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https://read.qxmd.com/read/30761636/high-dose-vitamin-d-supplementation-is-associated-with-an-improvement-in-serum-markers-of-liver-function
#1
Hamidreza Tavakoli, Hossein Rostami, Amir Avan, Mohammad Bagherniya, Gordon A Ferns, Sayyed Saeid Khayyatzadeh, Majid Ghayour-Mobarhan
Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (ϒGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls...
February 13, 2019: BioFactors
https://read.qxmd.com/read/30755798/risk-of-dengue-transmission-in-cocody-abidjan-ivory-coast
#2
Diakarida Fofana, Jean Michel Vianney Beugré, Genevieve Lydie Yao-Acapovi, Sevidzem Silas Lendzele
In recent years, an upsurge of vector-borne diseases has been reported in several parts of the world. Among these is dengue fever, the first arbovirus transmitted by mosquitoes of the genus Aedes . After the detection of the dengue virus serological types (type 1, 2, and 3) in the health district of Cocody-Bingerville in Ivory Coast, entomological investigations were carried out in the city of Cocody (host of most cases) to evaluate the risk of transmission of the disease in view of an effective vector control...
2019: Journal of Parasitology Research
https://read.qxmd.com/read/30753067/multifunctional-copper-i-coordination-polymers-with-aromatic-mono-and-ditopic-thioamides
#3
Javier Troyano, Eduardo Zapata, Josefina Perles, Pilar Amo-Ochoa, Vanesa Fernández-Moreira, José I Martínez, Félix Zamora, Salomé Delgado
Direct reactions under ambient conditions between CuX (X = Br, I) and thiobenzamide (TBA) were carried out at different ratios, giving rise to the formation of a series of one-dimensional (1D) coordination polymers, (CPs) [CuI(TBA)] n (1), [Cu3 I3 (TBA)2 ] n (4), and [CuBr(TBA)] n (5), as well as two molecular complexes, [CuI(TBA)3 ] (2) and [Cu2 I2 (TBA)4 ]·2MeCN (3). Recrystallization of 1 and 5 yielded a series of isostructural 1D CP solvated species, [CuI(TBA)·S] n ] n (1·S; S = tetrahydrofuran, acetone, methanol) and [CuBr(TBA)·S] n (5·S; S = tetrahydrofuran, acetone), respectively...
February 12, 2019: Inorganic Chemistry
https://read.qxmd.com/read/30744543/rho-kinase-inhibition-blunts-lesion-development-and-hemorrhage-in-murine-models-of-aggressive-pdcd10-ccm3-disease
#4
Robert Shenkar, Amy Peiper, Heidy Pardo, Thomas Moore, Rhonda Lightle, Romuald Girard, Nicholas Hobson, Sean P Polster, Janne Koskimäki, Dongdong Zhang, Seán B Lyne, Ying Cao, Kiranj Chaudagar, Laleh Saadat, Carol Gallione, Peter Pytel, James K Liao, Douglas Marchuk, Issam A Awad
Background and Purpose- Previously, murine models Krit1 +/- Msh2 -/ - and Ccm2 +/ - Trp53 -/ - showed a reduction or no effect on cerebral cavernous malformation (CCM) burden and favorable effects on lesional hemorrhage by the robust Rock (Rho-associated protein kinase) inhibitor fasudil and by simvastatin (a weak pleiotropic inhibitor of Rock). Herein, we concurrently investigated treatment of the more aggressive Pdcd10/Ccm3 model with fasudil, simvastatin, and higher dose atorvastatin to determined effectiveness of Rock inhibition...
February 12, 2019: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/30743277/-excessive-dynamic-airway-collapse
#5
Regine Mariette Perl, Volker Steger, Jürgen Hetzel, Marius Horger
No abstract text is available yet for this article.
February 11, 2019: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://read.qxmd.com/read/30739094/the-association-of-functional-status-with-mortality-and-dialysis-modality-change-results-from-the-peritoneal-dialysis-outcomes-and-practice-patterns-study-pdopps
#6
Karthik K Tennankore, Junhui Zhao, Angelo Karaboyas, Brian Bieber, Bruce M Robinson, Hal Morgenstern, Sarbjit V Jassal, Fredric O Finkelstein, Talerngsak Kanjanabuch, Areewan Cheawchanwattana, Ronald L Pisoni, James Sloand, Jeffrey Perl
BACKGROUND: Little is known about the prevalence of functional impairment in peritoneal dialysis (PD) patients, its variation by country, and its association with mortality or transfer to hemodialysis. METHODS: A prospective cohort study was conducted in PD patients from 7 countries in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) (2014 - 2017). Functional status (FS) was assessed by combining self-reports of 8 instrumental and 5 basic activities of daily living, using the Lawton-Brody and the Katz questionnaires...
