J P Torres, C Ibañez, R Valenzuela, S Bahamondes, V De la Maza, M Villarroel, P Coria, V Contardo, A M Álvarez, M Zubieta, V Gutierrez, K Ducasse, D Martínez, M E Santolaya
OBJECTIVES: To validate the efficacy and safety of withholding antimicrobial therapy in a new cohort of children with cancer and febrile neutropenia (FN) having a demonstrated viral respiratory tract infection (RTI). METHODS: Prospective, multicenter, non-inferiority, randomized study, approved by the ethical committee, in children presenting with FN at seven hospitals in Chile, evaluated at admission for diagnosis of bacterial and viral pathogens. Children who were positive for a respiratory virus (RV), negative for a bacterial pathogen and had a favorable evolution after 48-72 hours of antimicrobial therapy were randomized to either maintain or withhold antimicrobial therapy...
April 20, 2024: Clinical Microbiology and Infection