Valerie Y Chock, Haresh Kirpalani, Edward F Bell, Sylvia Tan, Susan R Hintz, M Bethany Ball, Emily Smith, Abhik Das, Yvonne C Loggins, Beena G Sood, Lina F Chalak, Myra H Wyckoff, Stephen D Kicklighter, Kathleen A Kennedy, Ravi M Patel, Waldemar A Carlo, Karen J Johnson, Kristi L Watterberg, Pablo J Sánchez, Abbot R Laptook, Ruth B Seabrook, C Michael Cotten, Toni Mancini, Gregory M Sokol, Robin K Ohls, Anna Maria Hibbs, Brenda B Poindexter, Anne Marie Reynolds, Sara B DeMauro, Sanjay Chawla, Mariana Baserga, Michele C Walsh, Rosemary D Higgins, Krisa P Van Meurs
IMPORTANCE: Preterm infants with varying degrees of anemia have different tissue oxygen saturation responses to red blood cell (RBC) transfusion, and low cerebral saturation may be associated with adverse outcomes. OBJECTIVE: To determine whether RBC transfusion in preterm infants is associated with increases in cerebral and mesenteric tissue saturation (Csat and Msat, respectively) or decreases in cerebral and mesenteric fractional tissue oxygen extraction (cFTOE and mFTOE, respectively) and whether associations vary based on degree of anemia, and to investigate the association of Csat with death or neurodevelopmental impairment (NDI) at 22 to 26 months corrected age...
September 5, 2023: JAMA Network Open