keyword
https://read.qxmd.com/read/38447671/reduced-nephron-endowment-in-six2-tgctg-mice-is-due-to-six3-misexpression-by-aberrant-enhancer-promoter-interactions-in-the-transgene
#21
JOURNAL ARTICLE
Alison J Perl, Han Liu, Matthew Hass, Nirpesh Adhikari, Praneet Chaturvedi, Yueh-Chiang Hu, Rulang Jiang, Yaping Liu, Raphael Kopan
BACKGROUND: Lifelong kidney function relies on the complement of nephrons generated during mammalian development from a mesenchymal nephron progenitor cell population. Low nephron endowment confers increased susceptibility to chronic kidney disease. Reduced nephron numbers in the popular Six2TGC transgenic mouse line may be due to disruption of a regulatory gene at the integration site and/or ectopic expression of a gene(s) contained within the transgene. METHODS: Targeted locus amplification (TLA) was performed to identify the integration site of the Six2TGC transgene...
March 6, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38435067/peritoneal-dialysis-after-cardiac-surgery-time-for-a-change-of-heart
#22
EDITORIAL
Osama El Shamy, Jeffrey Perl, Jenny I Shen
No abstract text is available yet for this article.
March 2024: Kidney medicine
https://read.qxmd.com/read/38434979/analysis-of-m-6-a-related-lncrnas-for-prognostic-and-immunotherapeutic-response-in-hepatocellular-carcinoma
#23
JOURNAL ARTICLE
Xingwei Wu, Shengnan Wang, Xiaoming Wu, Qianyi Chen, Jin Cheng, Zhilin Qi
Background: RNA methylation modifications are important post-translational modifications that are regulated in an epigenetic manner. Recently, N6 -methyladenosine (m6 A) RNA modifications have emerged as potential epigenetic markers in tumor biology. Methods: Gene expression and clinicopathological data of LIHC were obtained from the cancer genome atlas (TCGA) database. The relationship between long non-coding RNAs (lncRNAs) and m6 A-related genes was determined by gene expression analysis using Perl and R software...
2024: Journal of Cancer
https://read.qxmd.com/read/38427613/proteomic-changes-in-the-hippocampus-of-large-mammals-after-total-body-low-dose-radiation
#24
JOURNAL ARTICLE
Diego Iacono, Kathleen Hatch, Erin K Murphy, Jeremy Post, Robert N Cole, Daniel P Perl, Regina M Day
There is a growing interest in low dose radiation (LDR) to counteract neurodegeneration. However, LDR effects on normal brain have not been completely explored yet. Recent analyses showed that LDR exposure to normal brain tissue causes expression level changes of different proteins including neurodegeneration-associated proteins. We assessed the proteomic changes occurring in radiated vs. sham normal swine brains. Due to its involvement in various neurodegenerative processes, including those associated with cognitive changes after high dose radiation exposure, we focused on the hippocampus first...
2024: PloS One
https://read.qxmd.com/read/38423373/evaluation-of-bronchoalveolar-lavage-fluid-from-donkeys-using-four-different-cytological-stains-a-pilot-study
#25
JOURNAL ARTICLE
V Vitale, F Bindi, A Briganti, F Bonelli, C Parietti, M Sgorbini
Bronchoalveolar lavage fluid (BALF) cytology is used for the diagnosis of non-infectious lower airway inflammation in equids. Discrepancies have been reported in the differential cell count when different staining methods were used both in humans and horses. The objective of this study was to compare the results of BALF cytology in donkeys using four different staining methods: modified May-Grunwald Giemsa (mMGG), Diff-Quick (DQ), Toluidine blue (TB) and Perls Prussian blue (PPB). Nine healthy Amiata female donkeys were enrolled...
February 27, 2024: Journal of Equine Veterinary Science
https://read.qxmd.com/read/38422841/cancer-induced-morphological-changes-in-enteric-glial-cells-in-the-jejunum-of-walker-256-tumor-bearing-rats
#26
JOURNAL ARTICLE
Fabiana Galvão da Motta Lima, Maysa Pacheco Alvarez da Silva, Sabrina Silva Sestak, Flávia Alessandra Guarnier, Ana Paula de Oliveira, João Victor Kuller, Brian David Gulbransen, Juliana Vanessa Colombo Martins Perles, Jacqueline Nelisis Zanoni
Cancer-induced cachexia is associated with systemic inflammation and gastrointestinal dysfunction. How changes to cells of the enteric nervous system contribute to gut dysfunction in tumor development and cancer cachexia is unknown. Here, we tested the hypothesis that changes to enteric glia, a type of peripheral glia that surround enteric neurons and regulate gut homeostasis, are associated with tumor development and that supplementing with the antioxidant L-glutathione is protective against the changes induced...
