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https://read.qxmd.com/read/30746520/first-draft-genome-sequence-of-leishmania-viannia-lainsoni-strain-216-34-isolated-from-a-peruvian-clinical-case
#1
Wuling Lin, Dhwani Batra, Vidhya Narayanan, Lori A Rowe, Mili Sheth, Yueli Zheng, Phalasy Juieng, Vladimir Loparev, Marcos de Almeida
We present here the first draft genome sequence of Leishmania (Viannia) lainsoni strain 216-34, sequenced using PacBio and MiSeq platforms. PacBio contigs were generated from de novo assemblies using CANU version 1.6 and polished using Illumina reads.
February 2019: Microbiology resource announcements
https://read.qxmd.com/read/30715419/prognosis-of-malignant-pheochromocytoma-and-paraganglioma-mapp-prono-study-an-ens-t-retrospective-study
#2
Segolene Hescot, Maria Curras-Freixes, Timo Deutschbein, Anouk van Berkel, Delphine Vezzosi, Laurence Amar, Christelle de la Fouchardière, Nuria Valdes, Nando Riccardi, Christine Do Cao, Jerome Bertherat, Bernard Goichot, Felix Beuschlein, Delphine Drui, Letizia Canu, Patricia Niccoli, Sandrine Laboureau, Antoine Tabarin, Sophie Leboulleux, Bruna Calsina, Rossella Libé, Antongiulio Faggiano, Martin Schlumberger, Francoise Borson-Chazot, Massimo Mannelli, Anne-Paule Gimenez-Roqueplo, Philippe Caron, Henri J L M Timmers, Martin Fassnacht, Mercedes Robledo, Isabelle Borget, Eric Baudin
Background: Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for prognostic parameters of overall survival in MPP patients. Patients and Methods: Retrospective multicentric study of MPP characterized by a neck-thoraco-abdomino-pelvic CT or MRI at the time of malignancy diagnosis in European centers between 1998 and 2010. Results: We included 169 patients from 18 European centers...
February 1, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30665291/tracheostomy-after-total-thyroidectomy-indications-and-results-in-a-series-of-3214-operations
#3
Giuseppe Pisano, Gian Luigi Canu, Enrico Erdas, Fabio Medas, Pietro G Calò
No abstract text is available yet for this article.
January 18, 2019: Minerva Chirurgica
https://read.qxmd.com/read/30660595/natural-history-treatment-and-long-term-follow-up-of-patients-with-multiple-endocrine-neoplasia-type-2b-an-international-multicentre-retrospective-study
#4
Frederic Castinetti, Steven G Waguespack, Andreas Machens, Shinya Uchino, Kornelia Lazaar, Gabriella Sanso, Tobias Else, Sarka Dvorakova, Xiao Ping Qi, Rossella Elisei, Ana Luisa Maia, John Glod, Delmar Muniz Lourenço, Nuria Valdes, Jes Mathiesen, Nelson Wohllk, Tushar R Bandgar, Delphine Drui, Marta Korbonits, Maralyn R Druce, Caroline Brain, Tom Kurzawinski, Atila Patocs, Maria Joao Bugalho, Andre Lacroix, Philippe Caron, Patricia Fainstein-Day, Francoise Borson Chazot, Marc Klein, Thera P Links, Claudio Letizia, Laura Fugazzola, Olivier Chabre, Letizia Canu, Regis Cohen, Antoine Tabarin, Anita Spehar Uroic, Dominique Maiter, Sandrine Laboureau, Caterina Mian, Mariola Peczkowska, Frederic Sebag, Thierry Brue, Delphine Mirebeau-Prunier, Laurence Leclerc, Birke Bausch, Amandine Berdelou, Akihiro Sukurai, Petr Vlcek, Jolanta Krajewska, Marta Barontini, Carla Vaz Ferreira Vargas, Laura Valerio, Lucieli Ceolin, Srivandana Akshintala, Ana Hoff, Christian Godballe, Barbara Jarzab, Camilo Jimenez, Charis Eng, Tsuneo Imai, Martin Schlumberger, Elizabeth Grubbs, Henning Dralle, Hartmut P Neumann, Eric Baudin
BACKGROUND: Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection. METHODS: This study was a retrospective, multicentre, international study in patients carrying the Met918Thr RET variant with no age restrictions...
