potential ΔѰm, oxidative respiratory states, dehydrogenases activity, H2O2 production, Tau phosphorylation, and spatial memory in the Morris water maze (MWM)...
March 8, 2019: Toxicology Letters
Rita M Ryan, Roberta L Keller, Brenda B Poindexter, Carl T D'Angio, Pamela A Shaw, Scarlett L Bellamy, Paul E Moore, Christopher McPherson, James M Greenberg
OBJECTIVE: To determine patterns of respiratory medications used in neonatal intensive care unit graduates. STUDY DESIGN: The Prematurity Respiratory Outcomes Program enrolled 835 babies <29 weeks of gestation in the first week. Of 751 survivors, 738 (98%) completed at least 1, and 85% completed all 4, postdischarge medication usage in-person/telephone parental questionnaires requested at 3, 6, 9, and 12 months of corrected age. Respiratory drug usage over the first year of life after in neonatal intensive care unit discharge was analyzed...
March 8, 2019: Journal of Pediatrics
Cynthia Gyamfi-Bannerman, John A F Zupancic, Grecio Sandoval, William A Grobman, Sean C Blackwell, Alan T N Tita, Uma M Reddy, Lucky Jain, George R Saade, Dwight J Rouse, Jay D Iams, Erin A S Clark, John M Thorp, Edward K Chien, Alan M Peaceman, Ronald S Gibbs, Geeta K Swamy, Mary E Norton, Brian M Casey, Steve N Caritis, Jorge E Tolosa, Yoram Sorokin, J Peter VanDorsten
Importance: Administration of corticosteroids to women at high risk for delivery in the late preterm period (34-36 weeks' gestation) improves short-term neonatal outcomes. The cost implications of this intervention are not known. Objective: To compare the cost-effectiveness of treatment with antenatal corticosteroids with no treatment for women at risk for late preterm delivery. Design, Setting, and Participants: This secondary analysis of the Antenatal Late Preterm Steroids trial, a multicenter randomized clinical trial of antenatal corticosteroids vs placebo in women at risk for late preterm delivery conducted from October 30, 2010, to February 27, 2015...
March 11, 2019: JAMA Pediatrics
Kyoko Hazama, Takashi Shiihara, Hiroyuki Tsukagoshi, Takeshi Matsushige, Yuri Dowa, Mio Watanabe
BACKGROUND: Rhinovirus is a common respiratory pathogen for children throughout the year; nevertheless, its central nervous system involvement is extremely rare, and only two cases have been reported to date: meningitis and sepsis-like illness. PATIENT: A previously healthy 2-year-old Japanese boy developed fever, followed by seizures and lethargy. His cerebrospinal fluid cell count and protein level were slightly increased; brain magnetic resonance imaging showed abnormal intensities in the bilateral cerebellar dentate nuclei, which were prominent in diffusion-weighted images...
March 5, 2019: Brain & Development
Sai Sudha Mannemuddhu, William Clapp, Renee Modica, Melissa E Elder, Kiran Upadhyay
BACKGROUND: Anti-glomerular basement membrane (GBM) disease is caused by autoantibodies against the α3-chain of type IV collagen in the GBM. Common variable immunodeficiency (CVID) is a primary immunodeficiency manifested by hypogammaglobulinemia, inability to make functional antibody, and recurrent infections. This report extends the phenotype of CVID-associated autoimmune diseases to include anti-GBM disease. CASE PRESENTATION: A 15-year-old Caucasian female with prior normal renal function presented with nephrotic proteinuria, pedal edema, oliguria, acute kidney injury, and was found to have positive serum anti-GBM antibody...
2019: Clinical nephrology. Case studies
Yasukiyo Murakami, Tetsuo Fujita, Yoji Wakatabe, Masatsugu Iwamura
We describe an 81-year-old woman with metastatic renal cell carcinoma who did not recover from life-threatening interstitial pneumonitis induced by everolimus therapy. She received everolimus due to disease progression after sunitinib, but 2 months after starting everolimus treatment, she visited the emergency department after developing a sudden fever and dyspnea. Chest CT revealed diffuse ground-glass opacities, thickening of the interlobular septa, and consolidation throughout both lung fields. The diagnosis was surmised to be everolimus-induced interstitial pneumonitis...
2019: Case Reports in Urology
Masoomeh Mirzamoradi, Zahra Joshaghani, Fatemeh Hasani Nejhad, Mahya Vafaeenia, Zahra Heidar
BACKGROUND: Compared with vaginal delivery, early-term cesarean section (CS) is associated with an increased risk of neonatal respiratory morbidity. Given the role of steroids in lung maturation in preterm labor, few studies have investigated their effects on early-term delivery. Therefore, this study aimed to investigate the effect of antenatal betamethasone on neonatal respiratory morbidity in early-term elective cesarean (37-38 weeks and 6 d). METHODS: This randomized clinical trial was conducted in Mahdieh Hospital in Tehran in 2017...
