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Margo Mountjoy, Astrid Junge, Richard Budgett, Dominik Doerr, Michel Leglise, Stuart Miller, Jane Moran, Jeremy Foster
OBJECTIVE: To identify changes in International Federations' priorities and the barriers to implementing athlete and global health initiatives. Results should influence the work of the International Federation medical committees, the IOC and the Association of Summer Olympic International Federation. METHODS: The 28 Summer and 7 Winter International Federations participating in the most recent Olympic Games (2016; 2018) were surveyed to (i) identify the importance of 27 health topics, (ii) assess their progress on implementation health-related programmes and (iii) the barriers to implementation of these programmes...
March 15, 2019: British Journal of Sports Medicine
Amanda R Vest, Michael Chan, Anita Deswal, Michael M Givertz, Carolyn Lekavich, Terry Lennie, Sheldon E Litwin, Lauren Parsly, Jo Ellen Rodgers, Michael W Rich, P Christian Schulze, Aaron Slader, Akshay Desai
Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited...
March 12, 2019: Journal of Cardiac Failure
M Göbel, R Eming
BACKGROUND: Bullous pemphigoid, the most common autoimmune blistering disease of the skin in adults, is caused by autoantibodies against hemidesmosomal adhesion proteins (BP180/type XVII collagen and BP230), leading into subepidermal blistering. Therefore patients, mostly older than 70 years, show tight bullae and erosions of the skin and rarely at mucous membranes. PROBLEM: Usually the disease shows a chronically relapsing course. Thus there is a need for long-term topical corticosteroids and if necessary systemic immunosuppressives...
March 12, 2019: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Adrian Pona, Wasim Haidari, Sree S Kolli, Steven R Feldman
BACKGROUND: Patients with psoriasis have a growing interest in managing their disease through diet. OBJECTIVE: This review paper aims to analyze dietary interventions for psoriasis and their outcome. METHODS: Terms "psoriasis AND diet" were used to search PubMed database and 63 articles describing dietary changes influencing psoriasis were selected. RESULTS: Low calorie diet (LCD) improves Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) in conjunction with topical or systemic therapy, although LCD was unsuccessful in maintaining disease remission when patients discontinued concomitant cyclosporine or methotrexate therapy...
February 15, 2019: Dermatology Online Journal
Mike Taylor, George Ousler, Gail Torkildsen, Claire Walshe, Matthew C T Fyfe, Adele Rowley, Steve Webber, John D Sheppard, Ajay Duggal
Purpose: To evaluate the safety and efficacy of topical TOP1630, a novel nonsystemic kinase inhibitor, in dry eye disease (DED). Patients and methods: A randomized, double-masked, parallel-group trial of 0.1% TOP1630 ophthalmic solution TID or placebo (vehicle without active drug) was conducted in DED subjects (n=61). Key eligibility criteria consistent with enrolling a moderate to severe DED population included >6 months DED history; OSDI© score ≥18; Schirmer's test score ≤10 and ≥1 mm/5 minutes; tear film break-up time >1 and <7 seconds; and dry eye exacerbation in corneal staining and ocular discomfort in a Controlled Adverse Environment (CAE® )...
2019: Clinical Ophthalmology
Sergei V Jargin
It is evident from reviewing of scientific literature that the quality of argumentation in some areas of medical research has deteriorated during last decades. Publication of series of questionable reliability have been continued without making references to the published criticism; examples are discussed in this review. Another tendency is that drugs without proven efficiency are advertised, corresponding products patented and marketed as evidence-based medications. Professional publications are required to register drugs and dietary supplements to obtain permissions for the practical use; and such papers appeared, sometimes being of questionable reliability...
March 7, 2019: Recent Patents on Drug Delivery & Formulation
Haley Isaac, John Riehl
OBJECTIVES: This meta-analysis was performed to answer the following questions: (1) What is the expected outcome of SC dislocations left untreated? (2) What are the indications for closed reduction of SC dislocations? (3) What are the indications for open reduction of SC dislocations? (4) Does the evidence support the need for a cardiothoracic surgeon to be available for the open reduction of a SC dislocation? DATA SOURCES: Articles were obtained from the database EBSCOhost and supplemented by hand searching of bibliographies of included references...