January 16, 2019: Lancet Diabetes & Endocrinology
https://read.qxmd.com/read/30658940/impact-of-the-direct-acting-antiviral-agents-daas-on-chronic-hepatitis-c-in-sardinian-patients-with-transfusion-dependent-thalassemia-major
#5
Maria Laura Ponti, Federica Comitini, Debora Murgia, Roberto Ganga, Roberto Canu, Carlo Dessì, Maria Loreta Foschini, GianBattista Leoni, Maddalena Morittu, Maria Perra, Maria Paola Pilia, Maria Rosaria Casini, Antonietta Zappu, Raffaella Origa
BACKGROUND AND AIMS: Direct antiviral agents (DAAs) have revolutionised the standard of care for the treatment of hepatitis even in patients with hemoglobinopathies. The aim of this study is to show how, thanks to DAAs, HCV infection has been substantially eradicated in one of the biggest Centres for the management of Thalassemia in Europe. METHODS: Thalassemia major patients regularly transfused and iron chelated in Cagliari (Italy) who were HCV-RNA positive were evaluated for the potential prescription of antiviral therapy...
January 3, 2019: Digestive and Liver Disease
https://read.qxmd.com/read/30612488/treatment-with-d-chiro-inositol-and-alpha-lipoic-acid-in-the-management-of-polycystic-ovary-syndrome
#6
Franca Fruzzetti, Anna Capozzi, Alessandro Canu, Stefano Lello
To evaluate the effects of the combination of d-chiro inositol and alpha lipoic acid on menstrual cycles and insulin sensitivity in women with polycystic ovary syndrome (PCOS). Forty-one women with PCOS and 31 controls have been enrolled in the study. The menstrual cycle, BMI, homeostasis model assessment index (HOMA-I), and insulin secretion in response to an OGTT were evaluated before and after 6 months of treatment. During the observation period, the patients have been asked to not modify their diet and physical activity...
January 7, 2019: Gynecological Endocrinology
https://read.qxmd.com/read/30605869/added-value-of-multimodal-mri-to-the-clinical-diagnosis-of-primary-progressive-aphasia-variants
#7
Elisa Canu, Federica Agosta, Francesca Imperiale, Andrea Fontana, Francesca Caso, Edoardo Gioele Spinelli, Giuseppe Magnani, Andrea Falini, Giancarlo Comi, Massimo Filippi
OBJECTIVE: To determine the added value of multimodal structural magnetic resonance imaging (MRI) to language assessment in the differential diagnosis of primary progressive aphasia (PPA) variants. METHODS: 59 PPA patients [29 nonfluent (nfvPPA), 15 semantic (svPPA), 15 logopenic (lvPPA)] and 38 healthy controls underwent 3D T1-weighted and diffusion tensor (DT) MRI. PPA patients also performed a comprehensive language assessment. Cortical thickness measures and DT MRI indices of white matter tract integrity were obtained...
December 8, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://read.qxmd.com/read/30584016/automated-classification-of-alzheimer-s-disease-and-mild-cognitive-impairment-using-a-single-mri-and-deep-neural-networks
#8
Silvia Basaia, Federica Agosta, Luca Wagner, Elisa Canu, Giuseppe Magnani, Roberto Santangelo, Massimo Filippi
We built and validated a deep learning algorithm predicting the individual diagnosis of Alzheimer's disease (AD) and mild cognitive impairment who will convert to AD (c-MCI) based on a single cross-sectional brain structural MRI scan. Convolutional neural networks (CNNs) were applied on 3D T1-weighted images from ADNI and subjects recruited at our Institute (407 healthy controls [HC], 418 AD, 280 c-MCI, 533 stable MCI [s-MCI]). CNN performance was tested in distinguishing AD, c-MCI and s-MCI. High levels of accuracy were achieved in all the classifications, with the highest rates achieved in the AD vs HC classification tests using both the ADNI dataset only (99%) and the combined ADNI + non-ADNI dataset (98%)...
December 18, 2018: NeuroImage: Clinical
https://read.qxmd.com/read/30583117/maternal-admissions-to-intensive-care-units-in-france-trends-in-rates-causes-and-severity-from-2010-to-2014
#9
Y Barry, C Deneux-Tharaux, M Saucedo, V Goulet, I Guseva-Canu, N Regnault, A A Chantry
INTRODUCTION: Maternal intensive care unit admission is an indicator of severe maternal morbidity. The objective of this study was to estimate rates of maternal intensive care unit admission during or following pregnancy in France, and to describe the characteristics of women concerned, the severity of their condition, associated diagnoses, regional disparities, and temporal trends between 2010 and 2014. METHODS: Women hospitalised in France in intensive care units during pregnancy or up to 42 days after pregnancy between January 2010 and December 2014 were identified using the national hospital discharge database (PMSI-MCO)...
December 21, 2018: Anaesthesia, Critical Care & Pain Medicine
https://read.qxmd.com/read/30563602/pseudoangiomatous-stromal-hyperplasia-pash-presenting-as-axillary-lump-case-report-and-review-of-the-literature
#10
G L Canu, F Medas, A Ravarino, S Furcas, G Loi, G Cerrone, C Rossi, E Erdas, G Calò
Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon benign mesenchymal breast lesion. There are extremely rare reports of PASH arising in accessory breast tissue. To date, in literature, fewer than 10 cases of PASH occurring in axillary region have been described. We report a case presenting as axillary lump in a young woman. A 20-year-old female presented to our surgical unit for a progressively growing and painful palpable mass of the right axilla for about a year. Before surgery an ultrasound was performed...
