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Reactive c protein

Y Xia, Y Wang, H W He, X L Hong, Q Z An, H M Zhang, Y Long
Objective: To investigate the ability of white blood cell (WBC), procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in the super-elderly patients with bloodstream infection. Methods: It was a retrospective study. A total of 77 patients (≥85 years) admitted to the ICU of Peking Union Medical College Hospital from June, 2016 to December, 2017 were enrolled. The patients included 67 males and 10 females, with an age of 85-105 years and the average age was (92±5) years. According to the results of blood culture, patients were divided into positive blood culture group ( n= 50) and negative blood culture group ( n= 27)...
January 29, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Kazutaka Okita, Shingo Hatakeyama, Toshiaki Tanaka, Yoshinori Ikehata, Toshikazu Tanaka, Naoki Fujita, Yusuke Ishibashi, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Naoya Masumori, Hiroshi Kitamura, Chikara Ohyama
PURPOSE: To investigate the impact of the risk group disagreement between the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) models on prognosis. PATIENTS AND METHODS: We retrospectively evaluated 176 patients with metastatic renal-cell carcinoma who were treated with tyrosine kinase inhibitors as first-line therapy in 5 hospitals between October 2008 and August 2018. The risk group classification differences between the MSKCC and the IMDC models were evaluated using criteria of agreement (identical risk group in both the MSKCC and IMDC models) and disagreement (not identical risk group in both the MSKCC and IMDC models)...
January 17, 2019: Clinical Genitourinary Cancer
Gang Li, Peng Jia, Jian Zhao, Xingdan Wu, Yan Duan, Dong Liu, Ting Wang, Bin Liu
INTRODUCTION: We aimed to assess the performance of red blood cell distribution width (RDW), C-reactive protein (CRP) or the combination of both to predict clinical outcomes in pediatric non-cardiovascular critical illness. MATERIALS AND METHODS: We analyzed 404 pediatric non-cardiovascular critically ill patients admitted to pediatric intensive care unit (PICU). Potential predictors were identified using multivariable logistic regression. We also calculated the power of RDW and CRP additive to pediatric critical illness score (PCIS) to predict mortality with calculation of C-index value, integrated discrimination improvement (IDI) and net reclassification improvement (NRI) indices...
January 23, 2019: American Journal of Emergency Medicine
Cristian Palmiere, Silke Grabherr
Postmortem biochemical investigations in vitreous humor samples collected before and after performing multiphase postmortem computed tomography angiography were performed in the past and demonstrated that specific contrast material injection allowed perfusion and radiological identification of the main vessels of the eye to be obtained without any changes in vitreous humor composition. In the study presented herein, we aimed to test whether the injection of the same contrast material using the same postmortem angiography protocol might influence pericardial fluid composition...
February 2, 2019: Forensic Science International
Sumayya Shahzad, Somaiya Mateen, Asif Hasan, Shagufta Moin
BACKGROUND: Etiopathogenesis of myocardial infarction (MI) is contributed by oxidative injury and inflammatory response. The interplay of these processes determines outcomes in MI patients. However, studies showing the relationship of oxidative stress and inflammatory cytokines with prognosis and severity of MI are lacking. OBJECTIVE: The present study was designed to assess the degree of oxidative stress and inflammation in correlation with GRACE (Global Registry of Acute Coronary Events) risk score in patients of MI...
February 10, 2019: Immunobiology
M Benedetti, P Ciano, I Pergolini, S Ciotti, G Guercioni, G Ruffo, F Borghi, A Patriti, P Del Rio, M Scatizzi, S Mancini, G Garulli, A Carrara, F Pirozzi, S Scabini, A Liverani, G Baiocchi, R Campagnacci, A Muratore, G Longo, M Caricato, R Macarone Palmieri, N Vettoretto, M Ceccaroni, S Guadagni, E Bertocchi, D Cianflocca, M Lambertini, U Pace, M Baraghini, L Pandolfini, R Angeloni, A Lucchi, G Martorelli, G Tirone, M Motter, A Sciuto, A Martino, A P Luzzi, T Di Cesare, S Molfino, A Maurizi, P Marsanic, F Tomassini, S Santoni, G T Capolupo, P Amodio, E Arici, M Clementi, B Ruggeri, M Catarci
BACKGROUND: Anastomotic leakage (AL) is a dreaded major complication after colorectal surgery. There is no uniform definition of anastomotic dehiscence and leak. Over the years many risk factors have been identified (distance of anastomosis from anal verge, gender, BMI, ASA score) but none of these allows an early diagnosis of AL. The DUtch LeaKage (DULK) score, C reactive protein (CRP) and procalcitonin (PCT) have been identified as early predictors for anastomotic leakage starting from postoperative day (POD) 2-3...