February 26, 2019: Journal of Orthopaedic Trauma
Ahmed G Osman, Saqlain Haider, Amar G Chittiboyina, Ikhlas A Khan
BACKGROUND: Selecting the appropriate chemical and bio-markers for monitoring the quality, efficacy, and safety is critical for efficient and reliable assessment of traditional medicines derived from botanical sources. Chemical markers have been implicated primarily in establishing the analytical methodologies aiming at verification of the botanical sources of the raw materials, the extracts, and the finished products such as botanical dietary supplements and nutraceuticals. In addition, they have been employed in differentiation between crude or raw (unprocessed) and processed plant extracts, and identification as well as determination of potential toxicants and adulterants in herbal medicines...
February 15, 2019: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Rano Zakirova Engstrand, Lise Roll-Pettersson, Mara Westling Allodi, Tatja Hirvikoski
Little is known about needs of grandparents of young children with autism in family and community settings. This study investigated perceived needs of grandparents of preschool-aged children diagnosed with ASD in the cultural context of Sweden. Participants were 120 grandparents of children enrolled into autism intervention programs provided by the public disability services in Stockholm. The Grandparents' Needs Survey and the SDQ Impact supplement were used to collect data. Grandparents expressed most needs in topic areas of information and childcare...
March 1, 2019: Journal of Autism and Developmental Disorders
Mathieu Maltais, Philipe de Souto Barreto, Kristell Pother, Christelle Cantet, Sandrine Andrieu, Yves Rolland, Bruno Vellas
BACKGROUND: We tested the associations of a lifestyle multidomain intervention (MI), omega-3 supplementation (O3) or their combination with the change of clinically meaningful depressive symptoms in older adults. METHODS: Secondary analysis of the 3-year Multidomain Alzheimer Preventive Trial (MAPT), in which 1679 people, ≥70 years with memory complaints were randomized into: MI, O3, MI + O3, or placebo. MI was composed of nutritional and physical activity counselling and cognitive training...
February 25, 2019: Experimental Gerontology
Pavel Horky, Sylvie Skalickova, Lenka Urbankova, Daria Baholet, Silvia Kociova, Zuzana Bytesnikova, Eliska Kabourkova, Zuzana Lackova, Natalia Cernei, Milica Gagic, Vedran Milosavljevic, Vendula Smolikova, Eva Vaclavkova, Pavel Nevrkla, Pavel Knot, Olga Krystofova, David Hynek, Pavel Kopel, Jiri Skladanka, Vojtech Adam, Kristyna Smerkova
Background: Development of new nanomaterials that inhibit or kill bacteria is an important and timely research topic. For example, financial losses due to infectious diseases, such as diarrhea, are a major concern in livestock productions around the world. Antimicrobial nanoparticles (NPs) represent a promising alternative to antibiotics and may lower antibiotic use and consequently spread of antibiotic resistance traits among bacteria, including pathogens. Results: Four formulations of zinc nanoparticles (ZnA, ZnB, ZnC, and ZnD) based on phosphates with spherical (ZnA, ZnB) or irregular (ZnC, ZnD) morphology were prepared...
2019: Journal of Animal Science and Biotechnology
Klaudia Berk, Krzysztof Drygalski, Ewa Harasim-Symbor, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
AIMS: The aim of this study was to assess the effects of enterolactone (ENL) on lipid fractions fatty acids composition affecting hepatocyte inflammation development. MAIN METHODS: The experiments were conducted in HepG2 cells incubated with ENL and/or palmitic acid (16 h). Intracellular contents of free fatty acids (FFA), di- (DAG) and tri- (TAG) acylglycerol as well as their fatty acids compositions were assessed by Gas-Liquid Chromatography. Moreover, the ω-6/ω-3 ratios in the above mentioned lipids fractions were estimated...
February 22, 2019: Life Sciences
Alex E Mohr, Marc Girard, Melissah Rowe, Kevin J McGraw, Karen L Sweazea
Carotenoids are regarded as a cornerstone of avian vitality and coloration. Currently, the antioxidant potential of dietary carotenoids is debated for birds. Although some studies support a protective role, others report either no effect or pro-oxidant effects. However, the majority of research on this topic has not analyzed the oxidative status of a series of tissues in animals nor considered a range of carotenoid dosages. We investigated the effects of three levels of carotenoid supplementation on plasma, liver, adipose, heart and breast muscle oxidative damage in two congeneric species of waterfowl that exhibit marked differences in carotenoid coloration...
