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Sergey Mikhailovich Deyev, Anzhelika Vorobyeva, Alexey Schulga, Galina Proshkina, Rezan Güler, John Löfblom, Bogdan Mitran, Javad Garousi, Mohamed Altai, Jos Buijs, Anna Orlova, Vladimir Tolmachev
Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins which can be selected for binding to desirable molecular targets. High affinity and small size of DARPins render them promising probes for radionuclide molecular imaging. However, detailed knowledge on many factors influencing their imaging properties are still lacking. We have evaluated two human epidermal growth factor 2 (HER2)-specific DARPins with different size and binding properties. DARPins 9_29-H6 and G3-H6 were radiolabeled with iodine-125 and tricarbonyl technetium-99m and evaluated in vitro...
January 4, 2019: Molecular Pharmaceutics
#2
Gül Özçelik, Hafize Emine Sönmez, Sezgin Şahin, Ayşim Özağarı, Meral Torun Bayram, Rümeysa Yasemin Çiçek, Evrim Kargın Çakıcı, Elif Çomak, Kenan Barut, Nihal Şahin, Sevcan Bakkaloğlu, İbrahim Gökçe, Ali Düzova, Yelda Bilginer, Ceyhun Açarı, Engin Melek, Beltinge Demircioğlu Kılıç, Semanur Özdel, Amra Adroviç, Özgür Kasapçopur, Erbil Ünsal, Harika Alpay, Diclehan Orhan, Rezan Topaloğlu, Ruhan Düşünsel, Seza Özen
OBJECTIVE: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are very rare in childhood with an increased risk of morbidity and mortality. We aimed to evaluate renal prognostic factors in childhood AAV from the perspective of ANCA serotype, histopathological classification, and five-factor score (FFS). METHODS: Pediatric AAV patients from 11 referral centers in Turkey had been included to the study. The demographics, clinical findings, AAV subtypes, outcomes, and FFS were evaluated retrospectively...
January 4, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
#3
Rosanna Coppo, Graziella D'Arrigo, Giovanni Tripepi, Maria Luisa Russo, Ian S D Roberts, Shubha Bellur, Daniel Cattran, Terence H Cook, John Feehally, Vladimir Tesar, Dita Maixnerova, Licia Peruzzi, Alessandro Amore, Sigrid Lundberg, Anna Maria Di Palma, Loreto Gesualdo, Francesco Emma, Cristiana Rollino, Manuel Praga, Luigi Biancone, Antonello Pani, Sandro Feriozzi, Rosaria Polci, Jonathan Barratt, Lucia Del Vecchio, Francesco Locatelli, Alessandro Pierucci, Yasar Caliskan, Agnieszka Perkowska-Ptasinska, Magdalena Durlik, Elisabetta Moggia, José C Ballarin, Jack F M Wetzels, Dimitris Goumenos, Marios Papasotiriou, Kresimir Galesic, Luka Toric, Aikaterini Papagianni, Maria Stangou, Luisa Benozzi, Stefano Cusinato, Ulla Berg, Rezan Topaloglu, Milena Maggio, Mai Ots-Rosenberg, Marco D'Amico, Colin Geddes, Olga Balafa, Marco Quaglia, Raffaella Cravero, Calogero Lino Cirami, Bengt Fellstrom, Jürgen Floege, Jesus Egido, Francesca Mallamaci, Carmine Zoccali
Background: It is unknown whether renal pathology lesions in immunoglobulin A nephropathy (IgAN) correlate with renal outcomes over decades of follow-up. Methods: In 1130 patients of the original Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) cohort, we studied the relationship between the MEST score (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T), crescents (C) and other histological lesions with both a combined renal endpoint [50% estimated glomerular filtration rate (eGFR) loss or kidney failure] and the rate of eGFR decline over a follow-up period extending to 35 years [median 7 years (interquartile range 4...