November 2018: Il Giornale di Chirurgia
https://read.qxmd.com/read/30515664/francecoag-a-22-year-prospective-follow-up-of-the-national-french-cohort-of-patients-with-inherited-bleeding-disorders
#11
Alexandra Doncarli, Virginie Demiguel, Irina Guseva Canu, Véronique Goulet, Sophie Bayart, Thierry Calvez, Sabine Castet, Vincent Dalibard, Yohan Demay, Birgit Frotscher, Jenny Goudemand, Thierry Lambert, Vanessa Milien, Caroline Oudot, Thomas Sannié, Hervé Chambost
FranceCoag is an ongoing open prospective multicentre cohort project aimed at improving epidemiological knowledge about inherited bleeding disorders in France. The main objective of this article was to evaluate the project's progress as of the 30th December 2016. Between 1994 and this date, of the 10,047 patients included in the study, 384 (3.8%) were reported by clinicians to have died and 159 (1.6%) to be lost to follow-up. Among the remaining 9504 patients still being followed up, 5748 (60.5%) had haemophilia A, 1300 (13...
December 5, 2018: European Journal of Epidemiology
https://read.qxmd.com/read/30511903/the-potential-chondrogenic-effect-of-e-autumnalis-aqueous-extracts-on-porcine-adipose-derived-mscs
#12
Makwese Johannes Maepa, Cornelius Canu Ssemakulu, Keolebogile Shirley Caroline M Motaung
Articular cartilage defects are common, causing significant pain and morbidities. To date, tissue engineering techniques using adipose-derived mesenchymal stem cells have offered a promising modality for cartilage repair. In this study, we investigated the effects of Eucomis autumnalis (E. autumnalis) aqueous crude extracts in porcine adipose-derived mesenchymal stem cells (pADMSCs) to determine whether they can differentiate pADMSCs into chondrocytes. Porcine ADMSCs were prepared and treated with different concentrations of E...
December 4, 2018: Tissue Engineering. Part A
https://read.qxmd.com/read/30486103/cribrilinids-bryozoa-cheilostomata-associated-with-deep-water-coral-habitats-at-the-great-bahama-bank-slope-nw-atlantic-with-description-of-new-taxa
#13
A Rosso, L Beuck, A Vertino, R Sanfilippo, A Freiwald
Four cribrilinid bryozoans associated with deep-water corals (578-682 m depth) from the Great Bahama Bank slope, are described, two of them are new. The generic allocation of some species prompted us to raise the subgenera Puellina, Cribrilaria, and Glabrilaria to genus rank. The new combination Cribrilaria saginata (Winston, 2005) n. comb. is proposed. Genus Glabrilaria is reported from the NW Atlantic for the first time based on the description of Glabrilaria hirsuta Rosso n. sp. and Glabrilaria polita Rosso n...
November 23, 2018: Zootaxa
https://read.qxmd.com/read/30476173/fascin-1-is-a-novel-prognostic-biomarker-associated-with-tumor-invasiveness-in-adrenocortical-carcinoma
#14
Giada Poli, Carmen Ruggiero, Giulia Cantini, Letizia Canu, Gianna Baroni, Roberta Armignacco, Anne Jouinot, Raffaella Santi, Tonino Ercolino, Bruno Ragazzon, Guillaume Assie, Massimo Mannelli, Gabriella Nesi, Enzo Lalli, Michaela Luconi
CONTEXT: Novel tumor markers are urgently needed to better stratify adrenocortical cancer (ACC) patients and improve therapies for this aggressive neoplasm. OBJECTIVE: To assess the diagnostic and prognostic value of the actin-bundling protein fascin-1 (FSCN1) in adrenocortical tumors. DESIGN, SETTING AND PARTICIPANTS: A local series of 37 malignant/37 benign adrenocortical tumors at Careggi University Hospital and two independent validation ACC cohorts (Cochin, TCGA) from the European Network for the Study of Adrenal Tumors were studied...
November 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30458558/transcranial-color-coded-sonography-for-monitoring-idiopathic-intracranial-hypertension
#15
Andrea Naldi, Piergiorgio Lochner, Piera Canu, Roberto Settembre, Simona Alessi, Sandro Sanguigni
No abstract text is available yet for this article.