February 28, 2024: Acta Histochemica
https://read.qxmd.com/read/38420982/artificial-intelligence-in-cardiology
#27
JOURNAL ARTICLE
Leor Perl, Nadav Loebl, Ran Kornowski
No abstract text is available yet for this article.
February 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38420976/establishing-a-center-for-innovation-and-artificial-intelligence-in-a-tertiary-medical-center-successes-and-challenges
#28
JOURNAL ARTICLE
Nadav Loebl, Eytan Wirtheim, Leor Perl
BACKGROUND: The field of artificial intelligence (AI) is poised to significantly influence the future of medicine. With the accumulation of vast databases and recent advancements in computer science methods, AI's capabilities have been demonstrated in numerous areas, from diagnosis and morbidity prediction to patient treatment. Establishing an AI research and development unit within a medical center offers multiple advantages, particularly in fostering research and tapping into the immediate potential of AI at the patient's bedside...
February 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38409473/cerebral-white-matter-hyperintensities-indicate-severity-and-progression-of-coronary-artery-calcification
#29
JOURNAL ARTICLE
Markus Kneihsl, Thomas Gattringer, Edith Hofer, Peter P Rainer, Gerhard Ranner, Simon Fandler-Höfler, Melanie Haidegger, Sabine Perl, Christian Enzinger, Reinhold Schmidt
Cerebral white matter hyperintensities (WMH) have been associated with subclinical atherosclerosis including coronary artery calcification (CAC). However, previous studies on this association are limited by only cross-sectional analysis. We aimed to explore the relationship between WMH and CAC in elderly individuals both cross-sectionally and longitudinally. The study population consisted of elderly stroke- and dementia-free participants from the community-based Austrian Stroke Prevention Family Study (ASPFS)...
February 26, 2024: Scientific Reports
https://read.qxmd.com/read/38409356/dopamine-and-serotonin-in-human-substantia-nigra-track-social-context-and-value-signals-during-economic-exchange
#30
JOURNAL ARTICLE
Seth R Batten, Dan Bang, Brian H Kopell, Arianna N Davis, Matthew Heflin, Qixiu Fu, Ofer Perl, Kimia Ziafat, Alice Hashemi, Ignacio Saez, Leonardo S Barbosa, Thomas Twomey, Terry Lohrenz, Jason P White, Peter Dayan, Alexander W Charney, Martijn Figee, Helen S Mayberg, Kenneth T Kishida, Xiaosi Gu, P Read Montague
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players. They rejected more offers in the human than the computer condition, an effect of social context associated with higher overall levels of dopamine but not serotonin...
February 26, 2024: Nature Human Behaviour
https://read.qxmd.com/read/38409043/parsco-celebrating-10%C3%A2-years-of-a-unique-parasitology-summer-course
#31
EDITORIAL
Filipe Dantas-Torres, Marcos Antonio Bezerra-Santos, Jairo Alfonso Mendoza-Roldan, Riccardo Paolo Lia, Livia Perles, Juan Pedro Barrera, Renata Fagundes-Moreira, Mariaelisa Carbonara, Antonio Varcasia, Emanuele Brianti, Georgiana Deak, Alicia Rojas, Guadalupe Miró, Petr Volf, Gad Baneth, Domenico Otranto
ParSCo (Parasitology Summer Course) is an intense, 1-week-long summer course organized by the Parasitology Unit of the Department of Veterinary Medicine, University of Bari, Italy, with the support of the World Association for the Advancement of Veterinary Parasitology (WAAVP), the European Veterinary Parasitology College (EVPC) and Parasites and Vectors. The course, which is conducted in southern Italy, is planned for parasitologists and post-graduate students working in the field of parasitology. The course consists of theoretical and practical lessons, which include the collection, identification and diagnosis of parasites of pets, livestock and wildlife...