November 9, 2018: Nephrology, Dialysis, Transplantation
#4
Fehime K Eroglu, Fatih Ozaltin, Nazlı Gönç, Hülya Nalçacıoğlu, Z Birsin Özçakar, Dilek Yalnızoğlu, Şafak Güçer, Diclehan Orhan, Fatma Tuba Eminoğlu, Rahşan Göçmen, Ayfer Alikaşifoğlu, Rezan Topaloğlu, Ali Düzova
BACKGROUND: COQ2 mutations cause a rare infantile multisystemic disease with heterogeneous clinical features. Promising results have been reported in response to Coenzyme Q10 treatment, especially for kidney involvement, but little is known about the long-term outcomes. METHODS: We report four new patients from two families with the c.437G→A (p.Ser146Asn) mutation in COQ2 and the outcomes of two patients after long-term coenzyme Q10 treatment. RESULTS: Index cases from two families presented with vomiting, nephrotic range proteinuria, and diabetes in early infancy...
July 27, 2018: Pediatric Neurology
#5
Yasemin Cag, Oguz Karabay, Oguz Resat Sipahi, Firdevs Aksoy, Gul Durmus, Ayse Batirel, Oznur Ak, Zeliha Kocak-Tufan, Aynur Atilla, Nihal Piskin, Turkay Akbas, Serpil Erol, Derya Ozturk-Engin, Hulya Caskurlu, Ugur Onal, Haluk Erdogan, Aslıhan Demirel, Arzu Dogru, Rezan Harman, Aziz Ahmad Hamidi, Derya Karasu, Fatime Korkmaz, Pınar Korkmaz, Fatma Civelek Eser, Yalcin Onem, Sinem Cesur, Musa Salmanoglu, İlknur Erdem, Hüsrev Diktas, Haluk Vahaboglu
Sepsis is a severe clinical syndrome owing to its high mortality. Quick Sequential Organ Failure Assessment (qSOFA) score has been proposed for the prediction of fatal outcomes in sepsis syndrome in emergency departments. Due to the low predictive performance of the qSOFA score, we propose a modification to the score by adding age. We conducted a multicenter, retrospective cohort study among regional referral centers from various regions of the country. Participants recruited data of patients admitted to emergency departments and obtained a diagnosis of sepsis syndrome...
2018: PloS One
#6
Bogdan Mitran, Rezan Güler, Francis P Roche, Elin Lindström, Ram Kumar Selvaraju, Filippa Fleetwood, Sara S Rinne, Lena Claesson-Welsh, Vladimir Tolmachev, Stefan Ståhl, Anna Orlova, John Löfblom
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key mediator of angiogenesis and therefore a promising therapeutic target in malignancies including glioblastoma multiforme (GBM). Molecular imaging of VEGFR2 expression may enable patient stratification for antiangiogenic therapy. The goal of the current study was to evaluate the capacity of the novel anti-VEGFR2 biparatopic affibody conjugate (ZVEGFR2 -Bp2 ) for in vivo visualization of VEGFR2 expression in GBM. Methods: ZVEGFR2 -Bp2 coupled to a NODAGA chelator was generated and radiolabeled with indium-111...
2018: Theranostics
#7
Britta Höcker, Lukas Schneble, Luisa Murer, Andrea Carraro, Lars Pape, Birgitta Kranz, Jun Oh, Matthias Zirngibl, Luca Dello Strologo, Anja Büscher, Lutz T Weber, Atif Awan, Martin Pohl, Martin Bald, Nikoleta Printza, Krisztina Rusai, Licia Peruzzi, Rezan Topaloglu, Alexander Fichtner, Kai Krupka, Lennart Köster, Thomas Bruckner, Paul Schnitzler, Hans H Hirsch, Burkhard Tönshoff
BACKGROUND: BK polyomavirus-associated nephropathy (BKPyVAN) constitutes a serious cause of kidney allograft failure, but large-scale data in pediatric renal transplant recipients and a comprehensive analysis of specific risk factors are lacking. METHODS: We analyzed data of 313 patients in the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN) registry, with an observation period of 3.3 years (range, 1 - 5). The net state of immunosuppressive therapy was assessed by the modified Vasudev score...
