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Imported malaria

Qiang Zeng, Lisa Xie, Jing Zhang, Chau Vuong, Brittney Potter, Samantha Aylor, Jason Sousa, Chad Black, Qigui Li
Particle size is an important determinant of gastrointestinal absorption of compounds administrated orally. The present study evaluates the effect of a reduction in particle size assessed by homogenization, sonication, and homogenization plus sonication on the bioavailability of imidazolidinedione (IZ), an antimalarial compound with known causal prophylactic activity and radical cure of relapsing malaria. Formulations were administrated intragastrically to mice, and blood samples were collected for LC-MS/MS analysis...
March 1, 2019: Military Medicine
R M La Hoz, M I Morris
These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of tissue and blood protozoal infections in the pre- and post-transplant period. Significant new developments in the field have made it necessary to divide the previous single guideline published in 2013 into two sections, with the intestinal parasites separated from this guideline devoted to tissue and blood protozoa. The current update reflects the increased focus on donor screening and risk-based recipient monitoring for parasitic infections...
March 21, 2019: Clinical Transplantation
Dandan Wang, Zeming Zhang, Shuang Cui, Yingchi Zhao, Samuel Craft, Erol Fikrig, Fuping You
Platelet factor 4 (PF4) is an anti- Plasmodium component of platelets. It is expressed in megakaryocytes and released from platelets following infection with Plasmodium Innate immunity is crucial for the host anti- Plasmodium response, in which type I interferon plays an important role. Whether there is a crosstalk between innate immune signaling and the production of anti- Plasmodium defense peptides is unknown. Here, we demonstrate that E74 like ETS transcription factor 4 (ELF4), a type I interferon activator, can help protect the host from Plasmodium yoelii infection...
March 21, 2019: Journal of Biological Chemistry
Shahyad Azari-Hamidian, Behzad Norouzi, Ralph E Harbach
Mosquitoes (Diptera: Culicidae) are the most significant arthropods of medical importance because of the burden of diseases, such as malaria, encephalitis and filariasis, which are caused by pathogens and parasites they transmit to humans. In 2007, the most recently published checklist of Iranian mosquitoes included 64 species representing seven genera. Public databases were searched to the end of August 2018 for publications concerning the diseases in Iran caused by mosquito-borne pathogens. Pertinent information was extracted and analyzed, and the checklist of Iranian mosquitoes was updated...
March 18, 2019: Acta Tropica
John D Scott, Kerry L Clark, Lance A Durden
Wild birds transport ticks into Canada that harbor a diversity of zoonotic pathogens. However, medical practitioners often question how these zoonotic pathogens are present in their locality. In this study, we provide the first report of an Amblyomma inornatum tick cofeeding with a blacklegged tick, Ixodes scapularis , which parasitized a Veery, Catharus fuscescens -a neotropical songbird. Using the flagellin ( flaB ) gene of the Lyme disease bacterium, Borrelia burgdorferi sensu lato, and the 18S rRNA gene of the Babesia piroplasm, a malaria-like microorganism, we detected Borrelia burgdorferi sensu stricto and Babesia odocoilei , respectively, in an I...
March 20, 2019: Healthcare (Basel, Switzerland)
Qiyi He, Zhentian Yan, Fengling Si, Yong Zhou, Wenbo Fu, Bin Chen
background : The ATP-binding cassette (ABC) transporters family is one of the largest families of membrane proteins existing in all living organisms. Pyrethroid resistance has become the largest unique obstacle for mosquito control worldwide. ABC transporters are thought to be associated with pyrethroid resistance in some agricultural pests, but little information is known for mosquitoes. Herein, we investigated the diversity, location, characteristics, phylogenetics, and evolution of ABC transporter family of genes in the Anopheles sinensis genome, and identified the ABC transporter genes associated with pyrethroid resistance through expression profiles using RNA-seq and qPCR...
March 20, 2019: International Journal of Molecular Sciences
David Mariano, Darvin Scott Smith
PURPOSE OF REVIEW: Infectious diseases are a risk when traveling internationally, and it is important to know the potential disease burden of a region and take appropriate preventative actions before traveling. For individuals with HIV, there are special considerations and contradictions for various vaccines and medications as well as interactions with likely antiviral drugs. The purpose of this review is to summarize the vaccine and medication recommendations for travelers with HIV infection...