February 9, 2019: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://read.qxmd.com/read/30721156/rabl6a-inhibits-tumor-suppressive-pp2a-akt-signaling-to-drive-pancreatic-neuroendocrine-tumor-growth
#7
Shaikamjad Umesalma, Courtney A Kaemmer, Jordan L Kohlmeyer, Blake L Letney, Angela M Schab, Jacqueline A Reilly, Ryan M Sheehy, Jussara Hagen, Nitija Tiwari, Fenghuang Zhan, Mariah R Leidinger, Thomas M O'Dorisio, Joseph S Dillon, Ronald A Merrill, David K Meyerholz, Abbey L Perl, Bart J Brown, Terry A Braun, Aaron T Scott, Timothy Ginader, Agshin F Taghiyev, Gideon K Zamba, James R Howe, Stefan Strack, Andrew M Bellizzi, Goutham Narla, Benjamin W Darbro, Frederick W Quelle, Dawn E Quelle
Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically but tumor resistance invariably develops. A better understanding of factors regulating AKT/mTOR signaling and PNET pathogenesis is needed to improve current therapies. We discovered that RABL6A, a new oncogenic driver of PNET proliferation, is required for AKT activity. Silencing RABL6A caused PNET cell cycle arrest that coincided with selective loss of AKT-S473 (not T308) phosphorylation and AKT/mTOR inactivation...
February 5, 2019: Journal of Clinical Investigation
https://read.qxmd.com/read/30717607/lysed-erythrocyte-membranes-promote-vascular-calcification-possible-role-of-erythrocyte-derived-nitric-oxide
#8
Dimitrios N Tziakas, Georgios Chalikias, Maria Pavlaki, Dimitra Kareli, Rajinikanth Gogiraju, Astrid Hubert, Elsa Böhm, Petros Stamoulis, Ioannis Drosos, Petros Kikas, Dimitrios Mikroulis, Alexandra Giatromanolaki, George S Georgiadis, Fotios Konstantinou, Christos Argyriou, Thomas Münzel, Stavros V Konstantinides, Katrin Schäfer
BACKGROUND: Intraplaque hemorrhage promotes atherosclerosis progression, and erythrocytes may contribute to this process. In this study we examined the effects of red blood cells on smooth muscle cell mineralization and vascular calcification and possible mechanisms involved. METHODS: Erythrocytes were isolated from human and murine whole blood. Intact and lysed erythrocytes and their membrane fraction or specific erythrocyte components, were examined in vitro using diverse calcification assays, ex vivo using the murine aortic ring calcification model, and in vivo after murine erythrocyte membrane injection into neointimal lesions of hypercholesterolemic apolipoprotein E-deficient mice...
February 5, 2019: Circulation
https://read.qxmd.com/read/30715482/structural-efficacy-of-nsaids-cox-2-inhibitor-and-glucocorticoid-compared-with-tnf%C3%AE-blocker-a-study-in-adjuvant-induced-arthritis-rats
#9
Frank Verhoeven, Clément Prati, Perle Totoson, Romain Bordy, Daniel Wendling, Céline Demougeot
Objective: To evaluate radiographic outcomes after an early treatment for 21 days with etanercept, naproxen, celecoxib, prednisone or methotrexate in adjuvant-induced arthritis in rats. Methods: At the onset of arthritis, rats were daily treated with naproxen (10 mg/kg/day i.p.), celecoxib (3 mg/kg/day), prednisolone (10 mg/kg/day), etanercept (10 mg/kg/3 days), methotrexate (2 mg/kg/3 days) or saline solution (vehicle) for 21 days. The arthritis score was daily monitored...