January 2019: Il Giornale di Chirurgia
Taciana Pereira Sant'Ana Santos, Mariana de Menezes Pereira, Maria Isabel Schinoni, Geraldo Pedral Sampaio, Roque Aras, Maria Luiza Sousa Atta, Ajax M Atta
There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Twenty-six CHC patients, 35 individuals with atherosclerosis (Athero) and 27 healthy individuals were examined for risk factors for CVD, lipid profile, atherogenic risk indexes, and insulin resistance (IR)...
February 13, 2019: Cytokine
Joel L Ramirez, Warren J Gasper, Sukaynah A Khetani, Greg J Zahner, Nancy K Hills, Pete T Mitchell, Brian E Sansbury, Michael S Conte, Matthew Spite, S Marlene Grenon
BACKGROUND: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in patients with peripheral artery disease (PAD). MATERIALS AND METHODS: The OMEGA-PAD II trial was a double-blinded, randomized, placebo-controlled trial to assess the effect of 3 mo of high-dose oral n-3 PUFA supplementation on inflammation, endothelial function, and walking ability in patients with PAD...
February 13, 2019: Journal of Surgical Research
Sheng Chen, Xia-Chan Chen, Xiao-Hui Lou, Song-Quan Qian, Zhan-Wei Ruan
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is currently known as an acute phase protein and implicated in acute brain injury. Herein, we sought to gauge serum NGAL level in patients after acute (<24 h) spontaneous intracerebral hemorrhage (ICH) and to investigate its relation to neurological outcome. METHODS: Serum NGAL levels were measured in 106 patients and 106 controls. National Institutes of Health Stroke Scale (NIHSS) score, Glasgow coma scale (GCS) score, ICH score and hematoma volume were recorded for assessing hemorrhagic severity...
February 13, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Song Zhang, Shun Guo, Xiao-Bo Gao, An Liu, Wei Jiang, Xi Chen, Peng Yang, Lin-Na Liu, Lei Shi, Yan Zhang
Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that has been used to improve obesity and diabetes and for the treatment of hepatitis B. However, its effect on lipid metabolism disorders and vascular injury is unclear. Here, we investigated the effect of matrine on high-fat diet fed mice and oxidized low-density lipoprotein (ox-LDL)-induced human umbilical vein endothelial cells (HUVECs). Computational virtual docking analyses, phosphoinositide 3-kinase (PI3K) and protein kinase C-α (PKCα) inhibitors were used to localize matrine in vascular injuries...
February 15, 2019: Journal of Cellular and Molecular Medicine
Dorji Dorji, Ross M Graham, Abhishek K Singh, Joshua P Ramsay, Patricia Price, Silvia Lee
The resurgence of whooping cough reflects novel genetic variants of Bordetella pertussis and inadequate protection conferred by current acellular vaccines (aP). Biofilm is a source of novel vaccine candidates, including membrane protein assembly factor (BamB) and lipopolysaccharide assembly protein (LptD). Responses of BALB/c mice to candidate vaccines included IFN-γ and IL-17a production by spleen and lymph node cells, and serum IgG1 and IgG2a reactive with whole bacteria or aP. Protection was determined using bacterial cultured from lungs of vaccinated mice challenged with virulent B...
January 30, 2019: Cellular Immunology
Jae Eun Park, Youngwan Seo, Ji Sook Han
In this study, we investigated whether ( E )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone, a homoisoflavonoid compound isolated from Portulaca oleracea L., protects INS-1 pancreatic β cells against glucotoxicity-induced apoptosis. Treatment with high glucose (30 mM) induced apoptosis in INS-1 pancreatic β cells; however, the level of cell viability was significantly increased by treatment with ( E )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone. Treatment with 10⁻20 µM of ( E )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone dose-dependently increased cell viability and significantly decreased the intracellular level of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), and nitric oxide levels in INS-1 pancreatic β cells pretreated with high glucose...
February 14, 2019: Nutrients
Braj Raj Singh, Vijai Kumar Gupta, Farah Deeba, Rajesh Bajpai, Vivek Pandey, Alim H Naqvi, Dalip Kumar Upreti, Nicholas Gathergood, Yueming Jiang, Hesham A El Enshasy, Essam Nageh Sholkamy, Ashraf A Mostafa, Abd El-Latif Hesham, Brahma N Singh
Silver-based nanostructures are suitable for many biomedical applications, but to be useful therapeutic agents, the high toxicity of these nanomaterials must be eliminated. Here, we biosynthesize nontoxic and ultra-small silver nanoclusters (rsAg@NCs) using metabolites of usnioid lichen (a symbiotic association of algae and fungi) that exhibit excellent antimicrobial activity against fluconazole (FCZ)-resistant Candida albicans that is many times higher than chemically synthesized silver nanoparticles (AgNPs) and FCZ...
January 29, 2019: Biomolecules
Takashi Miki, Toru Miyoshi, Kazuhiko Kotani, Kunihisa Kohno, Hirohiko Asonuma, Satoru Sakuragi, Yasushi Koyama, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND AND AIMS: Oxidized high-density lipoprotein (oxHDL) is characterized by reduced anti-inflammatory properties compared with HDL. However, the role of oxHDL in the pathogenesis of coronary artery calcification (CAC), a marker of subclinical atherosclerosis, remains unclear. We prospectively investigated the association between the change in oxHDL and progression of CAC in a substudy of a multicenter study. METHODS: In the principal study, patients with a CAC score of 1-999 were treated with pitavastatin with/without eicosapentaenoic acid...