August 20, 2018: Transplantation
#8
Britta Höcker, Julia Tabatabai, Lukas Schneble, Jun Oh, Florian Thiel, Lars Pape, Krisztina Rusai, Rezan Topaloglu, Birgitta Kranz, Günter Klaus, Nikoleta Printza, Onder Yavascan, Alexander Fichtner, Kai Krupka, Thomas Bruckner, Rüdiger Waldherr, Michael Pawlita, Paul Schnitzler, Hans H Hirsch, Burkhard Tönshoff
BACKGROUND: JC polyomavirus (JCPyV)-associated nephropathy (JCPyVAN) is a severe, but rare complication in adult renal transplant (RTx) recipients. Related data in pediatric patients are scarce. METHODS: Based on the CERTAIN Registry, we therefore performed a multi-center, retrospective study on the JCPyV antibody status, prevalence of JCPyV replication, and its associated disease in 139 pediatric RTx recipients (mean age, 8.5 ± 5.3 years). JCPyV DNA in plasma and/or urine was measured by quantitative PCR at a median time of 3...
December 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
#9
Fadi G Mirza, Rezan Abdul-Kadir, Christian Breymann, Ian S Fraser, Ali Taher
Iron deficiency and iron deficiency anemia are highly prevalent among women throughout their lives. Some females are particularly vulnerable to iron deficiency/iron deficiency anemia, including those with heavy menstrual bleeding (HMB) and pregnant/postpartum women. Despite the high prevalence of iron deficiency/iron deficiency anemia in women, the condition is still underdiagnosed and therefore undertreated, with serious clinical consequences. Areas covered: The following review examines the impact of iron deficiency and iron deficiency anemia on clinical outcomes and quality of life in women from adolescence to post-menopause, paying particular attention to guidelines and current recommendations for diagnostic tests and management...
September 2018: Expert Review of Hematology
#10
Kamile Burcu Celik, Elif Ceylan Cengiz, Taner Sar, Burcu Dursun, Osman Ozturk, Meltem Yesilcimen Akbas, Rezan Demir-Cakan
Lithium-Sulfur (Li-S) batteries are mostly known for their high energy density and cost-effectiveness. However, their intrinsic problems hinder their implementation into the marketplace. The most pronounced problems are the parasitic reactions which occur between lithium polysulfides species and lithium metal anode, the volume expansion of sulfur (80%) at the end of discharge and the safety issues which are linked with the use of lithium metal. Herein this work, two approaches are applied to prevent these effects; one approach is the use of Li2 S as cathode material, instead of starting from sulfur powder, both to circumvent the volume expansion of sulfur taking place during discharge and to enable lithium-free anodes cell assembling (i...
November 15, 2018: Journal of Colloid and Interface Science
#11
Kathrin Burgmaier, Kevin Kunzmann, Gema Ariceta, Carsten Bergmann, Anja Katrin Buescher, Mathias Burgmaier, Ismail Dursun, Ali Duzova, Loai Eid, Florian Erger, Markus Feldkoetter, Matthias Galiano, Michaela Geßner, Heike Goebel, Ibrahim Gokce, Dieter Haffner, Nakysa Hooman, Bernd Hoppe, Augustina Jankauskiene, Guenter Klaus, Jens König, Mieczyslaw Litwin, Laura Massella, Djalila Mekahli, Engin Melek, Sevgi Mir, Lars Pape, Larisa Prikhodina, Bruno Ranchin, Raphael Schild, Tomas Seeman, Lale Sever, Rukshana Shroff, Neveen A Soliman, Stella Stabouli, Malgorzata Stanczyk, Yilmaz Tabel, Katarzyna Taranta-Janusz, Sara Testa, Julia Thumfart, Rezan Topaloglu, Lutz Thorsten Weber, Dorota Wicher, Elke Wühl, Simone Wygoda, Alev Yilmaz, Katarzyna Zachwieja, Ilona Zagozdzon, Klaus Zerres, Jörg Dötsch, Franz Schaefer, Max Christoph Liebau
OBJECTIVE: To identify prenatal, perinatal, and postnatal risk factors for dialysis within the first year of life in children with autosomal recessive polycystic kidney disease (ARPKD) as a basis for parental counseling after prenatal and perinatal diagnosis. STUDY DESIGN: A dataset comprising 385 patients from the ARegPKD international registry study was analyzed for potential risk markers for dialysis during the first year of life. RESULTS: Thirty-six out of 385 children (9...
