Tuong-Vi Nguyen, Sherri Lee Jones, Patricia Gower, Jimin Lew, Matthew D Albaugh, Kelly N Botteron, James J Hudziak, Vladimir S Fonov, D Louis Collins, Benjamin C Campbell, Linda Booij, Catherine Herba, Patricia Monnier, Simon Ducharme, Deborah Waber, James T McCracken
Estradiol is known to play an important role in the developing human brain, but little is known on the entire network of potential regions which might be affected and on how these effects may vary from childhood to early adulthood, which in turn can explain sexually differentiated behaviors. Here we examined the relationship between estradiol, cortico-amygdalar structural covariance, and cognitive or behavioral measures typically showing sex differences (verbal/spatial skills, anxious-depressed symptomatology) in 152 children and adolescents (6-22 years old)...
February 18, 2019: Journal of Neuroendocrinology