February 1, 2019: Atherosclerosis
Yuki Fujiwara, Koichiro Haruki, Hiroaki Shiba, Ryoga Hamura, Yoshihiro Shirai, Kenei Furukawa, Takeshi Gocho, Katsuhiko Yanaga
BACKGROUND: Inflammation-based prognostic scores are associated with tumor recurrence and survival in various cancers. The aim of this study was to identify the significance of inflammation-based prognostic scores and to detect the most useful score in patients with distal extrahepatic bile duct cancer after pancreaticoduodenectomy. METHODS: Between 2000 and 2015, 121 patients were enrolled in this retrospective study. The relationship between clinicopathological variables including various prognostic scores and disease-free (DFS) as well as overall (OS) survival was investigated by univariate analysis...
February 12, 2019: Journal of Surgical Research
Mari Archer, Onni Niemelä, Kaisa Luoto, Johanna Kultti, Mari Hämäläinen, Eeva Moilanen, Antti Koivukangas, Esa Leinonen, Olli Kampman
INTRODUCTION: The studies on the relations between alcohol consumption, the status of inflammation and depression have produced conflicting results. In this study we followed patients with major depressive disorders by monitoring biomarkers of inflammation together with biomarkers of heavy alcohol use. METHOD: The levels of IL-6 (interleukin-6), IL-8 (interleukin-8), hs-CRP (high sensitivity C-reactive protein), YKL-40 (also known as Chitinase-3-like protein 1 or CHI3L1) and biomarkers of alcohol consumption and liver status (GT, CDT, ALT, alkaline phosphatase) were measured at baseline and after 6 months of psychiatric treatment from 242 patients suffering from current major depressive disorder (MDD) with (n = 99) or without (n = 143) alcohol use disorder (AUD)...
February 12, 2019: Alcohol
Jinmei Su, Liufu Cui, Wenhao Yang, Huijing Shi, Cheng Jin, Rong Shu, Hongfen Li, Xiaofeng Zeng, Shouling Wu, Xiang Gao
BACKGROUND: A hospitalized-based cohort study suggested that elevated C-reactive protein (CRP) levels are associated with radiographic sacroiliitis progression in ankylosing spondylitis (AS) patients. However, data from community-based populations are limited. OBJECTIVE: We sought to determine the association between elevated CRP levels and AS diagnosis in a prospective community-based study of 129,681 Chinese adults over a follow-up period of 8 years. METHODS: We measured the plasma CRP concentration at baseline and every 2 years thereafter with the high-sensitivity (hs)-CRP test...
2019: PloS One
David S Vitale, Lindsey Hornung, Tom K Lin, Jaimie D Nathan, Swathi Prasad, Tyler Thompson, Maisam Abu-El-Haija
OBJECTIVE: The natural course of patients who develop acute pancreatitis (AP) can range from mild to severe acute pancreatitis (SAP). The aim of this study was to evaluate for early predictors of developing SAP during the first episode of AP in a prospective pediatric cohort. METHODS: Clinical data were prospectively collected and subsequently analyzed for pediatric patients presenting with their first episode of AP between March 2013 and January 2017 to Cincinnati Children's Hospital Medical Center...
February 14, 2019: Pancreas
Carine Parent, Irina Pokhvisneva, Hélène Gaudreau, Michael J Meaney, Patricia P Silveira
OBJECTIVE: The Avon Longitudinal Study of Parents and Children (ALSPAC) and Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) cohorts were used to determine if repeated exposure to gastroenteritis in early life could predict risk for psychiatric problems in childhood and in ALSPAC adolescents. We determined if inflammatory biomarkers moderate the association between repeated gastroenteritis and mental health in adolescents from ALSPAC. METHOD: Episodes of gastroenteritis from birth to 30 and 36 months were reported by mothers...
February 8, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
Tawfik Khoury, Saleh Daher, Muhammad Massarwa, David Hakimian, Ariel A Benson, Elez Viener, Raymond Farah, Amir Mari, Wadi Hazou, Anas Kadah, Wisam Sbeit, Mahmud Mahamid, Eran Israeli
BACKGROUND AND AIMS: A majority of acutely-ill Crohn's disease (CD) patients who present to Emergency Department (ED) will undergo an abdominal CT to rule out disease complications. We aimed to generate a simple non-invasive scoring model to predict the presence of an intra-abdominal abscess in CD patients in the ED. METHODS: We performed a retrospective case control study at four Israeli hospitals from January-1 st-2010 to May-30 th-2018. Inclusion criteria included patients with an established diagnosis of CD that had cross-sectional abdominal imaging performed...
February 14, 2019: Journal of Crohn's & Colitis
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