March 20, 2019: Current Infectious Disease Reports
Albert E Zhou, Andrea A Berry, Jason A Bailey, Andrew Pike, Antoine Dara, Sonia Agrawal, Emily M Stucke, Amed Ouattara, Drissa Coulibaly, Kirsten E Lyke, Matthew B Laurens, Matthew Adams, Shannon Takala-Harrison, Jozelyn Pablo, Algis Jasinskas, Rie Nakajima, Amadou Niangaly, Bourema Kouriba, Abdoulaye K Kone, J Alexandra Rowe, Ogobara K Doumbo, Mahamadou A Thera, Jigar J Patel, John C Tan, Philip L Felgner, Christopher V Plowe, Mark A Travassos
The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are potential targets in the development of natural immunity. Protein and peptide microarrays populated with RIFINs and STEVORs associated with severe malaria vulnerability in Malian children were probed with adult and pediatric sera to identify epitopes that reflect malaria exposure...
March 20, 2019: MSphere
Wang Xue-Dong, Jiang Ling, Huang Feng, Liu Bin, Rong Yi
OBJECTIVE: To evaluate the effects of WeChat publicity in imported malaria control in timber industry in Zhangjiagang City, so as to provide new ideas for the control of malaria imported from abroad. METHODS: The data of malaria epidemic in Zhangjiagang City was collected, and the contact way of the overseas personnel in timber industry in Zhangjiagang City were obtained. The knowledge of the prevention and control of malaria was propagandized by WeChat among these personnel, and the awareness situation of malaria control knowledge of this population was investigated by questionnaires before and after the WeChat publicity...
August 6, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Liu Su-Zhen, Ji Feng-Ying, Li Xue-Kui
OBJECTIVE: To investigate the epidemic situation and its epidemic characteristics of malaria in Qingdao City from 2012 to 2017, so as to provide the evidence for the prevention and control of malaria in this city. METHODS: The data of cases and epidemiological characteristics of malaria in Qingdao City, 2012-2017 were collected from the China's disease prevention and control system infectious disease report information management system and parasitic disease prevention and control information management system, and analyzed...
January 5, 2019: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Li Ai-Hua, Wang Lin, Li Sha-Sha
OBJECTIVE: To analyze the epidemic situation and epidemiological characteristics of malaria in Zhenjiang City from 2004 to 2017, so as to provide the evidence for formulating the reasonable strategies and measures for malaria prevention and control. METHODS: The epidemiological data of malaria in Zhenjiang City from 2004 to 2017 were collected and analyzed for the epidemic situation, epidemiological characteristics, species of Plasmodium , blood test status for febrile patients...
November 15, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Jessica Briggs, John Ategeka, Richard Kajubi, Teddy Ochieng, Abel Kakuru, Cephus Ssemanda, Razack Wasswa, Prasanna Jagannathan, Bryan Greenhouse, Isabel Rodriquez-Barraquer, Moses Kamya, Grant Dorsey
BACKGROUND: Placental malaria is a major cause of adverse birth outcomes. However, data are limited on the relationships between longitudinal measures of parasitemia during pregnancy and placental malaria. METHODS: Data come from 637 women enrolled in a randomized controlled trial of intermittent preventive treatment of malaria in pregnancy (IPTp) from Uganda. Plasmodium falciparum parasitemia was assessed using microscopy and ultrasensitive quantitative PCR at intervals of 28 days from 12-20 weeks gestation through delivery...
March 19, 2019: Journal of Infectious Diseases
Martin Amogre Ayanore, John Tetteh, Asiwome Ameko, Wisdom Kudzo Axame, Robert Kaba Alhassan, Augustine Adoliba Ayanore, Victor Mogre, Seth Owusu-Agyei
Introduction: Malaria is a major cause of morbidity and mortality worldwide, requiring individual and environmental level controls to prevent its adverse morbidity effects. This study examined reproductive-aged women's knowledge and care-seeking practices for malaria prevention and control in Ghana. Methods: The 2016 Ghana Malaria Indicator Survey data for reproductive-age women was analysed (n=5,150). Multilevel mixed-effects logistic regression model was used to determine factors associated with reproductive-aged women's knowledge and care-seeking practices for malaria...
2019: Journal of Tropical Medicine
Rebecca E Tweedell, Dingyin Tao, Timothy Hamerly, Tanisha M Robinson, Simon Larsen, Alexander G B Grønning, Alessandra M Norris, Jonas G King, Henry Chun Hin Law, Jan Baumbach, Elke S Bergmann-Leitner, Rhoel R Dinglasan
In vitro studies of liver stage (LS) development of the human malaria parasite Plasmodium falciparum are technically challenging; therefore, fundamental questions about hepatocyte receptors for invasion that can be targeted to prevent infection remain unanswered. To identify novel receptors and to further understand human hepatocyte susceptibility to P. falciparum sporozoite invasion, we created an optimized in vitro system by mimicking in vivo liver conditions and using the subcloned HC-04.J7 cell line that supports mean infection rates of 3-5% and early development of P...