August 2018: Journal of Pediatrics
#12
Florian Lüke, Raquel Blazquez, Rezan Fahrioglu Yamaci, Xin Lu, Benedikt Pregler, Stefan Hannus, Karin Menhart, Dirk Hellwig, Hans-Jürgen Wester, Saskia Kropf, Daniel Heudobler, Jirka Grosse, Jutta Moosbauer, Markus Hutterer, Peter Hau, Markus J Riemenschneider, Michaela Bayerlová, Annalen Bleckmann, Bernhard Polzer, Tim Beißbarth, Christoph A Klein, Tobias Pukrop
Brain and leptomeningeal metastasis (LMM) of non-small cell lung cancer is still associated with poor prognosis. Moreover, the current diagnostic standard for LMM often yields false negative results and the scientific progress in this field is still unsatisfying. We present a case of a 71-year old patient with an isolated LMM. While standard diagnostics could only diagnose a cancer of unknown primary, the use of [68 Ga]-Pentixafor-PET/CT (CXCR4-PET/CT, a radiotracer targeting CXCR4) and a liquid biopsy of the cerebrospinal fluid revealed the primary NSCLC...
April 10, 2018: Oncotarget
#13
Marcus Weitz, Guido F Laube, Maria Schmidt, Kai Krupka, Luisa Murer, Dominik Müller, Bernd Hoppe, Anja Büscher, Jens König, Martin Pohl, Therese Jungraithmayr, Florian Thiel, Heiko Billing, Ryszard Grenda, Jacek Rubik, Michael M Kaabak, Fatos Yalcinkaya, Rezan Topaloglu, Nicholas Webb, Luca Dello Strologo, Lars Pape, Silvio Nadalin, Burkhard Tönshoff
BACKGROUND: Infants with a body weight of less than 10 kg are often not considered to be suitable candidates for renal transplantation (RTx). The objective of this study was to evaluate this arbitrary weight threshold for pediatric RTx. METHODS: We conducted a multicenter, retrospective, match-controlled cohort study on infants weighing less than 10 kg at time of engrafting (low-weight group [LWG], n = 38) compared to a matched control group (n = 76) with a body weight of 10-15 kg, using data from the first 2 years post-transplant derived from the CERTAIN Registry...
June 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
#14
Ezgi Deniz Batu, Hafize Emine Sönmez, Bora Gülhan, Zehra Serap Arıcı, Rezan Topaloğlu, Yelda Bilginer
Batu ED, Sönmez HE, Gülhan B, Arıcı ZS, Topaloğlu R, Bilginer Y. Predictors of methotrexate response in Turkish children with oligoarticular and polyarticular juvenile idiopathic arthritis. Turk J Pediatr 2017; 59: 6-12. Methotrexate (MTX) is the most commonly used disease modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA). We aimed to define predictor factors for response to MTX in Turkish children with oligo- and polyarticular JIA. We reviewed the medical files of 59 oligo- and 57 polyarticular JIA patients seen in the clinic between May 2008 and May 2013 and who received MTX for ≥6 months...
2017: Turkish Journal of Pediatrics
#15
Anne-Sophie Ducloy-Bouthors, Andrea Baldini, Rezan Abdul-Kadir, Jacky Nizard
: Thromboembolic events in the pregnant and postpartum patient remain rare but potentially fatal complications. The aim of this section was to analyse the few prospective studies addressing the issue of thromboprophylaxis following a surgical procedure during and immediately after pregnancy, as well as national guidelines, and to propose European guidelines on this specific condition. Thromboprophylaxis is broadly recommended due to the combined risks of surgery and pregnancy or the postpartum period, regardless of the mode of delivery...