February 19, 2019: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Juan Mielgo-Ayuso, Julio Calleja-Gonzalez, Juan Del Coso, Aritz Urdampilleta, Patxi León-Guereño, Diego Fernández-Lázaro
Soccer is a complex team sport and success in this discipline depends on different factors such as physical fitness, player technique and team tactics, among others. In the last few years, several studies have described the impact of caffeine intake on soccer physical performance, but the results of these investigations have not been properly reviewed and summarized. The main objective of this review was to evaluate critically the effectiveness of a moderate dose of caffeine on soccer physical performance. A structured search was carried out following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the Medline/PubMed and Web of Science databases from January 2007 to November 2018...
February 20, 2019: Nutrients
Norihiko Yokoi, Georgi As Georgiev
Tear-film (TF) stability protects the ocular surface epithelium from desiccation and is ensured via cooperation between the ocular surface components including constituents of the TF and ocular surface epithelium. Thus, when those components are insufficient or impaired, the TF breakup that initiates dry eye occurs. Recently, new, commercially available eye drops have appeared in Japan that enable TF stabilization via targeted supplementation of deficient ocular surface components. Hence, a new layer-by-layer diagnosis and treatment concept for dry eye, termed tear-film-oriented diagnosis and tear-film-oriented therapy (TFOD and TFOT, respectively), have emerged and become widely accepted in Asian countries and beyond...
February 19, 2019: Japanese Journal of Ophthalmology
Jan-Christoph Edelmann, Dominik Mair, Daniel Ziesel, Martin Burtscher, Thomas Ussmueller
This work introduces a low-cost open-source electrocardiography (ECG) simulator comprising both MATLAB software for signal generation and a dedicated circuit board for signal output via a commercial sound card. Synthetic, rate-dependent ECG simulation is based on third-order polynomials that are calculated in sections for the main waves and spikes, respectively. Besides the heart rate, the output profile is fully adjustable with respect to Einthoven lead signals I-III, the amplitudes of the individual ECG waves and spikes, as well as the constitution and intensity of common distortions...
February 18, 2019: Journal of Medical Engineering & Technology
(no author information available yet)
Each abstract has been indexed according to the first author. Abstracts appear as they were submitted and have not undergone editing or the Oncology Nursing Forum's review process. Only abstracts that will be presented appear here. Poster numbers are subject to change. For updated poster numbers, visit or check the Congress guide. Data published in abstracts presented at the ONS 44th Annual Congress are embargoed until the conclusion of the presentation. Coverage and/or distribution of an abstract, poster, or any of its supplemental material to or by the news media, any commercial entity, or individuals, including the authors of said abstract, is strictly prohibited until the embargo is lifted...
March 1, 2019: Oncology Nursing Forum
(no author information available yet)
Each abstract has been indexed according to first author. Abstracts appear as they were submitted and have not undergone editing or the Oncology Nursing Forum's review process. Only abstracts that will be presented appear here. For Congress scheduling information, visit or check the Congress guide. Data published in abstracts presented at the ONS 44th Annual Congress are embargoed until the conclusion of the presentation. Coverage and/or distribution of an abstract, poster, or any of its supplemental material to or by the news media, any commercial entity, or individuals, including the authors of said abstract, is strictly prohibited until the embargo is lifted...
March 1, 2019: Oncology Nursing Forum
E I Karpov
The interest in the prostate cancer prevention is associated with high incidence and slow growth of tumor. Despite the lack of clinical guidelines for prostate cancer prevention, more and more studies are carried out dedicated to this topic. Since prostate cancer prevention requires prolonged use, the substances derived from food are seems to be the most appropriate. The two most well-known and studied substances are indole-3-carbinol (I3C), obtained from cruciferous plants, and epigallocatechin-3-gallate (EGCG), contained in green tea...
December 2018: Urologii︠a︡
P Shamna, V K Govindan, K A Abdul Nazeer
BACKGROUND AND OBJECTIVE: Retrieval of medical images from an anatomically diverse dataset is a challenging task. Objective of our present study is to analyse the automated medical image retrieval system incorporating topic and location probabilities to enhance the performance. MATERIALS AND METHODS: In this paper, we present an automated medical image retrieval system using Topic andLocation Model. The topic information is generated using Guided Latent Dirichlet Allocation (GuidedLDA) method...
February 6, 2019: Journal of Biomedical Informatics
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