February 26, 2024: Parasites & Vectors
https://read.qxmd.com/read/38397873/short-and-long-term-outcomes-of-patients-with-postoperative-arrhythmia-after-liver-surgery
#32
JOURNAL ARTICLE
Felix Rühlmann, Deborah Engelhardt, Alma Franziska Mackert, Mara Sophie Hedicke, Tobias Tichelbäcker, Andreas Leha, Markus Bernhardt, Michael Ghadimi, Thorsten Perl, Azadeh Azizian, Jochen Gaedcke
BACKGROUND: New-onset postoperative arrhythmia (PA) has previously been described as a pivotal risk factor for postoperative morbidity and mortality after visceral surgery. However, there is a lack of data concerning liver surgery. The incidence and impact of new-onset postoperative arrhythmia after liver surgery was, therefore, analyzed in a monocentric study. METHODS: In total, n = 460 patients (221 female, 239 male) who underwent liver surgery between January 2012 and April 2020 without any prior arrhythmia in their medical history were included in this retrospective analysis...
January 25, 2024: Biomedicines
https://read.qxmd.com/read/38397856/perioperative-limax-test-analysis-impact-of-portal-vein-embolisation-chemotherapy-and-major-liver-resection
#33
JOURNAL ARTICLE
Felix Rühlmann, Azadeh Azizian, Christian Moosmann, Markus Bernhardt, Jan Keck, Hannah Flebbe, Omar Al-Bourini, Ali Seif Amir Hosseini, Marian Grade, Thomas Lorf, Michael Ghadimi, Thorsten Perl, Jochen Gaedcke
BACKGROUND: Postoperative liver failure (PLF) is a severe complication after major liver resection (MLR). To increase the safety of patients, clinical bedside tests are of great importance. However, limitations of their applicability and validity impair their value. METHODS: Preoperative measurements of the liver maximum capacity (LiMAx) were performed in n = 40 patients, who underwent MLR (≥3 segments). Matched postoperative LiMAx was measured in n = 21 patients...
January 23, 2024: Biomedicines
https://read.qxmd.com/read/38389929/the-melon-fom-1-prv-resistance-gene-pair-correlated-spatial-expression-and-interaction-with-a-viral-protein
#34
JOURNAL ARTICLE
Michael Normantovich, Arie Amitzur, Sharon Offri, Ekaterina Pashkovsky, Yula Shnaider, Shahar Nizan, Ohad Yogev, Avi Jacob, Christopher G Taylor, Cécile Desbiez, Steven A Whitham, Amalia Bar-Ziv, Rafael Perl-Treves
The head-to-head oriented pair of melon resistance genes, Fom-1 and Prv , control resistance to Fusarium oxysporum races 0 and 2 and papaya ringspot virus (PRSV), respectively. They encode, via several RNA splice variants, TIR-NBS-LRR proteins, and Prv has a C-terminal extra domain with a second NBS homologous sequence. In other systems, paired R-proteins were shown to operate by "labor division," with one protein having an extra integrated domain that directly binds the pathogen's Avr factor, and the second protein executing the defense response...
February 2024: Plant Direct
https://read.qxmd.com/read/38382658/immmunometabolism-of-systemic-lupus-erythematosus
#35
REVIEW
Marlene Marte Furment, Andras Perl
Systemic lupus erythematosus (SLE) is a potentially fatal chronic autoimmune disease which is underlain by complex dysfunction of the innate and adaptive immune systems. Although a series of well-defined genetic and environmental factors have been implicated in disease etiology, neither the development nor the persistence of SLE is well understood. Given that several disease susceptibility genes and environmental factors interact and influence inflammatory lineage specification through metabolism, the field of immunometabolism has become a forefront of cutting edge research...