February 2018: European Journal of Anaesthesiology
#16
Cenk Conkbayir, Rezan Fahrioglu Yamaci, Pinar Gencer, Burc Barin, Genco Yucel, Cenk Eray Yildiz, Murat Ugurlucan, A Nazli Basak
BACKGROUND: The distribution of gene variants in the Turkish Cypriot population with coronary artery disease has not been investigated. In this study, we sought to research different genetic variants in the susceptibility to coronary artery disease and to identify possible associations between various clinical parameters and the genes involved in blood coagulation as well as glucose and lipid metabolism among the Turkish Cypriots and compared the results with the respective Turkish patients from Turkey...
October 30, 2017: Heart Surgery Forum
#17
Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Luca Dello Strologo, Nicholas J A Webb, Martin Bald, Gurkan Genc, Heiko Billing, Jens König, Anja Büscher, Markus J Kemper, Stephen D Marks, Martin Pohl, Marianne Wigger, Rezan Topaloglu, Susanne Rieger, Kai Krupka, Thomas Bruckner, Alexander Fichtner, Burkhard Tönshoff
BACKGROUND: Because infections constitute a major cause of morbidity and mortality in paediatric renal allograft recipients, avoidance of preventable systemic infections by vaccination before transplantation is of utmost importance. However, data on the completeness of vaccinations and factors associated with incomplete vaccination coverage are scarce. METHODS: Within the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national, retrospective study investigating the vaccination coverage before transplantation of 254 European children with end-stage renal disease (mean age 10...
February 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
#18
Ahmet Guner, Aykun Hakgor, Sabahattin Gunduz, Rezan Aksoy, Nuri Havan, Lutfi Ocal, Mehmet Celik, Emrah Bayam, Mehmet Ozkan
No abstract text is available yet for this article.
March 2018: Coronary Artery Disease
#19
Rezan Topaloglu, Bora Gulhan, Mihriban İnözü, Nur Canpolat, Alev Yilmaz, Aytül Noyan, İsmail Dursun, İbrahim Gökçe, Metin Kaya Gürgöze, Nurver Akinci, Esra Baskin, Erkin Serdaroğlu, Beltinge Demircioğlu Kiliç, Selçuk Yüksel, Duygu Övünç Hacihamdioğlu, Emine Korkmaz, Mutlu Hayran, Fatih Ozaltin
BACKGROUND AND OBJECTIVES: Infantile nephropathic cystinosis is a severe disease that occurs due to mutations in the cystinosis gene, and it is characterized by progressive dysfunction of multiple organs; >100 cystinosis gene mutations have been identified in multiple populations. Our study aimed to identify the clinical characteristics and spectrum of cystinosis gene mutations in Turkish pediatric patients with cystinosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We identified the clinical characteristics and spectrum of cystinosis gene mutations in Turkish patients with cystinosis in a multicenter registry that was established for data collection...
August 9, 2017: Clinical Journal of the American Society of Nephrology: CJASN
#20
Rezan Fahrioglu Yamaci, Scott P Fraser, Esra Battaloglu, Handan Kaya, Kamil Erguler, Christopher S Foster, Mustafa B A Djamgoz
Expression of the neonatal splice variant of the voltage-gated sodium channel α-subunit (VGSC) subtype Nav1.5 (nNav1.5), encoded by the gene SCN5A, was shown earlier to be upregulated in human breast cancer (BCa), both in vitro and in vivo. Channel activity promoted BCa invasion of Matrigel® in vitro and metastasis in vivo. Consequently, expression of nNav1.5 has been proposed as a functional biomarker of BCa cells with metastatic potential. Here, we have determined immunohistochemically both nNav1.5 and total VGSC (tVGSC) protein expression in a range of adult human tissues...
August 2017: Pathology, Research and Practice
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