February 1, 2019: Rheumatology
https://read.qxmd.com/read/30698636/risk-of-posttraumatic-stress-disorder-and-major-depression-in-civilian-patients-after-mild-traumatic-brain-injury-a-track-tbi-study
#10
Murray B Stein, Sonia Jain, Joseph T Giacino, Harvey Levin, Sureyya Dikmen, Lindsay D Nelson, Mary J Vassar, David O Okonkwo, Ramon Diaz-Arrastia, Claudia S Robertson, Pratik Mukherjee, Michael McCrea, Christine L Mac Donald, John K Yue, Esther Yuh, Xiaoying Sun, Laura Campbell-Sills, Nancy Temkin, Geoffrey T Manley, Opeolu Adeoye, Neeraj Badjatia, Kim Boase, Yelena Bodien, M Ross Bullock, Randall Chesnut, John D Corrigan, Karen Crawford, Ramon Diaz-Arrastia, Sureyya Dikmen, Ann-Christine Duhaime, Richard Ellenbogen, V Ramana Feeser, Adam Ferguson, Brandon Foreman, Raquel Gardner, Etienne Gaudette, Joseph T Giacino, Luis Gonzalez, Shankar Gopinath, Rao Gullapalli, J Claude Hemphill, Gillian Hotz, Sonia Jain, Frederick Korley, Joel Kramer, Natalie Kreitzer, Harvey Levin, Chris Lindsell, Joan Machamer, Christopher Madden, Alastair Martin, Thomas McAllister, Michael McCrea, Randall Merchant, Pratik Mukherjee, Lindsay D Nelson, Florence Noel, David O Okonkwo, Eva Palacios, Daniel Perl, Ava Puccio, Miri Rabinowitz, Claudia S Robertson, Jonathan Rosand, Angelle Sander, Gabriela Satris, David Schnyer, Seth Seabury, Mark Sherer, Murray B Stein, Sabrina Taylor, Arthur Toga, Nancy Temkin, Alex Valadka, Mary J Vassar, Paul Vespa, Kevin Wang, John K Yue, Esther Yuh, Ross Zafonte
Importance: Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), but little is known about factors that modify risk for these psychiatric sequelae, particularly in the civilian sector. Objective: To ascertain prevalence of and risk factors for PTSD and MDD among patients evaluated in the emergency department for mild TBI (mTBI). Design, Setting, and Participants: Prospective longitudinal cohort study (February 2014 to May 2018)...
January 30, 2019: JAMA Psychiatry
https://read.qxmd.com/read/30692232/transition-between-different-renal-replacement-modalities-gaps-in-knowledge-and-care-the-integrated-research-initiative
#11
REVIEW
Christopher Chan, Gill Combes, Simon Davies, Fred Finkelstein, Catherine Firanek, Rafael Gomez, Kitty J Jager, Vivek Jha George, David W Johnson, Mark Lambie, Magdalena Madero, Ikuto Masakane, Stephen McDonald, Madhukar Misra, Sandip Mitra, Thyago Moraes, Annie-Claire Nadeau-Fredette, Purna Mukhopadhyay, Jeff Perl, Ronald Pisoni, Bruce Robinson, Dong-Ryeol Ryu, Rajiv Saran, James Sloand, Nidhi Sukul, Allison Tong, Cheuk-Chun Szeto, Wim Van Biesen
Patients with end-stage kidney disease (ESKD) have different options to replace the function of their failing kidneys. The "integrated care" model considers treatment pathways rather than individual renal replacement therapy (RRT) techniques. In such a paradigm, the optimal strategy to plan and enact transitions between the different modalities is very relevant, but so far, only limited data on transitions have been published. Perspectives of patients, caregivers, and health professionals on the process of transitioning are even less well documented...
January 2019: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://read.qxmd.com/read/30689784/grimm-graph-imputation-and-matching-for-hla-genotypes
#12
Martin Maiers, Michael Halagan, Loren Gragert, Pradeep Bashyal, Jason Brelsford, Joel Schneider, Polina Lutsker, Yoram Louzoun
Motivation: For over 10 years allele-level HLA matching for bone marrow registries has been performed in a probabilistic context. HLA typing technologies provide ambiguous results in that they could not distinguish among all known HLA allele equences; therefore registries have implemented matching algorithms that provide lists of donor and cord blood units ordered in terms of the likelihood of allele-level matching at specific HLA loci. With the growth of registry sizes, current match algorithm implementations are unable to provide match results in real time...
January 28, 2019: Bioinformatics
https://read.qxmd.com/read/30675826/face-mask-use-and-persistence-of-livestock-associated-staphylococcus-aureus-nasal-carriage-among-industrial-hog-operation-workers-and-household-contacts-usa
#13
Maya L Nadimpalli, Jill R Stewart, Elizabeth Pierce, Nora Pisanic, David C Love, Devon Hall, Jesper Larsen, Karen C Carroll, Tsigereda Tekle, Trish M Perl, Christopher D Heaney
BACKGROUND: Industrial hog operation (IHO) workers may persistently carry antibiotic-resistant, livestock-associated Staphylococcus aureus in their nasal cavities. It is unclear whether IHO work activities can alter IHO workers' and their household members' exposure to these bacteria. OBJECTIVE: Our objective was to investigate the relationship of IHO work activities with persistence of antibiotic-resistant, livestock-associated S. aureus nasal carriage among IHO workers and their household members...