February 19, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38381797/parasites-and-microorganisms-associated-with-the-snakes-collected-for-the-festa-dei-serpari-in-cocullo-italy
#36
JOURNAL ARTICLE
Jairo Alfonso Mendoza-Roldan, Livia Perles, Ernesto Filippi, Nicole Szafranski, Gianpaolo Montinaro, Mariaelisa Carbonara, Riccardo Scalera, Pedro Paulo de Abreu Teles, Julia Walochnik, Domenico Otranto
While in much of the Western world snakes are feared, in the small, rural, mountainous town of Cocullo, in the middle of central Italy, snakes are annually collected and celebrated in a sacro-profane ritual. Every 1st of May, Serpari (snake catchers) capture and showcase dozens of non-venomous snakes to celebrate the ritual of San Domenico. In order to detect potential zoonotic pathogens within this unique epidemiological context, parasites and microorganisms of snakes harvested for the "festa dei serpari" ritual was investigated...
February 21, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38380866/whole-genome-wide-sequence-analysis-of-long-lived-families-long-life-family-study-identifies-mtus2-gene-associated-with-late-onset-alzheimer-s-disease
#37
JOURNAL ARTICLE
Laura Xicota, Stephanie Cosentino, Badri Vardarajan, Richard Mayeux, Thomas T Perls, Stacy L Andersen, Joseph M Zmuda, Bharat Thyagarajan, Anatoli Yashin, Mary K Wojczynski, Sharon Krinsky-McHale, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark E Mapstone, Nicole Schupf, Joseph H Lee, Sandra Barral
INTRODUCTION: Late-onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long-Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics. METHODS: We conducted a whole genome sequence analysis of 3475 LLFS members. Genetic associations were examined in six independent studies (N = 14,260) with a wide range of LOAD risk. Association analysis in a sub-sample of the LLFS cohort (N = 1739) evaluated the association of LOAD variants with beta amyloid (Aβ) levels...
February 21, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38378545/identification-of-functional-genes-in-liver-fibrosis-based-on-bioinformatics-analysis-of-a-lncrna-mediated-cerna-network
#38
JOURNAL ARTICLE
Feng Zhang, Siya Pei, Meifang Xiao
BACKGROUND: Liver fibrosis is a major global healths problem; nevertheless, its molecular mechanism are not completely clear. This study aimed to build a lncRNA-miRNA-mRNA network, identify potentially related lncRNAs, and explore the pathogenesis of liver fibrosis. MATERIALS AND METHODS: We used the Gene Expression Omnibus databases and bioinformatics analysis to identify differentially expressed genes (DEGs) between liver fibrosis and normal tissues. The ceRNA network was constructed according to the interactions between DElncRNA, miRNA, and DEmRNA...
February 20, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38378326/comparison-of-in-vivo-stiffness-of-tendons-commonly-used-for-anterior-cruciate-ligament-reconstruction-a-shear-wave-elastography-study
#39
JOURNAL ARTICLE
Mario Pasurka, Theo Falck, Joshua Kubach, Michael Simon, Stefan Söllner, Deike Strobel, Mario Perl, Marcel Betsch
RATIONALE AND OBJECTIVES: There are currently no studies investigating the in vivo stiffness of the most commonly used autografts for anterior cruciate ligament reconstruction (ACLR) using Shear wave elastography (SWE). We hypothesize that there are differences regarding the elastic properties between the three tendons commonly used for ACLR and that they are influenced by patient-related factors. MATERIALS AND METHODS: 80 healthy subjects (25 females, 55 males, age: 25...
February 19, 2024: Academic Radiology
https://read.qxmd.com/read/38366605/relationship-of-tissue-dimensions-and-three-captive-bolt-application-sites-on-cadaver-heads-from-mature-swine-sus-scrofa-domesticus-200%C3%A2-kg-body-weight
#40
JOURNAL ARTICLE
Karly N Anderson, Ashlynn A Kirk, Jennifer Berger, Arquimides A Reyes, Ruth Woiwode, Perle E Zhitnitskiy, Kurt D Vogel
Penetrating captive bolt (PCB) is a common method of euthanasia for swine but has not been evaluated for mature swine < 200 kg BW. The objectives were to determine tissue depth, brain contact plane, and visible brain tissue damage (BD) for the common FRONTAL (F) and alternative TEMPORAL (T) and BEHIND EAR (BE) placements for PCB use on sows and boars weighing < 200 kg. Cadaver heads were obtained from 30 sows and 30 boars (estimated body weight (BW), Mean ± SD; sows: 165.8 ± 22.4 kg; boars: 173...
February 15, 2024: Journal of Animal Science
keyword
keyword
168036
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.