November 20, 2018: Ultraschall in der Medizin
https://read.qxmd.com/read/30397222/early-movement-restriction-leads-to-maladaptive-plasticity-in-the-sensorimotor-cortex-and-to-movement-disorders
#16
Maxime Delcour, Michaël Russier, Francis Castets, Nathalie Turle-Lorenzo, Marie-Hélène Canu, Florence Cayetanot, Mary F Barbe, Jacques-Olivier Coq
Motor control and body representations in the central nervous system are built, i.e., patterned, during development by sensorimotor experience and somatosensory feedback/reafference. Yet, early emergence of locomotor disorders remains a matter of debate, especially in the absence of brain damage. For instance, children with developmental coordination disorders (DCD) display deficits in planning, executing and controlling movements, concomitant with deficits in executive functions. Thus, are early sensorimotor atypicalities at the origin of long-lasting abnormal development of brain anatomy and functions? We hypothesize that degraded locomotor outcomes in adulthood originate as a consequence of early atypical sensorimotor experiences that induce developmental disorganization of sensorimotor circuitry...
November 5, 2018: Scientific Reports
https://read.qxmd.com/read/30383267/ct-characteristics-of-pheochromocytoma-relevance-for-the-evaluation-of-adrenal-incidentaloma
#17
Letizia Canu, Janna A W Van Hemert, Michiel Kerstens, Robert P Hartman, Aakanksha Khanna, Ivana Kraljevic, Darko Kastelan, Corin Badiu, Urszula Ambroziak, Antoine Tabarin, Magalie Haissaguerre, Edward Buitenwerf, Anneke Visser, Massimo Mannelli, Wiebke Arlt, Vasileios Chortis, Isabelle Bourdeau, Nadia Gagnon, Marie Buchy, Francoise Borson-Chazot, Timo Deutschbein, Martin Fassnacht, H Alicja Hubalewska Dydejczyk, Marcin Motyka, Ewelina Rzepka, Ruth T Casey, Benjamin G Challis, Marcus Quinkler, Laurent Vroonen, Ariadni Spyroglou, Felix Beuschlein, Cristina Lamas, William F Young, Irina Bancos, Henri J L M Timmers
Background: Up to 7% of all adrenal incidentalomas (AIs) are pheochromocytomas (PCCs). In the evaluation of AI, it is generally recommended to exclude PCC by measurement plasma free or 24h urinary fractionated metanephrines. However, recent studies suggest to abstain from biochemical exclusion of PCC in cases of lesions with computed tomography (CT) characteristics of an adrenocortical adenoma (ACA). Aim: To determine the proportion of PCCs with ACA-like attenuation or contrast washout on CT...
October 31, 2018: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30313171/bryozoa-on-disarticulated-bivalve-shells-from-todos-os-santos-bay-northeastern-brazil-with-the-description-of-two-new-species
#18
Ana C S Almeida, Facelucia B C Souza, Jamile Farias, Orane F S Alves, Leandro M Vieira
As sessile organisms, bryozoans are among the commonest components of the encrusting communities on hard substrata. On unconsolidated bottoms, benthic animals and their carapaces, including mollusk shells, represent potential surfaces for encrustation. Here we describe the bryozoan fauna growing on disarticulated bivalve shells collected intertidally on Itaparica beach, Todos os Santos Bay, northeast Brazil. We examined a total of 382 valves representing seven species of bivalves, among which we found 82 valves of three bivalve species to be encrusted by bryozoans, with 109 bryozoan colonies detected overall...
June 18, 2018: Zootaxa
https://read.qxmd.com/read/30305834/estimation-of-pack-density-in-grey-wolf-canis-lupus-by-applying-spatially-explicit-capture-recapture-models-to-camera-trap-data-supported-by-genetic-monitoring
#19
Luca Mattioli, Antonio Canu, Daniela Passilongo, Massimo Scandura, Marco Apollonio
Background: Density estimation is a key issue in wildlife management but is particularly challenging and labour-intensive for elusive species. Recently developed approaches based on remotely collected data and capture-recapture models, though representing a valid alternative to more traditional methods, have found little application to species with limited morphological variation. We implemented a camera trap capture-recapture study to survey wolf packs in a 560-km2 area of Central Italy...
2018: Frontiers in Zoology
https://read.qxmd.com/read/30298114/emergency-laparoscopic-repair-of-giant-left-diaphragmatic-hernia-following-minimally-invasive-esophagectomy-description-of-a-case-and-review-of-the-literature
#20
Enrico Erdas, Gian Luigi Canu, Luca Gordini, Paolo Mura, Giulia Laconi, Giuseppe Pisano, Fabio Medas, Pietro Giorgio Calò
Postoperative diaphragmatic hernia (PDH) is an increasingly reported complication of esophageal cancer surgery. PDH occurs more frequently when minimally invasive techniques are employed, but very little is known about its pathogenesis. Currently, no consensus exists concerning preventive measures and its management. A 71-year-old man underwent minimally invasive esophagectomy for esophageal cancer. Three months later, he developed a giant PDH, which was repaired by direct suture via laparoscopic approach. A hypertensive pneumothorax occurred during surgery...
2018: Case Reports in Surgery
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