December 2018: Environmental Health Perspectives
https://read.qxmd.com/read/30675442/global-capacity-for-clinical-research-in-nephrology-a-survey-by-the-international-society-of-nephrology
#14
REVIEW
Ikechi G Okpechi, Mona Alrukhaimi, Gloria E Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Branko Braam, John Feehally, David C Harris, Vivekanand Jha, Kailash Jindal, David W Johnson, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Adeera Levin, Meaghan Lunney, Timothy Olusegun Olanrewaju, Vlado Perkovic, Jeffrey Perl, Harun Ur Rashid, Eric Rondeau, Babatunde Lawal Salako, Arian Samimi, Laura Sola, Irma Tchokhonelidze, Natasha Wiebe, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-Hui Zhao, Aminu K Bello
Due to the worldwide rising prevalence of chronic kidney disease (CKD), there is a need to develop strategies through well-designed clinical studies to guide decision making and improve delivery of care to CKD patients. A cross-sectional survey was conducted based on the International Society of Nephrology Global Kidney Health Atlas data. For this study, the survey assessed the capacity of various countries and world regions in participating in and conducting kidney research. Availability of national funding for clinical trials was low (27%, n  = 31), with the lowest figures obtained from Africa (7%, n  = 2) and South Asia (0%), whereas high-income countries in North America and Europe had the highest participation in clinical trials...
February 2018: Kidney International Supplements
https://read.qxmd.com/read/30675441/global-coverage-of-health-information-systems-for-kidney-disease-availability-challenges-and-opportunities-for-development
#15
REVIEW
Emily J See, Mona Alrukhaimi, Gloria E Ashuntantang, Aminu K Bello, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Branko Braam, John Feehally, David C Harris, Vivekanand Jha, Kailash Jindal, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Adeera Levin, Meaghan Lunney, Ikechi G Okpechi, Timothy Olusegun Olanrewaju, Mohamed A Osman, Jeffrey Perl, Bilal Qarni, Harun Ur Rashid, Ahmed Rateb, Eric Rondeau, Arian Samimi, Majid L N Sikosana, Laura Sola, Irma Tchokhonelidze, Natasha Wiebe, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-Hui Zhao, David W Johnson
Development and planning of health care services requires robust health information systems to define the burden of disease, inform policy development, and identify opportunities to improve service provision. The global coverage of kidney disease health information systems has not been well reported, despite their potential to enhance care. As part of the Global Kidney Health Atlas, a cross-sectional survey conducted by the International Society of Nephrology, data were collected from 117 United Nations member states on the coverage and scope of kidney disease health information systems and surveillance practices...
February 2018: Kidney International Supplements
https://read.qxmd.com/read/30675440/global-access-of-patients-with-kidney-disease-to-health-technologies-and-medications-findings-from-the-global-kidney-health-atlas-project
#16
REVIEW
Htay Htay, Mona Alrukhaimi, Gloria E Ashuntantang, Aminu K Bello, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Branko Braam, John Feehally, David C Harris, Vivekanand Jha, Kailash Jindal, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Peter G Kerr, Adeera Levin, Meaghan Lunney, Ikechi G Okpechi, Michelle E Olah, Timothy Olusegun Olanrewaju, Mohamed A Osman, Yasin Parpia, Jeffrey Perl, Bilal Qarni, Harun Ur Rashid, Ahmed Rateb, Eric Rondeau, Babatunde Lawal Salako, Laura Sola, Irma Tchokhonelidze, Marcello Tonelli, Natasha Wiebe, Isaac Wirzba, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-Hui Zhao, David W Johnson
Access to essential medications and health products is critical to effective management of kidney disease. Using data from the ISN Global Kidney Health Atlas multinational cross-sectional survey, global access of patients with kidney disease to essential medications and health products was examined. Overall, 125 countries participated, with 118 countries, composing 91.5% of the world's population, providing data on this domain. Most countries were unable to access eGFR and albuminuria in their primary care settings...
February 2018: Kidney International Supplements
https://read.qxmd.com/read/30675439/global-nephrology-workforce-gaps-and-opportunities-toward-a-sustainable-kidney-care-system
#17
REVIEW
Mohamed A Osman, Mona Alrukhaimi, Gloria E Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Branko Braam, Mark Courtney, John Feehally, David C Harris, Vivekanand Jha, Kailash Jindal, David W Johnson, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Scott Klarenbach, Adeera Levin, Meaghan Lunney, Ikechi G Okpechi, Timothy Olusegun Olanrewaju, Jeffrey Perl, Harun Ur Rashid, Eric Rondeau, Babatunde Lawal Salako, Arian Samimi, Laura Sola, Irma Tchokhonelidze, Natasha Wiebe, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-Hui Zhao, Aminu K Bello
The health workforce is the cornerstone of any health care system. An adequately trained and sufficiently staffed workforce is essential to reach universal health coverage. In particular, a nephrology workforce is critical to meet the growing worldwide burden of kidney disease. Despite some attempts, the global nephrology workforce and training capacity remains widely unknown. This multinational cross-sectional survey was part of the Global Kidney Health Atlas project, a new initiative administered by the International Society of Nephrology (ISN)...
