Ondrej Bonczek, Premysl Krejci, Lydie Izakovicova-Holla, Pavlina Cernochova, Igor Kiss, Borivoj Vojtesek
Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co-expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR and WNT10A genes are associated with tooth agenesis. Currently, variants in ATF1, DUSP10, CASC8, IRF6, KDF1, GREM2, LTBP3 and components and regulators of WNT signaling WNT10B, LRP6, DKK, KREMEN1 are at the forefront of interest...
November 29, 2020: Clinical Genetics