2019: Frontiers in Microbiology
Marta F Maia, Melissa Kapulu, Michelle Muthui, Martin G Wagah, Heather M Ferguson, Floyd E Dowell, Francesco Baldini, Lisa-Ranford Cartwright
BACKGROUND: Large-scale surveillance of mosquito populations is crucial to assess the intensity of vector-borne disease transmission and the impact of control interventions. However, there is a lack of accurate, cost-effective and high-throughput tools for mass-screening of vectors. METHODS: A total of 750 Anopheles gambiae (Keele strain) mosquitoes were fed Plasmodium falciparum NF54 gametocytes through standard membrane feeding assay (SMFA) and afterwards maintained in insectary conditions to allow for oocyst (8 days) and sporozoite development (14 days)...
March 19, 2019: Malaria Journal
Rekha Gautam, Yinxiao Xiang, Josh Lamstein, Yi Liang, Anna Bezryadina, Guo Liang, Tobias Hansson, Benjamin Wetzel, Daryl Preece, Adam White, Matthew Silverman, Susan Kazarian, Jingjun Xu, Roberto Morandotti, Zhigang Chen
Osmotic conditions play an important role in the cell properties of human red blood cells (RBCs), which are crucial for the pathological analysis of some blood diseases such as malaria. Over the past decades, numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes. Here, we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions. Specifically, we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions, where the strength of the optical nonlinearity increases with osmotic pressure on the cells...
2019: Light, Science & Applications
Jan-Gero Schloetel, Jörn Heine, Alan F Cowman, Michał Pasternak
Malaria remains a major burden world-wide, but the disease-causing parasites from the genus Plasmodium are difficult to study in vitro. Owing to the small size of the parasites, subcellular imaging poses a major challenge and the use of super-resolution techniques has been hindered by the parasites' sensitivity to light. This is particularly apparent during the blood-stage of the Plasmodium life cycle, which presents an important target for drug research. The iron-rich food vacuole of the parasite undergoes disintegration when illuminated with high-power lasers such as those required for high resolution in Stimulated Emission Depletion (STED) microscopy...
March 18, 2019: Scientific Reports
C Leblanc, C Vasse, P Minodier, P Mornand, J Naudin, B Quinet, J Y Siriez, F Sorge, N de Suremain, M Thellier, E Kendjo, A Faye, P Imbert
Since the 2007 French guidelines on imported Falciparum malaria, the epidemiology, treatment, and prevention of malaria have changed considerably requiring guidelines for all Plasmodium species to be updated. Over the past decade, the incidence of imported malaria has decreased in all age groups, reflecting the decrease in the incidence of malaria in endemic areas. The rates of severe pediatric cases have increased as in adults, but fatalities are rare. The parasitological diagnosis requires a thick blood smear (or a rapid immunochromatographic test) and a thin blood smear...
March 15, 2019: Médecine et Maladies Infectieuses
Sabrina Yahiya, Ainoa Rueda-Zubiaurre, Michael J Delves, Matthew J Fuchter, Jake Baum
In recent years, the research agenda to tackle global morbidity and mortality from malaria disease has shifted towards innovation, in the hope that efforts at the frontiers of scientific research may re-invigorate gains made towards eradication. Discovery of new antimalarial drugs with novel chemotypes or modes of action lie at the heart of these efforts. There is a particular interest in drug candidates that target stages of the malaria parasite lifecycle beyond the symptomatic asexual blood stages. This is especially important given the spectre of emerging drug resistance to all current frontline antimalarials...
March 12, 2019: Current Opinion in Chemical Biology
N Elket, E Kendjo, M Thellier, L Assoumou, V Potard, A Taieb, I Tantaoui, E Caumes, R Piarroux, C Roussel, P Buffet, D Costagliola, S Jauréguiberry
BACKGROUND: Little is known on the use of artesunate compared to quinine for the treatment of imported malaria cases in non-endemic countries with high level of care. Therefore, we compared the two treatments in terms of mortality, hospital and intensive care unit discharge rates. METHODS: We analyzed the cohort of all severe imported malaria patients reported to the French National Reference Center from 2011 to 2017. After controlling for differences between quinine and artesunate treated individuals using the inverse probability of treatment weighting method, 28 day mortality rate was compared between the groups as well as hospital and ICU discharge rates using Kaplan Meier estimation and weighted Cox proportional hazard models...
March 15, 2019: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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