February 2018: Kidney International Supplements
https://read.qxmd.com/read/30675438/global-overview-of-health-systems-oversight-and-financing-for-kidney-care
#18
REVIEW
Aminu K Bello, Mona Alrukhaimi, Gloria E Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Branko Braam, John Feehally, David C Harris, Vivekanand Jha, Kailash Jindal, David W Johnson, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Peter G Kerr, Meaghan Lunney, Timothy Olusegun Olanrewaju, Mohamed A Osman, Jeffrey Perl, Harun Ur Rashid, Ahmed Rateb, Eric Rondeau, Aminu Muhammad Sakajiki, Arian Samimi, Laura Sola, Irma Tchokhonelidze, Natasha Wiebe, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-Hui Zhao, Adeera Levin
Reliable governance and health financing are critical to the abilities of health systems in different countries to sustainably meet the health needs of their peoples, including those with kidney disease. A comprehensive understanding of existing systems and infrastructure is therefore necessary to globally identify gaps in kidney care and prioritize areas for improvement. This multinational, cross-sectional survey, conducted by the ISN as part of the Global Kidney Health Atlas, examined the oversight, financing, and perceived quality of infrastructure for kidney care across the world...
February 2018: Kidney International Supplements
https://read.qxmd.com/read/30675437/guidelines-policies-and-barriers-to-kidney-care-findings-from-a-global-survey
#19
REVIEW
Meaghan Lunney, Mona Alrukhaimi, Gloria E Ashuntantang, Aminu K Bello, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Vivekanand Jha, David W Johnson, Kamyar Kalantar-Zadeh, Rumeyza Kazancioglu, Michelle E Olah, Timothy Olusegun Olanrewaju, Mohamed A Osman, Yasin Parpia, Jeffrey Perl, Harun Ur Rashid, Ahmed Rateb, Eric Rondeau, Laura Sola, Irma Tchokhonelidze, Marcello Tonelli, Natasha Wiebe, Isaac Wirzba, Chih-Wei Yang, Feng Ye, Alexander Zemchenkov, Ming-Hui Zhao, Adeera Levin
An international survey led by the International Society of Nephrology in 2016 assessed the current capacity of kidney care worldwide. To better understand how governance and leadership guide kidney care, items pertinent to government priority, advocacy, and guidelines, among others, were examined. Of the 116 responding countries, 36% ( n  = 42) reported CKD as a government health care priority, which was associated with having an advocacy group (χ2 = 11.57; P  = 0.001). Nearly one-half (42%; 49 of 116) of countries reported an advocacy group for CKD, compared with only 19% (21 of 112) for AKI...
February 2018: Kidney International Supplements
https://read.qxmd.com/read/30664538/in-hospital-and-long-term-outcomes-of-hiv-positive-patients-undergoing-pci-according-to-kind-of-stent-a-meta-analysis
#20
Mattia Peyracchia, Roberto Verardi, Sergio Raposeiras Rubin, Emad Abu-Assi, Chiara Montrucchio, Leor Perl, Walter Grossomarra, Andrea Calcagno, Pierluigi Omedè, Antonio Montefusco, Stefano Bonora, Claudio Moretti, Maurizio D'Amico, Rinaldi Mauro, Fabrizio D'Ascenzo
BACKGROUND: Pathogenesis of cardiovascular disease in HIV-positive patients is related to the interaction between traditional and HIV-specific factors. Limited data are available regarding the prognosis of HIV-positive patients undergoing percutaneous coronary intervention (PCI). METHODS: All observational studies evaluating the prognosis of HIV-positive patients treated with PCI were included. In-hospital and long-term major adverse cardiac events (MACE) [composite endpoint of all-cause death or myocardial infarction (MI)] were the primary endpoints, whereas in-hospital and long-term all-cause death, cardiovascular death, MI, stent thrombosis, target vessel revascularization (TVR), target lesion revascularization (TLR), and bleeding complications were the secondary ones...
January 18, 2019: Journal of Cardiovascular Medicine
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