March 5, 2019: Journal of Maternal-fetal & Neonatal Medicine
Alia Halim, Haider Shirazi, Sadia Riaz, Syeda Shireen Gul, Wahid Ali
OBJECTIVE: To compare the need of mechanical ventilation between LISA (less invasive surfactant administration) method and conventional INSURE method (INtubation SURfactant administration and Extubation) in spontaneously breathing preterm infants with respiratory distress syndrome (RDS). STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of Neonatology, PIMS, Islamabad, from April to December 2017. METHODOLOGY: A total of 100 preterm infants <34 weeks gestation, on nasal CPAP requiring fraction of inspire oxygen (FiO2) >0...
March 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Munehiro Matsumoto, Kentaro Nagaoka, Masaru Suzuki, Satoshi Konno, Kei Takahashi, Taichi Takashina, Nobuhisa Ishiguro, Masaharu Nishimura
BACKGROUND: Until now, the prevalence of macrolide-resistant Mycoplasma pneumoniae (MP) infection among adult patients has been low, and severe MP pneumonia due to a macrolide-resistant strain has seldom been reported. Here, we describe a rare case of severe life-threatening MP pneumonia due to a macrolide-resistant strain in an adult, which was finally treated with fluoroquinolone and tetracycline after failed treatment with macrolide and corticosteroid. CASE PRESENTATION: A 39-year-old apparently healthy woman complained of fever and productive cough...
February 28, 2019: BMC Infectious Diseases
Haruka Takei, Naruhiko Ishiwada, Haruka Hishiki, Kenichi Takeshita, Sachiko Naito, Mamiko Endo, Naoki Shimojo
Detecting Pneumocystis jirovecii by bronchoalveolar lavage or lung biopsy is the gold standard for diagnosis of P. jirovecii pneumonia (PJP); however, these techniques are not always applicable in children because of their high invasiveness. We report two pediatric cases of PJP diagnosed by polymerase chain reaction (PCR) of gastric lavage that were successfully treated. To date, there are no reported cases of using PCR of gastric lavage to diagnose PJP. On the day of PJP onset, both the infants required respiratory support and infiltrative shadows were observed in both lung fields on chest radiography...
February 21, 2019: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Alfred Maroyi
Lannea schweinfurthii is a valuable medicinal plant species among different ethnic groups in tropical Africa. The aim of the current study was to review existing literature on the ethnomedicinal uses, phytochemistry and pharmacological properties of L. schweinfurthii in an effort to evaluate the therapeutic potential of the species. The relevant information on the ethnomedicinal uses, phytochemistry and pharmacological properties of L. schweinfurthii was generated from several sources including books, book chapters, theses, scientific reports and journal articles obtained from the library and internet sources such as SciFinder, Wiley, Web of Science, American Chemical Society publications, PubMed, BMC, Elsevier, Science Direct, Scielo and Scopus...
February 18, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhongheng Zhang, Peter Markus Spieth, Davide Chiumello, Hemant Goyal, Antoni Torres, John G Laffey, Yucai Hong
OBJECTIVES: There has been multiple advances in the management of acute respiratory distress syndrome, but the temporal trends in acute respiratory distress syndrome-related mortality are not well known. This study aimed to investigate the trends in mortality in acute respiratory distress syndrome patients over time and to explore the roles of daily fluid balance and ventilation variables in those patients. DESIGN: Secondary analysis of randomized controlled trials conducted by the Acute Respiratory Distress Syndrome Network from 1996 to 2013...
March 2019: Critical Care Medicine
Kaoru Katano, Toru Kurata, Shigeta Hagino, Yasuhiro Shoji, Shozo Sasaki, Itsuro Terada, Akemi Yoshikawa, Hirohisa Kitagawa, Takashi Fujimura
A 56-year-old man was admitted to our hospital because abdominal CT showed wall thickening of the ascending colon. Colonoscopyshowed type 4 colon cancer, diagnosed as poorlydifferentiated adenocarcinoma bybiopsy , with circumferential stenosis. Enhanced CT after admission also showed obstructive ileus and lymphadenopathy leading to a paraaortic lesion, but no other distant metastases were seen. Right hemicolectomywas performed. Histological examination showed poorlydifferentiated adenocarcinoma extending from the hepatic flexure to the terminal ileum, with marked invaded vessels and stromal fibrosis, which was diagnosed as type 4 colon cancer of scirrhous and lymphangiosis types...
January 2019: Gan to Kagaku Ryoho. Cancer & Chemotherapy
James D Cherry
Today, in the developed world, virtually all deaths due to Bordetella pertussis illnesses occur in young infants. Therefore, it is important to discuss severe pertussis and its prevention. Areas Covered: These infant deaths are frequently misdiagnosed. Pertussis in young infants is characterized by an afebrile cough illness with coryza, apnea, seizures, cyanosis and emesis. Severe illness is associated with high leukocyte and lymphocyte counts, rapid respiratory and cardiac rates and pneumonia. The main treatment for severe pertussis in young infants is exchange blood transfusion...
February 8, 2019: Expert Review of Vaccines
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